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The human study was approved by the Medical Research Ethics Committee of Peking University Health Science Center (IRB00001052-19095, IRB00001052-22159, IRB00001052-22018), and informed consent was obtained from all participants or their guardians. The animal experiments were approved by the Animal Care and Ethics Committee of Beijing Tongren Hospital (TRLAWEC2022-S109) and followed the ARVO guidelines.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance and ethics"}}]}}