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All procedures involving mice were conducted in accordance with the guidelines and ethical standards set by the Animal Ethics Committee in Wuhan University (protocol No. WP20210561). The research involving human subjects was approved by the Ethics Committee of Zhongnan Hospital of Wuhan University (protocol No. 2021074). Written informed consent was obtained from each enrolled participant, and all experiments were performed in accordance with the Declaration of Helsinki.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance and ethics"}}]}}