{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:15:29Z","timestamp":1793333729060,"version":"4.5.0"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci. China Life Sci."],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s11427-025-3051-3","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:49:34Z","timestamp":1762177774000},"page":"2640-2656","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["MECP2T203M mutation disrupts neurogenesis in human cerebral organoids by altering chromatin dynamics and transcriptional regulation"],"prefix":"10.1007","volume":"69","author":[{"given":"Zhihong","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"3051_CR1","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1038\/nmeth.4463","volume":"14","author":"S Aibar","year":"2017","unstructured":"Aibar, S., Gonz\u00e1lez-Blas, C.B., Moerman, T., Huynh-Thu, V.A., Imrichova, H., Hulselmans, G., Rambow, F., Marine, J.C., Geurts, P., Aerts, J., et al. (2017). SCENIC: single-cell regulatory network inference and clustering. Nat Methods 14, 1083\u20131086.","journal-title":"Nat Methods"},{"key":"3051_CR2","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/13810","volume":"23","author":"RE Amir","year":"1999","unstructured":"Amir, R.E., Van den Veyver, I.B., Wan, M., Tran, C.Q., Francke, U., and Zoghbi, H.Y. (1999). Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet 23, 185\u2013188.","journal-title":"Nat Genet"},{"key":"3051_CR3","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","volume":"31","author":"S Anders","year":"2015","unstructured":"Anders, S., Pyl, P.T., and Huber, W. (2015). HTSeq\u2014a Python framework to work with high-throughput sequencing data. Bioinformatics 31, 166\u2013169.","journal-title":"Bioinformatics"},{"key":"3051_CR4","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41576-019-0173-8","volume":"21","author":"R Andersson","year":"2020","unstructured":"Andersson, R., and Sandelin, A. (2020). Determinants of enhancer and promoter activities of regulatory elements. Nat Rev Genet 21, 71\u201387.","journal-title":"Nat Rev Genet"},{"key":"3051_CR5","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1097\/00005072-199503000-00006","volume":"54","author":"D Armstrong","year":"1995","unstructured":"Armstrong, D., Dunn, J.K., Antalffy, B., and Trivedi, R. (1995). Selective dendritic alterations in the cortex of Rett syndrome. J Neuropathol Exp Neurol 54, 195\u2013201.","journal-title":"J Neuropathol Exp Neurol"},{"key":"3051_CR6","doi-asserted-by":"publisher","first-page":"S72","DOI":"10.1016\/S0387-7604(01)00332-1","volume":"23","author":"DD Armstrong","year":"2001","unstructured":"Armstrong, D.D. (2001). Rett syndrome neuropathology review 2000. Brain Dev 23, S72\u2013S76.","journal-title":"Brain Dev"},{"key":"3051_CR7","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1101\/gr.169508.113","volume":"24","author":"PJ Balwierz","year":"2014","unstructured":"Balwierz, P.J., Pachkov, M., Arnold, P., Gruber, A.J., Zavolan, M., and van Nimwegen, E. (2014). ISMARA: automated modeling of genomic signals as a democracy of regulatory motifs. Genome Res 24, 869\u2013884.","journal-title":"Genome Res"},{"key":"3051_CR8","doi-asserted-by":"publisher","first-page":"2517","DOI":"10.1093\/cercor\/bhv078","volume":"26","author":"F Bedogni","year":"2016","unstructured":"Bedogni, F., Cobolli Gigli, C., Pozzi, D., Rossi, R.L., Scaramuzza, L., Rossetti, G., Pagani, M., Kilstrup-Nielsen, C., Matteoli, M., and Landsberger, N. (2016). Defects during Mecp2 null embryonic cortex development precede the onset of overt neurological symptoms. Cereb Cortex 26, 2517\u20132529.","journal-title":"Cereb Cortex"},{"key":"3051_CR9","doi-asserted-by":"publisher","first-page":"236","DOI":"10.3389\/fncel.2014.00236","volume":"8","author":"E Bellini","year":"2014","unstructured":"Bellini, E., Pavesi, G., Barbiero, I., Bergo, A., Chandola, C., Nawaz, M.S., Rusconi, L., Stefanelli, G., Strollo, M., Valente, M.M., et al. (2014). MeCP2 post-translational modifications: a mechanism to control its involvement in synaptic plasticity and homeostasis.? Front Cell Neurosci 8, 236.","journal-title":"Front Cell Neurosci"},{"key":"3051_CR10","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1093\/bioinformatics\/btp101","volume":"25","author":"G Bindea","year":"2009","unstructured":"Bindea, G., Mlecnik, B., Hackl, H., Charoentong, P., Tosolini, M., Kirilovsky, A., Fridman, W.H., Pages, F., Trajanoski, Z., and Galon, J. (2009). ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks. Bioinformatics 25, 1091\u20131093.","journal-title":"Bioinformatics"},{"key":"3051_CR11","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.molcel.2019.10.032","volume":"77","author":"LD Boxer","year":"2020","unstructured":"Boxer, L.D., Renthal, W., Greben, A.W., Whitwam, T., Silberfeld, A., Stroud, H., Li, E., Yang, M.G., Kinde, B., Griffith, E.C., et al. (2020). MeCP2 represses the rate of transcriptional initiation of highly methylated long genes. Mol Cell 77, 294\u2013309.e9.","journal-title":"Mol Cell"},{"key":"3051_CR12","doi-asserted-by":"publisher","first-page":"E5","DOI":"10.1038\/nature07784","volume":"457","author":"NJ Buckley","year":"2009","unstructured":"Buckley, N.J., Johnson, R., Sun, Y.M., and Stanton, L.W. (2009). Is REST a regulator of pluripotency? Nature 457, E5\u2013E6.","journal-title":"Nature"},{"key":"3051_CR13","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1086\/316913","volume":"67","author":"IM Buyse","year":"2000","unstructured":"Buyse, I.M., Fang, P., Hoon, K.T., Amir, R.E., Zoghbi, H.Y., and Roa, B.B. (2000). Diagnostic testing for Rett syndrome by DHPLC and direct sequencing analysis of the MECP2 gene: identification of several novel mutations and polymorphisms. Am J Hum Genet 67, 1428\u20131436.","journal-title":"Am J Hum Genet"},{"key":"3051_CR14","doi-asserted-by":"publisher","first-page":"eaba5933","DOI":"10.1126\/sciadv.aba5933","volume":"6","author":"AB Caldwell","year":"2020","unstructured":"Caldwell, A.B., Liu, Q., Schroth, G.P., Galasko, D.R., Yuan, S.H., Wagner, S.L., and Subramaniam, S. (2020). Dedifferentiation and neuronal repression define familial Alzheimer\u2019s disease. Sci Adv 6, eaba5933.","journal-title":"Sci Adv"},{"key":"3051_CR15","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1126\/science.1153252","volume":"320","author":"M Chahrour","year":"2008","unstructured":"Chahrour, M., Jung, S.Y., Shaw, C., Zhou, X., Wong, S.T.C., Qin, J., and Zoghbi, H.Y. (2008). MeCP2, a key contributor to neurological disease, activates and represses transcription. Science 320, 1224\u20131229.","journal-title":"Science"},{"key":"3051_CR16","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.neuron.2007.10.001","volume":"56","author":"M Chahrour","year":"2007","unstructured":"Chahrour, M., and Zoghbi, H.Y. (2007). The story of Rett syndrome: from clinic to neurobiology. Neuron 56, 422\u2013437.","journal-title":"Neuron"},{"key":"3051_CR17","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/85906","volume":"27","author":"RZ Chen","year":"2001","unstructured":"Chen, R.Z., Akbarian, S., Tudor, M., and Jaenisch, R. (2001). Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat Genet 27, 327\u2013331.","journal-title":"Nat Genet"},{"key":"3051_CR18","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s12264-021-00784-8","volume":"38","author":"J Cheng","year":"2021","unstructured":"Cheng, J., Zhao, Z., Chen, L., Li, Y., Du, R., Wu, Y., Zhu, Q., Fan, M., Duan, X., and Wu, H. (2021). Loss of O-GlcNAcylation on MeCP2 at threonine 203 leads to neurodevelopmental disorders. Neurosci Bull 38, 113\u2013134.","journal-title":"Neurosci Bull"},{"key":"3051_CR19","doi-asserted-by":"publisher","first-page":"42790","DOI":"10.1038\/srep42790","volume":"7","author":"TL Cheng","year":"2017","unstructured":"Cheng, T.L., Chen, J., Wan, H., Tang, B., Tian, W., Liao, L., and Qiu, Z. (2017). Regulation of mRNA splicing by MeCP2 via epigenetic modifications in the brain. Sci Rep 7, 42790.","journal-title":"Sci Rep"},{"key":"3051_CR20","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.devcel.2014.01.032","volume":"28","author":"TL Cheng","year":"2014","unstructured":"Cheng, T.L., Wang, Z., Liao, Q., Zhu, Y., Zhou, W.H., Xu, W., and Qiu, Z. (2014). MeCP2 suppresses nuclear MicroRNA processing and dendritic growth by regulating the DGCR8\/Drosha complex. Dev Cell 28, 547\u2013560.","journal-title":"Dev Cell"},{"key":"3051_CR21","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1093\/cercor\/bhx360","volume":"28","author":"C Cobolli Gigli","year":"2018","unstructured":"Cobolli Gigli, C., Scaramuzza, L., De Simone, M., Rossi, R.L., Pozzi, D., Pagani, M., Landsberger, N., and Bedogni, F. (2018). Lack of methyl-CpG Binding protein 2 (MeCP2) affects cell fate refinement during embryonic cortical development. Cerebral Cortex 28, 1846\u20131856.","journal-title":"Cerebral Cortex"},{"key":"3051_CR22","doi-asserted-by":"publisher","first-page":"5159","DOI":"10.1038\/s41380-023-02160-6","volume":"28","author":"FT Crews","year":"2023","unstructured":"Crews, F.T., Fisher, R.P., Qin, L., and Vetreno, R.P. (2023). HMGB1 neuroimmune signaling and REST-G9a gene repression contribute to ethanol-induced reversible suppression of the cholinergic neuron phenotype. Mol Psychiatry 28, 5159\u20135172.","journal-title":"Mol Psychiatry"},{"key":"3051_CR23","doi-asserted-by":"publisher","first-page":"eadh3707","DOI":"10.1126\/science.adh3707","volume":"384","author":"NP Daskalakis","year":"2024","unstructured":"Daskalakis, N.P., Iatrou, A., Chatzinakos, C., Jajoo, A., Snijders, C., Wylie, D., DiPietro, C.P., Tsatsani, I., Chen, C.Y., Pernia, C.D., et al. (2024). Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood. Science 384, eadh3707.","journal-title":"Science"},{"key":"3051_CR24","doi-asserted-by":"publisher","first-page":"e2300052120","DOI":"10.1073\/pnas.2300052120","volume":"120","author":"CM Dias","year":"2023","unstructured":"Dias, C.M., Issac, B., Sun, L., Lukowicz, A., Talukdar, M., Akula, S.K., Miller, M.B., Walsh, K., Rockowitz, S., and Walsh, C.A. (2023). Glial dysregulation in the human brain in fragile X-associated tremor\/ataxia syndrome. Proc Natl Acad Sci USA 120, e2300052120.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3051_CR25","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.tcb.2020.05.002","volume":"30","author":"MJ Emanuele","year":"2020","unstructured":"Emanuele, M.J., Enrico, T.P., Mouery, R.D., Wasserman, D., Nachum, S., and Tzur, A. (2020). Complex cartography: regulation of E2F transcription factors by Cyclin F and ubiquitin. Trends Cell Biol 30, 640\u2013652.","journal-title":"Trends Cell Biol"},{"key":"3051_CR26","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1038\/mp.2011.180","volume":"17","author":"N Farra","year":"2012","unstructured":"Farra, N., Zhang, W.B., Pasceri, P., Eubanks, J.H., Salter, M.W., and Ellis, J. (2012). Rett syndrome induced pluripotent stem cell-derived neurons reveal novel neurophysiological alterations. Mol Psychiatry 17, 1261\u20131271.","journal-title":"Mol Psychiatry"},{"key":"3051_CR27","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1016\/j.stem.2021.02.015","volume":"28","author":"JS Fleck","year":"2021","unstructured":"Fleck, J.S., Sanchfs-Calleja, F., He, Z., Santel, M., Boyle, M.J., Camp, J.G., and Treutlein, B. (2021). Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases. Cell Stem Cell 28, 1148\u20131159.e8.","journal-title":"Cell Stem Cell"},{"key":"3051_CR28","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1093\/jnen\/64.6.537","volume":"64","author":"T Fukuda","year":"2005","unstructured":"Fukuda, T., Itoh, M., Ichikawa, T., Washiyama, K., and Goto, Y. (2005). Delayed maturation of neuronal architecture and synaptogenesis in cerebral cortex of Mecp2-deficient mice. J Neuropathol Exp Neurol 64, 537\u2013544.","journal-title":"J Neuropathol Exp Neurol"},{"key":"3051_CR29","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1038\/nrc2271","volume":"7","author":"A Fusco","year":"2007","unstructured":"Fusco, A., and Fedele, M. (2007). Roles of HMGA proteins in cancer. Nat Rev Cancer 7, 899\u2013910.","journal-title":"Nat Rev Cancer"},{"key":"3051_CR30","doi-asserted-by":"publisher","first-page":"4838","DOI":"10.1007\/s12035-018-1412-2","volume":"56","author":"A Gandaglia","year":"2019","unstructured":"Gandaglia, A., Brivio, E., Carli, S., Palmieri, M., Bedogni, F., Stefanelli, G., Bergo, A., Leva, B., Cattaneo, C., Pizzamiglio, L., et al. (2019). A novel Mecp2Y120D knock-in model displays similar behavioral traits but distinct molecular features compared with the Mecp2-null mouse implying precision medicine for the treatment of Rett syndrome. Mol Neurobiol 56, 4838\u20134854.","journal-title":"Mol Neurobiol"},{"key":"3051_CR31","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1242\/jcs.167874","volume":"128","author":"H Gao","year":"2015","unstructured":"Gao, H., Bu, Y., Wu, Q., Wang, X., Chang, N., Lei, L., Chen, S., Liu, D., Zhu, X., Hu, K., et al. (2015). Mecp2 regulates neural cell differentiation by suppressing the Id1 to Her2 axis in zebrafish. J Cell Sci 128, 2340\u20132350.","journal-title":"J Cell Sci"},{"key":"3051_CR32","doi-asserted-by":"publisher","first-page":"20","DOI":"10.21037\/sci.2017.02.11","volume":"4","author":"M Gomathi","year":"2017","unstructured":"Gomathi, M., and Balachandar, V. (2017). Novel therapeutic approaches: Rett syndrome and human induced pluripotent stem cell technology. Stem Cell Investig 4, 20.","journal-title":"Stem Cell Investig"},{"key":"3051_CR33","doi-asserted-by":"publisher","first-page":"610427","DOI":"10.3389\/fcell.2020.610427","volume":"8","author":"AR Gomes","year":"2020","unstructured":"Gomes, A.R., Fernandes, T.G., Vaz, S.H., Silva, T.P., Bekman, E.P., Xapelli, S., Duarte, S., Ghazvini, M., Gribnau, J., Muotri, A.R., et al. (2020). Modeling Rett syndrome with human patient-specific forebrain organoids. Front Cell Dev Biol 8, 610427.","journal-title":"Front Cell Dev Biol"},{"key":"3051_CR34","doi-asserted-by":"publisher","first-page":"4577","DOI":"10.3390\/ijms20184577","volume":"20","author":"K Gulmez Karaca","year":"2019","unstructured":"Gulmez Karaca, K., Brito, D.V.C., and Oliveira, A.M.M. (2019). MeCP2: a critical regulator of chromatin in neurodevelopment and adult brain function. Int J Mol Sci 20, 4577.","journal-title":"Int J Mol Sci"},{"key":"3051_CR35","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/j.1651-2227.1985.tb10993.x","volume":"74","author":"B Hagberg","year":"1985","unstructured":"Hagberg, B. (1985). Rett\u2019s syndrome: prevalence and impact on progressive severe mental retardation in girls. Acta Paediatra 74, 405\u2013408.","journal-title":"Acta Paediatra"},{"key":"3051_CR36","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","volume":"184","author":"Y Hao","year":"2021","unstructured":"Hao, Y., Hao, S., Andersen-Nissen, E., Mauck Iii, W.M., Zheng, S., Butler, A., Lee, M.J., Wilk, A.J., Darby, C., Zager, M., et al. (2021). Integrated analysis of multimodal single-cell data. Cell 184, 3573\u20133587.e29.","journal-title":"Cell"},{"key":"3051_CR37","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.tins.2017.11.005","volume":"41","author":"PM Horvath","year":"2018","unstructured":"Horvath, P.M., and Monteggia, L.M. (2018). MeCP2 as an activator of gene expression. Trends Neurosci 41, 72\u201374.","journal-title":"Trends Neurosci"},{"key":"3051_CR38","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/561","volume":"19","author":"PL Jones","year":"1998","unstructured":"Jones, P.L., Veenstra, G.J.C., Wade, P.A., Vermaak, D., Kass, S.U., Landsberger, N., Strouboulis, J., and Wolffe, A.P. (1998). Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat Genet 19, 187\u2013191.","journal-title":"Nat Genet"},{"key":"3051_CR39","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1038\/s41593-021-00913-6","volume":"24","author":"Y Kang","year":"2021","unstructured":"Kang, Y., Zhou, Y., Li, Y., Han, Y., Xu, J., Niu, W., Li, Z., Liu, S., Feng, H., Huang, W., et al. (2021). A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies. Nat Neurosci 24, 1377\u20131391.","journal-title":"Nat Neurosci"},{"key":"3051_CR40","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.ijdevneu.2019.10.002","volume":"79","author":"M Kharrat","year":"2019","unstructured":"Kharrat, M., Triki, C., Maalej, M., Ncir, S., Ammar, M., Kammoun, F., and Fakhfakh, F. (2019). First description of an unusual novel double mutation in MECP 2 co-occurring with the m.827A>G mutation in the MT-RNR1 gene associated with angelman-like syndrome. Intl J Devlp Neurosci 79, 37\u201344.","journal-title":"Intl J Devlp Neurosci"},{"key":"3051_CR41","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","volume":"37","author":"D Kim","year":"2019","unstructured":"Kim, D., Paggi, J.M., Park, C., Bennett, C., and Salzberg, S.L. (2019). Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. Nat Biotechnol 37, 907\u2013915.","journal-title":"Nat Biotechnol"},{"key":"3051_CR42","doi-asserted-by":"publisher","first-page":"14169","DOI":"10.1073\/pnas.1018979108","volume":"108","author":"KY Kim","year":"2011","unstructured":"Kim, K.Y., Hysolli, E., and Park, I.H. (2011). Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome. Proc Natl Acad Sci USA 108, 14169\u201314174.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3051_CR43","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1002\/humu.23263","volume":"38","author":"R Krishnaraj","year":"2017","unstructured":"Krishnaraj, R., Ho, G., and Christodoulou, J. (2017). RettBASE: Rett syndrome database update. Hum Mutat 38, 922\u2013931.","journal-title":"Hum Mutat"},{"key":"3051_CR44","doi-asserted-by":"publisher","first-page":"6420","DOI":"10.1038\/s41467-023-42094-9","volume":"14","author":"N Kuwayama","year":"2023","unstructured":"Kuwayama, N., Kujirai, T., Kishi, Y., Hirano, R., Echigoya, K., Fang, L., Watanabe, S., Nakao, M., Suzuki, Y., Ishiguro, K., et al. (2023). HMGA2 directly mediates chromatin condensation in association with neuronal fate regulation. Nat Commun 14, 6420.","journal-title":"Nat Commun"},{"key":"3051_CR45","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/nature12517","volume":"501","author":"MA Lancaster","year":"2013","unstructured":"Lancaster, M.A., Renner, M., Martin, C.A., Wenzel, D., Bicknell, L.S., Hurles, M.E., Homfray, T., Penninger, J.M., Jackson, A.P., and Knoblich, J.A. (2013). Cerebral organoids model human brain development and microcephaly. Nature 501, 373\u2013379.","journal-title":"Nature"},{"key":"3051_CR46","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/s41586-020-2574-4","volume":"586","author":"CH Li","year":"2020","unstructured":"Li, C.H., Coffey, E.L., Dall\u2019Agnese, A., Hannett, N.M., Tang, X., Henninger, J.E., Platt, J. M., Oksuz, O., Zamudio, A.V., Afeyan, L.K., et al. (2020). MeCP2 links heterochromatin condensates and neurodevelopmental disease. Nature 586, 440\u2013444.","journal-title":"Nature"},{"key":"3051_CR47","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1016\/j.neuron.2024.04.007","volume":"112","author":"Y Liu","year":"2024","unstructured":"Liu, Y., Flamier, A., Bell, G.W., Diao, A.J., Whitfield, T.W., Wang, H.C., Wu, Y., Schulte, F., Friesen, M., Guo, R., et al. (2024). MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons. Neuron 112, 1943\u20131958.e10.","journal-title":"Neuron"},{"key":"3051_CR48","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love, M.I., Huber, W., and Anders, S. (2014). Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15, 550.","journal-title":"Genome Biol"},{"key":"3051_CR49","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s11427-023-2436-x","volume":"67","author":"L Luo","year":"2024","unstructured":"Luo, L., Wang, X., Lu, J., Chen, G., Luan, G., Li, W., Wang, Q., and Fang, F. (2024). Local field potentials, spiking activity, and receptive fields in human visual cortex. Sci China Life Sci 67, 543\u2013554.","journal-title":"Sci China Life Sci"},{"key":"3051_CR50","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1016\/j.cell.2012.11.022","volume":"151","author":"M Mell\u00e9n","year":"2012","unstructured":"Mell\u00e9n, M., Ayata, P., Dewell, S., Kriaucionis, S., and Heintz, N. (2012). MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system. Cell 151, 1417\u20131430.","journal-title":"Cell"},{"key":"3051_CR51","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1038\/mp.2017.86","volume":"23","author":"N Mellios","year":"2018","unstructured":"Mellios, N., Feldman, D.A., Sheridan, S.D., Ip, J.P.K., Kwok, S., Amoah, S.K., Rosen, B., Rodriguez, B.A., Crawford, B., Swaminathan, R., et al. (2018). MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling. Mol Psychiatry 23, 1051\u20131065.","journal-title":"Mol Psychiatry"},{"key":"3051_CR52","doi-asserted-by":"publisher","first-page":"109124","DOI":"10.1016\/j.celrep.2021.109124","volume":"35","author":"H Nakashima","year":"2021","unstructured":"Nakashima, H., Tsujimura, K., Irie, K., Imamura, T., Trujillo, C.A., Ishizu, M., Uesaka, M., Pan, M., Noguchi, H., Okada, K., et al. (2021). MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling. Cell Rep 35, 109124.","journal-title":"Cell Rep"},{"key":"3051_CR53","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/S0092-8674(00)81887-5","volume":"88","author":"X Nan","year":"1997","unstructured":"Nan, X., Campoy, F.J., and Bird, A. (1997). MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin. Cell 88, 471\u2013481.","journal-title":"Cell"},{"key":"3051_CR54","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1038\/30764","volume":"393","author":"X Nan","year":"1998","unstructured":"Nan, X., Ng, H.H., Johnson, C.A., Laherty, C.D., Turner, B.M., Eisenman, R.N., and Bird, A. (1998). Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393, 386\u2013389.","journal-title":"Nature"},{"key":"3051_CR55","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1038\/s41591-023-02398-1","volume":"29","author":"JL Neul","year":"2023","unstructured":"Neul, J.L., Percy, A.K., Benke, T.A., Berry-Kravis, E.M., Glaze, D.G., Marsh, E.D., Lin, T., Stankovic, S., Bishop, K.M., and Youakim, J.M. (2023). Trofinetide for the treatment of Rett syndrome: a randomized phase 3 study. Nat Med 29, 1468\u20131475.","journal-title":"Nat Med"},{"key":"3051_CR56","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.cell.2008.09.017","volume":"135","author":"J Nishino","year":"2008","unstructured":"Nishino, J., Kim, I., Chada, K., and Morrison, S.J. (2008). Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf expression. Cell 135, 227\u2013239.","journal-title":"Cell"},{"key":"3051_CR57","doi-asserted-by":"publisher","first-page":"3636","DOI":"10.1093\/nar\/gkae051","volume":"52","author":"D Ortega-Alarcon","year":"2024","unstructured":"Ortega-Alarcon, D., Claveria-Gimeno, R., Vega, S., Kalani, L., Jorge-Torres, O.C., Esteller, M., Ausio, J., Abian, O., and Velazquez-Campoy, A. (2024). Extending MeCP2 interactome: canonical nucleosomal histones interact with MeCP2. Nucleic Acids Res 52, 3636\u20133653.","journal-title":"Nucleic Acids Res"},{"key":"3051_CR58","doi-asserted-by":"publisher","first-page":"1172805","DOI":"10.3389\/fnins.2023.1172805","volume":"17","author":"M Palmieri","year":"2023","unstructured":"Palmieri, M., Pozzer, D., and Landsberger, N. (2023). Advanced genetic therapies for the treatment of Rett syndrome: state of the art and future perspectives. Front Neurosci 17, 1172805.","journal-title":"Front Neurosci"},{"key":"3051_CR59","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.tins.2020.05.002","volume":"43","author":"JD Paskus","year":"2020","unstructured":"Paskus, J.D., Herring, B.E., and Roche, K.W. (2020). Kalirin and Trio: RhoGEFs in synaptic transmission, plasticity, and complex brain disorders. Trends Neurosci 43, 505\u2013518.","journal-title":"Trends Neurosci"},{"key":"3051_CR60","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1203\/PDR.0b013e3181d4ecf7","volume":"67","author":"S Psoni","year":"2010","unstructured":"Psoni, S., Sofocleous, C., Traeger-Synodinos, J., Kitsiou-Tzeli, S., Kanavakis, E., and Fryssira-Kanioura, H. (2010). Phenotypic and genotypic variability in four males with MECP2 gene sequence aberrations including a novel deletion. Pediatr Res 67, 551\u2013556.","journal-title":"Pediatr Res"},{"key":"3051_CR61","doi-asserted-by":"publisher","first-page":"eadd4666","DOI":"10.1126\/scitranslmed.add4666","volume":"15","author":"J Qian","year":"2023","unstructured":"Qian, J., Guan, X., Xie, B., Xu, C., Niu, J., Tang, X., Li, C.H., Colecraft, H.M., Jaenisch, R., and Liu, X.S. (2023). Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons. Sci Transl Med 15, eadd4666.","journal-title":"Sci Transl Med"},{"key":"3051_CR62","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/s41587-024-02313-0","volume":"43","author":"P Reautschnig","year":"2025","unstructured":"Reautschnig, P., Fruhner, C., Wahn, N., Wiegand, C.P., Kragness, S., Yung, J.F., Hofacker, D.T., Fisk, J., Eidelman, M., Waffenschmidt, N., et al. (2025). Precise in vivo RNA base editing with a wobble-enhanced circular CLUSTER guide RNA. Nat Biotechnol 43, 545\u2013557.","journal-title":"Nat Biotechnol"},{"key":"3051_CR63","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1038\/nature05734","volume":"446","author":"SK Reddy","year":"2007","unstructured":"Reddy, S.K., Rape, M., Margansky, W.A., and Kirschner, M.W. (2007). Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation. Nature 446, 921\u2013925.","journal-title":"Nature"},{"key":"3051_CR64","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/nbt.1754","volume":"29","author":"JT Robinson","year":"2011","unstructured":"Robinson, J.T., Thorvaldsd\u00f3ttir, H., Winckler, W., Guttman, M., Lander, E.S., Getz, G., and Mesirov, J.P. (2011). Integrative genomics viewer. Nat Biotechnol 29, 24\u201326.","journal-title":"Nat Biotechnol"},{"key":"3051_CR65","doi-asserted-by":"publisher","first-page":"4858","DOI":"10.1038\/ncomms5858","volume":"5","author":"TA Russell","year":"2014","unstructured":"Russell, T.A., Blizinsky, K.D., Cobia, D.J., Cahill, M.E., Xie, Z., Sweet, R.A., Duan, J., Gejman, P.V., Wang, L., Csernansky, J.G., et al. (2014). A sequence variant in human KALRN impairs protein function and coincides with reduced cortical thickness. Nat Commun 5, 4858.","journal-title":"Nat Commun"},{"key":"3051_CR66","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1038\/s41593-021-00906-5","volume":"24","author":"RA Samarasinghe","year":"2021","unstructured":"Samarasinghe, R.A., Miranda, O.A., Buth, J.E., Mitchell, S., Ferando, I., Watanabe, M., Allison, T.F., Kurdian, A., Fotion, N.N., Gandal, M.J., et al. (2021). Identification of neural oscillations and epileptiform changes in human brain organoids. Nat Neurosci 24, 1488\u20131500.","journal-title":"Nat Neurosci"},{"key":"3051_CR67","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/S1474-4422(20)30217-9","volume":"19","author":"AJ Sandweiss","year":"2020","unstructured":"Sandweiss, A.J., Brandt, V.L., and Zoghbi, H.Y. (2020). Advances in understanding of Rett syndrome and MECP2 duplication syndrome: prospects for future therapies. Lancet Neurol 19, 689\u2013698.","journal-title":"Lancet Neurol"},{"key":"3051_CR68","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1002\/ajmg.a.20571","volume":"126A","author":"C Schanen","year":"2004","unstructured":"Schanen, C., Houwink, E.J.F., Dorrani, N., Lane, J., Everett, R., Feng, A., Cantor, R.M., and Percy, A. (2004). Phenotypic manifestations of MECP2 mutations in classical and atypical Rett syndrome. Am J Med Genet Pt A 126A, 129\u2013140.","journal-title":"Am J Med Genet Pt A"},{"key":"3051_CR69","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon, P., Markiel, A., Ozier, O., Baliga, N.S., Wang, J.T., Ramage, D., Amin, N., Schwikowski, B., and Ideker, T. (2003). Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13, 2498\u20132504.","journal-title":"Genome Res"},{"key":"3051_CR70","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/nrm3934","volume":"16","author":"S Sivakumar","year":"2015","unstructured":"Sivakumar, S., and Gorbsky, G.J. (2015). Spatiotemporal regulation of the anaphase-promoting complex in mitosis. Nat Rev Mol Cell Biol 16, 82\u201394.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3051_CR71","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian, A., Tamayo, P., Mootha, V.K., Mukherjee, S., Ebert, B.L., Gillette, M.A., Paulovich, A., Pomeroy, S.L., Golub, T.R., Lander, E.S., et al. (2005). Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102, 15545\u201315550.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3051_CR72","doi-asserted-by":"publisher","first-page":"e135763","DOI":"10.1172\/JCI135763","volume":"131","author":"XY Tang","year":"2021","unstructured":"Tang, X.Y., Xu, L., Wang, J., Hong, Y., Wang, Y., Zhu, Q., Wang, D., Zhang, X.Y., Liu, C.Y., Fang, K.H., et al. (2021). DSCAM\/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome. J Clin Invest 131, e135763.","journal-title":"J Clin Invest"},{"key":"3051_CR73","doi-asserted-by":"publisher","first-page":"4652","DOI":"10.1038\/s41380-020-0821-6","volume":"26","author":"A Thomazeau","year":"2021","unstructured":"Thomazeau, A., Bosch, M., Essayan-Perez, S., Barnes, S.A., De Jesus-Cortes, H., and Bear, M.F. (2021). Dissociation of functional and structural plasticity of dendritic spines during NMDAR and mGluR-dependent long-term synaptic depression in wild-type and fragile X model mice. Mol Psychiatry 26, 4652\u20134669.","journal-title":"Mol Psychiatry"},{"key":"3051_CR74","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1093\/brain\/awad282","volume":"147","author":"A Tiberi","year":"2024","unstructured":"Tiberi, A., Borgonovo, G., Testa, G., Pacifico, P., Jacob, A., Di Caprio, M., Totaro, V., Calvello, M., Cattaneo, A., and Capsoni, S. (2024). Reversal of neurological deficits by painless nerve growth factor in a mouse model of Rett syndrome. Brain 147, 122\u2013134.","journal-title":"Brain"},{"key":"3051_CR75","doi-asserted-by":"publisher","first-page":"20565","DOI":"10.1038\/s41598-024-71040-y","volume":"14","author":"DL Tomasello","year":"2024","unstructured":"Tomasello, D.L., Barrasa, M.I., Mankus, D., Alarcon, K.I., Lytton-Jean, A.K.R., Liu, X. S., and Jaenisch, R. (2024). Mitochondrial dysfunction and increased reactive oxygen species production in MECP2 mutant astrocytes and their impact on neurons. Sci Rep 14, 20565.","journal-title":"Sci Rep"},{"key":"3051_CR76","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.expneurol.2009.05.001","volume":"219","author":"K Tsujimura","year":"2009","unstructured":"Tsujimura, K., Abematsu, M., Kohyama, J., Namihira, M., and Nakashima, K. (2009). Neuronal differentiation of neural precursor cells is promoted by the methyl-CpG-binding protein MeCP2. Exp Neurol 219, 104\u2013111.","journal-title":"Exp Neurol"},{"key":"3051_CR77","doi-asserted-by":"publisher","first-page":"15536","DOI":"10.1073\/pnas.242566899","volume":"99","author":"M Tudor","year":"2002","unstructured":"Tudor, M., Akbarian, S., Chen, R.Z., and Jaenisch, R. (2002). Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain. Proc Natl Acad Sci USA 99, 15536\u201315541.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3051_CR78","doi-asserted-by":"publisher","first-page":"e2310344120","DOI":"10.1073\/pnas.2310344120","volume":"120","author":"CP Tzeng","year":"2023","unstructured":"Tzeng, C.P., Whitwam, T., Boxer, L.D., Li, E., Silberfeld, A., Trowbridge, S., Mei, K., Lin, C., Shamah, R., Griffith, E.C., et al. (2023). Activity-induced MeCP2 phosphorylation regulates retinogeniculate synapse refinement. Proc Natl Acad Sci USA 120, e2310344120.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3051_CR79","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1136\/jmg.2007.049452","volume":"44","author":"L Villard","year":"2007","unstructured":"Villard, L. (2007). MECP2 mutations in males. J Med Genet 44, 417\u2013423.","journal-title":"J Med Genet"},{"key":"3051_CR80","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1007\/s11427-024-2770-x","volume":"68","author":"J Wang","year":"2025","unstructured":"Wang, J., Ye, F., Chai, H., Jiang, Y., Wang, T., Ran, X., Xia, Q., Xu, Z., Fu, Y., Zhang, G., et al. (2025). Advances and applications in single-cell and spatial genomics. Sci China Life Sci 68, 1226\u20131282.","journal-title":"Sci China Life Sci"},{"key":"3051_CR81","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/s41422-020-0288-7","volume":"30","author":"L Wang","year":"2020","unstructured":"Wang, L., Hu, M., Zuo, M.Q., Zhao, J., Wu, D., Huang, L., Wen, Y., Li, Y., Chen, P., Bao, X., et al. (2020). Rett syndrome-causing mutations compromise MeCP2-mediated liquid-liquid phase separation of chromatin. Cell Res 30, 393\u2013407.","journal-title":"Cell Res"},{"key":"3051_CR82","doi-asserted-by":"publisher","first-page":"e585","DOI":"10.1002\/cpz1.585","volume":"2","author":"Q Wang","year":"2022","unstructured":"Wang, Q., Li, M., Wu, T., Zhan, L., Li, L., Chen, M., Xie, W., Xie, Z., Hu, E., Xu, S., et al. (2022). Exploring epigenomic datasets by ChIPseeker. Curr Protocols 2, e585.","journal-title":"Curr Protocols"},{"key":"3051_CR83","doi-asserted-by":"publisher","first-page":"20220133","DOI":"10.1002\/EXP.20220133","volume":"3","author":"T Wang","year":"2023","unstructured":"Wang, T., Song, Z., Zhao, X., Wu, Y., Wu, L., Haghparast, A., and Wu, H. (2023). Spatial transcriptomic analysis of the mouse brain following chronic social defeat stress. Exploration 3, 20220133.","journal-title":"Exploration"},{"key":"3051_CR84","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.molcel.2020.05.016","volume":"79","author":"Y Xiang","year":"2020","unstructured":"Xiang, Y., Tanaka, Y., Patterson, B., Hwang, S.M., Hysolli, E., Cakir, B., Kim, K.Y., Wang, W., Kang, Y.J., Clement, E.M., et al. (2020). Dysregulation of BRD4 function underlies the functional abnormalities of MeCP2 mutant neurons. Mol Cell 79, 84\u201398.e9.","journal-title":"Mol Cell"},{"key":"3051_CR85","doi-asserted-by":"publisher","first-page":"3452","DOI":"10.1016\/j.neuron.2024.07.020","volume":"112","author":"G Yang","year":"2024","unstructured":"Yang, G., Yang, Y., Song, Z., Chen, L., Liu, F., Li, Y., Jiang, S., Xue, S., Pei, J., Wu, Y., et al. (2024a). Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration. Neuron 112, 3452\u20133469.e9.","journal-title":"Neuron"},{"key":"3051_CR86","doi-asserted-by":"publisher","first-page":"RP89912","DOI":"10.7554\/eLife.89912.3","volume":"12","author":"J Yang","year":"2024","unstructured":"Yang, J., Zou, S., Qiu, Z., Lai, M., Long, Q., Chen, H., Lai, P., Zhang, S., Rao, Z., Xie, X., et al. (2024b). Mecp2 fine-tunes quiescence exit by targeting nuclear receptors. eLife 12, RP89912.","journal-title":"eLife"},{"key":"3051_CR87","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1038\/s43587-023-00449-3","volume":"3","author":"RW Yeo","year":"2023","unstructured":"Yeo, R.W., Zhou, O.Y., Zhong, B.L., Sun, E.D., Navarro Negredo, P., Nair, S., Sharmin, M., Ruetz, T.J., Wilson, M., Kundaje, A., et al. (2023). Chromatin accessibility dynamics of neurogenic niche cells reveal defects in neural stem cell adhesion and migration during aging. Nat Aging 3, 866\u2013893.","journal-title":"Nat Aging"},{"key":"3051_CR88","doi-asserted-by":"publisher","first-page":"e78079","DOI":"10.7554\/eLife.78079","volume":"11","author":"M Yildirim","year":"2022","unstructured":"Yildirim, M., Delepine, C., Feldman, D., Pham, V.A., Chou, S., Ip, J., Nott, A., Tsai, L. H., Ming, G.L., So, P.T., et al. (2022). Label-free three-photon imaging of intact human cerebral organoids for tracking early events in brain development and deficits in Rett syndrome. eLife 11, e78079.","journal-title":"eLife"},{"key":"3051_CR89","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu, G., Wang, L.G., Han, Y., and He, Q.Y. (2012). clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS-J Integr Biol 16, 284\u2013287.","journal-title":"OMICS-J Integr Biol"},{"key":"3051_CR90","doi-asserted-by":"publisher","first-page":"2756","DOI":"10.1038\/s41467-022-30325-4","volume":"13","author":"S Yu","year":"2022","unstructured":"Yu, S., Zhou, C., He, J., Yao, Z., Huang, X., Rong, B., Zhu, H., Wang, S., Chen, S., Wang, X., et al. (2022). BMP4 drives primed to na\u00efve transition through PGC-like state. Nat Commun 13, 2756.","journal-title":"Nat Commun"},{"key":"3051_CR91","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41540-022-00247-4","volume":"8","author":"R Yue","year":"2022","unstructured":"Yue, R., and Dutta, A. (2022). Computational systems biology in disease modeling and control, review and perspectives. NPJ Syst Biol Appl 8, 1\u20136.","journal-title":"NPJ Syst Biol Appl"},{"key":"3051_CR92","doi-asserted-by":"publisher","first-page":"5136","DOI":"10.1038\/s41467-024-49368-w","volume":"15","author":"J Zhang","year":"2024","unstructured":"Zhang, J., Li, H., and Niswander, L.A. (2024a). m5C methylated lncRncr3-MeCP2 interaction restricts miR124a-initiated neurogenesis. Nat Commun 15, 5136.","journal-title":"Nat Commun"},{"key":"3051_CR93","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1016\/j.celrep.2019.07.014","volume":"28","author":"R Zhang","year":"2019","unstructured":"Zhang, R., Boareto, M., Engler, A., Louvi, A., Giachino, C., Iber, D., and Taylor, V. (2019). Id4 downstream of Notch2 maintains neural stem cell quiescence in the adult hippocampus. Cell Rep 28, 1485\u20131498.e6.","journal-title":"Cell Rep"},{"key":"3051_CR94","doi-asserted-by":"publisher","first-page":"e162434","DOI":"10.1172\/JCI162434","volume":"133","author":"S Zhang","year":"2023","unstructured":"Zhang, S., You, X., Zheng, Y., Shen, Y., Xiong, X., and Sun, Y. (2023). The UBE2C\/CDH1\/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells. J Clin Invest 133, e162434.","journal-title":"J Clin Invest"},{"key":"3051_CR95","doi-asserted-by":"publisher","first-page":"113930","DOI":"10.1016\/j.celrep.2024.113930","volume":"43","author":"Y Zhang","year":"2024","unstructured":"Zhang, Y., Song, Z., Wu, R., Kong, X., Zhang, H., Li, S., Gong, X., Gong, S., Cheng, J., Yuan, F., et al. (2024b). PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA. Cell Rep 43, 113930.","journal-title":"Cell Rep"},{"key":"3051_CR96","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1126\/science.1089071","volume":"302","author":"HY Zoghbi","year":"2003","unstructured":"Zoghbi, H.Y. (2003). Postnatal neurodevelopmental disorders: meeting at the synapse? Science 302, 826\u2013830.","journal-title":"Science"}],"container-title":["Science China Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-025-3051-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11427-025-3051-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-025-3051-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T16:01:49Z","timestamp":1784908909000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11427-025-3051-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,30]]},"references-count":96,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["3051"],"URL":"https:\/\/doi.org\/10.1007\/s11427-025-3051-3","relation":{},"ISSN":["1674-7305","1869-1889"],"issn-type":[{"value":"1674-7305","type":"print"},{"value":"1869-1889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,30]]},"assertion":[{"value":"22 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest. This study was approved by the ethics committee of the Beijing Institute of Basic Medical Sciences (approval no. AF\/SC-08\/02.374).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance and ethics"}}]}}