{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:48:49Z","timestamp":1792075729848,"version":"4.4.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci. China Life Sci."],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s11427-025-3233-3","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T04:05:34Z","timestamp":1774929934000},"page":"1980-1991","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrating spatial and single-cell transcriptomics analysis reveals MYCN-UBE2C-TFRC signaling endows ferroptosis resistance in neuroectodermal tumors"],"prefix":"10.1007","volume":"69","author":[{"given":"Jie","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjia","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qili","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyizha","family":"Mengjiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Zong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanglin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiwei","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renbing","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyang","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianqun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"3233_CR1","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1038\/s43018-022-00355-4","volume":"3","author":"H Alborzinia","year":"2022","unstructured":"Alborzinia, H., Fl\u00f3rez, A.F., Kreth, S., Br\u00fcckner, L.M., Yildiz, U., Gartlgruber, M., Odoni, D.I., Poschet, G., Garbowicz, K., Shao, C., et al. (2022). MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis. Nat Cancer 3, 471\u2013485.","journal-title":"Nat Cancer"},{"key":"3233_CR2","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1038\/nature08822","volume":"463","author":"R Beroukhim","year":"2010","unstructured":"Beroukhim, R., Mermel, C.H., Porter, D., Wei, G., Raychaudhuri, S., Donovan, J., Barretina, J., Boehm, J.S., Dobson, J., Urashima, M., et al. (2010). The landscape of somatic copy-number alteration across human cancers. Nature 463, 899\u2013905.","journal-title":"Nature"},{"key":"3233_CR3","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.tibs.2015.11.012","volume":"41","author":"AR Bogdan","year":"2016","unstructured":"Bogdan, A.R., Miyazawa, M., Hashimoto, K., and Tsuji, Y. (2016). Regulators of iron homeostasis: new players in metabolism, cell death, and disease. Trends Biochem Sci 41, 274\u2013286.","journal-title":"Trends Biochem Sci"},{"key":"3233_CR4","doi-asserted-by":"publisher","first-page":"6041","DOI":"10.1093\/nar\/gky366","volume":"46","author":"P Chai","year":"2018","unstructured":"Chai, P., Jia, R., Jia, R., Pan, H., Wang, S., Ni, H., Wang, H., Zhou, C., Shi, Y., Ge, S., et al. (2018). Dynamic chromosomal tuning of a novel GAU1 lncing driver at chr12p13.32 accelerates tumorigenesis. Nucleic Acids Res 46, 6041\u20136056.","journal-title":"Nucleic Acids Res"},{"key":"3233_CR5","doi-asserted-by":"publisher","first-page":"11057","DOI":"10.1038\/ncomms11057","volume":"7","author":"Y Chen","year":"2016","unstructured":"Chen, Y., Zhou, C., Ji, W., Mei, Z., Hu, B., Zhang, W., Zhang, D., Wang, J., Liu, X., Ouyang, G., et al. (2016). ELL targets c-Myc for proteasomal degradation and suppresses tumour growth. Nat Commun 7, 11057.","journal-title":"Nat Commun"},{"key":"3233_CR6","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1038\/s41388-021-01712-w","volume":"40","author":"BB Cheung","year":"2021","unstructured":"Cheung, B.B., Kleynhans, A., Mittra, R., Kim, P.Y., Holien, J.K., Nagy, Z., Ciampa, O. C., Seneviratne, J.A., Mayoh, C., Raipuria, M., et al. (2021). A novel combination therapy targeting ubiquitin-specific protease 5 in MYCN-driven neuroblastoma. Oncogene 40, 2367\u20132381.","journal-title":"Oncogene"},{"key":"3233_CR7","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1056\/NEJMra1803083","volume":"390","author":"D Cobrinik","year":"2024","unstructured":"Cobrinik, D. (2024). Retinoblastoma origins and destinations. N Engl J Med 390, 1408\u20131419.","journal-title":"N Engl J Med"},{"key":"3233_CR8","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/s41571-021-00549-2","volume":"19","author":"R Dhanasekaran","year":"2022","unstructured":"Dhanasekaran, R., Deutzmann, A., Mahauad-Fernandez, W.D., Hansen, A.S., Gouw, A.M., and Felsher, D.W. (2022). The MYC oncogene\u2014the grand orchestrator of cancer growth and immune evasion. Nat Rev Clin Oncol 19, 23\u201336.","journal-title":"Nat Rev Clin Oncol"},{"key":"3233_CR9","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1186\/s13046-019-1492-5","volume":"38","author":"Y Ding","year":"2019","unstructured":"Ding, Y., Yang, J., Ma, Y., Yao, T., Chen, X., Ge, S., Wang, L., and Fan, X. (2019). MYCN and PRC1 cooperatively repress docosahexaenoic acid synthesis in neuroblastoma via ELOVL2. J Exp Clin Cancer Res 38, 498.","journal-title":"J Exp Clin Cancer Res"},{"key":"3233_CR10","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","volume":"59","author":"M Gao","year":"2015","unstructured":"Gao, M., Monian, P., Quadri, N., Ramasamy, R., and Jiang, X. (2015). Glutaminolysis and transferrin regulate ferroptosis. Mol Cell 59, 298\u2013308.","journal-title":"Mol Cell"},{"key":"3233_CR11","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1158\/2159-8290.CD-19-1500","volume":"11","author":"X Hong","year":"2021","unstructured":"Hong, X., Roh, W., Sullivan, R.J., Wong, K.H.K., Wittner, B.S., Guo, H., Dubash, T.D., Sade-Feldman, M., Wesley, B., Horwitz, E., et al. (2021). The lipogenic regulator SREBP2 induces transferrin in circulating melanoma cells and suppresses ferroptosis. Cancer Discov 11, 678\u2013695.","journal-title":"Cancer Discov"},{"key":"3233_CR12","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/nrc3984","volume":"15","author":"TR Kress","year":"2015","unstructured":"Kress, T.R., Sab\u00f2, A., and Amati, B. (2015). MYC: connecting selective transcriptional control to global RNA production. Nat Rev Cancer 15, 593\u2013607.","journal-title":"Nat Rev Cancer"},{"key":"3233_CR13","doi-asserted-by":"publisher","first-page":"5578","DOI":"10.1038\/s41467-021-25792-0","volume":"12","author":"J Liu","year":"2021","unstructured":"Liu, J., Ottaviani, D., Sefta, M., Desbrousses, C., Chapeaublanc, E., Aschero, R., Sirab, N., Lubieniecki, F., Lamas, G., Tonon, L., et al. (2021). A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal\/ganglion cell gene expression. Nat Commun 12, 5578.","journal-title":"Nat Commun"},{"key":"3233_CR14","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/s41419-021-03790-w","volume":"12","author":"Y Lu","year":"2021","unstructured":"Lu, Y., Yang, Q., Su, Y., Ji, Y., Li, G., Yang, X., Xu, L., Lu, Z., Dong, J., Wu, Y., et al. (2021). MYCN mediates TFRC-dependent ferroptosis and reveals vulnerabilities in neuroblastoma. Cell Death Dis 12, 511.","journal-title":"Cell Death Dis"},{"key":"3233_CR15","doi-asserted-by":"publisher","first-page":"16078","DOI":"10.1038\/nrdp.2016.78","volume":"2","author":"KK Matthay","year":"2016","unstructured":"Matthay, K.K., Maris, J.M., Schleiermacher, G., Nakagawara, A., Mackall, C.L., Diller, L., and Weiss, W.A. (2016). Neuroblastoma. Nat Rev Dis Primers 2, 16078.","journal-title":"Nat Rev Dis Primers"},{"key":"3233_CR16","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1038\/s41467-021-22143-x","volume":"12","author":"Z Nagy","year":"2021","unstructured":"Nagy, Z., Seneviratne, J.A., Kanikevich, M., Chang, W., Mayoh, C., Venkat, P., Du, Y., Jiang, C., Salib, A., Koach, J., et al. (2021). An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability. Nat Commun 12, 1881.","journal-title":"Nat Commun"},{"key":"3233_CR17","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41572-019-0063-6","volume":"5","author":"PA Northcott","year":"2019","unstructured":"Northcott, P.A., Robinson, G.W., Kratz, C.P., Mabbott, D.J., Pomeroy, S.L., Clifford, S. C., Rutkowski, S., Ellison, D.W., Malkin, D., Taylor, M.D. et al. (2019). Medulloblastoma. Nat Rev Dis Primers 5, 11.","journal-title":"Nat Rev Dis Primers"},{"key":"3233_CR18","doi-asserted-by":"publisher","first-page":"4969","DOI":"10.1073\/pnas.1802279115","volume":"115","author":"XY Qin","year":"2018","unstructured":"Qin, X.Y., Suzuki, H., Honda, M., Okada, H., Kaneko, S., Inoue, I., Ebisui, E., Hashimoto, K., Carninci, P., Kanki, K., et al. (2018). Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid. Proc Natl Acad Sci USA 115, 4969\u20134974.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3233_CR19","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1007\/s00401-016-1569-6","volume":"131","author":"V Ramaswamy","year":"2016","unstructured":"Ramaswamy, V., Remke, M., Bouffet, E., Bailey, S., Clifford, S.C., Doz, F., Kool, M., Dufour, C., Vassal, G., Milde, T., et al. (2016). Risk stratification of childhood medulloblastoma in the molecular era: the current consensus. Acta Neuropathol 131, 821\u2013831.","journal-title":"Acta Neuropathol"},{"key":"3233_CR20","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1158\/2159-8290.CD-17-0273","volume":"8","author":"DS Rickman","year":"2018","unstructured":"Rickman, D.S., Schulte, J.H., and Eilers, M. (2018). The expanding world of N-MYC-driven tumors. Cancer Discov 8, 150\u2013163.","journal-title":"Cancer Discov"},{"key":"3233_CR21","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3390\/genes8040113","volume":"8","author":"MV Ruiz-P\u00e9rez","year":"2017","unstructured":"Ruiz-P\u00e9rez, M.V., Henley, A.B., and Arsenian-Henriksson, M. (2017). The MYCN protein in health and disease. Genes 8, 113.","journal-title":"Genes"},{"key":"3233_CR22","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","volume":"185","author":"BR Stockwell","year":"2022","unstructured":"Stockwell, B.R. (2022). Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications. Cell 185, 2401\u20132421.","journal-title":"Cell"},{"key":"3233_CR23","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1038\/s41419-021-04390-4","volume":"12","author":"J Yang","year":"2021","unstructured":"Yang, J., Li, Y., Han, Y., Feng, Y., Zhou, M., Zong, C., He, X., Jia, R., Xu, X., and Fan, J. (2021). Single-cell transcriptome profiling reveals intratumoural heterogeneity and malignant progression in retinoblastoma. Cell Death Dis 12, 1100.","journal-title":"Cell Death Dis"},{"key":"3233_CR24","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/s41419-023-06030-5","volume":"14","author":"X Zhang","year":"2023","unstructured":"Zhang, X., Cong, X., Jin, X., Liu, Y., Zhang, T., Fan, X., Shi, X., Zhang, X., Wang, X., Yang, Y.G., et al. (2023). Deficiency of BAP1 inhibits neuroblastoma tumorigenesis through destabilization of MYCN. Cell Death Dis 14, 504.","journal-title":"Cell Death Dis"}],"container-title":["Science China Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-025-3233-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11427-025-3233-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-025-3233-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T08:00:52Z","timestamp":1780732852000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11427-025-3233-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,26]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["3233"],"URL":"https:\/\/doi.org\/10.1007\/s11427-025-3233-3","relation":{},"ISSN":["1674-7305","1869-1889"],"issn-type":[{"value":"1674-7305","type":"print"},{"value":"1869-1889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,26]]},"assertion":[{"value":"3 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest. All experimental procedures were approved by the Ethics Committee of the Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine (Approval No. SH9H-2019-T185-2). The animal experiment procedures complied with the Declaration of Helsinki. All experimental procedures were approved by the Laboratory Animal Ethics Committee of the Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine (Approval No. SH9H-2023-A772-1).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance and ethics"}}]}}