{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:52:39Z","timestamp":1792270359105,"version":"4.4.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T00:00:00Z","timestamp":1428969600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroimmune Pharmacol"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1007\/s11481-015-9601-5","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T03:05:41Z","timestamp":1428894341000},"page":"468-476","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":191,"title":["Activation of the Macrophage \u03b17 Nicotinic Acetylcholine Receptor and Control of Inflammation"],"prefix":"10.1007","volume":"10","author":[{"given":"Carlos A.","family":"B\u00e1ez-Pag\u00e1n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Delgado-V\u00e9lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Lasalde-Dominicci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,4,14]]},"reference":[{"key":"9601_CR1","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1111\/j.1460-9568.1997.tb01702.x","volume":"9","author":"M Alkondon","year":"1997","unstructured":"Alkondon M, Pereira EF, Cortes WS et al (1997) Choline is a selective agonist of alpha7 nicotinic acetylcholine receptors in the rat brain neurons. Eur J Neurosci 9:2734\u20132742","journal-title":"Eur J Neurosci"},{"key":"9601_CR2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0304-4157(98)00004-5","volume":"1376","author":"HR Arias","year":"1998","unstructured":"Arias HR (1998) Binding sites for exogenous and endogenous non-competitive inhibitors of the nicotinic acetylcholine receptor. Biochim Biophys Acta 1376:173\u2013220","journal-title":"Biochim Biophys Acta"},{"key":"9601_CR3","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jneuroim.2010.09.008","volume":"230","author":"R Benfante","year":"2011","unstructured":"Benfante R, Antonini RA, De Pizzol M et al (2011) Expression of the \u03b17 nAChR subunit duplicate form (CHRFAM7A) is down-regulated in the monocytic cell line THP-1 on treatment with LPS. J Neuroimmunol 230:74\u201384. doi: 10.1016\/j.jneuroim.2010.09.008","journal-title":"J Neuroimmunol"},{"key":"9601_CR4","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35013070","volume":"405","author":"LV Borovikova","year":"2000","unstructured":"Borovikova LV, Ivanova S, Zhang M et al (2000) Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405:458\u2013462. doi: 10.1038\/35013070","journal-title":"Nature"},{"key":"9601_CR5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10456-011-9246-9","volume":"15","author":"KC Brown","year":"2012","unstructured":"Brown KC, Lau JK, Dom AM et al (2012) MG624, an \u03b17-nAChR antagonist, inhibits angiogenesis via the Egr-1\/FGF2 pathway. Angiogenesis 15:99\u2013114. doi: 10.1007\/s10456-011-9246-9","journal-title":"Angiogenesis"},{"key":"9601_CR6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/(SICI)1097-0029(20000401)49:1<73::AID-JEMT8>3.0.CO;2-L","volume":"49","author":"J Cartaud","year":"2000","unstructured":"Cartaud J, Cartaud A, Kordeli E et al (2000) The torpedo electrocyte: a model system to study membrane-cytoskeleton interactions at the postsynaptic membrane. Microsc Res Tech 49:73\u201383. doi: 10.1002\/(SICI)1097-0029(20000401)49:1<73::AID-JEMT8>3.0.CO;2-L","journal-title":"Microsc Res Tech"},{"key":"9601_CR7","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0896-6273(00)80616-9","volume":"21","author":"JP Changeux","year":"1998","unstructured":"Changeux JP, Edelstein SJ (1998) Allosteric receptors after 30\u00a0years. Neuron 21:959\u2013980","journal-title":"Neuron"},{"key":"9601_CR8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0165-6147(92)90094-M","volume":"13","author":"JP Changeux","year":"1992","unstructured":"Changeux JP, Devillers-Thi\u00e9ry A, Galzi JL, Bertrand D (1992) New mutants to explore nicotinic receptor functions. Trends Pharmacol Sci 13:299\u2013301","journal-title":"Trends Pharmacol Sci"},{"key":"9601_CR9","doi-asserted-by":"crossref","first-page":"9836","DOI":"10.1523\/JNEUROSCI.3497-05.2005","volume":"25","author":"E Charpantier","year":"2005","unstructured":"Charpantier E, Wiesner A, Huh K-H et al (2005) Alpha7 neuronal nicotinic acetylcholine receptors are negatively regulated by tyrosine phosphorylation and Src-family kinases. J Neurosci 25:9836\u20139849. doi: 10.1523\/JNEUROSCI. 3497-05.2005","journal-title":"J Neurosci"},{"key":"9601_CR10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF02780338","volume":"4","author":"VB Cockcroft","year":"1990","unstructured":"Cockcroft VB, Osguthorpe DJ, Barnard EA et al (1990) Ligand-gated ion channels. Homology and diversity. Mol Neurobiol 4:129\u2013169. doi: 10.1007\/BF02780338","journal-title":"Mol Neurobiol"},{"key":"9601_CR11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/350235a0","volume":"350","author":"E Cooper","year":"1991","unstructured":"Cooper E, Couturier S, Ballivet M (1991) Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor. Nature 350:235\u2013238. doi: 10.1038\/350235a0","journal-title":"Nature"},{"key":"9601_CR12","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1146\/annurev.pharmtox.40.1.431","volume":"40","author":"PJ Corringer","year":"2000","unstructured":"Corringer PJ, Le Nov\u00e8re N, Changeux JP (2000) Nicotinic receptors at the amino acid level. Annu Rev Pharmacol Toxicol 40:431\u2013458. doi: 10.1146\/annurev.pharmtox.40.1.431","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"9601_CR13","doi-asserted-by":"crossref","first-page":"13870","DOI":"10.1523\/JNEUROSCI.2652-11.2011","volume":"31","author":"CJB daCosta","year":"2011","unstructured":"daCosta CJB, Free CR, Corradi J et al (2011) Single-channel and structural foundations of neuronal \u03b17 acetylcholine receptor potentiation. J Neurosci 31:13870\u201313879. doi: 10.1523\/JNEUROSCI. 2652-11.2011","journal-title":"J Neurosci"},{"key":"9601_CR14","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/ni1229","volume":"6","author":"WJ Jonge De","year":"2005","unstructured":"De Jonge WJ, van der Zanden EP, The FO et al (2005) Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nat Immunol 6:844\u2013851. doi: 10.1038\/ni1229","journal-title":"Nat Immunol"},{"key":"9601_CR15","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1074\/jbc.M110.180067","volume":"286","author":"AM Lucas-Cerrillo De","year":"2011","unstructured":"De Lucas-Cerrillo AM, Maldifassi MC, Arnalich F et al (2011) Function of partially duplicated human \u03b177 nicotinic receptor subunit CHRFAM7A gene: potential implications for the cholinergic anti-inflammatory response. J Biol Chem 286:594\u2013606. doi: 10.1074\/jbc.M110.180067","journal-title":"J Biol Chem"},{"key":"9601_CR16","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jneuroim.2008.03.004","volume":"196","author":"M Delgado-V\u00e9lez","year":"2008","unstructured":"Delgado-V\u00e9lez M, Lugo-Chinchilla A, Lizardo L et al (2008) Chronic exposure of human macrophages in vitro to morphine and methadone induces a putative tolerant\/dependent state. J Neuroimmunol 196:94\u2013100. doi: 10.1016\/j.jneuroim.2008.03.004","journal-title":"J Neuroimmunol"},{"key":"9601_CR17","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF02505755","volume":"136","author":"A Devillers-Thi\u00e9ry","year":"1993","unstructured":"Devillers-Thi\u00e9ry A, Galzi JL, Eisel\u00e9 JL et al (1993) Functional architecture of the nicotinic acetylcholine receptor: a prototype of ligand-gated ion channels. J Membr Biol 136:97\u2013112","journal-title":"J Membr Biol"},{"key":"9601_CR18","doi-asserted-by":"crossref","first-page":"15457","DOI":"10.1016\/S0021-9258(19)84851-2","volume":"264","author":"M DiPaola","year":"1989","unstructured":"DiPaola M, Czajkowski C, Karlin A (1989) The sidedness of the COOH terminus of the acetylcholine receptor delta subunit. J Biol Chem 264:15457\u201315463","journal-title":"J Biol Chem"},{"key":"9601_CR19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1146\/annurev.pa.31.040191.000345","volume":"31","author":"JL Galzi","year":"1991","unstructured":"Galzi JL, Revah F, Bessis A, Changeux JP (1991) Functional architecture of the nicotinic acetylcholine receptor: from electric organ to brain. Annu Rev Pharmacol Toxicol 31:37\u201372. doi: 10.1146\/annurev.pa.31.040191.000345","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"9601_CR20","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ceca.2008.10.003","volume":"45","author":"D Gilbert","year":"2009","unstructured":"Gilbert D, Lecchi M, Arnaudeau S et al (2009) Local and global calcium signals associated with the opening of neuronal alpha7 nicotinic acetylcholine receptors. Cell Calcium 45:198\u2013207. doi: 10.1016\/j.ceca.2008.10.003","journal-title":"Cell Calcium"},{"key":"9601_CR21","doi-asserted-by":"crossref","first-page":"4396","DOI":"10.1523\/JNEUROSCI.5269-04.2005","volume":"25","author":"RS Hurst","year":"2005","unstructured":"Hurst RS, Haj\u00f3s M, Raggenbass M et al (2005) A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. J Neurosci 25:4396\u20134405. doi: 10.1523\/JNEUROSCI. 5269-04.2005","journal-title":"J Neurosci"},{"key":"9601_CR22","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0014-5793(01)02702-8","volume":"504","author":"V Itier","year":"2001","unstructured":"Itier V, Bertrand D (2001) Neuronal nicotinic receptors: from protein structure to function. FEBS Lett 504:118\u2013125","journal-title":"FEBS Lett"},{"key":"9601_CR23","doi-asserted-by":"crossref","first-page":"24735","DOI":"10.1074\/jbc.M110.204859","volume":"286","author":"Y Joe","year":"2011","unstructured":"Joe Y, Kim HJ, Kim S et al (2011) Tristetraprolin mediates anti-inflammatory effects of nicotine in lipopolysaccharide-stimulated macrophages. J Biol Chem 286:24735\u201324742. doi: 10.1074\/jbc.M110.204859","journal-title":"J Biol Chem"},{"key":"9601_CR24","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1111\/j.1742-4658.2007.05935.x","volume":"274","author":"D Kalamida","year":"2007","unstructured":"Kalamida D, Poulas K, Avramopoulou V et al (2007) Muscle and neuronal nicotinic acetylcholine receptors. Structure, function and pathogenicity. FEBS J 274:3799\u20133845. doi: 10.1111\/j.1742-4658.2007.05935.x","journal-title":"FEBS J"},{"key":"9601_CR25","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nrn731","volume":"3","author":"A Karlin","year":"2002","unstructured":"Karlin A (2002) Emerging structure of the nicotinic acetylcholine receptors. Nat Rev Neurosci 3:102\u2013114. doi: 10.1038\/nrn731","journal-title":"Nat Rev Neurosci"},{"key":"9601_CR26","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/0896-6273(95)90004-7","volume":"15","author":"A Karlin","year":"1995","unstructured":"Karlin A, Akabas MH (1995) Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins. Neuron 15:1231\u20131244","journal-title":"Neuron"},{"key":"9601_CR27","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1093\/infdis\/jit669","volume":"209","author":"T-H Kim","year":"2014","unstructured":"Kim T-H, Kim S-J, Lee S-M (2014) Stimulation of the \u03b17 nicotinic acetylcholine receptor protects against sepsis by inhibiting Toll-like receptor via phosphoinositide 3-kinase activation. J Infect Dis 209:1668\u20131677. doi: 10.1093\/infdis\/jit669","journal-title":"J Infect Dis"},{"key":"9601_CR28","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/S0006-3495(99)77390-X","volume":"76","author":"N Nov\u00e8re Le","year":"1999","unstructured":"Le Nov\u00e8re N, Corringer PJ, Changeux JP (1999) Improved secondary structure predictions for a nicotinic receptor subunit: incorporation of solvent accessibility and experimental data into a two-dimensional representation. Biophys J 76:2329\u20132345. doi: 10.1016\/S0006-3495(99)77390-X","journal-title":"Biophys J"},{"key":"9601_CR29","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/neu.10153","volume":"53","author":"N Nov\u00e8re Le","year":"2002","unstructured":"Le Nov\u00e8re N, Corringer P-J, Changeux J-P (2002) The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences. J Neurobiol 53:447\u2013456. doi: 10.1002\/neu.10153","journal-title":"J Neurobiol"},{"key":"9601_CR30","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1309\/1N2NAYWQ53QVR6FX","volume":"38","author":"C Lueders","year":"2007","unstructured":"Lueders C, Danne O, M\u00fcller C et al (2007) Evaluation of a chemiluminescent assay for analysis of choline in human plasma and whole blood. Lab Med 38:726\u2013728. doi: 10.1309\/1N2NAYWQ53QVR6FX","journal-title":"Lab Med"},{"key":"9601_CR31","doi-asserted-by":"crossref","first-page":"e108397","DOI":"10.1371\/journal.pone.0108397","volume":"9","author":"MC Maldifassi","year":"2014","unstructured":"Maldifassi MC, Atienza G, Arnalich F et al (2014) A new IRAK-M-mediated mechanism implicated in the anti-inflammatory effect of nicotine via \u03b17 nicotinic receptors in human macrophages. PLoS ONE 9:e108397. doi: 10.1371\/journal.pone.0108397","journal-title":"PLoS ONE"},{"key":"9601_CR32","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF00713026","volume":"9","author":"EL Ochoa","year":"1989","unstructured":"Ochoa EL, Chattopadhyay A, McNamee MG (1989) Desensitization of the nicotinic acetylcholine receptor: molecular mechanisms and effect of modulators. Cell Mol Neurobiol 9:141\u2013178","journal-title":"Cell Mol Neurobiol"},{"key":"9601_CR33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2014.01.029","volume":"89","author":"RL Papke","year":"2014","unstructured":"Papke RL (2014) Merging old and new perspectives on nicotinic acetylcholine receptors. Biochem Pharmacol 89:1\u201311. doi: 10.1016\/j.bcp.2014.01.029","journal-title":"Biochem Pharmacol"},{"key":"9601_CR34","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2119\/2008-00079.Parrish","volume":"14","author":"WR Parrish","year":"2008","unstructured":"Parrish WR, Rosas-Ballina M, Gallowitsch-Puerta M et al (2008) Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling. Mol Med 14:567\u2013574. doi: 10.2119\/2008-00079.Parrish","journal-title":"Mol Med"},{"key":"9601_CR35","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0301-0082(99)00045-3","volume":"61","author":"D Paterson","year":"2000","unstructured":"Paterson D, Nordberg A (2000) Neuronal nicotinic receptors in the human brain. Prog Neurobiol 61:75\u2013111","journal-title":"Prog Neurobiol"},{"key":"9601_CR36","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1021\/pr800731z","volume":"8","author":"JA Paulo","year":"2009","unstructured":"Paulo JA, Brucker WJ, Hawrot E (2009) Proteomic analysis of an alpha7 nicotinic acetylcholine receptor interactome. J Proteome Res 8:1849\u20131858. doi: 10.1021\/pr800731z","journal-title":"J Proteome Res"},{"key":"9601_CR37","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1002\/eji.201040540","volume":"40","author":"G Pe\u00f1a","year":"2010","unstructured":"Pe\u00f1a G, Cai B, Liu J et al (2010) Unphosphorylated STAT3 modulates alpha 7 nicotinic receptor signaling and cytokine production in sepsis. Eur J Immunol 40:2580\u20132589. doi: 10.1002\/eji.201040540","journal-title":"Eur J Immunol"},{"key":"9601_CR38","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1209985","volume":"334","author":"M Rosas-Ballina","year":"2011","unstructured":"Rosas-Ballina M, Olofsson PS, Ochani M et al (2011) Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit. Science 334:98\u2013101. doi: 10.1126\/science.1209985","journal-title":"Science"},{"key":"9601_CR39","doi-asserted-by":"crossref","first-page":"574","DOI":"10.2174\/138945012800398874","volume":"13","author":"P Russo","year":"2012","unstructured":"Russo P, Taly A (2012) \u03b17-Nicotinic acetylcholine receptors: an old actor for new different roles. Curr Drug Targets 13:574\u2013578","journal-title":"Curr Drug Targets"},{"key":"9601_CR40","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1158\/1541-7786.MCR-13-0541","volume":"12","author":"C Schaal","year":"2014","unstructured":"Schaal C, Chellappan SP (2014) Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers. Mol Cancer Res 12:14\u201323. doi: 10.1158\/1541-7786.MCR-13-0541","journal-title":"Mol Cancer Res"},{"key":"9601_CR41","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/aps.2009.64","volume":"30","author":"J Shen","year":"2009","unstructured":"Shen J, Yakel JL (2009) Nicotinic acetylcholine receptor-mediated calcium signaling in the nervous system. Acta Pharmacol Sin 30:673\u2013680. doi: 10.1038\/aps.2009.64","journal-title":"Acta Pharmacol Sin"},{"key":"9601_CR42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1189\/jlb.0209106","volume":"86","author":"MV Skok","year":"2009","unstructured":"Skok MV (2009) Editorial: To channel or not to channel? Functioning of nicotinic acetylcholine receptors in leukocytes. J Leukoc Biol 86:1\u20133. doi: 10.1189\/JLB.0209106","journal-title":"J Leukoc Biol"},{"key":"9601_CR43","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1152\/advan.00094.2013","volume":"38","author":"E Sundman","year":"2014","unstructured":"Sundman E, Olofsson PS (2014) Neural control of the immune system. Adv Physiol Educ 38:135\u2013139","journal-title":"Adv Physiol Educ"},{"key":"9601_CR44","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1089\/ars.2010.3555","volume":"14","author":"K Tsoyi","year":"2011","unstructured":"Tsoyi K, Jang HJ, Kim JW et al (2011) Stimulation of alpha7 nicotinic acetylcholine receptor by nicotine attenuates inflammatory response in macrophages and improves survival in experimental model of sepsis through heme oxygenase-1 induction. Antioxid Redox Signal 14:2057\u20132070. doi: 10.1089\/ars.2010.3555","journal-title":"Antioxid Redox Signal"},{"key":"9601_CR45","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0165-5728(02)00057-7","volume":"126","author":"Y Villiger","year":"2002","unstructured":"Villiger Y, Szanto I, Jaconi S et al (2002) Expression of an alpha7 duplicate nicotinic acetylcholine receptor-related protein in human leukocytes. J Neuroimmunol 126:86\u201398","journal-title":"J Neuroimmunol"},{"key":"9601_CR46","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature01339","volume":"421","author":"H Wang","year":"2003","unstructured":"Wang H, Yu M, Ochani M et al (2003) Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 421:384\u2013388. doi: 10.1038\/nature01339","journal-title":"Nature"},{"key":"9601_CR47","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/nm1124","volume":"10","author":"H Wang","year":"2004","unstructured":"Wang H, Liao H, Ochani M et al (2004) Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat Med 10:1216\u20131221. doi: 10.1038\/nm1124","journal-title":"Nat Med"},{"key":"9601_CR48","doi-asserted-by":"crossref","first-page":"26451","DOI":"10.1074\/jbc.M114.582858","volume":"289","author":"Y Wang","year":"2014","unstructured":"Wang Y, Xiao C, Indersmitten T et al (2014) The duplicated \u03b17 subunits assemble and form functional nicotinic receptors with the full-length \u03b17. J Biol Chem 289:26451\u201326463. doi: 10.1074\/jbc.M114.582858","journal-title":"J Biol Chem"},{"key":"9601_CR49","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1101\/gad.1553707","volume":"21","author":"J Yang","year":"2007","unstructured":"Yang J, Liao X, Agarwal MK et al (2007) Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB. Genes Dev 21:1396\u20131408. doi: 10.1101\/gad.1553707","journal-title":"Genes Dev"},{"key":"9601_CR50","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1365-2249.2006.03169.x","volume":"146","author":"H Yoshikawa","year":"2006","unstructured":"Yoshikawa H, Kurokawa M, Ozaki N et al (2006) Nicotine inhibits the production of proinflammatory mediators in human monocytes by suppression of I-kappaB phosphorylation and nuclear factor-kappaB transcriptional activity through nicotinic acetylcholine receptor alpha7. Clin Exp Immunol 146:116\u2013123. doi: 10.1111\/j.1365-2249.2006.03169.x","journal-title":"Clin Exp Immunol"},{"key":"9601_CR51","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0896-6273(94)90161-9","volume":"12","author":"ZW Zhang","year":"1994","unstructured":"Zhang ZW, Vijayaraghavan S, Berg DK (1994) Neuronal acetylcholine receptors that bind alpha-bungarotoxin with high affinity function as ligand-gated ion channels. Neuron 12:167\u2013177","journal-title":"Neuron"}],"container-title":["Journal of Neuroimmune Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11481-015-9601-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11481-015-9601-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11481-015-9601-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T23:21:30Z","timestamp":1651706490000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11481-015-9601-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,14]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["9601"],"URL":"https:\/\/doi.org\/10.1007\/s11481-015-9601-5","relation":{},"ISSN":["1557-1890","1557-1904"],"issn-type":[{"value":"1557-1890","type":"print"},{"value":"1557-1904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,14]]}}}