{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:45:00Z","timestamp":1791499500878,"version":"4.3.4"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T00:00:00Z","timestamp":1519776000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T00:00:00Z","timestamp":1519776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS077873"],"award-info":[{"award-number":["R01 NS077873"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroimmune Pharmacol"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s11481-018-9780-y","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T05:40:39Z","timestamp":1519796439000},"page":"237-253","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Inflammasome Activation by Methamphetamine Potentiates Lipopolysaccharide Stimulation of IL-1\u03b2 Production in Microglia"],"prefix":"10.1007","volume":"13","author":[{"given":"Enquan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianuo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3450-8876","authenticated-orcid":false,"given":"Huangui","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,28]]},"reference":[{"key":"9780_CR1","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.pnpbp.2014.04.008","volume":"53","author":"G Attarzadeh-Yazdi","year":"2014","unstructured":"Attarzadeh-Yazdi G, Arezoomandan R, Haghparast A (2014) Minocycline, an antibiotic with inhibitory effect on microglial activation, attenuates the maintenance and reinstatement of methamphetamine-seeking behavior in rat. Prog Neuro-Psychopharmacol Biol Psychiatry 53:142\u2013148","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"9780_CR2","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.ejphar.2010.04.010","volume":"637","author":"PM Beardsley","year":"2010","unstructured":"Beardsley PM, Shelton KL, Hendrick E, Johnson KW (2010) The glial cell modulator and phosphodiesterase inhibitor, AV411 (ibudilast), attenuates prime- and stress-induced methamphetamine relapse. Eur J Pharmacol 637:102\u2013108","journal-title":"Eur J Pharmacol"},{"key":"9780_CR3","doi-asserted-by":"publisher","first-page":"6434","DOI":"10.1038\/onc.2008.310","volume":"27","author":"P Boya","year":"2008","unstructured":"Boya P, Kroemer G (2008) Lysosomal membrane permeabilization in cell death. Oncogene 27:6434\u20136451","journal-title":"Oncogene"},{"key":"9780_CR4","doi-asserted-by":"publisher","first-page":"3927","DOI":"10.1038\/sj.onc.1206622","volume":"22","author":"P Boya","year":"2003","unstructured":"Boya P, Gonzalez-Polo RA, Poncet D, Andreau K, Vieira HL, Roumier T, Perfettini JL, Kroemer G (2003) Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine. Oncogene 22:3927\u20133936","journal-title":"Oncogene"},{"key":"9780_CR5","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1113\/EP085135","volume":"100","author":"D Brough","year":"2015","unstructured":"Brough D, Rothwell NJ, Allan SM (2015) Interleukin-1 as a pharmacological target in acute brain injury. Exp Physiol 100:1488\u20131494","journal-title":"Exp Physiol"},{"key":"9780_CR6","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.drugalcdep.2011.06.013","volume":"120","author":"RC Callaghan","year":"2012","unstructured":"Callaghan RC, Cunningham JK, Sykes J, Kish SJ (2012) Increased risk of Parkinson's disease in individuals hospitalized with conditions related to the use of methamphetamine or other amphetamine-type drugs. Drug Alcohol Depend 120:35\u201340","journal-title":"Drug Alcohol Depend"},{"issue":"Suppl 1","key":"9780_CR7","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/j.1360-0443.2006.01782.x","volume":"102","author":"L Chang","year":"2007","unstructured":"Chang L, Alicata D, Ernst T, Volkow N (2007) Structural and metabolic brain changes in the striatum associated with methamphetamine abuse. Addiction 102(Suppl 1):16\u201332","journal-title":"Addiction"},{"key":"9780_CR8","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s11481-009-9164-4","volume":"4","author":"CA Colton","year":"2009","unstructured":"Colton CA (2009) Heterogeneity of microglial activation in the innate immune response in the brain. J NeuroImmune Pharmacol 4:399\u2013418","journal-title":"J NeuroImmune Pharmacol"},{"key":"9780_CR9","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.1523\/JNEUROSCI.14-04-02260.1994","volume":"14","author":"JF Cubells","year":"1994","unstructured":"Cubells JF, Rayport S, Rajendran G, Sulzer D (1994) Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress. J Neurosci 14:2260\u20132271","journal-title":"J Neurosci"},{"key":"9780_CR10","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.drugpo.2009.11.007","volume":"21","author":"L Degenhardt","year":"2010","unstructured":"Degenhardt L, Mathers B, Guarinieri M, Panda S, Phillips B, Strathdee SA, Tyndall M, Wiessing L, Wodak A, Howard J, Reference Group to the United Nations on HIV, injecting drug u (2010) Meth\/amphetamine use and associated HIV: implications for global policy and public health. Int J Drug Policy 21:347\u2013358","journal-title":"Int J Drug Policy"},{"key":"9780_CR11","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1126\/science.1156995","volume":"320","author":"C Dostert","year":"2008","unstructured":"Dostert C, Petrilli V, Van Bruggen R, Steele C, Mossman BT, Tschopp J (2008) Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 320:674\u2013677","journal-title":"Science"},{"key":"9780_CR12","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.mam.2006.08.005","volume":"27","author":"EL Eskelinen","year":"2006","unstructured":"Eskelinen EL (2006) Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy. Mol Asp Med 27:495\u2013502","journal-title":"Mol Asp Med"},{"key":"9780_CR13","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1385\/NMM:2:1:71","volume":"2","author":"G Flora","year":"2002","unstructured":"Flora G, Lee YW, Nath A, Maragos W, Hennig B, Toborek M (2002) Methamphetamine-induced TNF-alpha gene expression and activation of AP-1 in discrete regions of mouse brain potential role of reactive oxygen intermediates and lipid peroxidation. Neuromolecular Med 2:71\u201385","journal-title":"Neuromolecular Med"},{"key":"9780_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbi.2015.03.010","volume":"48","author":"MG Frank","year":"2015","unstructured":"Frank MG, Weber MD, Watkins LR, Maier SF (2015) Stress sounds the alarmin: the role of the danger-associated molecular pattern HMGB1 in stress-induced neuroinflammatory priming. Brain Behav Immun 48:1\u20137","journal-title":"Brain Behav Immun"},{"key":"9780_CR15","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.bbi.2015.08.001","volume":"51","author":"MG Frank","year":"2016","unstructured":"Frank MG, Adhikary S, Sobesky JL, Weber MD, Watkins LR, Maier SF (2016) The danger-associated molecular pattern HMGB1 mediates the neuroinflammatory effects of methamphetamine. Brain Behav Immun 51:99\u2013108","journal-title":"Brain Behav Immun"},{"key":"9780_CR16","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1111\/jnc.12201","volume":"125","author":"DM Friend","year":"2013","unstructured":"Friend DM, Keefe KA (2013) Glial reactivity in resistance to methamphetamine-induced neurotoxicity. J Neurochem 125:566\u2013574","journal-title":"J Neurochem"},{"key":"9780_CR17","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.tox.2013.07.016","volume":"312","author":"I Funakoshi-Hirose","year":"2013","unstructured":"Funakoshi-Hirose I, Aki T, Unuma K, Funakoshi T, Noritake K, Uemura K (2013) Distinct effects of methamphetamine on autophagy-lysosome and ubiquitin-proteasome systems in HL-1 cultured mouse atrial cardiomyocytes. Toxicology 312:74\u201382","journal-title":"Toxicology"},{"key":"9780_CR18","doi-asserted-by":"publisher","first-page":"32608","DOI":"10.1074\/jbc.273.49.32608","volume":"273","author":"M Garcia-Calvo","year":"1998","unstructured":"Garcia-Calvo M, Peterson EP, Leiting B, Ruel R, Nicholson DW, Thornberry NA (1998) Inhibition of human caspases by peptide-based and macromolecular inhibitors. J Biol Chem 273:32608\u201332613","journal-title":"J Biol Chem"},{"key":"9780_CR19","doi-asserted-by":"publisher","first-page":"3881","DOI":"10.4049\/jimmunol.1301974","volume":"192","author":"MG Ghonime","year":"2014","unstructured":"Ghonime MG, Shamaa OR, Das S, Eldomany RA, Fernandes-Alnemri T, Alnemri ES, Gavrilin MA, Wewers MD (2014) Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function. J Immunol 192:3881\u20133888","journal-title":"J Immunol"},{"key":"9780_CR20","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1111\/j.1521-0391.2010.00061.x","volume":"19","author":"S Glasner-Edwards","year":"2010","unstructured":"Glasner-Edwards S, Mooney LJ, Marinelli-Casey P, Hillhouse M, Ang A, Rawson R, Methamphetamine Treatment Project Corporate A (2010) Anxiety disorders among methamphetamine dependent adults: association with post-treatment functioning. Am J Addict 19:385\u2013390","journal-title":"Am J Addict"},{"key":"9780_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jneuroim.2014.07.012","volume":"274","author":"H Gonzalez","year":"2014","unstructured":"Gonzalez H, Elgueta D, Montoya A, Pacheco R (2014) Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases. J Neuroimmunol 274:1\u201313","journal-title":"J Neuroimmunol"},{"key":"9780_CR22","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.4161\/cc.25317","volume":"12","author":"ME Guicciardi","year":"2013","unstructured":"Guicciardi ME, Gores GJ (2013) Complete lysosomal disruption: a route to necrosis, not to the inflammasome. Cell Cycle 12:1995\u20131995","journal-title":"Cell Cycle"},{"key":"9780_CR23","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/ni.1636","volume":"9","author":"A Halle","year":"2008","unstructured":"Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, Fitzgerald KA, Latz E, Moore KJ, Golenbock DT (2008) The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol 9:857\u2013865","journal-title":"Nat Immunol"},{"key":"9780_CR24","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.it.2012.03.001","volume":"33","author":"R Hanamsagar","year":"2012","unstructured":"Hanamsagar R, Hanke ML, Kielian T (2012) Toll-like receptor (TLR) and inflammasome actions in the central nervous system. Trends Immunol 33:333\u2013342","journal-title":"Trends Immunol"},{"key":"9780_CR25","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.biopsych.2006.03.019","volume":"61","author":"K Hashimoto","year":"2007","unstructured":"Hashimoto K, Tsukada H, Nishiyama S, Fukumoto D, Kakiuchi T, Iyo M (2007) Protective effects of minocycline on the reduction of dopamine transporters in the striatum after administration of methamphetamine: a positron emission tomography study in conscious monkeys. Biol Psychiatry 61:577\u2013581","journal-title":"Biol Psychiatry"},{"key":"9780_CR26","doi-asserted-by":"publisher","first-page":"5230","DOI":"10.4049\/jimmunol.1301490","volume":"191","author":"ME Heid","year":"2013","unstructured":"Heid ME, Keyel PA, Kamga C, Shiva S, Watkins SC, Salter RD (2013) Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation. J Immunol 191:5230\u20135238","journal-title":"J Immunol"},{"key":"9780_CR27","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1002\/jcb.240560116","volume":"56","author":"PA Hill","year":"1994","unstructured":"Hill PA, Buttle DJ, Jones SJ, Boyde A, Murata M, Reynolds JJ, Meikle MC (1994) Inhibition of bone resorption by selective inactivators of cysteine proteinases. J Cell Biochem 56:118\u2013130","journal-title":"J Cell Biochem"},{"issue":"1","key":"9780_CR28","first-page":"e47","volume":"1","author":"HM Houdek","year":"2014","unstructured":"Houdek HM, Larson J, Watt JA, Rosenberger TA (2014) Bacterial lipopolysaccharide induces a dose-dependent activation of neuroglia and loss of basal forebrain cholinergic cells in the rat brain. Inflamm Cell Signal 1(1):e47","journal-title":"Inflamm Cell Signal"},{"key":"9780_CR29","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1096\/fj.03-0295com","volume":"18","author":"S Jayanthi","year":"2004","unstructured":"Jayanthi S, Deng X, Noailles PA, Ladenheim B, Cadet JL (2004) Methamphetamine induces neuronal apoptosis via cross-talks between endoplasmic reticulum and mitochondria-dependent death cascades. FASEB J 18:238\u2013251","journal-title":"FASEB J"},{"key":"9780_CR30","doi-asserted-by":"publisher","first-page":"36617","DOI":"10.1074\/jbc.M112.407130","volume":"287","author":"C Juliana","year":"2012","unstructured":"Juliana C, Fernandes-Alnemri T, Kang S, Farias A, Qin F, Alnemri ES (2012) Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation. J Biol Chem 287:36617\u201336622","journal-title":"J Biol Chem"},{"key":"9780_CR31","doi-asserted-by":"publisher","first-page":"C83","DOI":"10.1152\/ajpcell.00298.2015","volume":"311","author":"MA Katsnelson","year":"2016","unstructured":"Katsnelson MA, Lozada-Soto KM, Russo HM, Miller BA, Dubyak GR (2016) NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K+ efflux and Ca2+ influx. Am J Physiol Cell Physiol 311:C83\u2013C100","journal-title":"Am J Physiol Cell Physiol"},{"key":"9780_CR32","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1111\/j.1471-4159.2012.07864.x","volume":"122","author":"KA Kelly","year":"2012","unstructured":"Kelly KA, Miller DB, Bowyer JF, O'Callaghan JP (2012) Chronic exposure to corticosterone enhances the neuroinflammatory and neurotoxic responses to methamphetamine. J Neurochem 122:995\u20131009","journal-title":"J Neurochem"},{"key":"9780_CR33","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.brainresrev.2009.03.002","volume":"60","author":"IN Krasnova","year":"2009","unstructured":"Krasnova IN, Cadet JL (2009) Methamphetamine toxicity and messengers of death. Brain Res Rev 60:379\u2013407","journal-title":"Brain Res Rev"},{"key":"9780_CR34","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.expneurol.2004.01.010","volume":"187","author":"MJ LaVoie","year":"2004","unstructured":"LaVoie MJ, Card JP, Hastings TG (2004) Microglial activation precedes dopamine terminal pathology in methamphetamine-induced neurotoxicity. Exp Neurol 187:47\u201357","journal-title":"Exp Neurol"},{"key":"9780_CR35","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/1742-2094-5-37","volume":"5","author":"JW Lee","year":"2008","unstructured":"Lee JW, Lee YK, Yuk DY, Choi DY, Ban SB, Oh KW, Hong JT (2008) Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation. J Neuroinflammation 5:37","journal-title":"J Neuroinflammation"},{"key":"9780_CR36","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1007\/s10495-009-0393-z","volume":"14","author":"HL Liang","year":"2009","unstructured":"Liang HL, Arsenault J, Mortensen J, Park F, Johnson CP, Nilakantan V (2009) Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cells. Apoptosis 14:1176\u20131189","journal-title":"Apoptosis"},{"key":"9780_CR37","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1097\/FPC.0b013e328331e68f","volume":"19","author":"L Liu","year":"2009","unstructured":"Liu L, Hutchinson MR, White JM, Somogyi AA, Coller JK (2009) Association of IL-1B genetic polymorphisms with an increased risk of opioid and alcohol dependence. Pharmacogenet Genomics 19:869\u2013876","journal-title":"Pharmacogenet Genomics"},{"key":"9780_CR38","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/j.bbi.2011.03.016","volume":"25","author":"L Liu","year":"2011","unstructured":"Liu L, Coller JK, Watkins LR, Somogyi AA, Hutchinson MR (2011) Naloxone-precipitated morphine withdrawal behavior and brain IL-1beta expression: comparison of different mouse strains. Brain Behav Immun 25:1223\u20131232","journal-title":"Brain Behav Immun"},{"key":"9780_CR39","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2011.140","volume":"3","author":"J Liu","year":"2012","unstructured":"Liu J, Xu C, Chen L, Xu P, Xiong H (2012) Involvement of Kv1.3 and p38 MAPK signaling in HIV-1 glycoprotein 120-induced microglia neurotoxicity. Cell Death Dis 3:e254","journal-title":"Cell Death Dis"},{"key":"9780_CR40","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/B978-0-12-801284-0.00007-5","volume":"118","author":"JM Loftis","year":"2014","unstructured":"Loftis JM, Janowsky A (2014) Neuroimmune basis of methamphetamine toxicity. Int Rev Neurobiol 118:165\u2013197","journal-title":"Int Rev Neurobiol"},{"key":"9780_CR41","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.cytogfr.2011.10.001","volume":"22","author":"G Lopez-Castejon","year":"2011","unstructured":"Lopez-Castejon G, Brough D (2011) Understanding the mechanism of IL-1beta secretion. Cytokine Growth Factor Rev 22:189\u2013195","journal-title":"Cytokine Growth Factor Rev"},{"key":"9780_CR42","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.nurt.2010.05.014","volume":"7","author":"ME Lull","year":"2010","unstructured":"Lull ME, Block ML (2010) Microglial activation and chronic neurodegeneration. Neurotherapeutics 7:354\u2013365","journal-title":"Neurotherapeutics"},{"key":"9780_CR43","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00210-013-0919-3","volume":"387","author":"V Mashayekhi","year":"2014","unstructured":"Mashayekhi V, Eskandari MR, Kobarfard F, Khajeamiri A, Hosseini MJ (2014) Induction of mitochondrial permeability transition (MPT) pore opening and ROS formation as a mechanism for methamphetamine-induced mitochondrial toxicity. Naunyn Schmiedeberg's Arch Pharmacol 387:47\u201358","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"9780_CR44","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0022-3565(24)38016-4","volume":"288","author":"WP Melega","year":"1999","unstructured":"Melega WP, Cho AK, Schmitz D, Kuczenski R, Segal DS (1999) L-methamphetamine pharmacokinetics and pharmacodynamics for assessment of in vivo deprenyl-derived l-methamphetamine. J Pharmacol Exp Ther 288:752\u2013758","journal-title":"J Pharmacol Exp Ther"},{"key":"9780_CR45","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1002\/syn.20365","volume":"61","author":"WP Melega","year":"2007","unstructured":"Melega WP, Cho AK, Harvey D, Lacan G (2007) Methamphetamine blood concentrations in human abusers: application to pharmacokinetic modeling. Synapse 61:216\u2013220","journal-title":"Synapse"},{"key":"9780_CR46","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1038\/ni.2550","volume":"14","author":"T Misawa","year":"2013","unstructured":"Misawa T, Takahama M, Kozaki T, Lee H, Zou J, Saitoh T, Akira S (2013) Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat Immunol 14:454\u2013460","journal-title":"Nat Immunol"},{"key":"9780_CR47","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/j.immuni.2013.05.016","volume":"38","author":"R Munoz-Planillo","year":"2013","unstructured":"Munoz-Planillo R, Kuffa P, Martinez-Colon G, Smith BL, Rajendiran TM, Nunez G (2013) K(+) efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity 38:1142\u20131153","journal-title":"Immunity"},{"key":"9780_CR48","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1523\/JNEUROSCI.4847-03.2004","volume":"24","author":"A Nakajima","year":"2004","unstructured":"Nakajima A, Yamada K, Nagai T, Uchiyama T, Miyamoto Y, Mamiya T, He J, Nitta A, Mizuno M, Tran MH, Seto A, Yoshimura M, Kitaichi K, Hasegawa T, Saito K, Yamada Y, Seishima M, Sekikawa K, Kim HC, Nabeshima T (2004) Role of tumor necrosis factor-alpha in methamphetamine-induced drug dependence and neurotoxicity. J Neurosci 24:2212\u20132225","journal-title":"J Neurosci"},{"key":"9780_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2012.05.017","volume":"1466","author":"A Nara","year":"2012","unstructured":"Nara A, Aki T, Funakoshi T, Unuma K, Uemura K (2012) Hyperstimulation of macropinocytosis leads to lysosomal dysfunction during exposure to methamphetamine in SH-SY5Y cells. Brain Res 1466:1\u201314","journal-title":"Brain Res"},{"key":"9780_CR50","doi-asserted-by":"publisher","first-page":"4327","DOI":"10.1128\/IAI.00730-09","volume":"77","author":"ZL Newman","year":"2009","unstructured":"Newman ZL, Leppla SH, Moayeri M (2009) CA-074Me protection against anthrax lethal toxin. Infect Immun 77:4327\u20134336","journal-title":"Infect Immun"},{"key":"9780_CR51","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3389\/fnins.2015.00069","volume":"9","author":"NA Northrop","year":"2015","unstructured":"Northrop NA, Yamamoto BK (2015) Methamphetamine effects on blood-brain barrier structure and function. Front Neurosci 9:69","journal-title":"Front Neurosci"},{"key":"9780_CR52","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.neulet.2014.10.016","volume":"584","author":"J Park","year":"2015","unstructured":"Park J, Min JS, Kim B, Chae UB, Yun JW, Choi MS, Kong IK, Chang KT, Lee DS (2015) Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-kappaB pathways. Neurosci Lett 584:191\u2013196","journal-title":"Neurosci Lett"},{"key":"9780_CR53","first-page":"193","volume":"6","author":"VH Perry","year":"2010","unstructured":"Perry VH, Nicoll JA, Holmes C (2010) Microglia in neurodegenerative disease. Nature reviews 6:193\u2013201","journal-title":"Nature reviews"},{"key":"9780_CR54","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.4049\/jimmunol.0903691","volume":"185","author":"R Potula","year":"2010","unstructured":"Potula R, Hawkins BJ, Cenna JM, Fan S, Dykstra H, Ramirez SH, Morsey B, Brodie MR, Persidsky Y (2010) Methamphetamine causes mitrochondrial oxidative damage in human T lymphocytes leading to functional impairment. J Immunol 185:2867\u20132876","journal-title":"J Immunol"},{"key":"9780_CR55","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.phrs.2017.03.009","volume":"120","author":"MD Prakash","year":"2017","unstructured":"Prakash MD, Tangalakis K, Antonipillai J, Stojanovska L, Nurgali K, Apostolopoulos V (2017) Methamphetamine: effects on the brain, gut and immune system. Pharmacol Res 120:60\u201367","journal-title":"Pharmacol Res"},{"key":"9780_CR56","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1002\/glia.20467","volume":"55","author":"L Qin","year":"2007","unstructured":"Qin L, Wu X, Block ML, Liu Y, Breese GR, Hong JS, Knapp DJ, Crews FT (2007) Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia 55:453\u2013462","journal-title":"Glia"},{"key":"9780_CR57","doi-asserted-by":"publisher","first-page":"E337","DOI":"10.1007\/BF02854904","volume":"8","author":"MS Quinton","year":"2006","unstructured":"Quinton MS, Yamamoto BK (2006) Causes and consequences of methamphetamine and MDMA toxicity. AAPS J 8:E337\u2013E347","journal-title":"AAPS J"},{"key":"9780_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S1355617704101021","volume":"10","author":"JD Rippeth","year":"2004","unstructured":"Rippeth JD, Heaton RK, Carey CL, Marcotte TD, Moore DJ, Gonzalez R, Wolfson T, Grant I (2004) Methamphetamine dependence increases risk of neuropsychological impairment in HIV infected persons. J Int Neuropsychol Soc 10:1\u201314","journal-title":"J Int Neuropsychol Soc"},{"key":"9780_CR59","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/S0022-3565(24)35387-X","volume":"292","author":"GJ Riviere","year":"2000","unstructured":"Riviere GJ, Gentry WB, Owens SM (2000) Disposition of methamphetamine and its metabolite amphetamine in brain and other tissues in rats after intravenous administration. J Pharmacol Exp Ther 292:1042\u20131047","journal-title":"J Pharmacol Exp Ther"},{"key":"9780_CR60","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.expneurol.2014.01.020","volume":"254","author":"MJ Robson","year":"2014","unstructured":"Robson MJ, Turner RC, Naser ZJ, McCurdy CR, O'Callaghan JP, Huber JD, Matsumoto RR (2014) SN79, a sigma receptor antagonist, attenuates methamphetamine-induced astrogliosis through a blockade of OSMR\/gp130 signaling and STAT3 phosphorylation. Exp Neurol 254:180\u2013189","journal-title":"Exp Neurol"},{"key":"9780_CR61","first-page":"445","volume":"8","author":"SA Salamanca","year":"2014","unstructured":"Salamanca SA, Sorrentino EE, Nosanchuk JD, Martinez LR (2014) Impact of methamphetamine on infection and immunity. Front Neurosci 8:445","journal-title":"Front Neurosci"},{"key":"9780_CR62","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41531-017-0032-2","volume":"3","author":"S Sarkar","year":"2017","unstructured":"Sarkar S, Malovic E, Harishchandra DS, Ghaisas S, Panicker N, Charli A, Palanisamy BN, Rokad D, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG (2017) Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease. NPJ Parkinsons Dis 3:30","journal-title":"NPJ Parkinsons Dis"},{"key":"9780_CR63","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","volume":"9","author":"CA Schneider","year":"2012","unstructured":"Schneider CA, Rasband WS, Eliceiri KW (2012) NIH image to ImageJ: 25 years of image analysis. Nat Methods 9:671\u2013675","journal-title":"Nat Methods"},{"key":"9780_CR64","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s11065-007-9031-0","volume":"17","author":"JC Scott","year":"2007","unstructured":"Scott JC, Woods SP, Matt GE, Meyer RA, Heaton RK, Atkinson JH, Grant I (2007) Neurocognitive effects of methamphetamine: a critical review and meta-analysis. Neuropsychol Rev 17:275\u2013297","journal-title":"Neuropsychol Rev"},{"key":"9780_CR65","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1176\/appi.ajp.158.8.1206","volume":"158","author":"Y Sekine","year":"2001","unstructured":"Sekine Y, Iyo M, Ouchi Y, Matsunaga T, Tsukada H, Okada H, Yoshikawa E, Futatsubashi M, Takei N, Mori N (2001) Methamphetamine-related psychiatric symptoms and reduced brain dopamine transporters studied with PET. Am J Psychiatry 158:1206\u20131214","journal-title":"Am J Psychiatry"},{"key":"9780_CR66","doi-asserted-by":"publisher","first-page":"5756","DOI":"10.1523\/JNEUROSCI.1179-08.2008","volume":"28","author":"Y Sekine","year":"2008","unstructured":"Sekine Y, Ouchi Y, Sugihara G, Takei N, Yoshikawa E, Nakamura K, Iwata Y, Tsuchiya KJ, Suda S, Suzuki K, Kawai M, Takebayashi K, Yamamoto S, Matsuzaki H, Ueki T, Mori N, Gold MS, Cadet JL (2008) Methamphetamine causes microglial activation in the brains of human abusers. J Neurosci 28:5756\u20135761","journal-title":"J Neurosci"},{"key":"9780_CR67","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/1742-2094-9-73","volume":"9","author":"F Shi","year":"2012","unstructured":"Shi F, Yang L, Kouadir M, Yang Y, Wang J, Zhou X, Yin X, Zhao D (2012) The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation. J Neuroinflammation 9:73","journal-title":"J Neuroinflammation"},{"key":"9780_CR68","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1016\/j.neuroimage.2011.05.041","volume":"57","author":"T Shiba","year":"2011","unstructured":"Shiba T, Yamato M, Kudo W, Watanabe T, Utsumi H, Yamada K (2011) In vivo imaging of mitochondrial function in methamphetamine-treated rats. NeuroImage 57:866\u2013872","journal-title":"NeuroImage"},{"key":"9780_CR69","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.ejphar.2013.01.016","volume":"701","author":"SE Snider","year":"2013","unstructured":"Snider SE, Hendrick ES, Beardsley PM (2013) Glial cell modulators attenuate methamphetamine self-administration in the rat. Eur J Pharmacol 701:124\u2013130","journal-title":"Eur J Pharmacol"},{"key":"9780_CR70","doi-asserted-by":"publisher","first-page":"4486","DOI":"10.1007\/s12035-016-9988-x","volume":"54","author":"A Stojakovic","year":"2017","unstructured":"Stojakovic A, Paz-Filho G, Arcos-Burgos M, Licinio J, Wong ML, Mastronardi CA (2017) Role of the IL-1 pathway in dopaminergic neurodegeneration and decreased voluntary movement. Mol Neurobiol 54:4486\u20134495","journal-title":"Mol Neurobiol"},{"key":"9780_CR71","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.brainres.2005.05.049","volume":"1050","author":"DM Thomas","year":"2005","unstructured":"Thomas DM, Kuhn DM (2005a) MK-801 and dextromethorphan block microglial activation and protect against methamphetamine-induced neurotoxicity. Brain Res 1050:190\u2013198","journal-title":"Brain Res"},{"key":"9780_CR72","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1111\/j.1471-4159.2004.02906.x","volume":"92","author":"DM Thomas","year":"2005","unstructured":"Thomas DM, Kuhn DM (2005b) Attenuated microglial activation mediates tolerance to the neurotoxic effects of methamphetamine. J Neurochem 92:790\u2013797","journal-title":"J Neurochem"},{"key":"9780_CR73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1124\/jpet.104.070961","volume":"311","author":"DM Thomas","year":"2004","unstructured":"Thomas DM, Walker PD, Benjamins JA, Geddes TJ, Kuhn DM (2004) Methamphetamine neurotoxicity in dopamine nerve endings of the striatum is associated with microglial activation. J Pharmacol Exp Ther 311:1\u20137","journal-title":"J Pharmacol Exp Ther"},{"key":"9780_CR74","doi-asserted-by":"crossref","unstructured":"Tian C, Murrin LC, Zheng JC (2009) Mitochondrial fragmentation is involved in methamphetamine-induced cell death in rat hippocampal neural progenitor cells. PLoS One 4:e5546","DOI":"10.1371\/journal.pone.0005546"},{"key":"9780_CR75","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/nri2725","volume":"10","author":"J Tschopp","year":"2010","unstructured":"Tschopp J, Schroder K (2010) NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? Nat Rev Immunol 10:210\u2013215","journal-title":"Nat Rev Immunol"},{"key":"9780_CR76","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1038\/ncomms4209","volume":"5","author":"N Van Opdenbosch","year":"2014","unstructured":"Van Opdenbosch N, Gurung P, Vande Walle L, Fossoul A, Kanneganti TD, Lamkanfi M (2014) Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation. Nat Commun 5:3209","journal-title":"Nat Commun"},{"key":"9780_CR77","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/j.neubiorev.2010.09.010","volume":"35","author":"K Wager-Smith","year":"2011","unstructured":"Wager-Smith K, Markou A (2011) Depression: a repair response to stress-induced neuronal microdamage that can grade into a chronic neuroinflammatory condition? Neurosci Biobehav Rev 35:742\u2013764","journal-title":"Neurosci Biobehav Rev"},{"key":"9780_CR78","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/0092-8674(94)90303-4","volume":"78","author":"NP Walker","year":"1994","unstructured":"Walker NP, Talanian RV, Brady KD, Dang LC, Bump NJ, Ferenz CR, Franklin S, Ghayur T, Hackett MC, Hammill LD et al (1994) Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20\/p10)2 homodimer. Cell 78:343\u2013352","journal-title":"Cell"},{"key":"9780_CR79","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/nrn3638","volume":"15","author":"JG Walsh","year":"2014","unstructured":"Walsh JG, Muruve DA, Power C (2014) Inflammasomes in the CNS. Nat Rev Neurosci 15:84\u201397","journal-title":"Nat Rev Neurosci"},{"key":"9780_CR80","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1523\/JNEUROSCI.3561-14.2015","volume":"35","author":"MD Weber","year":"2015","unstructured":"Weber MD, Frank MG, Tracey KJ, Watkins LR, Maier SF (2015) Stress induces the danger-associated molecular pattern HMGB-1 in the hippocampus of male Sprague Dawley rats: a priming stimulus of microglia and the NLRP3 inflammasome. J Neurosci 35:316\u2013324","journal-title":"J Neurosci"},{"key":"9780_CR81","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.taap.2007.01.011","volume":"220","author":"CW Wu","year":"2007","unstructured":"Wu CW, Ping YH, Yen JC, Chang CY, Wang SF, Yeh CL, Chi CW, Lee HC (2007) Enhanced oxidative stress and aberrant mitochondrial biogenesis in human neuroblastoma SH-SY5Y cells during methamphetamine induced apoptosis. Toxicol Appl Pharmacol 220:243\u2013251","journal-title":"Toxicol Appl Pharmacol"},{"key":"9780_CR82","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1111\/jnc.12263","volume":"125","author":"L Ye","year":"2013","unstructured":"Ye L, Huang Y, Zhao L, Li Y, Sun L, Zhou Y, Qian G, Zheng JC (2013) IL-1beta and TNF-alpha induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase. J Neurochem 125:897\u2013908","journal-title":"J Neurochem"},{"key":"9780_CR83","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1124\/jpet.107.121483","volume":"322","author":"MC Zerrate","year":"2007","unstructured":"Zerrate MC, Pletnikov M, Connors SL, Vargas DL, Seidler FJ, Zimmerman AW, Slotkin TA, Pardo CA (2007) Neuroinflammation and behavioral abnormalities after neonatal terbutaline treatment in rats: implications for autism. J Pharmacol Exp Ther 322:16\u201322","journal-title":"J Pharmacol Exp Ther"},{"key":"9780_CR84","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1016\/j.pnpbp.2006.05.015","volume":"30","author":"L Zhang","year":"2006","unstructured":"Zhang L, Kitaichi K, Fujimoto Y, Nakayama H, Shimizu E, Iyo M, Hashimoto K (2006) Protective effects of minocycline on behavioral changes and neurotoxicity in mice after administration of methamphetamine. Prog Neuro-Psychopharmacol Biol Psychiatry 30:1381\u20131393","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"9780_CR85","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nature09663","volume":"469","author":"R Zhou","year":"2011","unstructured":"Zhou R, Yazdi AS, Menu P, Tschopp J (2011) A role for mitochondria in NLRP3 inflammasome activation. Nature 469:221\u2013225","journal-title":"Nature"}],"container-title":["Journal of Neuroimmune Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11481-018-9780-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11481-018-9780-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11481-018-9780-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T02:48:51Z","timestamp":1751424531000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11481-018-9780-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,28]]},"references-count":85,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["9780"],"URL":"https:\/\/doi.org\/10.1007\/s11481-018-9780-y","relation":{},"ISSN":["1557-1890","1557-1904"],"issn-type":[{"value":"1557-1890","type":"print"},{"value":"1557-1904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,28]]},"assertion":[{"value":"14 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed. All procedures performed in studies involving animals were in accordance with the ethical standards of University of Nebraska Medical Center, Omaha, NE, USA.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}