{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:49:23Z","timestamp":1790185763936,"version":"4.1.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci. China Life Sci."],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s11427-024-3060-0","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T05:28:08Z","timestamp":1769750888000},"page":"896-911","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Targeting senescent cells in aged adipose tissue induced by ovarian cancer with the NF-\u03baB inhibitor quercetin and resveratrol impedes the growth and metastasis of ovarian cancer"],"prefix":"10.1007","volume":"69","author":[{"given":"Jia","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Zhe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajing","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"3060_CR1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s13287-023-03297-5","volume":"14","author":"G Ai","year":"2023","unstructured":"Ai, G., Meng, M., Guo, J., Li, C., Zhu, J., Liu, L., Liu, B., Yang, W., Shao, X., Cheng, Z., et al. (2023). Adipose-derived stem cells promote the repair of chemotherapy-induced premature ovarian failure by inhibiting granulosa cells apoptosis and senescence. Stem Cell Res Ther 14, 75.","journal-title":"Stem Cell Res Ther"},{"key":"3060_CR2","doi-asserted-by":"publisher","first-page":"104471","DOI":"10.1016\/j.critrevonc.2024.104471","volume":"202","author":"M Aizaz","year":"2024","unstructured":"Aizaz, M., Khan, A.S., Khan, M., Musazade, E., and Yang, G. (2024). Advancements in tumor-infiltrating lymphocytes: historical insights, contemporary milestones, and future directions in oncology therapy. Crit Rev Oncol Hematol 202, 104471.","journal-title":"Crit Rev Oncol Hematol"},{"key":"3060_CR3","doi-asserted-by":"publisher","first-page":"6162","DOI":"10.1038\/s41467-024-50441-7","volume":"15","author":"B Assouline","year":"2024","unstructured":"Assouline, B., Kahn, R., Hodali, L., Condiotti, R., Engel, Y., Elyada, E., Mordechai-Heyn, T., Pitarresi, J.R., Atias, D., Steinberg, E., et al. (2024). Senescent cancer-associated fibroblasts in pancreatic adenocarcinoma restrict CD8+ T cell activation and limit responsiveness to immunotherapy in mice. Nat Commun 15, 6162.","journal-title":"Nat Commun"},{"key":"3060_CR4","first-page":"229","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray, F., Laversanne, M., Sung, H., Ferlay, J., Siegel, R.L., Soerjomataram, I., and Jemal, A. (2024). Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74, 229\u2013263.","journal-title":"CA Cancer J Clin"},{"key":"3060_CR5","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1038\/s41591-022-01923-y","volume":"28","author":"S Chaib","year":"2022","unstructured":"Chaib, S., Tchkonia, T., and Kirkland, J.L. (2022). Cellular senescence and senolytics: the path to the clinic. Nat Med 28, 1556\u20131568.","journal-title":"Nat Med"},{"key":"3060_CR6","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.1007\/s11427-023-2343-y","volume":"66","author":"G Chen","year":"2023","unstructured":"Chen, G., Sun, L., Gu, X., Ai, L., Yang, J., Zhang, Z., Hou, P., Wang, Y., Ou, X., Jiang, X., et al. (2023). FSIP1 enhances the therapeutic sensitivity to CDK4\/6 inhibitors in triple-negative breast cancer patients by activating the Nanog pathway. Sci China Life Sci 66, 2805\u20132817.","journal-title":"Sci China Life Sci"},{"key":"3060_CR7","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.semcancer.2022.02.005","volume":"86","author":"L Chibaya","year":"2022","unstructured":"Chibaya, L., Snyder, J., and Ruscetti, M. (2022). Senescence and the tumor-immune landscape: implications for cancer immunotherapy. Semin Cancer Biol 86, 827\u2013845.","journal-title":"Semin Cancer Biol"},{"key":"3060_CR8","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1038\/nm.4000","volume":"21","author":"BG Childs","year":"2015","unstructured":"Childs, B.G., Durik, M., Baker, D.J., and van Deursen, J.M. (2015). Cellular senescence in aging and age-related disease: from mechanisms to therapy. Nat Med 21, 1424\u20131435.","journal-title":"Nat Med"},{"key":"3060_CR9","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1146\/annurev-pathmechdis-031521-022116","volume":"18","author":"JW Clancy","year":"2023","unstructured":"Clancy, J.W., and D\u2019Souza-Schorey, C. (2023). Tumor-derived extracellular vesicles: multifunctional entities in the tumor microenvironment. Annu Rev Pathol Mech Dis 18, 205\u2013229.","journal-title":"Annu Rev Pathol Mech Dis"},{"key":"3060_CR10","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/s13048-020-00718-4","volume":"13","author":"L Dai","year":"2020","unstructured":"Dai, L., Song, K., and Di, W. (2020). Adipocytes: active facilitators in epithelial ovarian cancer progression? J Ovarian Res 13, 115.","journal-title":"J Ovarian Res"},{"key":"3060_CR11","doi-asserted-by":"publisher","first-page":"16589","DOI":"10.3390\/ijms242316589","volume":"24","author":"A Duarte Mendes","year":"2023","unstructured":"Duarte Mendes, A., Freitas, A.R., Vicente, R., Vitorino, M., Vaz Batista, M., Silva, M., and Braga, S. (2023). Adipocyte microenvironment in ovarian cancer: a critical contributor? Int J Mol Sci 24, 16589.","journal-title":"Int J Mol Sci"},{"key":"3060_CR12","doi-asserted-by":"publisher","first-page":"eadj5705","DOI":"10.1126\/scitranslmed.adj5705","volume":"16","author":"G Fan","year":"2024","unstructured":"Fan, G., Yu, B., Tang, L., Zhu, R., Chen, J., Zhu, Y., Huang, H., Zhou, L., Liu, J., Wang, W., et al. (2024). TSPAN8+ myofibroblastic cancer-associated fibroblasts promote chemoresistance in patients with breast cancer. Sci Transl Med 16, eadj5705.","journal-title":"Sci Transl Med"},{"key":"3060_CR13","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.3390\/cells11091433","volume":"11","author":"ES Fridman","year":"2022","unstructured":"Fridman, E.S., Ginini, L., and Gil, Z. (2022). The role of extracellular vesicles in metabolic reprogramming of the tumor microenvironment. Cells 11, 1433.","journal-title":"Cells"},{"key":"3060_CR14","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1080\/01635580903441196","volume":"62","author":"AB Granado-Serrano","year":"2010","unstructured":"Granado-Serrano, A.B., Mart\u00edn, M.A., Bravo, L., Goya, L., and Ramos, S. (2010). Quercetin modulates NF-\u03baB and AP-1\/JNK pathways to induce cell death in human hepatoma cells. Nutr Cancer 62, 390\u2013401.","journal-title":"Nutr Cancer"},{"key":"3060_CR15","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1126\/science.1140735","volume":"319","author":"TD Halazonetis","year":"2008","unstructured":"Halazonetis, T.D., Gorgoulis, V.G., and Bartek, J. (2008). An oncogene-induced DNA damage model for cancer development. Science 319, 1352\u20131355.","journal-title":"Science"},{"key":"3060_CR16","doi-asserted-by":"publisher","first-page":"2626","DOI":"10.3324\/haematol.2022.281915","volume":"108","author":"Y Jia","year":"2023","unstructured":"Jia, Y., Han, L., Ramage, C.L., Wang, Z., Weng, C.C., Yang, L., Colla, S., Ma, H., Zhang, W., Andreeff, M., et al. (2023). Co-targeting BCL-XL and BCL-2 by PROTAC 753B eliminates leukemia cells and enhances efficacy of chemotherapy by targeting senescent cells. Haematologica 108, 2626\u20132638.","journal-title":"Haematologica"},{"key":"3060_CR17","doi-asserted-by":"publisher","first-page":"677","DOI":"10.3390\/vaccines12060677","volume":"12","author":"K Kaur","year":"2024","unstructured":"Kaur, K., Sanghu, J., Memarzadeh, S., and Jewett, A. (2024). Exploring the potential of natural killer cell-based immunotherapy in targeting high-grade serous ovarian carcinomas. Vaccines 12, 677.","journal-title":"Vaccines"},{"key":"3060_CR18","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1038\/s43018-023-00617-9","volume":"4","author":"PA Konstantinopoulos","year":"2023","unstructured":"Konstantinopoulos, P.A., and Matulonis, U.A. (2023). Clinical and translational advances in ovarian cancer therapy. Nat Cancer 4, 1239\u20131257.","journal-title":"Nat Cancer"},{"key":"3060_CR19","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/s41568-022-00491-0","volume":"22","author":"TJ Laskowski","year":"2022","unstructured":"Laskowski, T.J., Biederst\u00e4dt, A., and Rezvani, K. (2022). Natural killer cells in antitumour adoptive cell immunotherapy. Nat Rev Cancer 22, 557\u2013575.","journal-title":"Nat Rev Cancer"},{"key":"3060_CR20","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/nrc2723","volume":"9","author":"AJ Levine","year":"2009","unstructured":"Levine, A.J., and Oren, M. (2009). The first 30 years of p53: growing ever more complex. Nat Rev Cancer 9, 749\u2013758.","journal-title":"Nat Rev Cancer"},{"key":"3060_CR21","first-page":"280","volume":"69","author":"S Lheureux","year":"2019","unstructured":"Lheureux, S., Braunstein, M., and Oza, A.M. (2019). Epithelial ovarian cancer: evolution of management in the era of precision medicine. CA Cancer J Clin 69, 280\u2013304.","journal-title":"CA Cancer J Clin"},{"key":"3060_CR22","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/s41392-023-01502-8","volume":"8","author":"X Li","year":"2023","unstructured":"Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., and Huang, H. (2023). Inflammation and aging: signaling pathways and intervention therapies. Sig Transduct Target Ther 8, 239.","journal-title":"Sig Transduct Target Ther"},{"key":"3060_CR23","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s41392-023-01407-6","volume":"8","author":"D Lin","year":"2023","unstructured":"Lin, D., Shen, Y., and Liang, T. (2023). Oncolytic virotherapy: basic principles, recent advances and future directions. Sig Transduct Target Ther 8, 156.","journal-title":"Sig Transduct Target Ther"},{"key":"3060_CR24","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3390\/cells8010054","volume":"8","author":"J Liu","year":"2019","unstructured":"Liu, J., Wang, L., Wang, Z., and Liu, J.P. (2019). Roles of telomere biology in cell senescence, replicative and chronological ageing. Cells 8, 54.","journal-title":"Cells"},{"key":"3060_CR25","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/s41419-023-06211-2","volume":"14","author":"S Liu","year":"2023","unstructured":"Liu, S., Wang, W., Hu, S., Jia, B., Tuo, B., Sun, H., Wang, Q., Liu, Y., and Sun, Z. (2023). Radiotherapy remodels the tumor microenvironment for enhancing immunotherapeutic sensitivity. Cell Death Dis 14, 679.","journal-title":"Cell Death Dis"},{"key":"3060_CR26","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1038\/s41580-025-00842-3","volume":"26","author":"Y Liu","year":"2025","unstructured":"Liu, Y., Stockwell, B.R., Jiang, X., and Gu, W. (2025). p53-regulated non-apoptotic cell death pathways and their relevance in cancer and other diseases. Nat Rev Mol Cell Biol 26, 600\u2013614.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3060_CR27","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s11427-023-2434-8","volume":"67","author":"Y Liu","year":"2024","unstructured":"Liu, Y., Wang, Y., Liu, B., Liu, W., Ma, Y., Cao, Y., Yan, S., Zhang, P., Zhou, L., Zhan, Q., et al. (2024). Targeting lncRNA16 by GalNAc-siRNA conjugates facilitates chemotherapeutic sensibilization via the HBB\/NDUFAF5\/ROS pathway. Sci China Life Sci 67, 663\u2013679.","journal-title":"Sci China Life Sci"},{"key":"3060_CR28","doi-asserted-by":"publisher","first-page":"2138","DOI":"10.1007\/s11427-022-2288-4","volume":"66","author":"Y Luo","year":"2023","unstructured":"Luo, Y., He, M., Yang, J., Zhang, F., Chen, J., Wen, X., Fan, J., Fan, X., Chai, P., and Jia, R. (2023). A novel MYCN-YTHDF1 cascade contributes to retinoblastoma tumor growth by eliciting m6A-dependent activation of multiple oncogenes. Sci China Life Sci 66, 2138\u20132151.","journal-title":"Sci China Life Sci"},{"key":"3060_CR29","doi-asserted-by":"publisher","first-page":"2885","DOI":"10.1038\/s41388-018-0637-x","volume":"38","author":"T Motohara","year":"2019","unstructured":"Motohara, T., Masuda, K., Morotti, M., Zheng, Y., El-Sahhar, S., Chong, K.Y., Wietek, N., Alsaadi, A., Carrami, E.M., Hu, Z., et al. (2019). An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment. Oncogene 38, 2885\u20132898.","journal-title":"Oncogene"},{"key":"3060_CR30","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1038\/nm.2492","volume":"17","author":"KM Nieman","year":"2011","unstructured":"Nieman, K.M., Kenny, H.A., Penicka, C.V., Ladanyi, A., Buell-Gutbrod, R., Zillhardt, M.R., Romero, I.L., Carey, M.S., Mills, G.B., Hotamisligil, G.S., et al. (2011). Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med 17, 1498\u20131503.","journal-title":"Nat Med"},{"key":"3060_CR31","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s41232-022-00197-8","volume":"42","author":"N Ohtani","year":"2022","unstructured":"Ohtani, N. (2022). The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis? Inflamm Regener 42, 11.","journal-title":"Inflamm Regener"},{"key":"3060_CR32","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1038\/s41419-022-04752-6","volume":"13","author":"MY Ou","year":"2022","unstructured":"Ou, M.Y., Zhang, H., Tan, P.C., Zhou, S.B., and Li, Q.F. (2022). Adipose tissue aging: mechanisms and therapeutic implications. Cell Death Dis 13, 300.","journal-title":"Cell Death Dis"},{"key":"3060_CR33","doi-asserted-by":"publisher","first-page":"8448","DOI":"10.3390\/ijms25158448","volume":"25","author":"F Pacifico","year":"2024","unstructured":"Pacifico, F., Magni, F., Leonardi, A., and Crescenzi, E. (2024). Therapy-induced senescence: novel approaches for markers identification. Int J Mol Sci 25, 8448.","journal-title":"Int J Mol Sci"},{"key":"3060_CR34","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1146\/annurev-pharmtox-050120-105018","volume":"61","author":"PD Robbins","year":"2021","unstructured":"Robbins, P.D., Jurk, D., Khosla, S., Kirkland, J.L., LeBrasseur, N.K., Miller, J.D., Passos, J.F., Pignolo, R.J., Tchkonia, T., and Niedernhofer, L.J. (2021). Senolytic drugs: reducing senescent cell viability to extend health span. Annu Rev Pharmacol Toxicol 61, 779\u2013803.","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"3060_CR35","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/s41571-022-00668-4","volume":"19","author":"CA Schmitt","year":"2022","unstructured":"Schmitt, C.A., Wang, B., and Demaria, M. (2022). Senescence and cancer\u2014role and therapeutic opportunities. Nat Rev Clin Oncol 19, 619\u2013636.","journal-title":"Nat Rev Clin Oncol"},{"key":"3060_CR36","doi-asserted-by":"publisher","first-page":"2795","DOI":"10.1038\/onc.2010.46","volume":"29","author":"G Schneider","year":"2010","unstructured":"Schneider, G., Henrich, A., Greiner, G., Wolf, V., Lovas, A., Wieczorek, M., Wagner, T., Reichardt, S., von Werder, A., Schmid, R.M., et al. (2010). Cross talk between stimulated NF-\u03baB and the tumor suppressor p53. Oncogene 29, 2795\u20132806.","journal-title":"Oncogene"},{"key":"3060_CR37","doi-asserted-by":"publisher","first-page":"836922","DOI":"10.3389\/fimmu.2022.836922","volume":"13","author":"AG Souza","year":"2022","unstructured":"Souza, A.G., and Colli, L.M. (2022). Extracellular vesicles and interleukins: novel frontiers in diagnostic and therapeutic for cancer. Front Immunol 13, 836922.","journal-title":"Front Immunol"},{"key":"3060_CR38","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41408-021-00459-7","volume":"11","author":"RC Sterner","year":"2021","unstructured":"Sterner, R.C., and Sterner, R.M. (2021). CAR-T cell therapy: current limitations and potential strategies. Blood Cancer J 11, 69.","journal-title":"Blood Cancer J"},{"key":"3060_CR39","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s13193-018-0856-1","volume":"10","author":"PH Sugarbaker","year":"2019","unstructured":"Sugarbaker, P.H. (2019). Prevention and treatment of peritoneal metastases: a comprehensive review. Ind J Surg Oncol 10, 3\u201323.","journal-title":"Ind J Surg Oncol"},{"key":"3060_CR40","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.ccell.2023.02.014","volume":"41","author":"C Tay","year":"2023","unstructured":"Tay, C., Tanaka, A., and Sakaguchi, S. (2023). Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy. Cancer Cell 41, 450\u2013465.","journal-title":"Cancer Cell"},{"key":"3060_CR41","doi-asserted-by":"publisher","first-page":"154846","DOI":"10.1016\/j.prp.2023.154846","volume":"251","author":"M Tufail","year":"2023","unstructured":"Tufail, M. (2023). Unlocking the potential of the tumor microenvironment for cancer therapy. Pathol Res Pract 251, 154846.","journal-title":"Pathol Res Pract"},{"key":"3060_CR42","doi-asserted-by":"publisher","first-page":"e12945","DOI":"10.1111\/acel.12945","volume":"18","author":"A Walaszczyk","year":"2019","unstructured":"Walaszczyk, A., Dookun, E., Redgrave, R., Tual-Chalot, S., Victorelli, S., Spyridopoulos, I., Owens, A., Arthur, H.M., Passos, J.F., and Richardson, G.D. (2019). Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction. Aging Cell 18, e12945.","journal-title":"Aging Cell"},{"key":"3060_CR43","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1038\/s41580-024-00727-x","volume":"25","author":"B Wang","year":"2024","unstructured":"Wang, B., Han, J., Elisseeff, J.H., and Demaria, M. (2024a). The senescence-associated secretory phenotype and its physiological and pathological implications. Nat Rev Mol Cell Biol 25, 958\u2013978.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3060_CR44","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s11427-023-2554-y","volume":"68","author":"J Wang","year":"2025","unstructured":"Wang, J., Zhou, W., Xu, Y., Duan, J., Zhou, Q., Wang, G., Li, L., Xu, C., Wang, W., Cai, S., et al. (2025). Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retrospective analyses of the POPLAR\/OAK and CHOICE-01 trials. Sci China Life Sci 68, 249\u2013262.","journal-title":"Sci China Life Sci"},{"key":"3060_CR45","doi-asserted-by":"publisher","first-page":"116474","DOI":"10.1016\/j.biopha.2024.116474","volume":"174","author":"L Wang","year":"2024","unstructured":"Wang, L., Xiong, B., Lu, W., Cheng, Y., Zhu, J., Ai, G., Zhang, X., Liu, X., and Cheng, Z. (2024b). Senolytic drugs dasatinib and quercetin combined with Carboplatin or Olaparib reduced the peritoneal and adipose tissue metastasis of ovarian cancer. Biomed Pharmacother 174, 116474.","journal-title":"Biomed Pharmacother"},{"key":"3060_CR46","doi-asserted-by":"publisher","first-page":"116349","DOI":"10.1016\/j.bcp.2024.116349","volume":"226","author":"Q Xin","year":"2024","unstructured":"Xin, Q., Chen, Y., Sun, X., Li, R., Wu, Y., and Huang, X. (2024). CAR-T therapy for ovarian cancer: recent advances and future directions. Biochem Pharmacol 226, 116349.","journal-title":"Biochem Pharmacol"},{"key":"3060_CR47","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41586-021-03547-7","volume":"594","author":"MJ Yousefzadeh","year":"2021","unstructured":"Yousefzadeh, M.J., Flores, R.R., Zhu, Y., Schmiechen, Z.C., Brooks, R.W., Trussoni, C. E., Cui, Y., Angelini, L., Lee, K.A., McGowan, S.J., et al. (2021). An aged immune system drives senescence and ageing of solid organs. Nature 594, 100\u2013105.","journal-title":"Nature"},{"key":"3060_CR48","doi-asserted-by":"publisher","first-page":"e158450","DOI":"10.1172\/JCI158450","volume":"132","author":"L Zhang","year":"2022","unstructured":"Zhang, L., Pitcher, L.E., Yousefzadeh, M.J., Niedernhofer, L.J., Robbins, P.D., and Zhu, Y. (2022). Cellular senescence: a key therapeutic target in aging and diseases. J Clin Invest 132, e158450.","journal-title":"J Clin Invest"},{"key":"3060_CR49","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/s41392-021-00658-5","volume":"6","author":"H Zhao","year":"2021","unstructured":"Zhao, H., Wu, L., Yan, G., Chen, Y., Zhou, M., Wu, Y., and Li, Y. (2021). Inflammation and tumor progression: signaling pathways and targeted intervention. Sig Transduct Target Ther 6, 263.","journal-title":"Sig Transduct Target Ther"},{"key":"3060_CR50","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1007\/s11427-023-2556-4","volume":"68","author":"C Zheng","year":"2025","unstructured":"Zheng, C., Song, L., Yu, C., Zhu, L., Zhang, J., Wang, N., Liu, M., Li, S., Wang, L., Shen, Z., et al. (2025). Palindrome-mediated DNA nanotubes with cell-specific aptamers to improve targeted antitumor effects and reduce toxicity on non-small cell lung cancer. Sci China Life Sci 68, 454\u2013466.","journal-title":"Sci China Life Sci"},{"key":"3060_CR51","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1038\/s43018-023-00599-8","volume":"4","author":"X Zheng","year":"2023","unstructured":"Zheng, X., Wang, X., Cheng, X., Liu, Z., Yin, Y., Li, X., Huang, Z., Wang, Z., Guo, W., Ginhoux, F., et al. (2023). Single-cell analyses implicate ascites in remodeling the ecosystems of primary and metastatic tumors in ovarian cancer. Nat Cancer 4, 1138\u20131156.","journal-title":"Nat Cancer"}],"container-title":["Science China Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-024-3060-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11427-024-3060-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-024-3060-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:05:05Z","timestamp":1772791505000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11427-024-3060-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,21]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["3060"],"URL":"https:\/\/doi.org\/10.1007\/s11427-024-3060-0","relation":{},"ISSN":["1674-7305","1869-1889"],"issn-type":[{"value":"1674-7305","type":"print"},{"value":"1869-1889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,21]]},"assertion":[{"value":"12 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest. All animal experiments and animal care were conducted according to the guidelines of the ethics committee of Shanghai General Hospital (2019SQ057).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance and ethics"}}]}}