{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:52:49Z","timestamp":1785527569011,"version":"3.56.0"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci. China Life Sci."],"DOI":"10.1007\/s11427-025-3385-2","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:06:06Z","timestamp":1785207966000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["TRMT10A maintains lipid homeostasis independently of its tRNA m1G9 methyltransferase activity"],"prefix":"10.1007","author":[{"given":"Huihui","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanpeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyang","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongteng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyong","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru-Juan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"3385_CR1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.molcel.2005.10.036","volume":"21","author":"A Alexandrov","year":"2006","unstructured":"Alexandrov, A., Chernyakov, I., Gu, W., Hiley, S.L., Hughes, T.R., Grayhack, E.J., and Phizicky, E.M. (2006). Rapid tRNA decay can result from lack of nonessential modifications. Mol Cell 21, 87\u201396.","journal-title":"Mol Cell"},{"key":"3385_CR2","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1053\/j.gastro.2019.12.054","volume":"158","author":"V Azzu","year":"2020","unstructured":"Azzu, V., Vacca, M., Virtue, S., Allison, M., and Vidal-Puig, A. (2020). Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in nonalcoholic fatty liver disease. Gastroenterology 158, 1899\u20131912.","journal-title":"Gastroenterology"},{"key":"3385_CR3","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.trecan.2020.10.004","volume":"7","author":"M Bacci","year":"2021","unstructured":"Bacci, M., Lorito, N., Smiriglia, A., and Morandi, A. (2021). Fat and furious: lipid metabolism in antitumoral therapy response and resistance. Trends Cancer 7, 198\u2013213.","journal-title":"Trends Cancer"},{"key":"3385_CR4","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.1002\/j.1460-2075.1991.tb07864.x","volume":"10","author":"R Basavappa","year":"1991","unstructured":"Basavappa, R., and Sigler, P.B. (1991). The 3 A crystal structure of yeast initiator tRNA: functional implications in initiator\/elongator discrimination. EMBO J 10, 3105\u20133111.","journal-title":"EMBO J"},{"key":"3385_CR5","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1126\/science.2471265","volume":"244","author":"GR Bj\u00f6rk","year":"1989","unstructured":"Bj\u00f6rk, G.R., Wikstr\u00f6m, P.M., and Bystr\u00f6m, A.S. (1989). Prevention of translational frameshifting by the modified nucleoside 1-methylguanosine. Science 244, 986\u2013989.","journal-title":"Science"},{"key":"3385_CR6","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1261\/rna.056531.116","volume":"22","author":"WC Clark","year":"2016","unstructured":"Clark, W.C., Evans, M.E., Dominissini, D., Zheng, G., and Pan, T. (2016). tRNA base methylation identification and quantification via high-throughput sequencing. RNA 22, 1771\u20131784.","journal-title":"RNA"},{"key":"3385_CR7","doi-asserted-by":"publisher","first-page":"W242","DOI":"10.1093\/nar\/gky354","volume":"46","author":"JP Concordet","year":"2018","unstructured":"Concordet, J.P., and Haeussler, M. (2018). CRISPOR: intuitive guide selection for CRISPR\/Cas9 genome editing experiments and screens. Nucleic Acids Res 46, W242\u2013W245.","journal-title":"Nucleic Acids Res"},{"key":"3385_CR8","doi-asserted-by":"publisher","first-page":"10302","DOI":"10.1093\/nar\/gky839","volume":"46","author":"C Cosentino","year":"2018","unstructured":"Cosentino, C., Toivonen, S., Diaz Villamil, E., Atta, M., Ravanat, J.L., Demine, S., Schiavo, A.A., Pachera, N., Deglasse, J.P., Jonas, J.C., et al. (2018). Pancreatic \u03b2-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes. Nucleic Acids Res 46, 10302\u201310318.","journal-title":"Nucleic Acids Res"},{"key":"3385_CR9","doi-asserted-by":"publisher","first-page":"eadp5332","DOI":"10.1126\/sciadv.adp5332","volume":"10","author":"L Cui","year":"2024","unstructured":"Cui, L., Wu, Y., Chen, Z., Li, B., Cai, J., Chang, Z., Xiao, W., Wang, Y., Yang, N., Wang, Y., et al. (2024). N6-methyladenosine modification-tuned lipid metabolism controls skin immune homeostasis via regulating neutrophil chemotaxis. Sci Adv 10, eadp5332.","journal-title":"Sci Adv"},{"key":"3385_CR10","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.7150\/ijbs.80233","volume":"19","author":"W Cui","year":"2023","unstructured":"Cui, W., Zhao, D., Jiang, J., Tang, F., Zhang, C., and Duan, C. (2023). tRNA modifications and modifying enzymes in disease, the potential therapeutic targets. Int J Biol Sci 19, 1146\u20131162.","journal-title":"Int J Biol Sci"},{"key":"3385_CR11","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.cmet.2013.05.017","volume":"18","author":"E Currie","year":"2013","unstructured":"Currie, E., Schulze, A., Zechner, R., Walther, T.C., and FareseJr., R.V. (2013). Cellular fatty acid metabolism and cancer. Cell Metab 18, 153\u2013161.","journal-title":"Cell Metab"},{"key":"3385_CR12","doi-asserted-by":"publisher","first-page":"4486","DOI":"10.1093\/nar\/gkl609","volume":"34","author":"AT De Souza","year":"2006","unstructured":"De Souza, A.T., Dai, X., Spencer, A.G., Reppen, T., Menzie, A., Roesch, P.L., He, Y., Caguyong, M.J., Bloomer, S., Herweijer, H., et al. (2006). Transcriptional and phenotypic comparisons of Ppara knockout and siRNA knockdown mice. Nucleic Acids Res 34, 4486\u20134494.","journal-title":"Nucleic Acids Res"},{"key":"3385_CR13","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/nbt.3437","volume":"34","author":"JG Doench","year":"2016","unstructured":"Doench, J.G., Fusi, N., Sullender, M., Hegde, M., Vaimberg, E.W., Donovan, K.F., Smith, I., Tothova, Z., Wilen, C., Orchard, R., et al. (2016). Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9. Nat Biotechnol 34, 184\u2013191.","journal-title":"Nat Biotechnol"},{"key":"3385_CR14","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s40364-024-00681-y","volume":"12","author":"T Feng","year":"2024","unstructured":"Feng, T., Zhang, H., Zhou, Y., Zhu, Y., Shi, S., Li, K., Lin, P., and Chen, J. (2024). Roles of posttranslational modifications in lipid metabolism and cancer progression. Biomark Res 12, 141.","journal-title":"Biomark Res"},{"key":"3385_CR15","doi-asserted-by":"publisher","first-page":"11855","DOI":"10.1093\/nar\/gkab879","volume":"49","author":"H Fukuda","year":"2021","unstructured":"Fukuda, H., Chujo, T., Wei, F.Y., Shi, S.L., Hirayama, M., Kaitsuka, T., Yamamoto, T., Oshiumi, H., and Tomizawa, K. (2021). Cooperative methylation of human tRNA3Lys at positions A58 and U54 drives the early and late steps of HIV-1 replication. Nucleic Acids Res 49, 11855\u201311867.","journal-title":"Nucleic Acids Res"},{"key":"3385_CR16","doi-asserted-by":"publisher","first-page":"2550","DOI":"10.1007\/s11427-024-2886-2","volume":"68","author":"Y Gao","year":"2025","unstructured":"Gao, Y., Liu, X., and Li, J. (2025). Targeting tRNA methyltransferases: from molecular mechanisms to drug discovery. Sci China Life Sci 68, 2550\u20132567.","journal-title":"Sci China Life Sci"},{"key":"3385_CR17","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1136\/jmedgenet-2014-102282","volume":"51","author":"D Gillis","year":"2014","unstructured":"Gillis, D., Krishnamohan, A., Yaacov, B., Shaag, A., Jackman, J.E., and Elpeleg, O. (2014). TRMT10A dysfunction is associated with abnormalities in glucose homeostasis, short stature and microcephaly. J Med Genet 51, 581\u2013586.","journal-title":"J Med Genet"},{"key":"3385_CR18","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1261\/rna.966208","volume":"14","author":"M Gustavsson","year":"2008","unstructured":"Gustavsson, M., and Ronne, H. (2008). Evidence that tRNA modifying enzymes are important in vivo targets for 5-fluorouracil in yeast. RNA 14, 666\u2013674.","journal-title":"RNA"},{"key":"3385_CR19","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s13059-016-1012-2","volume":"17","author":"M Haeussler","year":"2016","unstructured":"Haeussler, M., Sch\u00f6nig, K., Eckert, H., Eschstruth, A., Miann\u00e9, J., Renaud, J.B., Schneider-Maunoury, S., Shkumatava, A., Teboul, L., Kent, J., et al. (2016). Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR. Genome Biol 17, 148.","journal-title":"Genome Biol"},{"key":"3385_CR20","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/s43587-023-00556-1","volume":"4","author":"H He","year":"2024","unstructured":"He, H., Wang, Y., Zhang, X., Li, X., Liu, C., Yan, D., Deng, H., Sun, W., Yi, C., and Wang, J. (2024). Age-related noncanonical TRMT6-TRMT61A signaling impairs hematopoietic stem cells. Nat Aging 4, 213\u2013230.","journal-title":"Nat Aging"},{"key":"3385_CR21","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3390\/cells11010004","volume":"11","author":"TDJr Hinds","year":"2021","unstructured":"Hinds, T.D.Jr., Kipp, Z.A., Xu, M., Yiannikouris, F.B., Morris, A.J., Stec, D.F., Wahli, W., and Stec, D.E. (2021). Adipose-specific PPAR\u03b1 knockout mice have increased lipogenesis by PASK-SREBP1 signaling and a polarity shift to inflammatory macrophages in white adipose tissue. Cells 11, 4.","journal-title":"Cells"},{"key":"3385_CR22","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.cell.2008.09.013","volume":"135","author":"J Holzmann","year":"2008","unstructured":"Holzmann, J., Frank, P., L\u00f6ffler, E., Bennett, K.L., Gerner, C., and Rossmanith, W. (2008). RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme. Cell 135, 462\u2013474.","journal-title":"Cell"},{"key":"3385_CR23","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1261\/rna.072090.119","volume":"25","author":"NW Howell","year":"2019","unstructured":"Howell, N.W., Jora, M., Jepson, B.F., Limbach, P.A., and Jackman, J.E. (2019). Distinct substrate specificities of the human tRNA methyltransferases TRMT10A and TRMT10B. RNA 25, 1366\u20131376.","journal-title":"RNA"},{"key":"3385_CR24","doi-asserted-by":"publisher","first-page":"e1003888","DOI":"10.1371\/journal.pgen.1003888","volume":"9","author":"M Igoillo-Esteve","year":"2013","unstructured":"Igoillo-Esteve, M., Genin, A., Lambert, N., D\u00e9sir, J., Pirson, I., Abdulkarim, B., Simonis, N., Drielsma, A., Marselli, L., Marchetti, P., et al. (2013). tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans. PLoS Genet 9, e1003888.","journal-title":"PLoS Genet"},{"key":"3385_CR25","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1261\/rna.5070303","volume":"9","author":"JE Jackman","year":"2003","unstructured":"Jackman, J.E., Montange, R.K., Malik, H.S., and Phizicky, E.M. (2003). Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9. RNA 9, 574\u2013585.","journal-title":"RNA"},{"key":"3385_CR26","doi-asserted-by":"publisher","first-page":"e3001297","DOI":"10.1371\/journal.pbio.3001297","volume":"19","author":"Y Jin","year":"2021","unstructured":"Jin, Y., Zhang, B., Lu, J., Song, Y., Wang, W., Zhang, W., Shao, F., Gong, M., Wang, M., Liang, X., et al. (2021). Long noncoding RNA PM maintains cerebellar synaptic integrity and Cbln1 activation via Pax6\/Mll1-mediated H3K4me3. PLoS Biol 19, e3001297.","journal-title":"PLoS Biol"},{"key":"3385_CR27","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1101\/gad.1183804","volume":"18","author":"S Kadaba","year":"2004","unstructured":"Kadaba, S., Krueger, A., Trice, T., Krecic, A.M., Hinnebusch, A.G., and Anderson, J. (2004). Nuclear surveillance and degradation of hypomodified initiator tRNAMet in S. cerevisiae. Genes Dev 18, 1227\u20131240.","journal-title":"Genes Dev"},{"key":"3385_CR28","doi-asserted-by":"publisher","first-page":"9019","DOI":"10.1093\/nar\/gkx620","volume":"45","author":"A Krishnamohan","year":"2017","unstructured":"Krishnamohan, A., and Jackman, J.E. (2017). Mechanistic features of the atypical tRNA m1G9 SPOUT methyltransferase, Trm10. Nucleic Acids Res 45, 9019\u20139029.","journal-title":"Nucleic Acids Res"},{"key":"3385_CR29","doi-asserted-by":"publisher","first-page":"18801","DOI":"10.1074\/jbc.M800233200","volume":"283","author":"S Kurata","year":"2008","unstructured":"Kurata, S., Weixlbaumer, A., Ohtsuki, T., Shimazaki, T., Wada, T., Kirino, Y., Takai, K., Watanabe, K., Ramakrishnan, V., and Suzuki, T. (2008). Modified uridines with C5-methylene substituents at the first position of the tRNA anticodon stabilize U.G wobble pairing during decoding. J Biol Chem 283, 18801\u201318811.","journal-title":"J Biol Chem"},{"key":"3385_CR30","doi-asserted-by":"publisher","first-page":"EMBJ2021108544","DOI":"10.15252\/embj.2021108544","volume":"41","author":"H Li","year":"2022","unstructured":"Li, H., Dong, H., Xu, B., Xiong, Q., Li, C., Yang, W., Li, J., Huang, Z., Zeng, Q., Wang, E., et al. (2022). A dual role of human tRNA methyltransferase hTrmt13 in regulating translation and transcription. EMBO J 41, EMBJ2021108544.","journal-title":"EMBO J"},{"key":"3385_CR31","doi-asserted-by":"publisher","first-page":"e50095","DOI":"10.15252\/embr.202050095","volume":"21","author":"J Li","year":"2020","unstructured":"Li, J., Wang, Y.N., Xu, B.S., Liu, Y.P., Zhou, M., Long, T., Li, H., Dong, H., Nie, Y., Chen, P.R., et al. (2020). Intellectual disability-associated gene ftsj1 is responsible for 2\u2032-O-methylation of specific tRNAs. EMBO Rep 21, e50095.","journal-title":"EMBO Rep"},{"key":"3385_CR32","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/s41589-022-01017-3","volume":"18","author":"SA Lim","year":"2022","unstructured":"Lim, S.A., Su, W., Chapman, N.M., and Chi, H. (2022). Lipid metabolism in T cell signaling and function. Nat Chem Biol 18, 470\u2013481.","journal-title":"Nat Chem Biol"},{"key":"3385_CR33","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1080\/15476286.2021.1980694","volume":"18","author":"Y Liu","year":"2021","unstructured":"Liu, Y., Zhao, Y., Wu, R., Chen, Y., Chen, W., Liu, Y., Luo, Y., Huang, C., Zeng, B., Liao, X., et al. (2021). mRNA m5C controls adipogenesis by promoting CDKN1A mRNA export and translation. RNA Biol 18, 711\u2013721.","journal-title":"RNA Biol"},{"key":"3385_CR34","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1038\/s41569-021-00569-6","volume":"18","author":"D Montaigne","year":"2021","unstructured":"Montaigne, D., Butruille, L., and Staels, B. (2021). PPAR control of metabolism and cardiovascular functions. Nat Rev Cardiol 18, 809\u2013823.","journal-title":"Nat Rev Cardiol"},{"key":"3385_CR35","doi-asserted-by":"publisher","first-page":"912","DOI":"10.12688\/f1000research.7106.1","volume":"4","author":"M Narayanan","year":"2015","unstructured":"Narayanan, M., Ramsey, K., Grebe, T., Schrauwen, I., Szelinger, S., Huentelman, M., Craig, D., and Narayanan, V. (2015). Case Report: compound heterozygous nonsense mutations in TRMT10A are associated with microcephaly, delayed development, and periventricular white matter hyperintensities. F1000Res 4, 912.","journal-title":"F1000Res"},{"key":"3385_CR36","doi-asserted-by":"publisher","first-page":"7782","DOI":"10.1073\/pnas.1913448117","volume":"117","author":"RJ Ontiveros","year":"2020","unstructured":"Ontiveros, R.J., Shen, H., Stoute, J., Yanas, A., Cui, Y., Zhang, Y., and Liu, K.F. (2020). Coordination of mRNA and tRNA methylations by TRMT10A. Proc Natl Acad Sci USA 117, 7782\u20137791.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3385_CR37","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/s41576-022-00501-9","volume":"23","author":"EA Orellana","year":"2022","unstructured":"Orellana, E.A., Siegal, E., and Gregory, R.I. (2022). tRNA dysregulation and disease. Nat Rev Genet 23, 651\u2013664.","journal-title":"Nat Rev Genet"},{"key":"3385_CR38","doi-asserted-by":"publisher","first-page":"990","DOI":"10.4161\/rna.20531","volume":"9","author":"A Patil","year":"2012","unstructured":"Patil, A., Chan, C., Dyavaiah, M., Rooney, J.P., and Dedon, P. (2012). Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications. RNA Biol 9, 990\u20131001.","journal-title":"RNA Biol"},{"key":"3385_CR39","doi-asserted-by":"publisher","first-page":"216170","DOI":"10.1016\/j.canlet.2023.216170","volume":"563","author":"D Ren","year":"2023","unstructured":"Ren, D., Mo, Y., Yang, M., Wang, D., Wang, Y., Yan, Q., Guo, C., Xiong, W., Wang, F., and Zeng, Z. (2023). Emerging roles of tRNA in cancer. Cancer Lett 563, 216170.","journal-title":"Cancer Lett"},{"key":"3385_CR40","doi-asserted-by":"publisher","first-page":"101572","DOI":"10.1016\/j.diabet.2024.101572","volume":"50","author":"C Samhani","year":"2024","unstructured":"Samhani, C., Guerci, B., and Larose, C. (2024). Discovery of a TRMT10A mutation in a case of atypical diabetes: case report. Diabetes Metab 50, 101572.","journal-title":"Diabetes Metab"},{"key":"3385_CR41","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1093\/nar\/gkt869","volume":"42","author":"Z Shao","year":"2014","unstructured":"Shao, Z., Yan, W., Peng, J., Zuo, X., Zou, Y., Li, F., Gong, D., Ma, R., Wu, J., Shi, Y., et al. (2014). Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. Nucleic Acids Res 42, 509\u2013525.","journal-title":"Nucleic Acids Res"},{"key":"3385_CR42","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/nmeth.2857","volume":"11","author":"B Shen","year":"2014","unstructured":"Shen, B., Zhang, W., Zhang, J., Zhou, J., Wang, J., Chen, L., Wang, L., Hodgkins, A., Iyer, V., Huang, X., et al. (2014). Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects. Nat Methods 11, 399\u2013402.","journal-title":"Nat Methods"},{"key":"3385_CR43","doi-asserted-by":"publisher","first-page":"2995","DOI":"10.1007\/s11427-025-3020-2","volume":"68","author":"Y Si","year":"2025","unstructured":"Si, Y., Du, H., Li, S., Zhang, C., Wang, J., Wang, S., and Zhou, J. (2025). Nitrate-driven maintenance of lipid homeostasis by M2 macrophages alleviates atherosclerosis via downregulation of LOX1 expression and reduction of lipid deposition. Sci China Life Sci 68, 2995\u20133009.","journal-title":"Sci China Life Sci"},{"key":"3385_CR44","doi-asserted-by":"publisher","first-page":"90","DOI":"10.4274\/jcrpe.galenos.2021.2021.0110","volume":"15","author":"Z \u015e\u0131klar","year":"2023","unstructured":"\u015e\u0131klar, Z., Kontbay, T., Colclough, K., Patel, K.A., and Berberoglu, M. (2023). Expanding the phenotype of TRMT10A mutations: case report and a review of the existing cases. Jcrpe 15, 90\u201396.","journal-title":"Jcrpe"},{"key":"3385_CR45","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1038\/s41589-019-0420-5","volume":"16","author":"J Song","year":"2020","unstructured":"Song, J., Zhuang, Y., Zhu, C., Meng, H., Lu, B., Xie, B., Peng, J., Li, M., and Yi, C. (2020). Differential roles of human PUS10 in miRNA processing and tRNA pseudouridylation. Nat Chem Biol 16, 160\u2013169.","journal-title":"Nat Chem Biol"},{"key":"3385_CR46","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1093\/nar\/26.1.148","volume":"26","author":"M Sprinzl","year":"1998","unstructured":"Sprinzl, M. (1998). Compilation of tRNA sequences and sequences of tRNA genes. Nucleic Acids Res 26, 148\u2013153.","journal-title":"Nucleic Acids Res"},{"key":"3385_CR47","doi-asserted-by":"publisher","first-page":"13396","DOI":"10.1021\/bi0013039","volume":"39","author":"JW Stuart","year":"2000","unstructured":"Stuart, J.W., Gdaniec, Z., Guenther, R., Marszalek, M., Sochacka, E., Malkiewicz, A., and Agris, P.F. (2000). Functional anticodon architecture of human tRNALys3 includes disruption of intraloop hydrogen bonding by the naturally occurring amino acid modification, t6A. Biochemistry 39, 13396\u201313404.","journal-title":"Biochemistry"},{"key":"3385_CR48","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.jmb.2003.09.058","volume":"334","author":"JW Stuart","year":"2003","unstructured":"Stuart, J.W., Koshlap, K.M., Guenther, R., and Agris, P.F. (2003). Naturally-occurring modification restricts the anticodon domain conformational space of tRNA Phe. J Mol Biol 334, 901\u2013918.","journal-title":"J Mol Biol"},{"key":"3385_CR49","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/s41580-021-00342-0","volume":"22","author":"T Suzuki","year":"2021","unstructured":"Suzuki, T. (2021). The expanding world of tRNA modifications and their disease relevance. Nat Rev Mol Cell Biol 22, 375\u2013392.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3385_CR50","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1261\/rna.039651.113","volume":"19","author":"WE Swinehart","year":"2013","unstructured":"Swinehart, W.E., Henderson, J.C., and Jackman, J.E. (2013). Unexpected expansion of tRNA substrate recognition by the yeast m1G9 methyltransferase Trm10. RNA 19, 1137\u20131146.","journal-title":"RNA"},{"key":"3385_CR51","doi-asserted-by":"publisher","first-page":"9230","DOI":"10.1093\/nar\/gkae520","volume":"52","author":"R Tresky","year":"2024","unstructured":"Tresky, R., Miyamoto, Y., Nagayoshi, Y., Yabuki, Y., Araki, K., Takahashi, Y., Komohara, Y., Ge, H., Nishiguchi, K., Fukuda, T., et al. (2024). TRMT10A dysfunction perturbs codon translation of initiator methionine and glutamine and impairs brain functions in mice. Nucleic Acids Res 52, 9230\u20139246.","journal-title":"Nucleic Acids Res"},{"key":"3385_CR52","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1093\/nar\/gkv1369","volume":"44","author":"B Van Laer","year":"2016","unstructured":"Van Laer, B., Roovers, M., Wauters, L., Kasprzak, J.M., Dyzma, M., Deyaert, E., Kumar Singh, R., Feller, A., Bujnicki, J.M., Droogmans, L., et al. (2016). Structural and functional insights into tRNA binding and adenosine N1-methylation by an archaeal Trm10 homologue. Nucleic Acids Res 44, 940\u2013953.","journal-title":"Nucleic Acids Res"},{"key":"3385_CR53","doi-asserted-by":"publisher","first-page":"6157","DOI":"10.1093\/nar\/gkaa353","volume":"48","author":"E Vilardo","year":"2020","unstructured":"Vilardo, E., Amman, F., Toth, U., Kotter, A., Helm, M., and Rossmanith, W. (2020). Functional characterization of the human tRNA methyltransferases TRMT10A and TRMT10B. Nucleic Acids Res 48, 6157\u20136169.","journal-title":"Nucleic Acids Res"},{"key":"3385_CR54","doi-asserted-by":"publisher","first-page":"11583","DOI":"10.1093\/nar\/gks910","volume":"40","author":"E Vilardo","year":"2012","unstructured":"Vilardo, E., Nachbagauer, C., Buzet, A., Taschner, A., Holzmann, J., and Rossmanith, W. (2012). A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase\u2014extensive moonlighting in mitochondrial tRNA biogenesis. Nucleic Acids Res 40, 11583\u201311593.","journal-title":"Nucleic Acids Res"},{"key":"3385_CR55","first-page":"11126","volume":"46","author":"E Vilardo","year":"2018","unstructured":"Vilardo, E., Nachbagauer, C., Buzet, A., Taschner, A., Holzmann, J., and Rossmanith, W. (2018). A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase\u2014extensive moonlighting in mitochondrial tRNA biogenesis. Nucleic Acids Res 46, 11126.","journal-title":"Nucleic Acids Res"},{"key":"3385_CR56","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1038\/s41589-020-0601-2","volume":"16","author":"L Wang","year":"2020","unstructured":"Wang, L., Song, C., Wang, N., Li, S., Liu, Q., Sun, Z., Wang, K., Yu, S.C., and Yang, Q. (2020a). NADP modulates RNA m6A methylation and adipogenesis via enhancing FTO activity. Nat Chem Biol 16, 1394\u20131402.","journal-title":"Nat Chem Biol"},{"key":"3385_CR57","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/j.cmet.2020.03.010","volume":"31","author":"X Wang","year":"2020","unstructured":"Wang, X., Cai, B., Yang, X., Sonubi, O.O., Zheng, Z., Ramakrishnan, R., Shi, H., Valenti, L., Pajvani, U.B., Sandhu, J., et al. (2020b). Cholesterol stabilizes TAZ in hepatocytes to promote experimental non-alcoholic steatohepatitis. Cell Metab 31, 969\u2013986.e7.","journal-title":"Cell Metab"},{"key":"3385_CR58","doi-asserted-by":"publisher","first-page":"132057","DOI":"10.1016\/j.ijbiomac.2024.132057","volume":"270","author":"X Wang","year":"2024","unstructured":"Wang, X., Gan, M., Wang, Y., Wang, S., Lei, Y., Wang, K., Zhang, X., Chen, L., Zhao, Y., Niu, L., et al. (2024). Comprehensive review on lipid metabolism and RNA methylation: biological mechanisms, perspectives and challenges. Int J Biol Macromol 270, 132057.","journal-title":"Int J Biol Macromol"},{"key":"3385_CR59","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/j.tcb.2023.04.002","volume":"33","author":"Y Wang","year":"2023","unstructured":"Wang, Y., Tao, E.W., Tan, J., Gao, Q.Y., Chen, Y.X., and Fang, J.Y. (2023). tRNA modifications: insights into their role in human cancers. Trends Cell Biol 33, 1035\u20131048.","journal-title":"Trends Cell Biol"},{"key":"3385_CR60","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s41419-025-07548-6","volume":"16","author":"D Wei","year":"2025","unstructured":"Wei, D., Zhai, B., Zeng, H., Liu, L., Gao, H., Xiang, S., Liu, X., Ma, J., Lin, Y., Yao, Y., et al. (2025). TRMT10A regulates tRNA-ArgCCT m1G9 modification to generate tRNA-derived fragments influencing vasculogenic mimicry formation in glioblastoma. Cell Death Dis 16, 209.","journal-title":"Cell Death Dis"},{"key":"3385_CR61","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1002\/hep.32538","volume":"77","author":"T Yan","year":"2023","unstructured":"Yan, T., Luo, Y., Yan, N., Hamada, K., Zhao, N., Xia, Y., Wang, P., Zhao, C., Qi, D., Yang, S., et al. (2023). Intestinal peroxisome proliferator-activated receptor \u03b1-fatty acid-binding protein 1 axis modulates nonalcoholic steatohepatitis. Hepatology 77, 239\u2013255.","journal-title":"Hepatology"},{"key":"3385_CR62","doi-asserted-by":"publisher","first-page":"11900","DOI":"10.1093\/nar\/gkab927","volume":"49","author":"WQ Yang","year":"2021","unstructured":"Yang, W.Q., Xiong, Q.P., Ge, J.Y., Li, H., Zhu, W.Y., Nie, Y., Lin, X., Lv, D., Li, J., Lin, H., et al. (2021). THUMPD3\u2013TRMT112 is a m2G methyltransferase working on a broad range of tRNA substrates. Nucleic Acids Res 49, 11900\u201311919.","journal-title":"Nucleic Acids Res"},{"key":"3385_CR63","doi-asserted-by":"publisher","first-page":"3291","DOI":"10.1093\/nar\/gkad1243","volume":"52","author":"WQ Yang","year":"2024","unstructured":"Yang, W.Q., Ge, J.Y., Zhang, X., Zhu, W.Y., Lin, L., Shi, Y., Xu, B., and Liu, R.J. (2024). THUMPD2 catalyzes the N2-methylation of U6 snRNA of the spliceosome catalytic center and regulates pre-mRNA splicing and retinal degeneration. Nucleic Acids Res 52, 3291\u20133309.","journal-title":"Nucleic Acids Res"},{"key":"3385_CR64","doi-asserted-by":"publisher","first-page":"eadw7989","DOI":"10.1126\/sciadv.adw7989","volume":"11","author":"Y Yang","year":"2025","unstructured":"Yang, Y., Liu, Q., Li, X., Zhang, H., Xu, X., Ma, Q., Nowsheen, S., Aziz, K., Li, Y.X., Lou, Z., et al. (2025). Targeting the ATM-TRMT10A-BRCA1 axis confers synthetic lethality to PARP inhibition in metastatic castration-resistant prostate cancer. Sci Adv 11, eadw7989.","journal-title":"Sci Adv"},{"key":"3385_CR65","doi-asserted-by":"publisher","first-page":"3499","DOI":"10.1007\/s11427-024-2782-1","volume":"68","author":"SY Yao","year":"2025","unstructured":"Yao, S.Y., and Zhou, X.L. (2025). Tangled but ordered human mitochondrial tRNA maturation. Sci China Life Sci 68, 3499\u20133501.","journal-title":"Sci China Life Sci"},{"key":"3385_CR66","doi-asserted-by":"publisher","first-page":"e21","DOI":"10.1111\/dme.13024","volume":"33","author":"TW Yew","year":"2016","unstructured":"Yew, T.W., McCreight, L., Colclough, K., Ellard, S., and Pearson, E.R. (2016). tRNA methyltransferase homologue gene TRMT10A mutation in young adult-onset diabetes with intellectual disability, microcephaly and epilepsy. Diabet Med 33, e21\u201325.","journal-title":"Diabet Med"},{"key":"3385_CR67","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/s41574-023-00845-0","volume":"19","author":"A Zadoorian","year":"2023","unstructured":"Zadoorian, A., Du, X., and Yang, H. (2023). Lipid droplet biogenesis and functions in health and disease. Nat Rev Endocrinol 19, 443\u2013459.","journal-title":"Nat Rev Endocrinol"},{"key":"3385_CR68","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.cmet.2011.12.018","volume":"15","author":"R Zechner","year":"2012","unstructured":"Zechner, R., Zimmermann, R., Eichmann, T.O., Kohlwein, S.D., Haemmerle, G., Lass, A., and Madeo, F. (2012). FAT SIGNALS\u2014lipases and lipolysis in lipid metabolism and signaling. Cell Metab 15, 279\u2013291.","journal-title":"Cell Metab"},{"key":"3385_CR69","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1007\/s11427-024-2827-y","volume":"68","author":"F Zhang","year":"2025","unstructured":"Zhang, F., Song, J., Wu, H., Lin, K., Wang, C., Zeng, L., Kong, X., Zou, K., Diao, H., Wang, Z., et al. (2025). A novel deacetylase inhibitor KLX suppresses liver fibrosis by deacetylating PPARy through promoting ubiquitination-mediated HDAC1 degradation. Sci China Life Sci 68, 1740\u20131754.","journal-title":"Sci China Life Sci"},{"key":"3385_CR70","doi-asserted-by":"publisher","first-page":"2678","DOI":"10.1007\/s11427-024-2602-7","volume":"67","author":"W Zhang","year":"2024","unstructured":"Zhang, W., Wang, L., Wang, Y., Fang, Y., Cao, R., Fang, Z., Han, D., Huang, X., Gu, Z., Zhang, Y., et al. (2024). Inhibition of the RXRA-PPAR\u03b1-FABP4 signaling pathway alleviates vascular cellular aging by an SGLT2 inhibitor in an atherosclerotic mice model. Sci China Life Sci 67, 2678\u20132691.","journal-title":"Sci China Life Sci"},{"key":"3385_CR71","doi-asserted-by":"publisher","first-page":"169091","DOI":"10.1016\/j.jmb.2025.169091","volume":"437","author":"W Zhang","year":"2025","unstructured":"Zhang, W., and Westhof, E. (2025). The biology of tRNA t6A modification and hypermodifications\u2014biogenesis and disease relevance. J Mol Biol 437, 169091.","journal-title":"J Mol Biol"},{"key":"3385_CR72","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/s11427-024-2989-x","volume":"69","author":"N Zhu","year":"2026","unstructured":"Zhu, N., Yang, Y.L., Liu, Y.T., Lu, Z.Z., Wang, Y., Luo, Y.L., Meng, N., Yuan, Y., Zhong, Q., and Zeng, M.S. (2026). Transcriptome-wide identification of glycoRNAs by Clier-seq pipeline. Sci China Life Sci 69, 72\u201384.","journal-title":"Sci China Life Sci"}],"container-title":["Science China Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-025-3385-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11427-025-3385-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-025-3385-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:13:06Z","timestamp":1785521586000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11427-025-3385-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":72,"alternative-id":["3385"],"URL":"https:\/\/doi.org\/10.1007\/s11427-025-3385-2","relation":{},"ISSN":["1674-7305","1869-1889"],"issn-type":[{"value":"1674-7305","type":"print"},{"value":"1869-1889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,24]]},"assertion":[{"value":"29 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of Interest. All animal procedures were approved by the Institutional Animal Care and Use Committee of the University of Science and Technology of China and Nanjing Medical University (Permission number: USTCACUC25100124087 and IACUC-1601125-1).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance and ethics"}}]}}