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The corresponding authors had full access to all the data in the study and, with the support of the full author group, had final responsibility for the decision to submit for publication. Xiaoping Zhao and Wei Li are the cofounders of Shanghai Vitalgen BioPharma Co., Ltd. Shan Ding, Gui Cao, Xianfeng Wang, Li Feng, Hongxia Mao, and Hua Lv are employees of Shanghai Vitalgen BioPharma Co., Ltd., who provided VGN-R09b for this study. All procedures involving human participants were conducted in accordance with the ethical standards of the institutional and national research committees and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. 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