{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T01:59:51Z","timestamp":1788400791036,"version":"build-2803163510"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci. China Life Sci."],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s11427-025-3089-5","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:54:14Z","timestamp":1769075654000},"page":"1562-1577","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The vinculin-\u03b2-catenin axis promotes bone formation and repair: an essential prerequisite for the anti-osteoporotic efficacy of sclerostin-neutralizing antibody"],"prefix":"10.1007","volume":"69","author":[{"given":"Sixiong","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianglong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YuJia","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinnan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanqing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingxuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyang","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuenong","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhi","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"3089_CR1","doi-asserted-by":"publisher","first-page":"14583","DOI":"10.3390\/ijms241914583","volume":"24","author":"B Adejuyigbe","year":"2023","unstructured":"Adejuyigbe, B., Kallini, J., Chiou, D., and Kallini, J.R. (2023). Osteoporosis: molecular pathology, diagnostics, and therapeutics. Int J Mol Sci 24, 14583.","journal-title":"Int J Mol Sci"},{"key":"3089_CR2","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1101\/gad.277003","volume":"17","author":"A Aszodi","year":"2003","unstructured":"Aszodi, A., Hunziker, E.B., Brakebusch, C., and F\u00e4ssler, R. (2003). \u03b21 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis. Genes Dev 17, 2465\u20132479.","journal-title":"Genes Dev"},{"key":"3089_CR3","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.cell.2014.06.013","volume":"158","author":"L Azzolin","year":"2014","unstructured":"Azzolin, L., Panciera, T., Soligo, S., Enzo, E., Bicciato, S., Dupont, S., Bresolin, S., Frasson, C., Basso, G., Guzzardo, V., et al. (2014). YAP\/TAZ incorporation in the \u03b2-catenin destruction complex orchestrates the Wnt response. Cell 158, 157\u2013170.","journal-title":"Cell"},{"key":"3089_CR4","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nm.3074","volume":"19","author":"R Baron","year":"2013","unstructured":"Baron, R., and Kneissel, M. (2013). WNT signaling in bone homeostasis and disease: from human mutations to treatments. Nat Med 19, 179\u2013192.","journal-title":"Nat Med"},{"key":"3089_CR5","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.1007\/s00018-017-2511-3","volume":"74","author":"JL Bays","year":"2017","unstructured":"Bays, J.L., and DeMali, K.A. (2017). Vinculin in cell-cell and cell-matrix adhesions. Cell Mol Life Sci 74, 2999\u20133009.","journal-title":"Cell Mol Life Sci"},{"key":"3089_CR6","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jneuroim.2015.07.012","volume":"287","author":"M Beppu","year":"2015","unstructured":"Beppu, M., Sawai, S., Satoh, M., Mori, M., Kazami, T., Misawa, S., Shibuya, K., Ishibashi, M., Sogawa, K., Kado, S., et al. (2015). Autoantibodies against vinculin in patients with chronic inflammatory demyelinating polyneuropathy. J Neuroimmunol 287, 9\u201315.","journal-title":"J Neuroimmunol"},{"key":"3089_CR7","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.devcel.2021.02.020","volume":"56","author":"R Biswas","year":"2021","unstructured":"Biswas, R., Banerjee, A., Lembo, S., Zhao, Z., Lakshmanan, V., Lim, R., Le, S., Nakasaki, M., Kutyavin, V., Wright, G., et al. (2021). Mechanical instability of adherens junctions overrides intrinsic quiescence of hair follicle stem cells. Dev Cell 56, 761\u2013780.e7.","journal-title":"Dev Cell"},{"key":"3089_CR8","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1002\/jbmr.141","volume":"25","author":"ML Bouxsein","year":"2010","unstructured":"Bouxsein, M.L., Boyd, S.K., Christiansen, B.A., Guldberg, R.E., Jepsen, K.J., and M\u00fcller, R. (2010). Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J Bone Miner Res 25, 1468\u20131486.","journal-title":"J Bone Miner Res"},{"key":"3089_CR9","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/nrendo.2013.154","volume":"9","author":"E Canalis","year":"2013","unstructured":"Canalis, E. (2013). Wnt signalling in osteoporosis: mechanisms and novel therapeutic approaches. Nat Rev Endocrinol 9, 575\u2013583.","journal-title":"Nat Rev Endocrinol"},{"key":"3089_CR10","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/s41413-019-0073-8","volume":"8","author":"H Cao","year":"2020","unstructured":"Cao, H., Yan, Q., Wang, D., Lai, Y., Zhou, B., Zhang, Q., Jin, W., Lin, S., Lei, Y., Ma, L., et al. (2020). Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice. Bone Res 8, 2.","journal-title":"Bone Res"},{"key":"3089_CR11","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/s41413-021-00179-5","volume":"10","author":"S Chen","year":"2022","unstructured":"Chen, S., Wu, X., Lai, Y., Chen, D., Bai, X., Liu, S., Wu, Y., Chen, M., Lai, Y., Cao, H., et al. (2022). Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc. Bone Res 10, 5.","journal-title":"Bone Res"},{"key":"3089_CR12","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/jbmr.1805","volume":"28","author":"DW Dempster","year":"2013","unstructured":"Dempster, D.W., Compston, J.E., Drezner, M.K., Glorieux, F.H., Kanis, J.A., Malluche, H., Meunier, P.J., Ott, S.M., Recker, R.R., and Parfitt, A.M. (2013). Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 28, 2\u201317.","journal-title":"J Bone Miner Res"},{"key":"3089_CR13","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/s41392-020-00328-y","volume":"5","author":"X Fu","year":"2020","unstructured":"Fu, X., Zhou, B., Yan, Q., Tao, C., Qin, L., Wu, X., Lin, S., Chen, S., Lai, Y., Zou, X., et al. (2020). Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice. Sig Transduct Target Ther 5, 297.","journal-title":"Sig Transduct Target Ther"},{"key":"3089_CR14","doi-asserted-by":"publisher","first-page":"2492","DOI":"10.2337\/db21-0392","volume":"70","author":"H Gao","year":"2021","unstructured":"Gao, H., Zhong, Y., Ding, Z., Lin, S., Hou, X., Tang, W., Zhou, X., Zou, X., Shao, J., Yang, F., et al. (2021). Pinch loss ameliorates obesity, glucose intolerance, and fatty liver by modulating adipocyte apoptosis in mice. Diabetes 70, 2492\u20132505.","journal-title":"Diabetes"},{"key":"3089_CR15","doi-asserted-by":"publisher","first-page":"e81792","DOI":"10.7554\/eLife.81792","volume":"12","author":"H Gao","year":"2023","unstructured":"Gao, H., Zhong, Y., Zhou, L., Lin, S., Hou, X., Ding, Z., Li, Y., Yao, Q., Cao, H., Zou, X., et al. (2023). Kindlin-2 inhibits TNF\/NF-\u03baB-Caspase 8 pathway in hepatocytes to maintain liver development and function. eLife 12, e81792.","journal-title":"eLife"},{"key":"3089_CR16","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1038\/s41467-022-28692-z","volume":"13","author":"H Gao","year":"2022","unstructured":"Gao, H., Zhou, L., Zhong, Y., Ding, Z., Lin, S., Hou, X., Zhou, X., Shao, J., Yang, F., Zou, X., et al. (2022). Kindlin-2 haploinsufficiency protects against fatty liver by targeting Foxo1 in mice. Nat Commun 13, 1025.","journal-title":"Nat Commun"},{"key":"3089_CR17","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1083\/jcb.201612177","volume":"217","author":"L Guo","year":"2018","unstructured":"Guo, L., Cai, T., Chen, K., Wang, R., Wang, J., Cui, C., Yuan, J., Zhang, K., Liu, Z., Deng, Y., et al. (2018). Kindlin-2 regulates mesenchymal stem cell differentiation through control of YAP1\/TAZ. J Cell Biol 217, 1431\u20131451.","journal-title":"J Cell Biol"},{"key":"3089_CR18","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/s41392-025-02313-9","volume":"10","author":"X Han","year":"2025","unstructured":"Han, X., Liao, R., Li, X., Zhang, C., Huo, S., Qin, L., Xiong, Y., He, T., Xiao, G., and Zhang, T. (2025). Mesenchymal stem cells in treating human diseases: molecular mechanisms and clinical studies. Sig Transduct Target Ther 10, 262.","journal-title":"Sig Transduct Target Ther"},{"key":"3089_CR19","doi-asserted-by":"publisher","first-page":"32448","DOI":"10.1074\/jbc.272.51.32448","volume":"272","author":"RB Hazan","year":"1997","unstructured":"Hazan, R.B., Kang, L., Roe, S., Borgen, P.I., and Rimm, D.L. (1997). Vinculin is associated with the E-cadherin adhesion complex. J Biol Chem 272, 32448\u201332453.","journal-title":"J Biol Chem"},{"key":"3089_CR20","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.devcel.2005.02.013","volume":"8","author":"TP Hill","year":"2005","unstructured":"Hill, T.P., Sp\u00e4ter, D., Taketo, M.M., Birchmeier, W., and Hartmann, C. (2005). Canonical Wnt\/\u03b2-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev Cell 8, 727\u2013738.","journal-title":"Dev Cell"},{"key":"3089_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/684736","volume":"2013","author":"AW James","year":"2013","unstructured":"James, A.W. (2013). Review of signaling pathways governing MSC osteogenic and adipogenic differentiation. Scientifica 2013, 1\u201317.","journal-title":"Scientifica"},{"key":"3089_CR22","first-page":"4101","volume":"22","author":"L Jiang","year":"2020","unstructured":"Jiang, L., Li, J., Zhang, C., Shang, Y., and Lin, J. (2020). YAP-mediated crosstalk between the Wnt and Hippo signaling pathways (Review). Mol Med Rep 22, 4101.","journal-title":"Mol Med Rep"},{"key":"3089_CR23","first-page":"587","volume":"40","author":"M Katoh","year":"2017","unstructured":"Katoh, M., and Katoh, M. (2017). Molecular genetics and targeted therapy of WNT-related human diseases (Review). Int J Mol Med 40, 587.","journal-title":"Int J Mol Med"},{"key":"3089_CR24","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/s00428-003-0804-4","volume":"443","author":"S Kawai","year":"2003","unstructured":"Kawai, S., Enzan, H., Hayashi, Y., Jin, Y.L., Guo, L.M., Miyazaki, E., Toi, M., Kuroda, N., Hiroi, M., Saibara, T., et al. (2003). Vinculin: a novel marker for quiescent and activated hepatic stellate cells in human and rat livers. Virchows Archiv 443, 78\u201386.","journal-title":"Virchows Archiv"},{"key":"3089_CR25","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/S2213-8587(17)30188-2","volume":"5","author":"S Khosla","year":"2017","unstructured":"Khosla, S., and Hofbauer, L.C. (2017). Osteoporosis treatment: recent developments and ongoing challenges. Lancet Diabetes Endocrinol 5, 898\u2013907.","journal-title":"Lancet Diabetes Endocrinol"},{"key":"3089_CR26","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1093\/abbs\/gms084","volume":"45","author":"WM Konsavage","year":"2013","unstructured":"Konsavage, W.M., and Yochum, G.S. (2013). Intersection of Hippo\/YAP and Wnt\/\u03b2-catenin signaling pathways. Acta Biochim Biophys Sin 45, 71\u201379.","journal-title":"Acta Biochim Biophys Sin"},{"key":"3089_CR27","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/ncb3478","volume":"19","author":"A Labernadie","year":"2017","unstructured":"Labernadie, A., Kato, T., Brugu\u00e9s, A., Serra-Picamal, X., Derzsi, S., Arwert, E., Weston, A., Gonz\u00e1lez-Tarrag\u00f3, V., Elosegui-Artola, A., Albertazzi, L., et al. (2017). A mechanically active heterotypic E-cadherin\/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion. Nat Cell Biol 19, 224\u2013237.","journal-title":"Nat Cell Biol"},{"key":"3089_CR28","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.cell.2016.09.023","volume":"167","author":"RL Lamason","year":"2016","unstructured":"Lamason, R.L., Bastounis, E., Kafai, N.M., Serrano, R., del \u00c1lamo, J.C., Theriot, J.A., and Welch, M.D. (2016). Rickettsia Sca4 reduces vinculin-mediated intercellular tension to promote spread. Cell 167, 670\u2013683.e10.","journal-title":"Cell"},{"key":"3089_CR29","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.kint.2017.09.021","volume":"93","author":"F Lausecker","year":"2018","unstructured":"Lausecker, F., Tian, X., Inoue, K., Wang, Z., Pedigo, C.E., Hassan, H., Liu, C., Zimmer, M., Jinno, S., Huckle, A.L., et al. (2018). Vinculin is required to maintain glomerular barrier integrity. Kidney Int 93, 643\u2013655.","journal-title":"Kidney Int"},{"key":"3089_CR30","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1007\/s00709-012-0475-6","volume":"250","author":"JM Leerberg","year":"2013","unstructured":"Leerberg, J.M., and Yap, A.S. (2013). Vinculin, cadherin mechanotransduction and homeostasis of cell-cell junctions. Protoplasma 250, 817\u2013829.","journal-title":"Protoplasma"},{"key":"3089_CR31","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s41413-020-00108-y","volume":"8","author":"Y Lei","year":"2020","unstructured":"Lei, Y., Fu, X., Li, P., Lin, S., Yan, Q., Lai, Y., Liu, X., Wang, Y., Bai, X., Liu, C., et al. (2020). LIM domain proteins Pinch1\/2 regulate chondrogenesis and bone mass in mice. Bone Res 8, 37.","journal-title":"Bone Res"},{"key":"3089_CR32","first-page":"168","volume":"45","author":"Z Li","year":"2024","unstructured":"Li, Z., Zeng, X., Shi, B., Han, J., Wu, Z., Chen, X., Zhang, L., Li, N., Greenblatt, M., Huang, J., et al. (2024). Schnurri-3 controls osteogenic fate of Adipoq-lineage progenitors in bone marrow. J Orthop Transl 45, 168\u2013177.","journal-title":"J Orthop Transl"},{"key":"3089_CR33","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1016\/S0046-8177(97)90195-7","volume":"28","author":"B Lifschitz-Mercer","year":"1997","unstructured":"Lifschitz-Mercer, B., Czernobilsky, B., Feldberg, E., and Geiger, B. (1997). Expression of the adherens junction protein vinculin in human basal and squamous cell tumors: relationship to invasiveness and metastatic potential. Hum Pathol 28, 1230\u20131236.","journal-title":"Hum Pathol"},{"key":"3089_CR34","doi-asserted-by":"publisher","first-page":"806528","DOI":"10.3389\/fmolb.2022.806528","volume":"9","author":"X Lin","year":"2022","unstructured":"Lin, X., Zhang, H., Liu, J., Wu, C.L., McDavid, A., Boyce, B.F., and Xing, L. (2022). Aged callus skeletal stem\/progenitor cells contain an inflammatory osteogenic population with increased IRF and NF-\u03baB pathways and reduced osteogenic potential. Front Mol Biosci 9, 806528.","journal-title":"Front Mol Biosci"},{"key":"3089_CR35","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.actbio.2018.11.010","volume":"83","author":"C Liu","year":"2019","unstructured":"Liu, C., Chiang, B., Lewin Mejia, D., Luker, K.E., Luker, G.D., and Lee, A. (2019). Mammary fibroblasts remodel fibrillar collagen microstructure in a biomimetic nanocomposite hydrogel. Acta BioMater 83, 221\u2013232.","journal-title":"Acta BioMater"},{"key":"3089_CR36","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1002\/gene.10092","volume":"33","author":"M Logan","year":"2002","unstructured":"Logan, M., Martin, J.F., Nagy, A., Lobe, C., Olson, E.N., and Tabin, C.J. (2002). Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis 33, 77\u201380.","journal-title":"Genesis"},{"key":"3089_CR37","doi-asserted-by":"publisher","first-page":"a008334","DOI":"10.1101\/cshperspect.a008334","volume":"5","author":"F Long","year":"2013","unstructured":"Long, F., and Ornitz, D.M. (2013). Development of the endochondral skeleton. Cold Spring Harb Perspect Biol 5, a008334.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"3089_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/4356359","volume":"2020","author":"S Maacha","year":"2020","unstructured":"Maacha, S., Sidahmed, H., Jacob, S., Gentilcore, G., Calzone, R., Grivel, J.C., and Cugno, C. (2020). Paracrine mechanisms of mesenchymal stromal cells in angiogenesis. Stem Cells Int 2020, 1\u201312.","journal-title":"Stem Cells Int"},{"key":"3089_CR39","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s40265-019-01072-6","volume":"79","author":"A Markham","year":"2019","unstructured":"Markham, A. (2019). Romosozumab: first global approval. Drugs 79, 471\u2013476.","journal-title":"Drugs"},{"key":"3089_CR40","doi-asserted-by":"publisher","first-page":"27","DOI":"10.4248\/BR201301004","volume":"1","author":"KA Maupin","year":"2013","unstructured":"Maupin, K.A., Droscha, C.J., and Williams, B.O. (2013). A comprehensive overview of skeletal phenotypes associated with alterations in Wnt\/\u03b2-catenin signaling in humans and mice. Bone Res 1, 27\u201371.","journal-title":"Bone Res"},{"key":"3089_CR41","first-page":"131","volume":"38","author":"JJ Olsen","year":"2017","unstructured":"Olsen, J.J., Pohl, S., Deshmukh, A., Visweswaran, M., Ward, N.C., Arfuso, F., Agostino, M., and Dharmarajan, A. (2017). The role of Wnt signalling in angiogenesis. Clin Biochem Rev 38, 131\u2013142.","journal-title":"Clin Biochem Rev"},{"key":"3089_CR42","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1242\/jcs.056432","volume":"123","author":"X Peng","year":"2010","unstructured":"Peng, X., Cuff, L.E., Lawton, C.D., and DeMali, K.A. (2010). Vinculin regulates cell-surface E-cadherin expression by binding to \u03b2-catenin. J Cell Sci 123, 567\u2013577.","journal-title":"J Cell Sci"},{"key":"3089_CR43","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1038\/s43587-021-00105-8","volume":"1","author":"A Pouikli","year":"2021","unstructured":"Pouikli, A., Parekh, S., Maleszewska, M., Nikopoulou, C., Baghdadi, M., Tripodi, I., Folz-Donahue, K., Hinze, Y., Mesaros, A., Hoey, D., et al. (2021). Chromatin remodeling due to degradation of citrate carrier impairs osteogenesis of aged mesenchymal stem cells. Nat Aging 1, 810\u2013825.","journal-title":"Nat Aging"},{"key":"3089_CR44","doi-asserted-by":"publisher","first-page":"23780","DOI":"10.1074\/jbc.M109.039347","volume":"284","author":"A Raducanu","year":"2009","unstructured":"Raducanu, A., Hunziker, E.B., Drosse, I., and Asz\u00f3di, A. (2009). \u03b21 integrin deficiency results in multiple abnormalities of the knee joint. J Biol Chem 284, 23780\u201323792.","journal-title":"J Biol Chem"},{"key":"3089_CR45","doi-asserted-by":"publisher","first-page":"a007997","DOI":"10.1101\/cshperspect.a007997","volume":"4","author":"JB Regard","year":"2012","unstructured":"Regard, J.B., Zhong, Z., Williams, B.O., and Yang, Y. (2012). Wnt signaling in bone development and disease: making stronger bone with Wnts. Cold Spring Harb Perspect Biol 4, a007997.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"3089_CR46","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1016\/S0140-6736(21)02646-5","volume":"399","author":"IR Reid","year":"2022","unstructured":"Reid, I.R., and Billington, E.O. (2022). Drug therapy for osteoporosis in older adults. Lancet 399, 1080\u20131092.","journal-title":"Lancet"},{"key":"3089_CR47","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.matbio.2015.12.009","volume":"52\u201354","author":"Y Ren","year":"2016","unstructured":"Ren, Y., Han, X., Jing, Y., Yuan, B., Ke, H., Liu, M., and Feng, J.Q. (2016). Sclerostin antibody (Scl-Ab) improves osteomalacia phenotype in dentin matrix protein 1 (Dmp1) knockout mice with little impact on serum levels of phosphorus and FGF23. Matrix Biol 52\u201354, 151\u2013161.","journal-title":"Matrix Biol"},{"key":"3089_CR48","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1056\/NEJMoa1708322","volume":"377","author":"KG Saag","year":"2017","unstructured":"Saag, K.G., Petersen, J., Brandi, M.L., Karaplis, A.C., Lorentzon, M., Thomas, T., Maddox, J., Fan, M., Meisner, P.D., and Grauer, A. (2017). Romosozumab or alendronate for fracture prevention in women with osteoporosis. N Engl J Med 377, 1417\u20131427.","journal-title":"N Engl J Med"},{"key":"3089_CR49","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/S0945-053X(00)00122-0","volume":"19","author":"K Sakai","year":"2001","unstructured":"Sakai, K., Hiripi, L., Glumoff, V., Brandau, O., Eerola, R., Vuorio, E., B\u00f6sze, Z., F\u00e4ssler, R., and Asz\u00f3di, A. (2001). Stage-and tissue-specific expression of a Col2a1-Cre fusion gene in transgenic mice. Matrix Biol 19, 761\u2013767.","journal-title":"Matrix Biol"},{"key":"3089_CR50","doi-asserted-by":"publisher","first-page":"e393","DOI":"10.1002\/cpz1.393","volume":"2","author":"AM Sarmin","year":"2022","unstructured":"Sarmin, A.M., and Connelly, J.T. (2022). Fabrication of human skin equivalents using decellularized extracellular matrix. Curr Protocols 2, e393.","journal-title":"Curr Protocols"},{"key":"3089_CR51","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s13059-018-1468-3","volume":"19","author":"IML Somorjai","year":"2018","unstructured":"Somorjai, I.M.L., Mart\u00ed-Solans, J., Diaz-Gracia, M., Nishida, H., Imai, K.S., Escriv\u00e0, H., Ca\u00f1estro, C., and Albalat, R. (2018). Wnt evolution and function shuffling in liberal and conservative chordate genomes. Genome Biol 19, 98.","journal-title":"Genome Biol"},{"key":"3089_CR52","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1007\/s11427-023-2541-x","volume":"67","author":"H Tao","year":"2024","unstructured":"Tao, H., Wang, Q., Chen, K., Zhu, P., Gu, Y., and Geng, D. (2024). Metal ion metabolism and osteoporosis: possible implications for pharmaceutical biotechnology and tissue engineering. Sci China Life Sci 67, 1763\u20131765.","journal-title":"Sci China Life Sci"},{"key":"3089_CR53","doi-asserted-by":"publisher","first-page":"e131692","DOI":"10.1172\/jci.insight.131692","volume":"4","author":"Y Wang","year":"2019","unstructured":"Wang, Y., Yan, Q., Zhao, Y., Liu, X., Lin, S., Zhang, P., Ma, L., Lai, Y., Bai, X., Liu, C., et al. (2019). Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice. JCI Insight 4, e131692.","journal-title":"JCI Insight"},{"key":"3089_CR54","doi-asserted-by":"publisher","first-page":"7531","DOI":"10.1038\/ncomms8531","volume":"6","author":"C Wu","year":"2015","unstructured":"Wu, C., Jiao, H., Lai, Y., Zheng, W., Chen, K., Qu, H., Deng, W., Song, P., Zhu, K., Cao, H., et al. (2015). Kindlin-2 controls TGF-\u03b2 signalling and Sox9 expression to regulate chondrogenesis. Nat Commun 6, 7531.","journal-title":"Nat Commun"},{"key":"3089_CR55","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1186\/s12967-023-04563-z","volume":"21","author":"D Wu","year":"2023","unstructured":"Wu, D., Li, L., Wen, Z., and Wang, G. (2023a). Romosozumab in osteoporosis: yesterday, today and tomorrow. J Transl Med 21, 668.","journal-title":"J Transl Med"},{"key":"3089_CR56","doi-asserted-by":"publisher","first-page":"1116128","DOI":"10.3389\/fcell.2023.1116128","volume":"11","author":"X Wu","year":"2023","unstructured":"Wu, X., Lin, S., Liao, R., Yao, Q., Lin, L., Zou, X., and Xiao, G. (2023b). Brief research report: effects of Pinch deficiency on cartilage homeostasis in adult mice. Front Cell Dev Biol 11, 1116128.","journal-title":"Front Cell Dev Biol"},{"key":"3089_CR57","doi-asserted-by":"publisher","first-page":"21450","DOI":"10.1074\/jbc.M111.331249","volume":"287","author":"G Xiao","year":"2012","unstructured":"Xiao, G., Cheng, H., Cao, H., Chen, K., Tu, Y., Yu, S., Jiao, H., Yang, S., Im, H.J., Chen, D., et al. (2012). Critical role of filamin-binding LIM protein 1 (FBLP-1)\/migfilin in regulation of bone remodeling. J Biol Chem 287, 21450\u201321460.","journal-title":"J Biol Chem"},{"key":"3089_CR58","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1242\/dev.125.2.327","volume":"125","author":"W Xu","year":"1998","unstructured":"Xu, W., Baribault, H., and Adamson, E.D. (1998). Vinculin knockout results in heart and brain defects during embryonic development. Development 125, 327\u2013337.","journal-title":"Development"},{"key":"3089_CR59","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s00198-015-3308-6","volume":"27","author":"W Yao","year":"2016","unstructured":"Yao, W., Dai, W., Jiang, L., Lay, E.Y.A., Zhong, Z., Ritchie, R.O., Li, X., Ke, H., and Lane, N.E. (2016). Sclerostin-antibody treatment of glucocorticoid-induced osteoporosis maintained bone mass and strength. Osteoporos Int 27, 283\u2013294.","journal-title":"Osteoporos Int"},{"key":"3089_CR60","doi-asserted-by":"publisher","first-page":"7522","DOI":"10.1128\/MCB.00728-07","volume":"27","author":"AE Zemljic-Harpf","year":"2007","unstructured":"Zemljic-Harpf, A.E., Miller, J.C., Henderson, S.A., Wright, A.T., Manso, A.M., Elsherif, L., Dalton, N.D., Thor, A.K., Perkins, G.A., McCulloch, A.D., et al. (2007). Cardiacmyocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy. Mol Cell Biol 27, 7522\u20137537.","journal-title":"Mol Cell Biol"},{"key":"3089_CR61","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/S0002-9440(10)63364-0","volume":"165","author":"AE Zemljic-Harpf","year":"2004","unstructured":"Zemljic-Harpf, A.E., Ponrartana, S., Avalos, R.T., Jordan, M.C., Roos, K.P., Dalton, N. D., Phan, V.Q., Adamson, E.D., and Ross, R.S. (2004). Heterozygous inactivation of the vinculin gene predisposes to stress-induced cardiomyopathy. Am J Pathol 165, 1033\u20131044.","journal-title":"Am J Pathol"},{"key":"3089_CR62","doi-asserted-by":"publisher","first-page":"e52779","DOI":"10.7554\/eLife.52779","volume":"9","author":"T Zhou","year":"2020","unstructured":"Zhou, T., Gao, B., Fan, Y., Liu, Y., Feng, S., Cong, Q., Zhang, X., Zhou, Y., Yadav, P.S., Lin, J., et al. (2020). Piezo1\/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-\u03b2-catenin. eLife 9, e52779.","journal-title":"eLife"}],"container-title":["Science China Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-025-3089-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11427-025-3089-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-025-3089-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T11:01:56Z","timestamp":1777719716000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11427-025-3089-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,14]]},"references-count":62,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["3089"],"URL":"https:\/\/doi.org\/10.1007\/s11427-025-3089-5","relation":{},"ISSN":["1674-7305","1869-1889"],"issn-type":[{"value":"1674-7305","type":"print"},{"value":"1869-1889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,14]]},"assertion":[{"value":"28 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest. All animal procedures were approved by the Institutional Animal Care and Use Committee of Southern University of Science and Technology (No. SUSTC-JY2020119). All experiments involving patients followed the ethical rules and procedures approved by the Medical Ethics Committee of The First Affiliated Hospital of Sun Yat-sen University (approval number: [2023]176).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance and ethics"}}]}}