{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:17:32Z","timestamp":1787879852185,"version":"build-2784847793"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci. China Life Sci."],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s11427-025-3149-4","type":"journal-article","created":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:51:30Z","timestamp":1772859090000},"page":"1604-1619","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Targeting methionine-induced pyroptosis enhances anti-tumor immunity"],"prefix":"10.1007","volume":"69","author":[{"given":"Mingzhu","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaolin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguo","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeng-Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun-Ying","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"3149_CR1","doi-asserted-by":"publisher","first-page":"4228","DOI":"10.1038\/s41467-021-24240-3","volume":"12","author":"Y Barekatain","year":"2021","unstructured":"Barekatain, Y., Ackroyd, J.J., Yan, V.C., Khadka, S., Wang, L., Chen, K.C., Poral, A.H., Tran, T., Georgiou, D.K., Arthur, K., et al. (2021). Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine. Nat Commun 12, 4228.","journal-title":"Nat Commun"},{"key":"3149_CR2","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/s41586-020-2682-1","volume":"585","author":"Y Bian","year":"2020","unstructured":"Bian, Y., Li, W., Kremer, D.M., Sajjakulnukit, P., Li, S., Crespo, J., Nwosu, Z.C., Zhang, L., Czerwonka, A., Pawlowska, A., et al. (2020). Cancer SLC43A2 alters T cell methionine metabolism and histone methylation. Nature 585, 277\u2013282.","journal-title":"Nature"},{"key":"3149_CR3","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/s41577-019-0228-2","volume":"20","author":"P Broz","year":"2020","unstructured":"Broz, P., Pelegr\u00edn, P., and Shao, F. (2020). The gasdermins, a protein family executing cell death and inflammation. Nat Rev Immunol 20, 143\u2013157.","journal-title":"Nat Rev Immunol"},{"key":"3149_CR4","doi-asserted-by":"publisher","first-page":"4193","DOI":"10.1038\/s41467-021-24348-6","volume":"12","author":"JP Bruce","year":"2021","unstructured":"Bruce, J.P., To, K.F., Lui, V.W.Y., Chung, G.T.Y., Chan, Y.Y., Tsang, C.M., Yip, K.Y., Ma, B.B.Y., Woo, J.K.S., Hui, E.P., et al. (2021). Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-\u03baB activation and immune escape. Nat Commun 12, 4193.","journal-title":"Nat Commun"},{"key":"3149_CR5","doi-asserted-by":"publisher","first-page":"eaav5562","DOI":"10.1126\/sciadv.aav5562","volume":"5","author":"R Chen","year":"2019","unstructured":"Chen, R., Zeng, L., Zhu, S., Liu, J., Zeh, H.J., Kroemer, G., Wang, H., Billiar, T.R., Jiang, J., Tang, D., et al. (2019). cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis. Sci Adv 5, eaav5562.","journal-title":"Sci Adv"},{"key":"3149_CR6","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1038\/s41586-024-08022-7","volume":"634","author":"Z Chi","year":"2024","unstructured":"Chi, Z., Chen, S., Yang, D., Cui, W., Lu, Y., Wang, Z., Li, M., Yu, W., Zhang, J., Jiang, Y., et al. (2024). Gasdermin D-mediated metabolic crosstalk promotes tissue repair. Nature 634, 1168\u20131177.","journal-title":"Nature"},{"key":"3149_CR7","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1038\/ng.356","volume":"41","author":"D Dankort","year":"2009","unstructured":"Dankort, D., Curley, D.P., Cartlidge, R.A., Nelson, B., Karnezis, A.N., Damsky Jr, W.E., You, M.J., DePinho, R.A., McMahon, M., and Bosenberg, M. (2009). BrafV600E cooperates with Pten loss to induce metastatic melanoma. Nat Genet 41, 544\u2013552.","journal-title":"Nat Genet"},{"key":"3149_CR8","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1158\/2159-8290.CD-19-0672","volume":"10","author":"DA Erkes","year":"2020","unstructured":"Erkes, D.A., Cai, W., Sanchez, I.M., Purwin, T.J., Rogers, C., Field, C.O., Berger, A.C., Hartsough, E.J., Rodeck, U., Alnemri, E.S., et al. (2020). Mutant BRAF and MEK inhibitors regulate the tumor immune microenvironment via pyroptosis. Cancer Discov 10, 254\u2013269.","journal-title":"Cancer Discov"},{"key":"3149_CR9","doi-asserted-by":"publisher","first-page":"4495","DOI":"10.1016\/j.cell.2021.06.028","volume":"184","author":"CL Evavold","year":"2021","unstructured":"Evavold, C.L., Hafner-Bratkovi\u010d, I., Devant, P., D\u2019Andrea, J.M., Ngwa, E.M., Bor\u0161i\u0107, E., Doench, J.G., LaFleur, M.W., Sharpe, A.H., Thiagarajah, J.R., et al. (2021). Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway. Cell 184, 4495\u20134511.e19.","journal-title":"Cell"},{"key":"3149_CR10","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/s41419-020-03347-3","volume":"12","author":"G Fan","year":"2021","unstructured":"Fan, G., Li, Y., Chen, J., Zong, Y., and Yang, X. (2021). DHA\/AA alleviates LPS-induced Kupffer cells pyroptosis via GPR120 interaction with NLRP3 to inhibit inflammasome complexes assembly. Cell Death Dis 12, 73.","journal-title":"Cell Death Dis"},{"key":"3149_CR11","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1016\/j.ccell.2023.05.005","volume":"41","author":"L Fang","year":"2023","unstructured":"Fang, L., Hao, Y., Yu, H., Gu, X., Peng, Q., Zhuo, H., Li, Y., Liu, Z., Wang, J., Chen, Y., et al. (2023). Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity. Cancer Cell 41, 1118\u20131133.e12.","journal-title":"Cancer Cell"},{"key":"3149_CR12","doi-asserted-by":"publisher","first-page":"6165","DOI":"10.1016\/j.cell.2024.08.007","volume":"187","author":"P Fontana","year":"2024","unstructured":"Fontana, P., Du, G., Zhang, Y., Zhang, H., Vora, S.M., Hu, J.J., Shi, M., Tufan, A.B., Healy, L.B., Xia, S., et al. (2024). Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity. Cell 187, 6165\u20136181.e22.","journal-title":"Cell"},{"key":"3149_CR13","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/s41586-019-1437-3","volume":"572","author":"X Gao","year":"2019","unstructured":"Gao, X., Sanderson, S.M., Dai, Z., Reid, M.A., Cooper, D.E., Lu, M., Richie Jr, J.P., Ciccarella, A., Calcagnotto, A., Mikhael, P.G., et al. (2019). Dietary methionine influences therapy in mouse cancer models and alters human metabolism. Nature 572, 397\u2013401.","journal-title":"Nature"},{"key":"3149_CR14","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1016\/j.ccell.2023.09.005","volume":"41","author":"D Gjuka","year":"2023","unstructured":"Gjuka, D., Adib, E., Garrison, K., Chen, J., Zhang, Y., Li, W., Boutz, D., Lamb, C., Tanno, Y., Nassar, A., et al. (2023). Enzyme-mediated depletion of methylthioadenosine restores T cell function in MTAP-deficient tumors and reverses immunotherapy resistance. Cancer Cell 41, 1774\u20131787.e9.","journal-title":"Cancer Cell"},{"key":"3149_CR15","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/s41587-020-0546-8","volume":"38","author":"MJ Goldman","year":"2020","unstructured":"Goldman, M.J., Craft, B., Hastie, M., Repecka, K., McDade, F., Kamath, A., Banerjee, A., Luo, Y., Rogers, D., Brooks, A.N., et al. (2020). Visualizing and interpreting cancer genomics data via the Xena platform. Nat Biotechnol 38, 675\u2013678.","journal-title":"Nat Biotechnol"},{"key":"3149_CR16","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1021\/acs.jmedchem.3c01770","volume":"67","author":"H He","year":"2024","unstructured":"He, H., Wang, Z., Peng, X., Qing, L., Zhang, Y., Fu, S., Xu, J., Li, Y., and Zhang, S. (2024). Identification of a sonically activated degrader of methionine adenosyl-transferase 2A by an in silico approach assisted with the hole-electron analysis. J Med Chem 67, 543\u2013554.","journal-title":"J Med Chem"},{"key":"3149_CR17","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.cmet.2020.07.016","volume":"32","author":"A Hooftman","year":"2020","unstructured":"Hooftman, A., Angiari, S., Hester, S., Corcoran, S.E., Runtsch, M.C., Ling, C., Ruzek, M.C., Slivka, P.F., McGettrick, A.F., Banahan, K., et al. (2020). The immunomodulatory metabolite itaconate modifies NLRP3 and inhibits inflammasome activation. Cell Metab 32, 468\u2013478.e7.","journal-title":"Cell Metab"},{"key":"3149_CR18","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1038\/s41590-020-0669-6","volume":"21","author":"JJ Hu","year":"2020","unstructured":"Hu, J.J., Liu, X., Xia, S., Zhang, Z., Zhang, Y., Zhao, J., Ruan, J., Luo, X., Lou, X., Bai, Y., et al. (2020). FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation. Nat Immunol 21, 736\u2013745.","journal-title":"Nat Immunol"},{"key":"3149_CR19","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1126\/science.abb9818","volume":"369","author":"F Humphries","year":"2020","unstructured":"Humphries, F., Shmuel-Galia, L., Ketelut-Carneiro, N., Li, S., Wang, B., Nemmara, V. V., Wilson, R., Jiang, Z., Khalighinejad, F., Muneeruddin, K., et al. (2020). Succination inactivates gasdermin D and blocks pyroptosis. Science 369, 1633\u20131637.","journal-title":"Science"},{"key":"3149_CR20","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1038\/s41467-021-21804-1","volume":"12","author":"MH Hung","year":"2021","unstructured":"Hung, M.H., Lee, J.S., Ma, C., Diggs, L.P., Heinrich, S., Chang, C.W., Ma, L., Forgues, M., Budhu, A., Chaisaingmongkol, J., et al. (2021). Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma. Nat Commun 12, 1455.","journal-title":"Nat Commun"},{"key":"3149_CR21","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.ccell.2020.12.010","volume":"39","author":"P Kalev","year":"2021","unstructured":"Kalev, P., Hyer, M.L., Gross, S., Konteatis, Z., Chen, C.C., Fletcher, M., Lein, M., Aguado-Fraile, E., Frank, V., Barnett, A., et al. (2021). MAT2A inhibition blocks the growth of MTAP-deleted cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage. Cancer Cell 39, 209\u2013224.e11.","journal-title":"Cancer Cell"},{"key":"3149_CR22","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/nature15541","volume":"526","author":"N Kayagaki","year":"2015","unstructured":"Kayagaki, N., Stowe, I.B., Lee, B.L., O\u2019Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q.T., et al. (2015). Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature 526, 666\u2013671.","journal-title":"Nature"},{"key":"3149_CR23","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1126\/science.aad5214","volume":"351","author":"GV Kryukov","year":"2016","unstructured":"Kryukov, G.V., Wilson, F.H., Ruth, J.R., Paulk, J., Tsherniak, A., Marlow, S.E., Vazquez, F., Weir, B.A., Fitzgerald, M.E., Tanaka, M., et al. (2016). MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells. Science 351, 1214\u20131218.","journal-title":"Science"},{"key":"3149_CR24","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/s41392-022-01017-8","volume":"7","author":"JT Li","year":"2022","unstructured":"Li, J.T., Yang, H., Lei, M.Z., Zhu, W.P., Su, Y., Li, K.Y., Zhu, W.Y., Wang, J., Zhang, L., Qu, J., et al. (2022). Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA. Sig Transduct Target Ther 7, 192.","journal-title":"Sig Transduct Target Ther"},{"key":"3149_CR25","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/s41556-019-0455-6","volume":"22","author":"JT Li","year":"2020","unstructured":"Li, J.T., Yin, M., Wang, D., Wang, J., Lei, M.Z., Zhang, Y., Liu, Y., Zhang, L., Zou, S.W., Hu, L.P., et al. (2020). BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma. Nat Cell Biol 22, 167\u2013174.","journal-title":"Nat Cell Biol"},{"key":"3149_CR26","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.celrep.2016.03.043","volume":"15","author":"K Marjon","year":"2016","unstructured":"Marjon, K., Cameron, M.J., Quang, P., Clasquin, M.F., Mandley, E., Kunii, K., McVay, M., Choe, S., Kernytsky, A., Gross, S., et al. (2016). MTAP deletions in cancer create vulnerability to targeting of the MAT2A\/PRMT5\/RIOK1 axis. Cell Rep 15, 574\u2013587.","journal-title":"Cell Rep"},{"key":"3149_CR27","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1126\/science.aad5944","volume":"351","author":"KJ Mavrakis","year":"2016","unstructured":"Mavrakis, K.J., McDonald, E.R. 3rd, Schlabach, M.R., Billy, E., Hoffman, G.R., deWeck, A., Ruddy, D.A., Venkatesan, K., Yu, J., McAllister, G., et al. (2016). Disordered methionine metabolism in MTAP\/CDKN2A-deleted cancers leads to dependence on PRMT5. Science 351, 1208\u20131213.","journal-title":"Science"},{"key":"3149_CR28","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/s41586-024-07585-9","volume":"631","author":"P Mehrotra","year":"2024","unstructured":"Mehrotra, P., Maschalidi, S., Boeckaerts, L., Mauer\u00f6der, C., Tixeira, R., Pinney, J., Burgoa Card\u00e1s, J., Sukhov, V., Incik, Y., Anderson, C.J., et al. (2024). Oxylipins and metabolites from pyroptotic cells act as promoters of tissue repair. Nature 631, 207\u2013215.","journal-title":"Nature"},{"key":"3149_CR29","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/nchembio.2384","volume":"13","author":"CL Quinlan","year":"2017","unstructured":"Quinlan, C.L., Kaiser, S.E., Bola\u00f1os, B., Nowlin, D., Grantner, R., Karlicek-Bryant, S., Feng, J.L., Jenkinson, S., Freeman-Cook, K., Dann, S.G., et al. (2017). Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A. Nat Chem Biol 13, 785\u2013792.","journal-title":"Nat Chem Biol"},{"key":"3149_CR30","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1007\/s11427-022-2365-1","volume":"67","author":"H Ruan","year":"2024","unstructured":"Ruan, H., Li, X., Zhou, L., Zheng, Z., Hua, R., Wang, X., Wang, Y., Fan, Y., Guo, S., Wang, L., et al. (2024). Melatonin decreases GSDME mediated mesothelial cell pyroptosis and prevents peritoneal fibrosis and ultrafiltration failure. Sci China Life Sci 67, 360\u2013378.","journal-title":"Sci China Life Sci"},{"key":"3149_CR31","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/nature15514","volume":"526","author":"J Shi","year":"2015","unstructured":"Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., and Shao, F. (2015). Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526, 660\u2013665.","journal-title":"Nature"},{"key":"3149_CR32","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.chembiol.2017.03.009","volume":"24","author":"CY Taabazuing","year":"2017","unstructured":"Taabazuing, C.Y., Okondo, M.C., and Bachovchin, D.A. (2017). Pyroptosis and apoptosis pathways engage in bidirectional crosstalk in monocytes and macrophages. Cell Chem Biol 24, 507\u2013514.e4.","journal-title":"Cell Chem Biol"},{"key":"3149_CR33","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1126\/science.aad0501","volume":"352","author":"I Tirosh","year":"2016","unstructured":"Tirosh, I., Izar, B., Prakadan, S.M., Wadsworth Ii, M.H., Treacy, D., Trombetta, J.J., Rotem, A., Rodman, C., Lian, C., Murphy, G., et al. (2016). Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq. Science 352, 189\u2013196.","journal-title":"Science"},{"key":"3149_CR34","doi-asserted-by":"publisher","first-page":"eabj3859","DOI":"10.1126\/sciimmunol.abj3859","volume":"6","author":"C Wang","year":"2021","unstructured":"Wang, C., Yang, T., Xiao, J., Xu, C., Alippe, Y., Sun, K., Kanneganti, T.D., Monahan, J. B., Abu-Amer, Y., Lieberman, J., et al. (2021). NLRP3 inflammasome activation triggers gasdermin D-independent inflammation. Sci Immunol 6, eabj3859.","journal-title":"Sci Immunol"},{"key":"3149_CR35","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.cmet.2022.02.010","volume":"34","author":"H Wang","year":"2022","unstructured":"Wang, H., Rong, X., Zhao, G., Zhou, Y., Xiao, Y., Ma, D., Jin, X., Wu, Y., Yan, Y., Yang, H., et al. (2022). The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer. Cell Metab 34, 581\u2013594.e8.","journal-title":"Cell Metab"},{"key":"3149_CR36","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/s41586-020-2079-1","volume":"579","author":"Q Wang","year":"2020","unstructured":"Wang, Q., Wang, Y., Ding, J., Wang, C., Zhou, X., Gao, W., Huang, H., Shao, F., and Liu, Z. (2020). A bioorthogonal system reveals antitumour immune function of pyroptosis. Nature 579, 421\u2013426.","journal-title":"Nature"},{"key":"3149_CR37","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nature22393","volume":"547","author":"Y Wang","year":"2017","unstructured":"Wang, Y., Gao, W., Shi, X., Ding, J., Liu, W., He, H., Wang, K., and Shao, F. (2017). Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature 547, 99\u2013103.","journal-title":"Nature"},{"key":"3149_CR38","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1038\/s41591-019-0423-5","volume":"25","author":"Z Wang","year":"2019","unstructured":"Wang, Z., Yip, L.Y., Lee, J.H.J., Wu, Z., Chew, H.Y., Chong, P.K.W., Teo, C.C., Ang, H. Y.K., Peh, K.L.E., Yuan, J., et al. (2019). Methionine is a metabolic dependency of tumor-initiating cells. Nat Med 25, 825\u2013837.","journal-title":"Nat Med"},{"key":"3149_CR39","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1007\/s11427-024-2648-0","volume":"68","author":"Q Xiong","year":"2025","unstructured":"Xiong, Q., Zhang, Y., Zheng, Y., and Zhu, Q. (2025). Regulation and application of m6A modification in tumor immunity. Sci China Life Sci 68, 974\u2013993.","journal-title":"Sci China Life Sci"},{"key":"3149_CR40","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.cmet.2020.11.018","volume":"33","author":"W Xu","year":"2021","unstructured":"Xu, W., Che, Y., Zhang, Q., Huang, H., Ding, C., Wang, Y., Wang, G., Cao, L., and Hao, H. (2021). Apaf-1 pyroptosome senses mitochondrial permeability transition. Cell Metab 33, 424\u2013436.e10.","journal-title":"Cell Metab"},{"key":"3149_CR41","doi-asserted-by":"publisher","first-page":"6973","DOI":"10.1038\/ncomms7973","volume":"6","author":"HB Yang","year":"2015","unstructured":"Yang, H.B., Xu, Y.Y., Zhao, X.N., Zou, S.W., Zhang, Y., Zhang, M., Li, J.T., Ren, F., Wang, L.Y., and Lei, Q.Y. (2015). Acetylation of MAT IIa represses tumour cell growth and is decreased in human hepatocellular cancer. Nat Commun 6, 6973.","journal-title":"Nat Commun"},{"key":"3149_CR42","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.1038\/ncomms3612","volume":"4","author":"K Yoshihara","year":"2013","unstructured":"Yoshihara, K., Shahmoradgoli, M., Mart\u00ednez, E., Vegesna, R., Kim, H., Torres-Garcia, W., Trevi\u00f1o, V., Shen, H., Laird, P.W., Levine, D.A., et al. (2013). Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun 4, 2612.","journal-title":"Nat Commun"},{"key":"3149_CR43","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/s41586-020-2071-9","volume":"579","author":"Z Zhang","year":"2020","unstructured":"Zhang, Z., Zhang, Y., Xia, S., Kong, Q., Li, S., Liu, X., Junqueira, C., Meza-Sosa, K.F., Mok, T.M.Y., Ansara, J., et al. (2020). Gasdermin E suppresses tumour growth by activating anti-tumour immunity. Nature 579, 415\u2013420.","journal-title":"Nature"},{"key":"3149_CR44","doi-asserted-by":"publisher","first-page":"108998","DOI":"10.1016\/j.celrep.2021.108998","volume":"35","author":"B Zhou","year":"2021","unstructured":"Zhou, B., and Abbott, D.W. (2021). Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases. Cell Rep 35, 108998.","journal-title":"Cell Rep"},{"key":"3149_CR45","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.ccell.2023.03.002","volume":"41","author":"W Zhou","year":"2023","unstructured":"Zhou, W., Liu, H., Yuan, Z., Zundell, J., Towers, M., Lin, J., Lombardi, S., Nie, H., Murphy, B., Yang, T., et al. (2023). Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis. Cancer Cell 41, 740\u2013756.e10.","journal-title":"Cancer Cell"}],"container-title":["Science China Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-025-3149-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11427-025-3149-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-025-3149-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T11:02:21Z","timestamp":1777719741000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11427-025-3149-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,2]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["3149"],"URL":"https:\/\/doi.org\/10.1007\/s11427-025-3149-4","relation":{},"ISSN":["1674-7305","1869-1889"],"issn-type":[{"value":"1674-7305","type":"print"},{"value":"1869-1889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,2]]},"assertion":[{"value":"27 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest. All animal experiments were approved by the Institutional Animal Care and Use Committee at Fudan University. All human tissues were obtained after the research by the FUSCC Ethics Committee. All patients signed a written consent form (2211264-17).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance and ethics"}}]}}