{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T22:49:48Z","timestamp":1772837388248,"version":"3.50.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci. China Life Sci."],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s11427-025-3013-9","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T23:01:35Z","timestamp":1751583695000},"page":"3104-3107","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dual-pressure theory: new developments and future directions"],"prefix":"10.1007","volume":"68","author":[{"given":"Ying","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"3013_CR1","doi-asserted-by":"publisher","first-page":"5770","DOI":"10.1007\/s12035-023-03430-8","volume":"60","author":"Y Cheng","year":"2023","unstructured":"Cheng, Y., Lin, D., Wu, S., Liu, Q., Yan, X., Ren, T., Zhang, J., and Wang, N. (2023). Cerebrospinal fluid pressure reduction induces glia-mediated retinal inflammation and leads to retinal ganglion cell injury in rats. Mol Neurobiol 60, 5770\u20135788.","journal-title":"Mol Neurobiol"},{"key":"3013_CR2","doi-asserted-by":"publisher","first-page":"9585","DOI":"10.1038\/srep09585","volume":"5","author":"J Gao","year":"2015","unstructured":"Gao, J., Liang, Y., Wang, F., Shen, R., Wong, T., Peng, Y., Friedman, D.S., and Wang, N. (2015). Retinal vessels change in primary angle-closure glaucoma: the Handan eye study. Sci Rep 5, 9585.","journal-title":"Sci Rep"},{"key":"3013_CR3","doi-asserted-by":"publisher","first-page":"100654","DOI":"10.1016\/j.mcpro.2023.100654","volume":"22","author":"D Lin","year":"2023","unstructured":"Lin, D., Wu, S., Cheng, Y., Yan, X., Liu, Q., Ren, T., Zhang, J., and Wang, N. (2023). Early proteomic characteristics and changes in the optic nerve head, optic nerve, and retina in a rat model of ocular hypertension. Mol Cell Proteomics 22, 100654.","journal-title":"Mol Cell Proteomics"},{"key":"3013_CR4","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1007\/s11427-018-9332-8","volume":"62","author":"L Liu","year":"2019","unstructured":"Liu, L., Li, X., Killer, H.E., Cao, K., Li, J., and Wang, N. (2019). Changes in retinal and choroidal morphology after cerebrospinal fluid pressure reduction: a Beijing iCOP study. Sci China Life Sci 62, 268\u2013271.","journal-title":"Sci China Life Sci"},{"key":"3013_CR5","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1080\/02713683.2021.1874024","volume":"46","author":"X Liu","year":"2021","unstructured":"Liu, X., Khodeiry, M.M., Lin, D., Sun, Y., Lin, C., Feng, W., Li, J., Wang, Y., Zhang, Q., Cao, K., et al. (2021). The association of acute cerebrospinal fluid pressure reduction with choroidal thickness. Curr Eye Res 46, 1193\u20131200.","journal-title":"Curr Eye Res"},{"key":"3013_CR6","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1007\/s11427-018-1585-8","volume":"63","author":"Y Mao","year":"2020","unstructured":"Mao, Y., Yang, D., Li, J., Liu, J., Hou, R., Zhang, Z., Yang, Y., Tian, L., Weinreb, R.N., and Wang, N. (2020). Finite element analysis of trans-lamina cribrosa pressure difference on optic nerve head biomechanics: the Beijing Intracranial and Intraocular Pressure Study. Sci China Life Sci 63, 1887\u20131894.","journal-title":"Sci China Life Sci"},{"key":"3013_CR7","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1038\/s41433-021-01740-6","volume":"36","author":"R Pang","year":"2022","unstructured":"Pang, R., Feng, S., Cao, K., Sun, Y., Guo, Y., Ma, D., Pang, C.P., Liu, X., Qian, J., Xie, Y., et al. (2022). Association of serum retinol concentration with normal-tension glaucoma. Eye 36, 1820\u20131825.","journal-title":"Eye"},{"key":"3013_CR8","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1038\/s41433-022-02323-9","volume":"37","author":"R Pang","year":"2023","unstructured":"Pang, R., Lin, D., Di, X., Liu, X., Gao, L., Chen, J., Jia, Y., Cao, K., Ren, T., Cheng, Y., et al. (2023). Reference values for trans-laminar cribrosa pressure difference and its association with systemic biometric factors. Eye 37, 2240\u20132245.","journal-title":"Eye"},{"key":"3013_CR9","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.ophtha.2009.06.058","volume":"117","author":"R Ren","year":"2010","unstructured":"Ren, R., Jonas, J.B., Tian, G., Zhen, Y., Ma, K., Li, S., Wang, H., Li, B., Zhang, X., and Wang, N. (2010). Cerebrospinal fluid pressure in glaucoma: a prospective study. Ophthalmology 117, 259\u2013266.","journal-title":"Ophthalmology"},{"key":"3013_CR10","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1002\/glia.24334","volume":"71","author":"Y Wan","year":"2023","unstructured":"Wan, Y., Wang, H., Fan, X., Bao, J., Wu, S., Liu, Q., Yan, X., Zhang, J., Jin, Z., Xiao, B., et al. (2023). Mechanosensitive channel Piezo1 is an essential regulator in cell cycle progression of optic nerve head astrocytes. Glia 71, 1233\u20131246.","journal-title":"Glia"},{"key":"3013_CR11","doi-asserted-by":"publisher","first-page":"eaaw3210","DOI":"10.1126\/scitranslmed.aaw3210","volume":"12","author":"X Wang","year":"2020","unstructured":"Wang, X., Lou, N., Eberhardt, A., Yang, Y., Kusk, P., Xu, Q., F\u00f6rstera, B., Peng, S., Shi, M., Ladr\u00f3n-de-Guevara, A., et al. (2020). An ocular glymphatic clearance system removes \u03b2-amyloid from the rodent eye. Sci Transl Med 12, eaaw3210.","journal-title":"Sci Transl Med"},{"key":"3013_CR12","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1007\/s11427-022-2271-x","volume":"66","author":"Y Xie","year":"2023","unstructured":"Xie, Y., Yang, D., Huang, A.S., Yang, Y., Han, Y., Sun, Y., Cao, K., Wang, H., Wu, S., Zhu, Q., et al. (2023). Retinal microvasculature is a potential biomarker for acute mountain sickness. Sci China Life Sci 66, 1290\u20131302.","journal-title":"Sci China Life Sci"},{"key":"3013_CR13","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s12883-023-03502-1","volume":"24","author":"X Yang","year":"2024","unstructured":"Yang, X., Gan, J., and Ji, Y. (2024). Association between cerebrospinal fluid pressure and cognition in patients with Alzheimer\u2019s disease and Lewy body dementia. BMC Neurol 24, 35.","journal-title":"BMC Neurol"},{"key":"3013_CR14","doi-asserted-by":"publisher","first-page":"2699","DOI":"10.1167\/iovs.17-22850","volume":"59","author":"YH Y\u00fccel","year":"2018","unstructured":"Y\u00fccel, Y.H., Cardinell, K., Khattak, S., Zhou, X., Lapinski, M., Cheng, F., and Gupta, N. (2018). Active lymphatic drainage from the eye measured by noninvasive photoacoustic imaging of near-infrared nanoparticles. Invest Ophthalmol Vis Sci 59, 2699.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3013_CR15","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1136\/bjo-2022-321065","volume":"107","author":"Y Zhang","year":"2023","unstructured":"Zhang, Y., Cao, K., Pang, R., Wang, N., Qu, X., Kang, J., Wang, N., and Liu, H. (2023). Non-invasive intracranial pressure estimation using ultrasonographic measurement of area of optic nerve subarachnoid space. Br J Ophthalmol 107, 1716\u20131721.","journal-title":"Br J Ophthalmol"}],"container-title":["Science China Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-025-3013-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11427-025-3013-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-025-3013-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T17:03:42Z","timestamp":1759597422000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11427-025-3013-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,2]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["3013"],"URL":"https:\/\/doi.org\/10.1007\/s11427-025-3013-9","relation":{},"ISSN":["1674-7305","1869-1889"],"issn-type":[{"value":"1674-7305","type":"print"},{"value":"1869-1889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,2]]},"assertion":[{"value":"13 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance and ethics"}}]}}