{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T07:08:52Z","timestamp":1789110532947,"version":"build-2803163510"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci. China Life Sci."],"DOI":"10.1007\/s11427-025-3508-5","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:57:46Z","timestamp":1789106266000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endothelial S1PR3 downregulation exacerbates pressure overload-induced cardiac remodeling by promoting fibrosis and inflammation"],"prefix":"10.1007","author":[{"given":"Xing","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao Wen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"3508_CR1","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1177\/0022034510389178","volume":"90","author":"JJ Aarthi","year":"2011","unstructured":"Aarthi, J.J., Darendeliler, M.A., and Pushparaj, P.N. (2011). Dissecting the role of the S1P\/S1PR axis in health and disease. J Dent Res 90, 841\u2013854.","journal-title":"J Dent Res"},{"key":"3508_CR2","doi-asserted-by":"publisher","first-page":"497","DOI":"10.3390\/pharmaceutics16040497","volume":"16","author":"A Al-Jarallah","year":"2024","unstructured":"Al-Jarallah, A., and Babiker, F.A. (2024). High-density lipoprotein signaling via sphingosine-1-phosphate receptors safeguards spontaneously hypertensive rats against myocardial ischemia\/reperfusion injury. Pharmaceutics 16, 497.","journal-title":"Pharmaceutics"},{"key":"3508_CR3","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41572-020-0151-7","volume":"6","author":"M Arrigo","year":"2020","unstructured":"Arrigo, M., Jessup, M., Mullens, W., Reza, N., Shah, A.M., Sliwa, K., and Mebazaa, A. (2020). Acute heart failure. Nat Rev Dis Primers 6, 16.","journal-title":"Nat Rev Dis Primers"},{"key":"3508_CR4","doi-asserted-by":"publisher","first-page":"4833","DOI":"10.1016\/j.cell.2024.07.012","volume":"187","author":"HG Augustin","year":"2024","unstructured":"Augustin, H.G., and Koh, G.Y. (2024). A systems view of the vascular endothelium in health and disease. Cell 187, 4833\u20134858.","journal-title":"Cell"},{"key":"3508_CR5","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1152\/physrev.00017.2002","volume":"83","author":"DL Brutsaert","year":"2003","unstructured":"Brutsaert, D.L. (2003). Cardiac endothelial-myocardial signaling: its role in cardiac growth, contractile performance, and rhythmicity. Physiol Rev 83, 59\u2013115.","journal-title":"Physiol Rev"},{"key":"3508_CR6","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1093\/cvr\/cvaa023","volume":"116","author":"PG Camici","year":"2020","unstructured":"Camici, P.G., Tsch\u00f6pe, C., Di Carli, M.F., Rimoldi, O., and Van Linthout, S. (2020). Coronary microvascular dysfunction in hypertrophy and heart failure. Cardiovasc Res 116, 806\u2013816.","journal-title":"Cardiovasc Res"},{"key":"3508_CR7","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1161\/HYPERTENSIONAHA.117.09088","volume":"70","author":"A Cantalupo","year":"2017","unstructured":"Cantalupo, A., Gargiulo, A., Dautaj, E., Liu, C., Zhang, Y., Hla, T., and Di Lorenzo, A. (2017). S1PR1 (sphingosine-1-phosphate receptor 1) signaling regulates blood flow and pressure. Hypertension 70, 426\u2013434.","journal-title":"Hypertension"},{"key":"3508_CR8","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.exger.2017.09.013","volume":"99","author":"AT Cao","year":"2017","unstructured":"Cao, A.T., Mackova, M., Kerage, D., Brindley, D.N., and Hemmings, D.G. (2017). Sexual dimorphism of metabolic and vascular dysfunction in aged mice and those lacking the sphingosine 1-phosphate receptor 3. Exp Gerontol 99, 87\u201397.","journal-title":"Exp Gerontol"},{"key":"3508_CR9","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1080\/21623945.2021.2021700","volume":"11","author":"S Chakrabarty","year":"2022","unstructured":"Chakrabarty, S., Bui, Q., Badeanlou, L., Hester, K., Chun, J., Ruf, W., Ciaraldi, T.P., and Samad, F. (2022). S1P\/S1PR3 signalling axis protects against obesity-induced metabolic dysfunction. Adipocyte 11, 69\u201383.","journal-title":"Adipocyte"},{"key":"3508_CR10","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.arcmed.2022.08.002","volume":"53","author":"K Chen","year":"2022","unstructured":"Chen, K., Wang, Z., Liu, C., Yang, X., and Jiang, J. (2022). Sphingosine-1-phosphate attenuates endoplasmic reticulum stress-induced cardiomyocyte apoptosis through sphingosine-1-phosphate receptor 1. Arch Med Res 53, 562\u2013573.","journal-title":"Arch Med Res"},{"key":"3508_CR11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.lfs.2018.10.047","volume":"215","author":"R Chen","year":"2018","unstructured":"Chen, R., Cai, X., Liu, J., Bai, B., and Li, X. (2018a). Sphingosine 1-phosphate promotes mesenchymal stem cell-mediated cardioprotection against myocardial infarction via ERK1\/2-MMP-9 and Akt signaling axis. Life Sci 215, 31\u201342.","journal-title":"Life Sci"},{"key":"3508_CR12","first-page":"334","volume":"15","author":"YZ Chen","year":"2018","unstructured":"Chen, Y.Z., Wang, F., Wang, H.J., and Liu, H.B. (2018b). Sphingosine 1 phosphate receptor-1 (S1PR1) signaling protects cardiac function by inhibiting cardiomyocyte autophagy. J Geriatr Cardiol 15, 334\u2013345.","journal-title":"J Geriatr Cardiol"},{"key":"3508_CR13","doi-asserted-by":"publisher","first-page":"1041533","DOI":"10.3389\/fimmu.2023.1041533","volume":"14","author":"Y Deng","year":"2023","unstructured":"Deng, Y., Huang, X., Hu, Y., Zhong, W., Zhang, H., Mo, C., Wang, H., Ding, B.S., and Wang, C. (2023). Deficiency of endothelial FGFR1 signaling via upregulation of ROCK2 activity aggravated ALI\/ARDS. Front Immunol 14, 1041533.","journal-title":"Front Immunol"},{"key":"3508_CR14","doi-asserted-by":"publisher","first-page":"3159","DOI":"10.1111\/jcmm.13596","volume":"22","author":"YF Dong","year":"2018","unstructured":"Dong, Y.F., Guo, R.B., Ji, J., Cao, L.L., Zhang, L., Chen, Z.Z., Huang, J.Y., Wu, J., Lu, J., and Sun, X.L. (2018). S1PR3 is essential for phosphorylated fingolimod to protect astrocytes against oxygen-glucose deprivation-induced neuroinflammation via inhibiting TLR2\/4-NF\u03baB signalling. J Cell Mol Medi 22, 3159\u20133166.","journal-title":"J Cell Mol Medi"},{"key":"3508_CR15","doi-asserted-by":"publisher","first-page":"105599","DOI":"10.1016\/j.phrs.2021.105599","volume":"168","author":"H Duan","year":"2021","unstructured":"Duan, H., Zhang, Q., Liu, J., Li, R., Wang, D., Peng, W., and Wu, C. (2021). Suppression of apoptosis in vascular endothelial cell, the promising way for natural medicines to treat atherosclerosis. Pharmacol Res 168, 105599.","journal-title":"Pharmacol Res"},{"key":"3508_CR16","doi-asserted-by":"publisher","first-page":"103244","DOI":"10.1016\/j.redox.2024.103244","volume":"75","author":"Y Duan","year":"2024","unstructured":"Duan, Y., Li, Q., Wu, J., Zhou, C., Liu, X., Yue, J., Chen, X., Liu, J., Zhang, Q., Zhang, Y., et al. (2024). A detrimental role of endothelial S1PR2 in cardiac ischemia-reperfusion injury via modulating mitochondrial dysfunction, NLRP3 inflamma-some activation, and pyroptosis. Redox Biol 75, 103244.","journal-title":"Redox Biol"},{"key":"3508_CR17","first-page":"R1597","volume":"298","author":"D Fliegner","year":"2010","unstructured":"Fliegner, D., Schubert, C., Penkalla, A., Witt, H., Kararigas, G., Dworatzek, E., Staub, E., Martus, P., Ruiz Noppinger, P., Kintscher, U., et al. (2010). Female sex and estrogen receptor-\u03b2 attenuate cardiac remodeling and apoptosis in pressure overload. Am J Physiol 298, R1597\u2013R1606.","journal-title":"Am J Physiol"},{"key":"3508_CR18","doi-asserted-by":"publisher","first-page":"2765","DOI":"10.1161\/CIRCULATIONAHA.119.039610","volume":"139","author":"JR Goldenberg","year":"2019","unstructured":"Goldenberg, J.R., Carley, A.N., Ji, R., Zhang, X., Fasano, M., Schulze, P.C., and Lewandowski, E.D. (2019). Preservation of acyl coenzyme A attenuates pathological and metabolic cardiac remodeling through selective lipid trafficking. Circulation 139, 2765\u20132777.","journal-title":"Circulation"},{"key":"3508_CR19","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12931-025-03435-y","volume":"27","author":"M Hao","year":"2025","unstructured":"Hao, M., Tang, G., Zhou, E., Fu, R., Wang, M.J., Jiang, H., Chen, X., Bai, L., Lv, X., and Jin, J. (2025). S1PR3 Inhibition in alveolar epithelial cells alleviates pulmonary fibrosis by enhancing alveolar barrier function. Respir Res 27, 15.","journal-title":"Respir Res"},{"key":"3508_CR20","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/nrcardio.2016.163","volume":"14","author":"J Hartupee","year":"2017","unstructured":"Hartupee, J., and Mann, D.L. (2017). Neurohormonal activation in heart failure with reduced ejection fraction. Nat Rev Cardiol 14, 30\u201338.","journal-title":"Nat Rev Cardiol"},{"key":"3508_CR21","doi-asserted-by":"publisher","first-page":"373","DOI":"10.4062\/biomolther.2018.215","volume":"27","author":"JY Heo","year":"2019","unstructured":"Heo, J.Y., and Im, D.S. (2019). Pro-Inflammatory role of S1P3 in macrophages. Biomol Ther 27, 373\u2013380.","journal-title":"Biomol Ther"},{"key":"3508_CR22","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1021\/cb300392z","volume":"7","author":"E Jo","year":"2012","unstructured":"Jo, E., Bhhatarai, B., Repetto, E., Guerrero, M., Riley, S., Brown, S.J., Kohno, Y., Roberts, E., Sch\u00fcrer, S.C., and Rosen, H. (2012). Novel selective allosteric and bitopic ligands for the S1P3 receptor. ACS Chem Biol 7, 1975\u20131983.","journal-title":"ACS Chem Biol"},{"key":"3508_CR23","doi-asserted-by":"publisher","first-page":"104793","DOI":"10.1016\/j.phrs.2020.104793","volume":"156","author":"E Jozefczuk","year":"2020","unstructured":"Jozefczuk, E., Guzik, T.J., and Siedlinski, M. (2020). Significance of sphingosine-1-phosphate in cardiovascular physiology and pathology. Pharmacol Res 156, 104793.","journal-title":"Pharmacol Res"},{"key":"3508_CR24","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1093\/cvr\/cvaa046","volume":"117","author":"Y Kuang","year":"2021","unstructured":"Kuang, Y., Li, X., Liu, X., Wei, L., Chen, X., Liu, J., Zhuang, T., Pi, J., Wang, Y., Zhu, C., et al. (2021). Vascular endothelial S1pr1 ameliorates adverse cardiac remodelling via stimulating reparative macrophage proliferation after myocardial infarction. Cardiovasc Res 117, 585\u2013599.","journal-title":"Cardiovasc Res"},{"key":"3508_CR25","first-page":"H2698","volume":"292","author":"LK Landeen","year":"2007","unstructured":"Landeen, L.K., Aroonsakool, N., Haga, J.H., Hu, B.S., and Giles, W.R. (2007). Sphingosine-1-phosphate receptor expression in cardiac fibroblasts is modulated by in vitro culture conditions. Am J Physiol 292, H2698\u2013H2711.","journal-title":"Am J Physiol"},{"key":"3508_CR26","first-page":"1","volume":"2012","author":"J Lee","year":"2012","unstructured":"Lee, J., Rhee, M.H., Kim, E., and Cho, J.Y. (2012). BAY 11-7082 is a broad-spectrum inhibitor with anti-inflammatory activity against multiple targets. Mediat Inflamm 2012, 1\u201311.","journal-title":"Mediat Inflamm"},{"key":"3508_CR27","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3389\/fimmu.2018.00048","volume":"9","author":"J Lee","year":"2018","unstructured":"Lee, J., Song, K.H., Kim, T., and Doh, J. (2018). Endothelial cell focal adhesion regulates transendothelial migration and subendothelial crawling of T cells. Front Immunol 9, 48.","journal-title":"Front Immunol"},{"key":"3508_CR28","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.addr.2021.03.021","volume":"173","author":"M Liu","year":"2021","unstructured":"Liu, M., L\u00f3pez de Juan Abad, B., and Cheng, K. (2021). Cardiac fibrosis: myofibroblast-mediated pathological regulation and drug delivery strategies. Adv Drug Deliver Rev 173, 504\u2013519.","journal-title":"Adv Drug Deliver Rev"},{"key":"3508_CR29","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.7150\/thno.103797","volume":"15","author":"X Liu","year":"2025","unstructured":"Liu, X., Yue, J., Zhou, C., Duan, Y., Chen, X., Liu, J., Zhuang, S., Luo, Y., Wu, J., Zhang, Y., et al. (2025). Cardiomyocyte S1PR1 promotes cardiac regeneration via AKT\/mTORC1 signaling pathway. Theranostics 15, 1524\u20131551.","journal-title":"Theranostics"},{"key":"3508_CR30","doi-asserted-by":"publisher","first-page":"732794","DOI":"10.3389\/fimmu.2021.732794","volume":"12","author":"Y Lu","year":"2021","unstructured":"Lu, Y., Xia, N., and Cheng, X. (2021). Regulatory T cells in chronic heart failure. Front Immunol 12, 732794.","journal-title":"Front Immunol"},{"key":"3508_CR31","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1161\/CIRCRESAHA.115.305376","volume":"118","author":"S Menazza","year":"2016","unstructured":"Menazza, S., and Murphy, E. (2016). The expanding complexity of estrogen receptor signaling in the cardiovascular system. Circ Res 118, 994\u20131007.","journal-title":"Circ Res"},{"key":"3508_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/923805","volume":"2014","author":"J Noireaud","year":"2014","unstructured":"Noireaud, J., and Andriantsitohaina, R. (2014). Recent insights in the paracrine modulation of cardiomyocyte contractility by cardiac endothelial cells. Biomed Res Int 2014, 1\u201310.","journal-title":"Biomed Res Int"},{"key":"3508_CR33","first-page":"84","volume":"7","author":"MB Olsen","year":"2022","unstructured":"Olsen, M.B., Gregersen, I., Sandanger, \u00d8., Yang, K., Sokolova, M., Halvorsen, B.E., Gullestad, L., Broch, K., Aukrust, P., and Louwe, M.C. (2022). Targeting the inflammasome in cardiovascular disease. JACC-Basic Transl Sci 7, 84\u201398.","journal-title":"JACC-Basic Transl Sci"},{"key":"3508_CR34","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jacc.2013.02.092","volume":"62","author":"WJ Paulus","year":"2013","unstructured":"Paulus, W.J., and Tsch\u00f6pe, C. (2013). A novel paradigm for heart failure with preserved ejection fraction. J Am Coll Cardiol 62, 263\u2013271.","journal-title":"J Am Coll Cardiol"},{"key":"3508_CR35","doi-asserted-by":"publisher","first-page":"21096","DOI":"10.1074\/jbc.272.34.21096","volume":"272","author":"JW Pierce","year":"1997","unstructured":"Pierce, J.W., Schoenleber, R., Jesmok, G., Best, J., Moore, S.A., Collins, T., and Gerritsen, M.E. (1997). Novel inhibitors of cytokine-induced iKba phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J Biol Chem 272, 21096\u201321103.","journal-title":"J Biol Chem"},{"key":"3508_CR36","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1161\/CIRCRESAHA.115.307778","volume":"118","author":"AR Pinto","year":"2016","unstructured":"Pinto, A.R., Ilinykh, A., Ivey, M.J., Kuwabara, J.T., D\u2019Antoni, M.L., Debuque, R., Chandran, A., Wang, L., Arora, K., Rosenthal, N.A., et al. (2016). Revisiting cardiac cellular composition. Circ Res 118, 400\u2013409.","journal-title":"Circ Res"},{"key":"3508_CR37","doi-asserted-by":"publisher","first-page":"101244","DOI":"10.1016\/j.gendis.2024.101244","volume":"12","author":"H Qiu","year":"2025","unstructured":"Qiu, H., Liu, J., You, J., Zhou, O., Hao, C., Shu, Y., Ma, D., Zou, W., Zhang, L., Liu, E., et al. (2025). Inhibition of sphingosine 1-phosphate receptor 3 ameliorates bleomycin-induced pulmonary fibrosis by suppressing macrophage M2 polarization. Genes Dis 12, 101244.","journal-title":"Genes Dis"},{"key":"3508_CR38","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0735-1097(00)00738-5","volume":"36","author":"SE Reis","year":"2000","unstructured":"Reis, S.E., Holubkov, R., Young, J.B., White, B.G., Cohn, J.N., and Feldman, A.M. (2000). Estrogen is associated with improved survival in aging women with congestive heart failure: analysis of the vesnarinone studies. J Am Coll Cardiol 36, 529\u2013533.","journal-title":"J Am Coll Cardiol"},{"key":"3508_CR39","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","volume":"76","author":"GA Roth","year":"2020","unstructured":"Roth, G.A., Mensah, G.A., Johnson, C.O., Addolorato, G., Ammirati, E., Baddour, L.M., Barengo, N.C., Beaton, A.Z., Benjamin, E.J., Benziger, C.P., et al. (2020). Global burden of cardiovascular diseases and risk factors, 1990\u20132019: update from the GBD 2019 study. J Am Coll Cardiol 76, 2982\u20133021.","journal-title":"J Am Coll Cardiol"},{"key":"3508_CR40","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.yjmcc.2016.06.001","volume":"97","author":"I Shimizu","year":"2016","unstructured":"Shimizu, I., and Minamino, T. (2016). Physiological and pathological cardiac hypertrophy. J Mol Cell Cardiol 97, 245\u2013262.","journal-title":"J Mol Cell Cardiol"},{"key":"3508_CR41","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/nri2974","volume":"11","author":"S Spiegel","year":"2011","unstructured":"Spiegel, S., and Milstien, S. (2011). The outs and the ins of sphingosine-1-phosphate in immunity. Nat Rev Immunol 11, 403\u2013415.","journal-title":"Nat Rev Immunol"},{"key":"3508_CR42","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.semcdb.2019.10.015","volume":"101","author":"X Sun","year":"2020","unstructured":"Sun, X., Nkennor, B., Mastikhina, O., Soon, K., and Nunes, S.S. (2020). Endothelium-mediated contributions to fibrosis. Semin Cell Dev Biol 101, 78\u201386.","journal-title":"Semin Cell Dev Biol"},{"key":"3508_CR43","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1093\/cvr\/cvp312","volume":"85","author":"N Takuwa","year":"2010","unstructured":"Takuwa, N., Ohkura, S.I., Takashima, S.I., Ohtani, K., Okamoto, Y., Tanaka, T., Hirano, K., Usui, S., Wang, F., Du, W., et al. (2010). S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species. Cardiovasc Res 85, 484\u2013493.","journal-title":"Cardiovasc Res"},{"key":"3508_CR44","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1161\/CIRCULATIONAHA.105.607135","volume":"114","author":"G Theilmeier","year":"2006","unstructured":"Theilmeier, G., Schmidt, C., Herrmann, J., Keul, P., Sch\u00e4fers, M., Herrgott, I., Mersmann, J., Larmann, J., Hermann, S., Stypmann, J., et al. (2006). High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia\/reperfusion injury in vivo via the S1P3 lysophospholipid receptor. Circulation 114, 1403\u20131409.","journal-title":"Circulation"},{"key":"3508_CR45","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1002\/cbin.10991","volume":"42","author":"H Wang","year":"2018","unstructured":"Wang, H., Huang, H., and Ding, S.F. (2018). Sphingosine-1-phosphate promotes the proliferation and attenuates apoptosis of Endothelial progenitor cells via S1PR1\/S1PR3\/PI3K\/Akt pathway. Cell Biol Int 42, 1492\u20131502.","journal-title":"Cell Biol Int"},{"key":"3508_CR46","doi-asserted-by":"publisher","first-page":"818","DOI":"10.3390\/biom13050818","volume":"13","author":"N Wang","year":"2023","unstructured":"Wang, N., Li, J.Y., Zeng, B., and Chen, G.L. (2023). Sphingosine-1-phosphate signaling in cardiovascular diseases. Biomolecules 13, 818.","journal-title":"Biomolecules"},{"key":"3508_CR47","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1161\/CIRCRESAHA.117.311648","volume":"122","author":"Y Yamada","year":"2018","unstructured":"Yamada, Y., Wakao, S., Kushida, Y., Minatoguchi, S., Mikami, A., Higashi, K., Baba, S., Shigemoto, T., Kuroda, Y., Kanamori, H., et al. (2018). S1P-S1PR2 axis mediates homing of muse cells into damaged heart for long-lasting tissue repair and functional recovery after acute myocardial infarction. Circ Res 122, 1069\u20131083.","journal-title":"Circ Res"},{"key":"3508_CR48","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1159\/000493611","volume":"49","author":"J Yang","year":"2018","unstructured":"Yang, J., Yang, L., Tian, L., Ji, X., Yang, L., and Li, L. (2018). Sphingosine 1-phosphate (S1P)\/S1P receptor2\/3 axis promotes inflammatory M1 polarization of bone marrow-derived monocyte\/macrophage via G(a)i\/o\/PI3K\/JNK pathway. Cell Physiol Biochem 49, 1677\u20131693.","journal-title":"Cell Physiol Biochem"},{"key":"3508_CR49","doi-asserted-by":"publisher","first-page":"114799","DOI":"10.1016\/j.biopha.2023.114799","volume":"163","author":"X Yang","year":"2023","unstructured":"Yang, X., Cheng, K., Wang, L.Y., and Jiang, J.G. (2023). The role of endothelial cell in cardiac hypertrophy: focusing on angiogenesis and intercellular crosstalk. Biomed Pharmacother 163, 114799.","journal-title":"Biomed Pharmacother"},{"key":"3508_CR50","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/s41374-020-00505-1","volume":"101","author":"S Yasuda","year":"2021","unstructured":"Yasuda, S., Sumioka, T., Iwanishi, H., Okada, Y., Miyajima, M., Ichikawa, K., Reinach, P.S., and Saika, S. (2021). Loss of sphingosine 1-phosphate receptor 3 gene function impairs injury-induced stromal angiogenesis in mouse cornea. Lab Invest 101, 245\u2013257.","journal-title":"Lab Invest"},{"key":"3508_CR51","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1007\/s11427-023-2452-2","volume":"67","author":"S Yuan","year":"2024","unstructured":"Yuan, S., Zhang, X., Zhan, J., Xie, R., Fan, J., Dai, B., Zhao, Y., Yin, Z., Liu, Q., Wang, D.W., et al. (2024). Fibroblast-localized lncRNA CFIRL promotes cardiac fibrosis and dysfunction in dilated cardiomyopathy. Sci China Life Sci 67, 1155\u20131169.","journal-title":"Sci China Life Sci"},{"key":"3508_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yjmcc.2016.12.008","volume":"103","author":"BS Yung","year":"2017","unstructured":"Yung, B.S., Brand, C.S., Xiang, S.Y., Gray, C.B.B., Means, C.K., Rosen, H., Chun, J., Purcell, N.H., Brown, J.H., and Miyamoto, S. (2017). Selective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection. J Mol Cell Cardiol 103, 1\u201310.","journal-title":"J Mol Cell Cardiol"},{"key":"3508_CR53","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1093\/cvr\/cvu050","volume":"102","author":"M Zhang","year":"2014","unstructured":"Zhang, M., and Shah, A.M. (2014). ROS signalling between endothelial cells and cardiac cells. Cardiovasc Res 102, 249\u2013257.","journal-title":"Cardiovasc Res"},{"key":"3508_CR54","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41392-020-00445-8","volume":"6","author":"X Zhang","year":"2021","unstructured":"Zhang, X., Yuan, S., Li, H., Zhan, J., Wang, F., Fan, J., Nie, X., Wang, Y., Wen, Z., Chen, Y., et al. (2021). The double face of miR-320: cardiomyocytes-derived miR-320 deteriorated while fibroblasts-derived miR-320 protected against heart failure induced by transverse aortic constriction. Sig Transduct Target Ther 6, 69.","journal-title":"Sig Transduct Target Ther"},{"key":"3508_CR55","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/s41422-021-00567-w","volume":"32","author":"C Zhao","year":"2022","unstructured":"Zhao, C., Cheng, L., Wang, W., Wang, H., Luo, Y., Feng, Y., Wang, X., Fu, H., Cai, Y., Yang, S., et al. (2022). Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3-Gi signaling complexes. Cell Res 32, 218\u2013221.","journal-title":"Cell Res"},{"key":"3508_CR56","doi-asserted-by":"publisher","first-page":"116575","DOI":"10.1016\/j.biopha.2024.116575","volume":"174","author":"AC Ziegler","year":"2024","unstructured":"Ziegler, A.C., Haider, R.S., Hoffmann, C., and Gr\u00e4ler, M.H. (2024). S1PR3 agonism and S1P lyase inhibition rescue mice in the severe state of experimental sepsis. Biomed Pharmacother 174, 116575.","journal-title":"Biomed Pharmacother"},{"key":"3508_CR57","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s10741-019-09881-3","volume":"25","author":"C Zuchi","year":"2020","unstructured":"Zuchi, C., Tritto, I., Carluccio, E., Mattei, C., Cattadori, G., and Ambrosio, G. (2020). Role of endothelial dysfunction in heart failure. Heart Fail Rev 25, 21\u201330.","journal-title":"Heart Fail Rev"}],"container-title":["Science China Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-025-3508-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11427-025-3508-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11427-025-3508-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T07:03:12Z","timestamp":1789110192000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11427-025-3508-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":57,"alternative-id":["3508"],"URL":"https:\/\/doi.org\/10.1007\/s11427-025-3508-5","relation":{},"ISSN":["1674-7305","1869-1889"],"issn-type":[{"value":"1674-7305","type":"print"},{"value":"1869-1889","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,8]]},"assertion":[{"value":"25 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of Interest. All animal experiments were conducted in compliance with the Guide for the Care and Use of Laboratory Animals published by the NIH and were approved by the Institutional Animal Research Committee of Tongji Medical College (Wuhan, China; approval number: T1-2025-09-020; item number: S-106-25-10-0A). All operations were performed under anesthesia induced with 1% pentobarbital sodium, and every effort was made to minimize animal suffering.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance and ethics"}}]}}