{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:53:49Z","timestamp":1790488429656,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,8,8]],"date-time":"2014-08-08T00:00:00Z","timestamp":1407456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroimmune Pharmacol"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1007\/s11481-014-9560-2","type":"journal-article","created":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T05:58:34Z","timestamp":1407391114000},"page":"679-689","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Pro-Inflammatory Interferon Gamma Signaling is Directly Associated with Stroke Induced Neurodegeneration"],"prefix":"10.1007","volume":"9","author":[{"given":"Hilary A.","family":"Seifert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Collier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cortney B.","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley A.","family":"Benkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison E.","family":"Willing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith R.","family":"Pennypacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,8]]},"reference":[{"issue":"2","key":"9560_CR1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2174\/156720206776875849","volume":"3","author":"CT Ajmo Jr","year":"2006","unstructured":"Ajmo CT Jr, Vernon DO, Collier L, Pennypacker KR, Cuevas J (2006) Sigma receptor activation reduces infarct size at 24\u00a0h after permanent middle cerebral artery occlusion in rats. Curr Neurovasc Res 3(2):89\u201398","journal-title":"Curr Neurovasc Res"},{"key":"9560_CR2","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1002\/jnr.21661","volume":"86","author":"CT Ajmo Jr","year":"2008","unstructured":"Ajmo CT Jr, Vernon DO, Collier L, Hall AA, Garbuzova-Davis S, Willing A, Pennypacker KR (2008) The spleen contributes to stroke-induced neurodegeneration. J Neurosci Res 86:2227\u20132234","journal-title":"J Neurosci Res"},{"key":"9560_CR3","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1146\/annurev.immunol.15.1.749","volume":"15","author":"U Boehm","year":"1997","unstructured":"Boehm U, Klamp T, Groot M, Howard JC (1997) Cellular responses to interferon-gamma. Annu Rev Immunol 15:749\u2013795","journal-title":"Annu Rev Immunol"},{"key":"9560_CR4","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/1742-2094-8-148","volume":"8","author":"M Das","year":"2011","unstructured":"Das M, Leonardo CC, Rangooni S, Mohapatra SS, Mohapatra S, Pennypacker KR (2011) Lateral fluid percussion injury of the brain induces CCL20 inflammatory chemokine expression in rats. J Neuroinflammation 8:148","journal-title":"J Neuroinflammation"},{"issue":"1","key":"9560_CR5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.brainres.2005.02.021","volume":"1042","author":"EA Duckworth","year":"2005","unstructured":"Duckworth EA, Butler TL, De Mesquita D, Collier SN, Collier L, Pennypacker KR (2005) Temporary focal ischemia in the mouse: technical aspects and patterns of Fluoro-Jade evident neurodegeneration. Brain Res 1042(1):29\u201336","journal-title":"Brain Res"},{"issue":"2","key":"9560_CR6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/icb.2010.158","volume":"89","author":"JR Groom","year":"2011","unstructured":"Groom JR, Luster AD (2011) CXCR3 ligands: redundant, collaborative and antagonistic functions. Immunol Cell Biol 89(2):207\u2013215","journal-title":"Immunol Cell Biol"},{"issue":"2","key":"9560_CR7","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/jnr.21857","volume":"87","author":"AA Hall","year":"2009","unstructured":"Hall AA, Guyer AG, Leonardo CC, Ajmo CT Jr, Collier LA, Willing AE, Pennypacker KR (2009) Human umbilical cord blood cells directly suppress ischemic oligodendrocyte cell death. J Neurosci Res 87(2):333\u2013341","journal-title":"J Neurosci Res"},{"issue":"11","key":"9560_CR8","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1038\/sj.jcbfm.9600482","volume":"27","author":"PD Hurn","year":"2007","unstructured":"Hurn PD, Subramanian S, Parker SM, Afentoulis ME, Kaler LJ, Vandenbark AA, Offner H (2007) T- and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammation. J Cereb Blood Flow Metab 27(11):1798\u20131805","journal-title":"J Cereb Blood Flow Metab"},{"issue":"1","key":"9560_CR9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.surg.2006.03.024","volume":"141","author":"H Jiang","year":"2007","unstructured":"Jiang H, Meng F, Li W, Tong L, Qiao H, Sun X (2007) Splenectomy ameliorates acute multiple organ damage induced by liver warm ischemia reperfusion in rats. Surgery 141(1):32\u201340","journal-title":"Surgery"},{"issue":"4","key":"9560_CR10","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/STROKEAHA.111.000633","volume":"44","author":"R Jin","year":"2013","unstructured":"Jin R, Zhu X, Liu L, Nanda A, Granger DN, Li G (2013) Simvastatin attenuates stroke-induced splenic atrophy and lung susceptibility to spontaneous bacterial infection in mice. Stroke 44(4):1135\u20131143","journal-title":"Stroke"},{"issue":"Pt 3","key":"9560_CR11","first-page":"616","volume":"131","author":"ST Lee","year":"2008","unstructured":"Lee ST, Chu K, Jung KH, Kim SJ, Kim DH, Kang KM, Hong NH, Kim JH, Ban JJ, Park HK, Kim SU, Park CG, Lee SK, Kim M, Roh JK (2008) Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke. Brain 131(Pt 3):616\u2013629","journal-title":"Brain"},{"key":"9560_CR12","author":"CC Leonardo","year":"2011","unstructured":"Leonardo CC, Pennypacker KR (2011) The splenic response to ischemic stroke: what have we learned from rodent models? Transl Stroke Res. doi: 10.1007\/s12975-0111-0075-3 , e pub April","journal-title":"Transl Stroke Res"},{"issue":"11","key":"9560_CR13","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1161\/CIRCRESAHA.110.227454","volume":"107","author":"F Leuschner","year":"2010","unstructured":"Leuschner F, Panizzi P, Chico-Calero I, Lee WW, Ueno T, Cortez-Retamozo V, Waterman P, Gorbatov R, Marinelli B, Iwamoto Y, Chudnovskiy A, Figueiredo JL, Sosnovik DE, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M (2010) Angiotensin-converting enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarction. Circ Res 107(11):1364\u20131373","journal-title":"Circ Res"},{"issue":"1","key":"9560_CR14","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/TA.0b013e3181f30fc9","volume":"71","author":"M Li","year":"2011","unstructured":"Li M, Li F, Luo C, Shan Y, Zhang L, Qian Z, Zhu G, Lin J, Feng H (2011) Immediate splenectomy decreases mortality and improves cognitive function of rats after severe traumatic brain injury. J Trauma 71(1):141\u2013147","journal-title":"J Trauma"},{"issue":"2","key":"9560_CR15","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nm.1927","volume":"15","author":"A Liesz","year":"2009","unstructured":"Liesz A, Suri-Payer E, Veltkamp C, Doerr H, Sommer C, Rivest S, Giese T, Veltkamp R (2009) Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat Med 15(2):192\u2013199","journal-title":"Nat Med"},{"issue":"Pt 3","key":"9560_CR16","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1093\/brain\/awr008","volume":"134","author":"A Liesz","year":"2011","unstructured":"Liesz A, Zhou W, Mracsko E, Karcher S, Bauer H, Schwarting S, Sun L, Bruder D, Stegemann S, Cerwenka A, Sommer C, Dalpke AH, Veltkamp R (2011) Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke. Brain 134(Pt 3):704\u2013720","journal-title":"Brain"},{"issue":"5","key":"9560_CR17","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1074\/jbc.M005652200","volume":"276","author":"P Loetscher","year":"2001","unstructured":"Loetscher P, Pellegrino A, Gong JH, Mattioli I, Loetscher M, Bardi G, Baggiolini M, Clark-Lewis I (2001) The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3. J Biol Chem 276(5):2986\u20132991","journal-title":"J Biol Chem"},{"key":"9560_CR18","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","volume":"20","author":"E Longa","year":"1989","unstructured":"Longa E, Weinstein P, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84\u201391","journal-title":"Stroke"},{"issue":"1","key":"9560_CR19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0952-7915(01)00308-9","volume":"14","author":"AD Luster","year":"2002","unstructured":"Luster AD (2002) The role of chemokines in linking innate and adaptive immunity. Curr Opin Immunol 14(1):129\u2013135","journal-title":"Curr Opin Immunol"},{"issue":"5","key":"9560_CR20","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/sj.jcbfm.9600217","volume":"26","author":"H Offner","year":"2006","unstructured":"Offner H, Subramanian S, Parker SM, Afentoulis ME, Vandenbark AA, Hurn PD (2006) Experimental stroke induces massive, rapid activation of the peripheral immune system. J Cereb Blood Flow Metab 26(5):654\u2013665","journal-title":"J Cereb Blood Flow Metab"},{"issue":"3","key":"9560_CR21","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1600-0676.1996.tb00726.x","volume":"16","author":"Y Okuaki","year":"1996","unstructured":"Okuaki Y, Miyazaki H, Zeniya M, Ishikawa T, Ohkawa Y, Tsuno S, Sakaguchi M, Hara M, Takahashi H, Toda G (1996) Splenectomy-reduced hepatic injury induced by ischemia\/reperfusion in the rat. Liver 16(3):188\u2013194","journal-title":"Liver"},{"key":"9560_CR22","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s12975-012-0206-5","volume":"3","author":"R Ostrowski","year":"2012","unstructured":"Ostrowski R, Schulte R, Nie Y, Ling T, Lee T, Manaenko A, Gridley D, Zhang J (2012) Acute splenic irradiation reduces brain injury in the rat focal ischemic stroke model. Transl Stroke Res 3:473\u2013481. doi: 10.1007\/s12975-012-0206-5","journal-title":"Transl Stroke Res"},{"issue":"10","key":"9560_CR23","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/S0022-3468(03)00497-4","volume":"38","author":"MC Savas","year":"2003","unstructured":"Savas MC, Ozguner M, Ozguner IF, Delibas N (2003) Splenectomy attenuates intestinal ischemia-reperfusion-induced acute lung injury. J Pediatr Surg 38(10):1465\u20131470","journal-title":"J Pediatr Surg"},{"issue":"1","key":"9560_CR24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0006-8993(96)01387-X","volume":"751","author":"LC Schmued","year":"1997","unstructured":"Schmued LC, Albertson C, Slikker W Jr (1997) Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration. Brain Res 751(1):37\u201346","journal-title":"Brain Res"},{"issue":"4","key":"9560_CR25","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1007\/s11481-012-9406-8","volume":"7","author":"HA Seifert","year":"2012","unstructured":"Seifert HA, Hall AA, Chapman CB, Collier LA, Willing AE, Pennypacker KR (2012a) A transient decrease in spleen size following stroke corresponds to splenocyte release into systemic circulation. J NeuroImmune Pharm 7(4):1017\u20131024. doi: 10.1007\/s11481-012-9406-8","journal-title":"J NeuroImmune Pharm"},{"issue":"2","key":"9560_CR26","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11011-012-9283-0","volume":"27","author":"HA Seifert","year":"2012","unstructured":"Seifert HA, Leonardo CC, Hall AA, Rowe DD, Collier LA, Benkovic SA, Willing AE, Pennypacker KR (2012b) The spleen contributes to stroke induced neurodegeneration through interferon gamma signaling. Metab Brain Dis 27(2):131\u2013141","journal-title":"Metab Brain Dis"},{"issue":"2","key":"9560_CR27","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.expneurol.2010.07.005","volume":"225","author":"PA Walker","year":"2010","unstructured":"Walker PA, Shah SK, Jimenez F, Gerber MH, Xue H, Cutrone R, Hamilton JA, Mays RW, Deans R, Pati S, Dash PK, Cox CS Jr (2010) Intravenous multipotent adult progenitor cell therapy for traumatic brain injury: preserving the blood brain barrier via an interaction with splenocytes. Exp Neurol 225(2):341\u2013352","journal-title":"Exp Neurol"},{"issue":"17","key":"9560_CR28","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1161\/CIRCULATIONAHA.105.593046","volume":"113","author":"G Yilmaz","year":"2006","unstructured":"Yilmaz G, Arumugam TV, Stokes KY, Granger DN (2006) Role of T lymphocytes and interferon-gamma in ischemic stroke. Circulation 113(17):2105\u20132112","journal-title":"Circulation"}],"container-title":["Journal of Neuroimmune Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11481-014-9560-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11481-014-9560-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11481-014-9560-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T16:06:29Z","timestamp":1559405189000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11481-014-9560-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,8]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["9560"],"URL":"https:\/\/doi.org\/10.1007\/s11481-014-9560-2","relation":{},"ISSN":["1557-1890","1557-1904"],"issn-type":[{"value":"1557-1890","type":"print"},{"value":"1557-1904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,8]]}}}