{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:49:55Z","timestamp":1791528595256,"version":"4.3.4"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci. China Life Sci."],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s11427-025-3276-4","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T13:58:14Z","timestamp":1780927094000},"page":"3299-3310","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The DNA-binding protein PfAP2-V regulates erythrocyte invasion and pathogenesis of the human malaria parasite Plasmodium falciparum"],"prefix":"10.1007","volume":"69","author":[{"given":"Yanxin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qilong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Sang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qijun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,28]]},"reference":[{"key":"3276_CR1","doi-asserted-by":"publisher","first-page":"3994","DOI":"10.1093\/nar\/gki709","volume":"33","author":"S Balaji","year":"2005","unstructured":"Balaji, S. (2005). Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains. Nucleic Acids Res 33, 3994\u20134006.","journal-title":"Nucleic Acids Res"},{"key":"3276_CR2","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/0092-8674(95)90054-3","volume":"82","author":"DI Baruch","year":"1995","unstructured":"Baruch, D.I., Pasloske, B.L., Singh, H.B., Bi, X., Ma, X.C., Feldman, M., Taraschi, T.F., and Howard, R.J. (1995). Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes. Cell 82, 77\u201387.","journal-title":"Cell"},{"key":"3276_CR3","doi-asserted-by":"publisher","first-page":"e1001165","DOI":"10.1371\/journal.ppat.1001165","volume":"6","author":"TL Campbell","year":"2010","unstructured":"Campbell, T.L., De Silva, E.K., Olszewski, K.L., Elemento, O., Llin\u00e1s, M., and Smith, J.D. (2010). Identification and genome-wide prediction of DNA binding specificities for the ApiAP2 family of regulators from the malaria parasite. PLoS Pathog 6, e1001165.","journal-title":"PLoS Pathog"},{"key":"3276_CR4","doi-asserted-by":"publisher","first-page":"e1009882","DOI":"10.1371\/journal.ppat.1009882","volume":"18","author":"OMS Carmo","year":"2022","unstructured":"Carmo, O.M.S., Shami, G.J., Cox, D., Liu, B., Blanch, A.J., Tiash, S., Tilley, L., Dixon, M. W.A., and Coppens, I. (2022). Deletion of the Plasmodium falciparum exported protein PTP7 leads to Maurer\u2019s clefts vesiculation, host cell remodeling defects, and loss of surface presentation of EMP1. PLoS Pathog 18, e1009882.","journal-title":"PLoS Pathog"},{"key":"3276_CR5","doi-asserted-by":"publisher","first-page":"e0181656","DOI":"10.1371\/journal.pone.0181656","volume":"12","author":"SC Charnaud","year":"2017","unstructured":"Charnaud, S.C., Dixon, M.W.A., Nie, C.Q., Chappell, L., Sanders, P.R., Nebl, T., Hanssen, E., Berriman, M., Chan, J.A., Blanch, A.J., et al. (2017). The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites. PLoS One 12, e0181656.","journal-title":"PLoS One"},{"key":"3276_CR6","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/28660","volume":"394","author":"Q Chen","year":"1998","unstructured":"Chen, Q., Fernandez, V., Sundstr\u00f6m, A., Schlichtherle, M., Datta, S., Hagblom, P., and Wahlgren, M. (1998). Developmental selection of var gene expression in Plasmodium falciparum. Nature 394, 392\u2013395.","journal-title":"Nature"},{"key":"3276_CR7","doi-asserted-by":"publisher","first-page":"e1003344","DOI":"10.1371\/journal.ppat.1003344","volume":"9","author":"CR Collins","year":"2013","unstructured":"Collins, C.R., Hackett, F., Strath, M., Penzo, M., Withers-Martinez, C., Baker, D.A., Blackman, M.J., and Sibley, L.D. (2013). Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress. PLoS Pathog 9, e1003344.","journal-title":"PLoS Pathog"},{"key":"3276_CR8","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.cell.2016.07.055","volume":"167","author":"AF Cowman","year":"2016","unstructured":"Cowman, A.F., Healer, J., Marapana, D., and Marsh, K. (2016). Malaria: biology and disease. Cell 167, 610\u2013624.","journal-title":"Cell"},{"key":"3276_CR9","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1146\/annurev-micro-090816-093841","volume":"71","author":"KW Deitsch","year":"2017","unstructured":"Deitsch, K.W., and Dzikowski, R. (2017). Variant gene expression and antigenic variation by malaria parasites. Annu Rev Microbiol 71, 625\u2013641.","journal-title":"Annu Rev Microbiol"},{"key":"3276_CR10","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1146\/annurev-micro-090817-062722","volume":"72","author":"MT Duraisingh","year":"2018","unstructured":"Duraisingh, M.T., and Skillman, K.M. (2018). Epigenetic variation and regulation in malaria parasites. Annu Rev Microbiol 72, 355\u2013375.","journal-title":"Annu Rev Microbiol"},{"key":"3276_CR11","doi-asserted-by":"publisher","first-page":"e0178523","DOI":"10.1128\/mbio.01785-23","volume":"14","author":"F Fan","year":"2023","unstructured":"Fan, F., Xue, L., Yin, X., Gupta, N., Shen, B., and Soldati-Favre, D. (2023). AP2XII-1 is a negative regulator of merogony and presexual commitment in Toxoplasma gondii. mBio 14, e0178523.","journal-title":"mBio"},{"key":"3276_CR12","doi-asserted-by":"publisher","first-page":"10931","DOI":"10.1073\/pnas.94.20.10931","volume":"94","author":"DA Fidock","year":"1997","unstructured":"Fidock, D.A., and Wellems, T.E. (1997). Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil. Proc Natl Acad Sci USA 94, 10931\u201310936.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3276_CR13","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/nature01097","volume":"419","author":"MJ Gardner","year":"2002","unstructured":"Gardner, M.J., Hall, N., Fung, E., White, O., Berriman, M., Hyman, R.W., Carlton, J.M., Pain, A., Nelson, K.E., Bowman, S., et al. (2002). Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419, 498\u2013511.","journal-title":"Nature"},{"key":"3276_CR14","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1038\/nbt.2925","volume":"32","author":"M Ghorbal","year":"2014","unstructured":"Ghorbal, M., Gorman, M., Macpherson, C.R., Martins, R.M., Scherf, A., and Lopez-Rubio, J.J. (2014). Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system. Nat Biotechnol 32, 819\u2013821.","journal-title":"Nat Biotechnol"},{"key":"3276_CR15","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.pt.2021.12.005","volume":"38","author":"PV Groomes","year":"2022","unstructured":"Groomes, P.V., Kanjee, U., and Duraisingh, M.T. (2022). RBC membrane biomechanics and Plasmodium falciparum invasion: probing beyond ligand-receptor interactions. Trends Parasitol 38, 302\u2013315.","journal-title":"Trends Parasitol"},{"key":"3276_CR16","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/978-1-0716-1681-9_2","volume":"2369","author":"MK Gupta","year":"2021","unstructured":"Gupta, M.K., Lenz, T., and Le Roch, K.G. (2021). Chromosomes conformation capture coupled with next-generation sequencing (Hi-C) in Plasmodium falciparum. Methods Mol Biol 2369, 15\u201325.","journal-title":"Methods Mol Biol"},{"key":"3276_CR17","doi-asserted-by":"publisher","first-page":"47","DOI":"10.4269\/ajtmh.2001.65.47","volume":"65","author":"A Heddini","year":"2001","unstructured":"Heddini, A., Chen, Q., Obiero, J., Kai, O., Fernandez, V., Marsh, K., Muller, W.A., and Wahlgren, M. (2001). Binding of Plasmodium falciparum-infected erythrocytes to soluble platelet endothelial cell adhesion molecule-1 (PECAM-1\/CD31): frequent recognition by clinical isolates. Am J Trop Med Hyg 65, 47\u201351.","journal-title":"Am J Trop Med Hyg"},{"key":"3276_CR18","doi-asserted-by":"publisher","first-page":"6260","DOI":"10.1074\/jbc.M809756200","volume":"284","author":"R Hora","year":"2009","unstructured":"Hora, R., Bridges, D.J., Craig, A., and Sharma, A. (2009). Erythrocytic casein kinase II regulates cytoadherence of Plasmodium falciparum-infected red blood cells. J Biol Chem 284, 6260\u20136269.","journal-title":"J Biol Chem"},{"key":"3276_CR19","doi-asserted-by":"publisher","first-page":"eaaw2619","DOI":"10.1126\/science.aaw2619","volume":"365","author":"VM Howick","year":"2019","unstructured":"Howick, V.M., Russell, A.J.C., Andrews, T., Heaton, H., Reid, A.J., Natarajan, K., Butungi, H., Metcalf, T., Verzier, L.H., Rayner, J.C., et al. (2019). The Malaria Cell Atlas: single parasite transcriptomes across the complete Plasmodium life cycle. Science 365, eaaw2619.","journal-title":"Science"},{"key":"3276_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijpara.2007.07.018","volume":"38","author":"LM Iyer","year":"2008","unstructured":"Iyer, L.M., Anantharaman, V., Wolf, M.Y., and Aravind, L. (2008). Comparative genomics of transcription factors and chromatin proteins in parasitic protists and other eukaryotes. Int J Parasitol 38, 1\u201331.","journal-title":"Int J Parasitol"},{"key":"3276_CR21","first-page":"1211","volume":"6","author":"KD Jofuku","year":"1994","unstructured":"Jofuku, K.D., den Boer, B.G., Van Montagu, M., and Okamuro, J.K. (1994). Control of Arabidopsis flower and seed development by the homeotic gene APETALA2. Plant Cell 6, 1211\u20131225.","journal-title":"Plant Cell"},{"key":"3276_CR22","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/j.ijpara.2010.04.008","volume":"40","author":"M Kadekoppala","year":"2010","unstructured":"Kadekoppala, M., and Holder, A.A. (2010). Merozoite surface proteins of the malaria parasite: the MSP1 complex and the MSP7 family. Int J Parasitol 40, 1155\u20131161.","journal-title":"Int J Parasitol"},{"key":"3276_CR23","doi-asserted-by":"publisher","first-page":"23640","DOI":"10.1038\/s41598-021-03059-4","volume":"11","author":"M Kashif","year":"2021","unstructured":"Kashif, M., Quadiri, A., and Singh, A.P. (2021). Essential role of a Plasmodium berghei heat shock protein (PBANKA_0938300) in gametocyte development. Sci Rep 11, 23640.","journal-title":"Sci Rep"},{"key":"3276_CR24","doi-asserted-by":"publisher","first-page":"3881","DOI":"10.1038\/s41598-017-03984-3","volume":"7","author":"E Knuepfer","year":"2017","unstructured":"Knuepfer, E., Napiorkowska, M., van Ooij, C., and Holder, A.A. (2017). Generating conditional gene knockouts in Plasmodium\u2014a toolkit to produce stable DiCre recombinase-expressing parasite lines using CRISPR\/Cas9. Sci Rep 7, 3881.","journal-title":"Sci Rep"},{"key":"3276_CR25","doi-asserted-by":"publisher","first-page":"20386","DOI":"10.1074\/jbc.M114.561670","volume":"289","author":"P Kumar","year":"2014","unstructured":"Kumar, P., Tripathi, A., Ranjan, R., Halbert, J., Gilberger, T., Doerig, C., and Sharma, P. (2014). Regulation of Plasmodium falciparum development by calcium-dependent protein kinase 7 (PfCDPK7). J Biol Chem 289, 20386\u201320395.","journal-title":"J Biol Chem"},{"key":"3276_CR26","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1111\/mmi.12381","volume":"90","author":"JE Lemieux","year":"2013","unstructured":"Lemieux, J.E., Kyes, S.A., Otto, T.D., Feller, A.I., Eastman, R.T., Pinches, R.A., Berriman, M., Su, X., and Newbold, C.I. (2013). Genome-wide profiling of chromosome interactions in Plasmodium falciparum characterizes nuclear architecture and reconfigurations associated with antigenic variation. Mol Microbiol 90, 519\u2013537.","journal-title":"Mol Microbiol"},{"key":"3276_CR27","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/s41392-025-02246-3","volume":"10","author":"Q Li","year":"2025","unstructured":"Li, Q., Liu, T., Lv, K., Liao, F., Wang, J., Tu, Y., and Chen, Q. (2025). Malaria: past, present, and future. Sig Transduct Target Ther 10, 188.","journal-title":"Sig Transduct Target Ther"},{"key":"3276_CR28","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s41592-021-01336-8","volume":"19","author":"MD Luecken","year":"2022","unstructured":"Luecken, M.D., B\u00fcttner, M., Chaichoompu, K., Danese, A., Interlandi, M., Mueller, M. F., Strobl, D.C., Zappia, L., Dugas, M., Colom\u00e9-Tatch\u00e9, M., et al. (2022). Benchmarking atlas-level data integration in single-cell genomics. Nat Methods 19, 41\u201350.","journal-title":"Nat Methods"},{"key":"3276_CR29","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1126\/science.8009217","volume":"264","author":"LH Miller","year":"1994","unstructured":"Miller, L.H., Good, M.F., and Milon, G. (1994). Malaria pathogenesis. Science 264, 1878\u20131883.","journal-title":"Science"},{"key":"3276_CR30","first-page":"173","volume":"7","author":"M Ohme-Takagi","year":"1995","unstructured":"Ohme-Takagi, M., and Shinshi, H. (1995). Ethylene-inducible DNA binding proteins that interact with an ethylene-responsive element. Plant Cell 7, 173\u2013182.","journal-title":"Plant Cell"},{"key":"3276_CR31","doi-asserted-by":"publisher","first-page":"2656","DOI":"10.1038\/s41467-018-04966-3","volume":"9","author":"HJ Painter","year":"2018","unstructured":"Painter, H.J., Chung, N.C., Sebastian, A., Albert, I., Storey, J.D., and Llin\u00e1s, M. (2018). Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development. Nat Commun 9, 2656.","journal-title":"Nat Commun"},{"key":"3276_CR32","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.chom.2013.11.007","volume":"14","author":"N Ponts","year":"2013","unstructured":"Ponts, N., Fu, L., Harris, E.Y., Zhang, J., Chung, D.W.D., Cervantes, M.C., Prudhomme, J., Atanasova-Penichon, V., Zehraoui, E., Bunnik, E.M., et al. (2013). Genome-wide mapping of DNA methylation in the human malaria parasite Plasmodium falciparum. Cell Host Microbe 14, 696\u2013706.","journal-title":"Cell Host Microbe"},{"key":"3276_CR33","doi-asserted-by":"publisher","first-page":"e73783","DOI":"10.1371\/journal.pone.0073783","volume":"8","author":"P Prommana","year":"2013","unstructured":"Prommana, P., Uthaipibull, C., Wongsombat, C., Kamchonwongpaisan, S., Yuthavong, Y., Knuepfer, E., Holder, A.A., Shaw, P.J., and Craig, A.G. (2013). Inducible knockdown of Plasmodium gene expression using the glmS ribozyme. PLoS One 8, e73783.","journal-title":"PLoS One"},{"key":"3276_CR34","doi-asserted-by":"publisher","first-page":"5414","DOI":"10.1073\/pnas.0408883102","volume":"102","author":"SA Ralph","year":"2005","unstructured":"Ralph, S.A., Scheidig-Benatar, C., and Scherf, A. (2005). Antigenic variation in Plasmodium falciparum is associated with movement of var loci between subnuclear locations. Proc Natl Acad Sci USA 102, 5414\u20135419.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3276_CR35","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.femsim.2004.01.010","volume":"41","author":"N Rasti","year":"2004","unstructured":"Rasti, N., Wahlgren, M., and Chen, Q. (2004). Molecular aspects of malaria pathogenesis. FEMS Immunol Med Microbiol 41, 9\u201326.","journal-title":"FEMS Immunol Med Microbiol"},{"key":"3276_CR36","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.chom.2017.05.006","volume":"21","author":"JM Santos","year":"2017","unstructured":"Santos, J.M., Josling, G., Ross, P., Joshi, P., Orchard, L., Campbell, T., Schieler, A., Cristea, I.M., and Llin\u00e1s, M. (2017). Red blood cell invasion by the malaria parasite is coordinated by the PfAP2-I transcription factor. Cell Host Microbe 21, 731\u2013741.e10.","journal-title":"Cell Host Microbe"},{"key":"3276_CR37","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.cell.2008.06.042","volume":"134","author":"A Scherf","year":"2008","unstructured":"Scherf, A., Rivi\u00e8re, L., and Lopez-Rubio, J.J. (2008). SnapShot: var gene expression in the malaria parasite. Cell 134, 190\u2013190.e1.","journal-title":"Cell"},{"key":"3276_CR38","doi-asserted-by":"publisher","first-page":"3413","DOI":"10.1093\/nar\/gkac176","volume":"50","author":"X Shang","year":"2022","unstructured":"Shang, X., Wang, C., Fan, Y., Guo, G., Wang, F., Zhao, Y., Sheng, F., Tang, J., He, X., Yu, X., et al. (2022). Genome-wide landscape of ApiAP2 transcription factors reveals a heterochromatin-associated regulatory network during Plasmodium falciparum blood-stage development. Nucleic Acids Res 50, 3413\u20133431.","journal-title":"Nucleic Acids Res"},{"key":"3276_CR39","doi-asserted-by":"publisher","first-page":"e12742","DOI":"10.1111\/cmi.12742","volume":"19","author":"M Sierra-Miranda","year":"2017","unstructured":"Sierra-Miranda, M., Vembar, S.S., Delgadillo, D.M., \u00c1vila-L\u00f3pez, P.A., Herrera-Solorio, A.M., Lozano Amado, D., Vargas, M., and Hernandez-Rivas, R. (2017). Pf AP2Tel, harbouring a non-canonical DNA-binding AP2 domain, binds to Plasmodium falciparum telomeres. Cell Microbiol 19, e12742.","journal-title":"Cell Microbiol"},{"key":"3276_CR40","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1038\/s41564-025-02038-z","volume":"10","author":"P Singh","year":"2025","unstructured":"Singh, P., Serizay, J., Couble, J., Cabahug, M.D., Rosa, C., Chen, P., Scherf, A., Koszul, R., Baumgarten, S., and Bryant, J.M. (2025). High-resolution map of the Plasmodium falciparum genome reveals MORC\/ApiAP2-mediated links between distant, functionally related genes. Nat Microbiol 10, 1665\u20131683.","journal-title":"Nat Microbiol"},{"key":"3276_CR41","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/0092-8674(95)90056-X","volume":"82","author":"JD Smith","year":"1995","unstructured":"Smith, J.D., Chitnis, C.E., Craig, A.G., Roberts, D.J., Hudson-Taylor, D.E., Peterson, D. S., Pinches, R., Newbold, C.I., and Miller, L.H. (1995). Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes. Cell 82, 101\u2013110.","journal-title":"Cell"},{"key":"3276_CR42","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1111\/j.1365-2958.2008.06235.x","volume":"68","author":"C Spycher","year":"2008","unstructured":"Spycher, C., Rug, M., Pachlatko, E., Hanssen, E., Ferguson, D., Cowman, A.F., Tilley, L., and Beck, H. (2008). The Maurer\u2019s cleft protein MAHRP1 is essential for trafficking of PfEMP1 to the surface of Plasmodium falciparum-infected erythrocytes. Mol Microbiol 68, 1300\u20131314.","journal-title":"Mol Microbiol"},{"key":"3276_CR43","doi-asserted-by":"publisher","first-page":"e00542-20","DOI":"10.1128\/mSphere.00542-20","volume":"5","author":"S Srivastava","year":"2020","unstructured":"Srivastava, S., White, M.W., Sullivan Jr., W.J., and Blader, I.J. (2020). Toxoplasma gondii AP2XII-2 contributes to proper progression through S-Phase of the cell cycle. mSphere 5, e00542-20.","journal-title":"mSphere"},{"key":"3276_CR44","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/0092-8674(95)90055-1","volume":"82","author":"X Su","year":"1995","unstructured":"Su, X., Heatwole, V.M., Wertheimer, S.P., Guinet, F., Herrfeldt, J.A., Peterson, D.S., Ravetch, J.A., and Wellems, T.E. (1995). The large diverse gene familyvar encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes. Cell 82, 89\u2013100.","journal-title":"Cell"},{"key":"3276_CR45","doi-asserted-by":"publisher","first-page":"e00019-19","DOI":"10.1128\/CMR.00019-19","volume":"32","author":"X Su","year":"2019","unstructured":"Su, X., Lane, K.D., Xia, L., S\u00e1, J.M., and Wellems, T.E. (2019). Plasmodium genomics and genetics: new insights into malaria pathogenesis, drug resistance, epidemiology, and evolution. Clin Microbiol Rev 32, e00019-19.","journal-title":"Clin Microbiol Rev"},{"key":"3276_CR46","doi-asserted-by":"publisher","first-page":"2154","DOI":"10.1038\/s41564-023-01497-6","volume":"8","author":"AK Subudhi","year":"2023","unstructured":"Subudhi, A.K., Green, J.L., Satyam, R., Salunke, R.P., Lenz, T., Shuaib, M., Isaioglou, I., Abel, S., Gupta, M., Esau, L., et al. (2023). DNA-binding protein PfAP2-P regulates parasite pathogenesis during malaria parasite blood stages. Nat Microbiol 8, 2154\u20132169.","journal-title":"Nat Microbiol"},{"key":"3276_CR47","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s11427-023-2561-0","volume":"68","author":"F Sun","year":"2025","unstructured":"Sun, F., Li, H., Sun, D., Fu, S., Gu, L., Shao, X., Wang, Q., Dong, X., Duan, B., Xing, F., et al. (2025). Single-cell omics: experimental workflow, data analyses and applications. Sci China Life Sci 68, 5\u2013102.","journal-title":"Sci China Life Sci"},{"key":"3276_CR48","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1101\/gr.205062.116","volume":"26","author":"P Sza\u0142aj","year":"2016","unstructured":"Sza\u0142aj, P., Tang, Z., Michalski, P., Pietal, M.J., Luo, O.J., Sadowski, M., Li, X., Radew, K., Ruan, Y., and Plewczynski, D. (2016). An integrated 3-Dimensional Genome Modeling Engine for data-driven simulation of spatial genome organization. Genome Res 26, 1697\u20131709.","journal-title":"Genome Res"},{"key":"3276_CR49","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1038\/s41564-021-00940-w","volume":"6","author":"E Tint\u00f3-Font","year":"2021","unstructured":"Tint\u00f3-Font, E., Michel-Tod\u00f3, L., Russell, T.J., Casas-Vila, N., Conway, D.J., Bozdech, Z., Llin\u00e1s, M., and Cort\u00e9s, A. (2021). A heat-shock response regulated by the PfAP2-HS transcription factor protects human malaria parasites from febrile temperatures. Nat Microbiol 6, 1163\u20131174.","journal-title":"Nat Microbiol"},{"key":"3276_CR50","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.chom.2018.03.007","volume":"23","author":"CG Toenhake","year":"2018","unstructured":"Toenhake, C.G., Fraschka, S.A.K., Vijayabaskar, M.S., Westhead, D.R., van Heeringen, S.J., and B\u00e1rtfai, R. (2018). Chromatin accessibility-based characterization of the gene regulatory network underlying Plasmodium falciparum blood-stage development. Cell Host Microbe 23, 557\u2013569.e9.","journal-title":"Cell Host Microbe"},{"key":"3276_CR51","doi-asserted-by":"publisher","first-page":"e214","DOI":"10.1016\/S2666-5247(24)00016-8","volume":"5","author":"P Venkatesan","year":"2024","unstructured":"Venkatesan, P. (2024). The 2023 WHO World malaria report. Lancet Microbe 5, e214.","journal-title":"Lancet Microbe"},{"key":"3276_CR52","doi-asserted-by":"publisher","first-page":"100001","DOI":"10.1074\/mcp.RA120.002375","volume":"20","author":"J Wang","year":"2021","unstructured":"Wang, J., Jiang, N., Sang, X., Yang, N., Feng, Y., Chen, R., Wang, X., and Chen, Q. (2021). Protein modification characteristics of the malaria parasite Plasmodium falciparum and the infected erythrocytes. Mol Cell Proteomics 20, 100001.","journal-title":"Mol Cell Proteomics"},{"key":"3276_CR53","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/s41467-024-44967-z","volume":"15","author":"JL Wang","year":"2024","unstructured":"Wang, J.L., Li, T.T., Zhang, N.Z., Wang, M., Sun, L.X., Zhang, Z.W., Fu, B.Q., Elsheikha, H.M., and Zhu, X.Q. (2024). The transcription factor AP2XI-2 is a key negative regulator of Toxoplasma gondii merogony. Nat Commun 15, 793.","journal-title":"Nat Commun"},{"key":"3276_CR54","doi-asserted-by":"publisher","first-page":"e1003943","DOI":"10.1371\/journal.ppat.1003943","volume":"10","author":"GJ Wright","year":"2014","unstructured":"Wright, G.J., and Rayner, J.C. (2014). Plasmodium falciparum erythrocyte invasion: combining function with immune evasion. PLoS Pathog 10, e1003943.","journal-title":"PLoS Pathog"},{"key":"3276_CR55","doi-asserted-by":"publisher","first-page":"625862","DOI":"10.3389\/fmicb.2020.625862","volume":"11","author":"Y Zhao","year":"2020","unstructured":"Zhao, Y., Wang, F., Wang, C., Zhang, X., Jiang, C., Ding, F., Shen, L., and Zhang, Q. (2020). Optimization of CRISPR\/Cas system for improving genome editing efficiency in Plasmodium falciparum. Front Microbiol 11, 625862.","journal-title":"Front Microbiol"},{"key":"3276_CR56","doi-asserted-by":"publisher","first-page":"e0351023","DOI":"10.1128\/mbio.03510-23","volume":"15","author":"K Zheng","year":"2024","unstructured":"Zheng, K., Li, Q., Jiang, N., Zhang, Y., Zheng, Y., Zhang, Y., Feng, Y., Chen, R., Sang, X., Chen, Q., et al. (2024). Plasmodium falciparum selectively degrades \u03b1-spectrin of infected erythrocytes after invasion. Mbio 15, e0351023.","journal-title":"Mbio"}],"container-title":["Science China Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-025-3276-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11427-025-3276-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-025-3276-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:02:32Z","timestamp":1791525752000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11427-025-3276-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,28]]},"references-count":56,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["3276"],"URL":"https:\/\/doi.org\/10.1007\/s11427-025-3276-4","relation":{},"ISSN":["1674-7305","1869-1889"],"issn-type":[{"value":"1674-7305","type":"print"},{"value":"1869-1889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,28]]},"assertion":[{"value":"30 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance and ethics"}}]}}