{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:41:18Z","timestamp":1777945278145,"version":"3.51.4"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci. China Life Sci."],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s11427-025-3184-y","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T15:38:45Z","timestamp":1771342725000},"page":"1443-1452","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Wnt signaling dysregulation drives Stargardt disease pathogenesis"],"prefix":"10.1007","volume":"69","author":[{"given":"Xiao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo-Lin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Ning","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Bing","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"3184_CR1","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/ng0397-236","volume":"15","author":"R Allikmets","year":"1997","unstructured":"Allikmets, R., Singh, N., Sun, H., Shroyer, N.F., Hutchinson, A., Chidambaram, A., Gerrard, B., Baird, L., Stauffer, D., Peiffer, A., et al. (1997). A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genet 15, 236\u2013246.","journal-title":"Nat Genet"},{"key":"3184_CR2","doi-asserted-by":"publisher","first-page":"e1002757","DOI":"10.1371\/journal.pgen.1002757","volume":"8","author":"K Bharti","year":"2012","unstructured":"Bharti, K., Gasper, M., Ou, J., Brucato, M., Clore-Gronenborn, K., Pickel, J., and Arnheiter, H. (2012). A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development. PLoS Genet 8, e1002757.","journal-title":"PLoS Genet"},{"key":"3184_CR3","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1001\/jamaophthalmol.2023.3188","volume":"141","author":"L Bianco","year":"2023","unstructured":"Bianco, L., Arrigo, A., Antropoli, A., Manitto, M.P., Martina, E., Aragona, E., Bandello, F., and Battaglia Parodi, M. (2023). Association between genotype and phenotype severity in ABCA4-associated retinopathy. JAMA Ophthalmol 141, 826.","journal-title":"JAMA Ophthalmol"},{"key":"3184_CR4","doi-asserted-by":"publisher","first-page":"3137","DOI":"10.1093\/bioinformatics\/btx373","volume":"33","author":"J Brown","year":"2017","unstructured":"Brown, J., Pirrung, M., McCue, L.A., and Wren, J. (2017). FQC dashboard: integrates FastQC results into a web-based, interactive, and extensible FASTQ quality control tool. Bioinformatics 33, 3137\u20133139.","journal-title":"Bioinformatics"},{"key":"3184_CR5","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.preteyeres.2008.08.002","volume":"27","author":"J Burke","year":"2008","unstructured":"Burke, J. (2008). Epithelial phenotype and the RPE: is the answer blowing in the Wnt? Prog Retinal Eye Res 27, 579\u2013595.","journal-title":"Prog Retinal Eye Res"},{"key":"3184_CR6","doi-asserted-by":"publisher","first-page":"2625","DOI":"10.1002\/stem.2414","volume":"34","author":"EE Capowski","year":"2016","unstructured":"Capowski, E.E., Wright, L.S., Liang, K., Phillips, M.J., Wallace, K., Petelinsek, A., Hagstrom, A., Pinilla, I., Borys, K., Lien, J., et al. (2016). Regulation of WNT signaling by VSX2 during optic vesicle patterning in human induced pluripotent stem cells. Stem Cells 34, 2625\u20132634.","journal-title":"Stem Cells"},{"key":"3184_CR7","doi-asserted-by":"publisher","first-page":"5059","DOI":"10.1074\/jbc.M111.315432","volume":"287","author":"Y Chen","year":"2012","unstructured":"Chen, Y., Okano, K., Maeda, T., Chauhan, V., Golczak, M., Maeda, A., and Palczewski, K. (2012). Mechanism of all-trans-retinal toxicity with implications for Stargardt disease and age-related macular degeneration. J Biol Chem 287, 5059\u20135069.","journal-title":"J Biol Chem"},{"key":"3184_CR8","doi-asserted-by":"publisher","first-page":"4739","DOI":"10.1167\/iovs.05-0805","volume":"46","author":"AV Cideciyan","year":"2005","unstructured":"Cideciyan, A.V., Swider, M., Aleman, T.S., Sumaroka, A., Schwartz, S.B., Roman, M.I., Milam, A.H., Bennett, J., Stone, E.M., and Jacobson, S.G. (2005). ABCA4-associated retinal degenerations spare structure and function of the human parapapillary retina. Invest Ophthalmol Vis Sci 46, 4739.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3184_CR9","doi-asserted-by":"publisher","first-page":"5946","DOI":"10.1167\/iovs.15-17698","volume":"56","author":"AV Cideciyan","year":"2015","unstructured":"Cideciyan, A.V., Swider, M., Schwartz, S.B., Stone, E.M., and Jacobson, S.G. (2015). Predicting progression of ABCA4-associated retinal degenerations based on longitudinal measurements of the leading disease front. Invest Ophthalmol Vis Sci 56, 5946.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3184_CR10","doi-asserted-by":"publisher","first-page":"e3469","DOI":"10.21769\/BioProtoc.3469","volume":"9","author":"A D\u2019Antonio-Chronowska","year":"2019","unstructured":"D\u2019Antonio-Chronowska, A., D\u2019Antonio, M., and Frazer, K. (2019). In vitro differentiation of human iPSC-derived retinal pigment epithelium cells (iPSC-RPE). Bio Protocol 9, e3469.","journal-title":"Bio Protocol"},{"key":"3184_CR11","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1016\/j.stemcr.2022.10.001","volume":"17","author":"M Farnoodian","year":"2022","unstructured":"Farnoodian, M., Bose, D., Khristov, V., Susaimanickam, P.J., Maddileti, S., Mariappan, I., Abu-Asab, M., Campos, M., Villasmil, R., Wan, Q., et al. (2022). Cell-autonomous lipid-handling defects in Stargardt iPSC-derived retinal pigment epithelium cells. Stem Cell Rep 17, 2438\u20132450.","journal-title":"Stem Cell Rep"},{"key":"3184_CR12","doi-asserted-by":"publisher","first-page":"1016182","DOI":"10.3389\/fcell.2022.1016182","volume":"10","author":"S Fuhrmann","year":"2022","unstructured":"Fuhrmann, S., Ramirez, S., Mina Abouda, M., and Campbell, C.D. (2022). Porcn is essential for growth and invagination of the mammalian optic cup. Front Cell Dev Biol 10, 1016182.","journal-title":"Front Cell Dev Biol"},{"key":"3184_CR13","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3390\/ijms22010185","volume":"22","author":"FA Garces","year":"2020","unstructured":"Garces, F.A., Scortecci, J.F., and Molday, R.S. (2020). Functional characterization of ABCA4 missense variants linked to Stargardt macular degeneration. Int J Mol Sci 22, 185.","journal-title":"Int J Mol Sci"},{"key":"3184_CR14","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1242\/dev.01571","volume":"132","author":"DJ Horsford","year":"2005","unstructured":"Horsford, D.J., Nguyen, M.T.T., Sellar, G.C., Kothary, R., Arnheiter, H., and McInnes, R.R. (2005). Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity. Development 132, 177\u2013187.","journal-title":"Development"},{"key":"3184_CR15","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.3317","volume":"12","author":"D Kim","year":"2015","unstructured":"Kim, D., Langmead, B., and Salzberg, S.L. (2015). HISAT: a fast spliced aligner with low memory requirements. Nat Methods 12, 357\u2013360.","journal-title":"Nat Methods"},{"key":"3184_CR16","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.ophtha.2014.08.032","volume":"122","author":"S Lambertus","year":"2015","unstructured":"Lambertus, S., van Huet, R.A.C., Bax, N.M., Hoefsloot, L.H., Cremers, F.P.M., Boon, C. J.F., Klevering, B.J., and Hoyng, C.B. (2015). Early-onset Stargardt disease: phenotypic and genotypic characteristics. Ophthalmology 122, 335\u2013344.","journal-title":"Ophthalmology"},{"key":"3184_CR17","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1167\/iovs.14-15835","volume":"56","author":"LL Leach","year":"2015","unstructured":"Leach, L.L., Buchholz, D.E., Nadar, V.P., Lowenstein, S.E., and Clegg, D.O. (2015). Canonical\/beta-catenin Wnt pathway activation improves retinal pigmented epithelium derivation from human embryonic stem cells. Invest Ophthalmol Vis Sci 56, 1002\u20131013.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3184_CR18","doi-asserted-by":"publisher","first-page":"E11120","DOI":"10.1073\/pnas.1802519115","volume":"115","author":"TL Lenis","year":"2018","unstructured":"Lenis, T.L., Hu, J., Ng, S.Y., Jiang, Z., Sarfare, S., Lloyd, M.B., Esposito, N.J., Samuel, W., Jaworski, C., Bok, D., et al. (2018). Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration. Proc Natl Acad Sci USA 115, E11120\u2013E11127.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3184_CR19","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.1007\/s11427-024-2816-0","volume":"68","author":"M Li","year":"2025","unstructured":"Li, M., Suzuki, K., Wang, M., Benner, C., Ku, M., Ma, L., Kobari, L., Kim, N.Y., Montserrat, N., Chang, C.J., et al. (2025). Dynamic WNT signaling controls differentiation of hematopoietic progenitor cells from human pluripotent stem cells. Sci China Life Sci 68, 2829\u20132841.","journal-title":"Sci China Life Sci"},{"key":"3184_CR20","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","volume":"30","author":"Y Liao","year":"2014","unstructured":"Liao, Y., Smyth, G.K., and Shi, W. (2014). featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics 30, 923\u2013930.","journal-title":"Bioinformatics"},{"key":"3184_CR21","doi-asserted-by":"publisher","first-page":"35414","DOI":"10.1038\/srep35414","volume":"6","author":"B Lin","year":"2016","unstructured":"Lin, B., Cai, X.B., Zheng, Z.L., Huang, X.F., Liu, X.L., Qu, J., and Jin, Z.B. (2016). Clinical and genetic analyses reveal novel pathogenic ABCA4 mutations in Stargardt disease families. Sci Rep 6, 35414.","journal-title":"Sci Rep"},{"key":"3184_CR22","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ajo.2004.02.056","volume":"138","author":"N Lois","year":"2004","unstructured":"Lois, N., Halfyard, A.S., Bird, A.C., Holder, G.E., and Fitzke, F.W. (2004). Fundus autofluorescence in Stargardt macular dystrophy-fundus flavimaculatus. Am J Ophthalmol 138, 55\u201363.","journal-title":"Am J Ophthalmol"},{"key":"3184_CR23","doi-asserted-by":"publisher","first-page":"10950","DOI":"10.1073\/pnas.1422818112","volume":"112","author":"J Maruotti","year":"2015","unstructured":"Maruotti, J., Sripathi, S.R., Bharti, K., Fuller, J., Wahlin, K.J., Ranganathan, V., Sluch, V.M., Berlinicke, C.A., Davis, J., Kim, C., et al. (2015). Small-molecule-directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells. Proc Natl Acad Sci USA 112, 10950\u201310955.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3184_CR24","doi-asserted-by":"publisher","first-page":"16698","DOI":"10.1073\/pnas.0905245106","volume":"106","author":"JS Meyer","year":"2009","unstructured":"Meyer, J.S., Shearer, R.L., Capowski, E.E., Wright, L.S., Wallace, K.A., McMillan, E.L., Zhang, S.C., and Gamm, D.M. (2009). Modeling early retinal development with human embryonic and induced pluripotent stem cells. Proc Natl Acad Sci USA 106, 16698\u201316703.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3184_CR25","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/77004","volume":"25","author":"LL Molday","year":"2000","unstructured":"Molday, L.L., Rabin, A.R., and Molday, R.S. (2000). ABCR expression in foveal cone photoreceptors and its role in Stargardt macular dystrophy. Nat Genet 25, 257\u2013258.","journal-title":"Nat Genet"},{"key":"3184_CR26","doi-asserted-by":"publisher","first-page":"3462","DOI":"10.3390\/cells11213462","volume":"11","author":"E Ng","year":"2022","unstructured":"Ng, E., Kady, N., Hu, J., Dave, A., Jiang, Z., Pei, J., Gorin, M., Matynia, A., and Radu, R. (2022). Membrane attack complex mediates retinal pigment epithelium cell death in Stargardt macular degeneration. Cells 11, 3462.","journal-title":"Cells"},{"key":"3184_CR27","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/j.cell.2015.07.013","volume":"162","author":"HW Park","year":"2015","unstructured":"Park, H.W., Kim, Y.C., Yu, B., Moroishi, T., Mo, J.S., Plouffe, S.W., Meng, Z., Lin, K.C., Yu, F.X., Alexander, C.M., et al. (2015). Alternative Wnt signaling activates YAP\/TAZ. Cell 162, 780\u2013794.","journal-title":"Cell"},{"key":"3184_CR28","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","volume":"26","author":"MD Robinson","year":"2010","unstructured":"Robinson, M.D., McCarthy, D.J., and Smyth, G.K. (2010). edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 26, 139\u2013140.","journal-title":"Bioinformatics"},{"key":"3184_CR29","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1167\/iovs.64.12.33","volume":"64","author":"J Sajovic","year":"2023","unstructured":"Sajovic, J., Megli\u010d, A., Corradi, Z., Khan, M., Maver, A., Vidmar, M.J., Hawlina, M., Cremers, F.P.M., and Fakin, A. (2023). ABCA4 variant c.5714+5G>A in trans with null alleles results in primary RPE damage. Invest Ophthalmol Vis Sci 64, 33.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3184_CR30","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1159\/000027498","volume":"214","author":"J Schwoerer","year":"2000","unstructured":"Schwoerer, J., Secr\u00e9tan, M., Zografos, L., and Piguet, B. (2000). Indocyanine green angiography in fundus flavimaculatus. Ophthalmologica 214, 240\u2013245.","journal-title":"Ophthalmologica"},{"key":"3184_CR31","doi-asserted-by":"publisher","first-page":"4471","DOI":"10.1167\/iovs.08-3139","volume":"50","author":"K Steindl-Kuscher","year":"2009","unstructured":"Steindl-Kuscher, K., Krugluger, W., Boulton, M.E., Haas, P., Schrattbauer, K., Feichtinger, H., Adlassnig, W., and Binder, S. (2009). Activation of the \u03b2-catenin signaling pathway and its impact on RPE cell cycle. Invest Ophthalmol Vis Sci 50, 4471.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3184_CR32","doi-asserted-by":"publisher","first-page":"dev146589","DOI":"10.1242\/dev.146589","volume":"145","author":"Z Steinhart","year":"2018","unstructured":"Steinhart, Z., and Angers, S. (2018). Wnt signaling in development and tissue homeostasis. Development 145, dev146589.","journal-title":"Development"},{"key":"3184_CR33","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/ng0997-15","volume":"17","author":"H Sun","year":"1997","unstructured":"Sun, H., and Nathans, J. (1997). Stargardt\u2019s ABCR is localized to the disc membrane of retinal rod outer segments. Nat Genet 17, 15\u201316.","journal-title":"Nat Genet"},{"key":"3184_CR34","doi-asserted-by":"publisher","first-page":"101803","DOI":"10.1016\/j.xpro.2022.101803","volume":"3","author":"H Surendran","year":"2022","unstructured":"Surendran, H., Soundararajan, L., Reddy K, V. B., Subramani, J., Stoddard, J., Reynaga, R., Tschetter, W., Ryals, R.C., and Pal, R. (2022). An improved protocol for generation and characterization of human-induced pluripotent stem cell-derived retinal pigment epithelium cells. STAR Protocols 3, 101803.","journal-title":"STAR Protocols"},{"key":"3184_CR35","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","volume":"131","author":"K Takahashi","year":"2007","unstructured":"Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., and Yamanaka, S. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861\u2013872.","journal-title":"Cell"},{"key":"3184_CR36","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1167\/iovs.63.6.5","volume":"63","author":"L Tian","year":"2022","unstructured":"Tian, L., Chen, C., Song, Y., Zhang, X., Xu, K., Xie, Y., Jin, Z.B., and Li, Y. (2022a). Phenotype-based genetic analysis reveals missing heritability of ABCA4-related retinopathy: deep intronic variants and copy number variations. Invest Ophthalmol Vis Sci 63, 5.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3184_CR37","doi-asserted-by":"publisher","first-page":"102894","DOI":"10.1016\/j.scr.2022.102894","volume":"64","author":"L Tian","year":"2022","unstructured":"Tian, L., Zhang, X., Xu, K., and Li, Y. (2022b). Induced pluripotent stem cell line BIOi003-A from a patient with ABCA4-associated retinal dystrophy carrying compound heterozygous c.(1222C>T;2919-884G>T) variants in ABCA4. Stem Cell Res 64, 102894.","journal-title":"Stem Cell Res"},{"key":"3184_CR38","doi-asserted-by":"publisher","first-page":"3410","DOI":"10.1007\/s11427-024-2936-y","volume":"68","author":"S Tian","year":"2025","unstructured":"Tian, S., Zong, R., Zhang, Y., Liu, Q., Wang, L., Wang, Y., and Zhao, J. (2025). WNT2\/2B double homologous knockout blocks lung development and formation in pigs. Sci China Life Sci 68, 3410\u20133412.","journal-title":"Sci China Life Sci"},{"key":"3184_CR39","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.ydbio.2016.03.023","volume":"413","author":"Z Wang","year":"2016","unstructured":"Wang, Z., Yasugi, S., and Ishii, Y. (2016). Chx10 functions as a regulator of molecular pathways controlling the regional identity in the primordial retina. Dev Biol 413, 104\u2013111.","journal-title":"Dev Biol"},{"key":"3184_CR40","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1242\/dev.032136","volume":"136","author":"P Westenskow","year":"2009","unstructured":"Westenskow, P., Piccolo, S., and Fuhrmann, S. (2009). \u03b2-catenin controls differentiation of the retinal pigment epithelium in the mouse optic cup by regulating Mitf and Otx2 expression. Development 136, 2505\u20132510.","journal-title":"Development"},{"key":"3184_CR41","doi-asserted-by":"publisher","first-page":"dev165902","DOI":"10.1242\/dev.165902","volume":"145","author":"KE Wiese","year":"2018","unstructured":"Wiese, K.E., Nusse, R., and van Amerongen, R. (2018). Wnt signalling: conquering complexity. Development 145, dev165902.","journal-title":"Development"},{"key":"3184_CR42","doi-asserted-by":"publisher","first-page":"14387","DOI":"10.1038\/s41598-020-70979-y","volume":"10","author":"K Ye","year":"2020","unstructured":"Ye, K., Takemoto, Y., Ito, A., Onda, M., Morimoto, N., Mandai, M., Takahashi, M., Kato, R., and Osakada, F. (2020). Reproducible production and image-based quality evaluation of retinal pigment epithelium sheets from human induced pluripotent stem cells. Sci Rep 10, 14387.","journal-title":"Sci Rep"},{"key":"3184_CR43","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1007\/s11427-023-2364-3","volume":"67","author":"BN Zhang","year":"2024","unstructured":"Zhang, B.N., Qi, B., Dong, C., Zhang, B., Cheng, J., Wang, X., Li, S., Zhuang, X., Chen, S., Duan, H., et al. (2024). The role of corneal endothelium in macular corneal dystrophy development and recurrence. Sci China Life Sci 67, 332\u2013344.","journal-title":"Sci China Life Sci"},{"key":"3184_CR44","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1007\/s11427-023-2531-3","volume":"67","author":"CJ Zhang","year":"2024","unstructured":"Zhang, C.J., and Jin, Z.B. (2024). Turning point of organoid transplantation: first-inhuman trial of iPSC-derived retinal organoid grafting in patients with retinitis pigmentosa. Sci China Life Sci 67, 1082\u20131084.","journal-title":"Sci China Life Sci"},{"key":"3184_CR45","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s13619-021-00097-1","volume":"10","author":"X Zhang","year":"2021","unstructured":"Zhang, X., Wang, W., and Jin, Z.B. (2021). Retinal organoids as models for development and diseases. Cell Regen 10, 33.","journal-title":"Cell Regen"},{"key":"3184_CR46","first-page":"705","volume":"36","author":"XH Zhang","year":"2021","unstructured":"Zhang, X.H., and Jin, Z.B. (2021). Patient iPSC-derived retinal organoids: observable retinal diseases in-a-dish. Histol Histopathol 36, 705\u2013710.","journal-title":"Histol Histopathol"}],"container-title":["Science China Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-025-3184-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11427-025-3184-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-025-3184-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T11:02:02Z","timestamp":1777719722000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11427-025-3184-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["3184"],"URL":"https:\/\/doi.org\/10.1007\/s11427-025-3184-y","relation":{},"ISSN":["1674-7305","1869-1889"],"issn-type":[{"value":"1674-7305","type":"print"},{"value":"1869-1889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]},"assertion":[{"value":"9 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest. The study was accomplished in accordance with the approval of the Ethics Committee, Beijing Tongren Hospital, Capital Medical University (TRECKY2021-186).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance and ethics"}}]}}