{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:48:29Z","timestamp":1791575309666,"version":"4.3.4"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci. China Life Sci."],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s11427-024-2911-8","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T02:01:54Z","timestamp":1750730514000},"page":"2707-2722","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["3-Indolepropionic acid confers PXR-p53 binding to mitigate deoxynivalenol-induced hepatocyte apoptosis"],"prefix":"10.1007","volume":"68","author":[{"given":"Yue","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zishen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyue","family":"Men","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiakun","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"2911_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.toxicon.2017.12.045","volume":"142","author":"MA Abdel-Wahhab","year":"2018","unstructured":"Abdel-Wahhab, M.A., El-Nekeety, A.A., Salman, A.S., Abdel-Aziem, S.H., Mehaya, F. M., and Hassan, N.S. (2018). Protective capabilities of silymarin and inulin nanoparticles against hepatic oxidative stress, genotoxicity and cytotoxicity of deoxynivalenol in rats. Toxicon 142, 1\u201313.","journal-title":"Toxicon"},{"key":"2911_CR2","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/S0887-2333(02)00059-0","volume":"16","author":"H Alm","year":"2002","unstructured":"Alm, H., Greising, T., Br\u00fcssow, K.P., Torner, H., and Tiemann, U. (2002). The influence of the mycotoxins deoxynivalenol and zearalenol on in vitro maturation of pig oocytes and in vitro culture of pig zygotes. Toxicol in Vitro 16, 643\u2013648.","journal-title":"Toxicol in Vitro"},{"key":"2911_CR3","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.molmed.2009.09.005","volume":"15","author":"JD Amaral","year":"2009","unstructured":"Amaral, J.D., Castro, R.E., Steer, C.J., and Rodrigues, C.M.P. (2009). p53 and the regulation of hepatocyte apoptosis: implications for disease pathogenesis. Trends Mol Med 15, 531\u2013541.","journal-title":"Trends Mol Med"},{"key":"2911_CR4","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/cdd.2017.169","volume":"25","author":"BJ Aubrey","year":"2018","unstructured":"Aubrey, B.J., Kelly, G.L., Janic, A., Herold, M.J., and Strasser, A. (2018). How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Cell Death Differ 25, 104\u2013113.","journal-title":"Cell Death Differ"},{"key":"2911_CR5","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.drudis.2014.11.011","volume":"20","author":"M Banerjee","year":"2015","unstructured":"Banerjee, M., Robbins, D., and Chen, T. (2015). Targeting xenobiotic receptors PXR and CAR in human diseases. Drug Discov Today 20, 618\u2013628.","journal-title":"Drug Discov Today"},{"key":"2911_CR6","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1007\/s00204-014-1348-x","volume":"89","author":"A Bitter","year":"2015","unstructured":"Bitter, A., R\u00fcmmele, P., Klein, K., Kandel, B.A., Rieger, J.K., N\u00fcssler, A.K., Zanger, U. M., Trauner, M., Schwab, M., and Burk, O. (2015). Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms. Arch Toxicol 89, 2089\u20132103.","journal-title":"Arch Toxicol"},{"key":"2911_CR7","doi-asserted-by":"publisher","first-page":"22804","DOI":"10.1074\/jbc.M700961200","volume":"282","author":"CL Brooks","year":"2007","unstructured":"Brooks, C.L., Li, M., and Gu, W. (2007). Mechanistic studies of MDM2-mediated ubiquitination in p53 regulation. J Biol Chem 282, 22804\u201322815.","journal-title":"J Biol Chem"},{"key":"2911_CR8","doi-asserted-by":"publisher","first-page":"189","DOI":"10.3892\/mmr.2024.13313","volume":"30","author":"Y Chen","year":"2024","unstructured":"Chen, Y., Li, Y., Li, X., Fang, Q., Li, F., Chen, S., and Chen, W. (2024). Indole-3-propionic acid alleviates intestinal epithelial cell injury via regulation of the TLR4\/NF-\u03baB pathway to improve intestinal barrier function. Mol Med Rep 30, 189.","journal-title":"Mol Med Rep"},{"key":"2911_CR9","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1007\/s11427-022-2409-0","volume":"66","author":"Z Dong","year":"2023","unstructured":"Dong, Z., Liu, S., Deng, Q., Li, G., Tang, Y., Wu, X., Wan, D., and Yin, Y. (2023). Role of iron in host-microbiota interaction and its effects on intestinal mucosal growth and immune plasticity in a piglet model. Sci China Life Sci 66, 2086\u20132098.","journal-title":"Sci China Life Sci"},{"key":"2911_CR10","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1124\/mol.113.085092","volume":"83","author":"A Elias","year":"2013","unstructured":"Elias, A., Wu, J., and Chen, T. (2013). Tumor suppressor protein p53 negatively regulates human pregnane X receptor activity. Mol Pharmacol 83, 1229\u20131236.","journal-title":"Mol Pharmacol"},{"key":"2911_CR11","doi-asserted-by":"publisher","first-page":"3368","DOI":"10.1038\/s41467-023-39118-9","volume":"14","author":"S Fan","year":"2023","unstructured":"Fan, S., Yan, Y., Xia, Y., Zhou, Z., Luo, L., Zhu, M., Han, Y., Yao, D., Zhang, L., Fang, M., et al. (2023). Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions. Nat Commun 14, 3368.","journal-title":"Nat Commun"},{"key":"2911_CR12","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1038\/s41418-023-01130-3","volume":"30","author":"Y Feng","year":"2023","unstructured":"Feng, Y., Guo, S., Zhao, Y., Dong, H., Qian, J., Hu, Y., Wu, L., Jia, Y., and Zhao, R. (2023). DNA 5mC and RNA m6A modification successively facilitates the initiation and perpetuation stages of HSC activation in liver fibrosis progression. Cell Death Differ 30, 1211\u20131220.","journal-title":"Cell Death Differ"},{"key":"2911_CR13","doi-asserted-by":"publisher","first-page":"e2308742","DOI":"10.1002\/advs.202308742","volume":"11","author":"Y Feng","year":"2024","unstructured":"Feng, Y., Shen, J., Lin, Z., Chen, Z., Zhou, M., and Ma, X. (2024). PXR activation relieves deoxynivalenol-induced liver oxidative stress via Malat1 lncRNA m6A demethylation. Adv Sci 11, e2308742.","journal-title":"Adv Sci"},{"key":"2911_CR14","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.fct.2017.12.066","volume":"112","author":"X Gao","year":"2018","unstructured":"Gao, X., Mu, P., Wen, J., Sun, Y., Chen, Q., and Deng, Y. (2018). Detoxification of trichothecene mycotoxins by a novel bacterium, Eggerthella sp. DII-9. Food Chem Toxicol 112, 310\u2013319.","journal-title":"DII-9. Food Chem Toxicol"},{"key":"2911_CR15","doi-asserted-by":"publisher","first-page":"4054","DOI":"10.1038\/s41467-024-48472-1","volume":"15","author":"E Garcia-Maldonado","year":"2024","unstructured":"Garcia-Maldonado, E., Huber, A.D., Chai, S.C., Nithianantham, S., Li, Y., Wu, J., Poudel, S., Miller, D.J., Seetharaman, J., and Chen, T. (2024). Chemical manipulation of an activation\/inhibition switch in the nuclear receptor PXR. Nat Commun 15, 4054.","journal-title":"Nat Commun"},{"key":"2911_CR16","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.toxlet.2005.10.007","volume":"163","author":"T Goyarts","year":"2006","unstructured":"Goyarts, T., and D\u00e4nicke, S. (2006). Bioavailability of the Fusarium toxin deoxynivalenol (DON) from naturally contaminated wheat for the pig. Toxicol Lett 163, 171\u2013182.","journal-title":"Toxicol Lett"},{"key":"2911_CR17","doi-asserted-by":"publisher","first-page":"6711","DOI":"10.1021\/jf400213q","volume":"61","author":"B Grenier","year":"2013","unstructured":"Grenier, B., Bracarense, A.P.F.L., Schwartz, H.E., Lucioli, J., Cossalter, A.M., Moll, W. D., Schatzmayr, G., and Oswald, I.P. (2013). Biotransformation approaches to alleviate the effects induced by Fusarium mycotoxins in swine. J Agric Food Chem 61, 6711\u20136719.","journal-title":"J Agric Food Chem"},{"key":"2911_CR18","doi-asserted-by":"publisher","first-page":"375","DOI":"10.3390\/toxins11070375","volume":"11","author":"C Gruber-Dorninger","year":"2019","unstructured":"Gruber-Dorninger, C., Jenkins, T., and Schatzmayr, G. (2019). Global mycotoxin occurrence in feed: a ten-year survey. Toxins 11, 375.","journal-title":"Toxins"},{"key":"2911_CR19","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1007\/s11427-024-2654-2","volume":"68","author":"L Guo","year":"2025","unstructured":"Guo, L., Xu, J., Zhou, W., Chen, S., Shi, H., Han, M., Yang, Z., Duan, Y., Pang, W., Yin, Y., et al. (2025). Metabolome and RNA-seq reveal discrepant metabolism and secretory metabolism profile in skeletal muscle between obese and lean pigs at different ages. Sci China Life Sci 68, 1102\u20131117.","journal-title":"Sci China Life Sci"},{"key":"2911_CR20","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s40104-019-0402-1","volume":"11","author":"P Guo","year":"2020","unstructured":"Guo, P., Zhang, K., Ma, X., and He, P. (2020). Clostridium species as probiotics: potentials and challenges. J Anim Sci Biotechnol 11, 24.","journal-title":"J Anim Sci Biotechnol"},{"key":"2911_CR21","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1111\/j.1440-1681.2009.05152.x","volume":"36","author":"R Guo","year":"2009","unstructured":"Guo, R., Zhong, L., and Ren, J. (2009). Overexpression of aldehyde dehydrogenase-2 attenuates chronic alcohol exposure-induced apoptosis, change in Akt and Pim signalling in liver. Clin Exp Pharmacol Physiol 36, 463\u2013468.","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"2911_CR22","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/S1535-6108(03)00244-7","volume":"4","author":"JR Jeffers","year":"2003","unstructured":"Jeffers, J.R., Parganas, E., Lee, Y., Yang, C., Wang, J.L., Brennan, J., MacLean, K.H., Han, J., Chittenden, T., Ihle, J.N., et al. (2003). Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 4, 321\u2013328.","journal-title":"Cancer Cell"},{"key":"2911_CR23","doi-asserted-by":"publisher","first-page":"131172","DOI":"10.1016\/j.jhazmat.2023.131172","volume":"451","author":"B Jia","year":"2023","unstructured":"Jia, B., Lin, H., Yu, S., Liu, N., Yu, D., and Wu, A. (2023). Mycotoxin deoxynivalenol-induced intestinal flora disorders, dysfunction and organ damage in broilers and pigs. J Hazard Mater 451, 131172.","journal-title":"J Hazard Mater"},{"key":"2911_CR24","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1007\/s11427-022-2339-0","volume":"66","author":"S Jin","year":"2023","unstructured":"Jin, S., He, L., Yang, C., He, X., Chen, H., Feng, Y., Tang, W., Li, J., Liu, D., and Li, T. (2023). Crosstalk between trace elements and T-cell immunity during early-life health in pigs. Sci China Life Sci 66, 1994\u20132005.","journal-title":"Sci China Life Sci"},{"key":"2911_CR25","first-page":"e04718","volume":"15","author":"HK Knutsen","year":"2017","unstructured":"Knutsen, H.K., Alexander, J., Barreg\u00e5rd, L., Bignami, M., Br\u00fcschweiler, B., Ceccatelli, S., Cottrill, B., Dinovi, M., Grasl-Kraupp, B., Hogstrand, C., et al. (2017). Risks to human and animal health related to the presence of deoxynivalenol and its acetylated and modified forms in food and feed. EFS2 15, e04718.","journal-title":"EFS2"},{"key":"2911_CR26","doi-asserted-by":"publisher","first-page":"2412669","DOI":"10.1080\/19490976.2024.2412669","volume":"16","author":"FF Krause","year":"2024","unstructured":"Krause, F.F., Mangold, K.I., Ruppert, A.L., Leister, H., Hellhund-Zingel, A., Lopez Krol, A., Pesek, J., Watzer, B., Winterberg, S., Raifer, H., et al. (2024). Clostridium sporogenes-derived metabolites protect mice against colonic inflammation. Gut Microbes 16, 2412669.","journal-title":"Gut Microbes"},{"key":"2911_CR27","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s10565-007-9015-0","volume":"24","author":"M Lasfer","year":"2008","unstructured":"Lasfer, M., Vadrot, N., Aoudjehane, L., Conti, F., Bringuier, A.F., Feldmann, G., and Reyl-Desmars, F. (2008). Cadmium induces mitochondria-dependent apoptosis of normal human hepatocytes. Cell Biol Toxicol 24, 55\u201362.","journal-title":"Cell Biol Toxicol"},{"key":"2911_CR28","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1021\/acs.jafc.0c05205","volume":"69","author":"J Li","year":"2021","unstructured":"Li, J., Zhang, L., Wu, T., Li, Y., Zhou, X., and Ruan, Z. (2021). Indole-3-propionic acid improved the intestinal barrier by enhancing epithelial barrier and mucus barrier. J Agric Food Chem 69, 1487\u20131495.","journal-title":"J Agric Food Chem"},{"key":"2911_CR29","doi-asserted-by":"publisher","first-page":"1141378","DOI":"10.3389\/fmicb.2023.1141378","volume":"14","author":"Y Li","year":"2023","unstructured":"Li, Y., Gao, H., Wang, R., and Xu, Q. (2023). Deoxynivalenol in food and feed: recent advances in decontamination strategies. Front Microbiol 14, 1141378.","journal-title":"Front Microbiol"},{"key":"2911_CR30","doi-asserted-by":"publisher","first-page":"5452","DOI":"10.1021\/acs.jafc.3c08044","volume":"72","author":"Y Li","year":"2024","unstructured":"Li, Y., Zhu, C., Yao, J., Zhu, C., Li, Z., Liu, H.Y., Zhu, M., Li, K., Ahmed, A.A., Li, S., et al. (2024). Lithocholic acid alleviates deoxynivalenol-induced inflammation and oxidative stress via PPAR\u03b3-mediated epigenetically transcriptional reprogramming in porcine intestinal epithelial cells. J Agric Food Chem 72, 5452\u20135462.","journal-title":"J Agric Food Chem"},{"key":"2911_CR31","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1002\/aro2.7","volume":"1","author":"C Liu","year":"2023","unstructured":"Liu, C., Ma, N., Feng, Y., Zhou, M., Li, H., Zhang, X., and Ma, X. (2023a). From probiotics to postbiotics: concepts and applications. Anim Res One Health 1, 92\u2013114.","journal-title":"Anim Res One Health"},{"key":"2911_CR32","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.1007\/s11427-022-2298-1","volume":"66","author":"S Liu","year":"2023","unstructured":"Liu, S., Dong, Z., Tang, W., Zhou, J., Guo, L., Gong, C., Liu, G., Wan, D., and Yin, Y. (2023b). Dietary iron regulates intestinal goblet cell function and alleviates Salmonella typhimurium invasion in mice. Sci China Life Sci 66, 2006\u20132019.","journal-title":"Sci China Life Sci"},{"key":"2911_CR33","doi-asserted-by":"publisher","first-page":"e54","DOI":"10.1002\/imt2.54","volume":"1","author":"N Ma","year":"2022","unstructured":"Ma, N., Chen, X., Johnston, L.J., and Ma, X. (2022). Gut microbiota-stem cell niche crosstalk: a new territory for maintaining intestinal homeostasis. iMeta 1, e54.","journal-title":"iMeta"},{"key":"2911_CR34","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3390\/toxins15020120","volume":"15","author":"JC Panisson","year":"2023","unstructured":"Panisson, J.C., Wellington, M.O., Bosompem, M.A., Nagl, V., Schwartz-Zimmermann, H.E., and Columbus, D.A. (2023). Urinary and serum concentration of deoxynivalenol (DON) and DON metabolites as an indicator of DON contamination in swine diets. Toxins 15, 120.","journal-title":"Toxins"},{"key":"2911_CR35","doi-asserted-by":"publisher","first-page":"90","DOI":"10.3390\/toxins14020090","volume":"14","author":"ACSM Pinto","year":"2022","unstructured":"Pinto, A.C.S.M., De Pierri, C.R., Evangelista, A.G., Gomes, A.S.L.P.B., and Luciano, F. B. (2022). Deoxynivalenol: toxicology, degradation by bacteria, and phylogenetic analysis. Toxins 14, 90.","journal-title":"Toxins"},{"key":"2911_CR36","doi-asserted-by":"crossref","unstructured":"Pondugula, S.R., Pavek, P., and Mani, S. (2016). Pregnane X receptor and cancer: context-specificity is key. Nucl Receptor Res 3.","DOI":"10.11131\/2016\/101198"},{"key":"2911_CR37","doi-asserted-by":"publisher","first-page":"16023","DOI":"10.1038\/cddiscovery.2016.23","volume":"2","author":"D Robbins","year":"2016","unstructured":"Robbins, D., Cherian, M., Wu, J., and Chen, T. (2016). Human pregnane X receptor compromises the function of p53 and promotes malignant transformation. Cell Death Discov 2, 16023.","journal-title":"Cell Death Discov"},{"key":"2911_CR38","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.livres.2018.12.002","volume":"2","author":"AI Shehu","year":"2018","unstructured":"Shehu, A.I., and Ma, X. (2018). Pregnane X receptor in drug-induced liver injury: friend or foe? Liver Res 2, 173\u2013179.","journal-title":"Liver Res"},{"key":"2911_CR39","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/cdd.2017.174","volume":"25","author":"KD Sullivan","year":"2018","unstructured":"Sullivan, K.D., Galbraith, M.D., Andrysik, Z., and Espinosa, J.M. (2018). Mechanisms of transcriptional regulation by p53. Cell Death Differ 25, 133\u2013143.","journal-title":"Cell Death Differ"},{"key":"2911_CR40","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.immuni.2014.06.014","volume":"41","author":"M Venkatesh","year":"2014","unstructured":"Venkatesh, M., Mukherjee, S., Wang, H., Li, H., Sun, K., Benechet, A.P., Qiu, Z., Maher, L., Redinbo, M.R., Phillips, R.S., et al. (2014). Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4. Immunity 41, 296\u2013310.","journal-title":"Immunity"},{"key":"2911_CR41","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.scitotenv.2018.09.133","volume":"651","author":"C Wang","year":"2019","unstructured":"Wang, C., Ku, P., Nie, X., Bao, S., Wang, Z., and Li, K. (2019). Effects of simvastatin on the PXR signaling pathway and the liver histology in Mugilogobius abei. Sci Total Environ 651, 399\u2013409.","journal-title":"Sci Total Environ"},{"key":"2911_CR42","doi-asserted-by":"publisher","first-page":"e0147613","DOI":"10.1371\/journal.pone.0147613","volume":"11","author":"L Wang","year":"2016","unstructured":"Wang, L., Shao, H., Luo, X., Wang, R., Li, Y., Li, Y., Luo, Y., Chen, Z., and Ma, W. (2016). Effect of ozone treatment on deoxynivalenol and wheat quality. PLoS One 11, e0147613.","journal-title":"PLoS One"},{"key":"2911_CR43","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1007\/s11427-022-2302-5","volume":"66","author":"L Xiao","year":"2023","unstructured":"Xiao, L., Tang, R., Wang, J., Wan, D., Yin, Y., and Xie, L. (2023). Gut microbiota bridges the iron homeostasis and host health. Sci China Life Sci 66, 1952\u20131975.","journal-title":"Sci China Life Sci"},{"key":"2911_CR44","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.apsb.2019.06.012","volume":"10","author":"Y Xing","year":"2020","unstructured":"Xing, Y., Yan, J., and Niu, Y. (2020). PXR: a center of transcriptional regulation in cancer. Acta Pharm Sin B 10, 197\u2013206.","journal-title":"Acta Pharm Sin B"},{"key":"2911_CR45","doi-asserted-by":"publisher","first-page":"132013","DOI":"10.1016\/j.jhazmat.2023.132013","volume":"459","author":"D Xue","year":"2023","unstructured":"Xue, D., Cheng, Y., Pang, T., Kuai, Y., An, Y., Wu, K., Li, Y., Lai, M., Wang, B., and Wang, S. (2023). Sodium butyrate alleviates deoxynivalenol-induced porcine intestinal barrier disruption by promoting mitochondrial homeostasis via PCK2 signaling. J Hazard Mater 459, 132013.","journal-title":"J Hazard Mater"},{"key":"2911_CR46","doi-asserted-by":"publisher","first-page":"122087","DOI":"10.1016\/j.jhazmat.2020.122087","volume":"389","author":"C Yang","year":"2020","unstructured":"Yang, C., Song, G., and Lim, W. (2020). Effects of mycotoxin-contaminated feed on farm animals. J Hazard Mater 389, 122087.","journal-title":"J Hazard Mater"},{"key":"2911_CR47","doi-asserted-by":"publisher","first-page":"3279","DOI":"10.1080\/10408398.2021.1995322","volume":"63","author":"J Zhang","year":"2023","unstructured":"Zhang, J., Pavek, P., Kamaraj, R., Ren, L., and Zhang, T. (2023). Dietary phytochemicals as modulators of human pregnane X receptor. Crit Rev Food Sci Nutr 63, 3279\u20133301.","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2911_CR48","doi-asserted-by":"publisher","first-page":"2056","DOI":"10.1007\/s11427-022-2226-1","volume":"66","author":"L Zhao","year":"2023","unstructured":"Zhao, L., Liu, M., Sun, H., Yang, J.C., Huang, Y.X., Huang, J.Q., Lei, X., and Sun, L.H. (2023). Selenium deficiency-induced multiple tissue damage with dysregulation of immune and redox homeostasis in broiler chicks under heat stress. Sci China Life Sci 66, 2056\u20132069.","journal-title":"Sci China Life Sci"},{"key":"2911_CR49","first-page":"1","volume":"51","author":"ZH Zhao","year":"2019","unstructured":"Zhao, Z.H., Xin, F.Z., Xue, Y., Hu, Z., Han, Y., Ma, F., Zhou, D., Liu, X.L., Cui, A., Liu, Z., et al. (2019). Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats. Exp Mol Med 51, 1\u201314.","journal-title":"Exp Mol Med"},{"key":"2911_CR50","doi-asserted-by":"publisher","first-page":"134601","DOI":"10.1016\/j.jhazmat.2024.134601","volume":"474","author":"B Zhou","year":"2024","unstructured":"Zhou, B., Xiao, K., Guo, J., Xu, Q., Xu, Q., Lv, Q., Zhu, H., Zhao, J., and Liu, Y. (2024). Necroptosis contributes to the intestinal toxicity of deoxynivalenol and is mediated by methyltransferase SETDB1. J Hazard Mater 474, 134601.","journal-title":"J Hazard Mater"},{"key":"2911_CR51","doi-asserted-by":"publisher","first-page":"10427","DOI":"10.1021\/acs.jafc.3c02499","volume":"71","author":"Q Zong","year":"2023","unstructured":"Zong, Q., Li, K., Qu, H., Hu, P., Xu, C., Wang, H., Wu, S., Wang, S., Liu, H.Y., Cai, D., et al. (2023). Sodium butyrate ameliorates deoxynivalenol-induced oxidative stress and inflammation in the porcine liver via NR4A2-mediated histone acetylation. J Agric Food Chem 71, 10427\u201310437.","journal-title":"J Agric Food Chem"}],"container-title":["Science China Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-024-2911-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11427-024-2911-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-024-2911-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T11:09:13Z","timestamp":1756897753000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11427-024-2911-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,20]]},"references-count":51,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["2911"],"URL":"https:\/\/doi.org\/10.1007\/s11427-024-2911-8","relation":{},"ISSN":["1674-7305","1869-1889"],"issn-type":[{"value":"1674-7305","type":"print"},{"value":"1869-1889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,20]]},"assertion":[{"value":"28 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest. All animal experiments (including mice and weaned piglets) were approved by the Animal Care and Use Committee of China Agricultural University, with approval number AW70012202-1-1.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance and ethics"}}]}}