{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:22:49Z","timestamp":1788538969096,"version":"build-2803163510"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA026356"],"award-info":[{"award-number":["DA026356"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA046258"],"award-info":[{"award-number":["DA046258"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroimmune Pharmacol"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1007\/s11481-019-09845-2","type":"journal-article","created":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T12:38:00Z","timestamp":1559392680000},"page":"551-564","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Involvement of Interferon Regulatory Factor 7 in Nicotine\u2019s Suppression of Antiviral Immune Responses"],"prefix":"10.1007","volume":"14","author":[{"given":"Haijun","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongli","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming D.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulie L.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,1]]},"reference":[{"key":"9845_CR1","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","volume":"124","author":"S Akira","year":"2006","unstructured":"Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124:783\u2013801","journal-title":"Cell"},{"key":"9845_CR2","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/35099560","volume":"413","author":"L Alexopoulou","year":"2001","unstructured":"Alexopoulou L, Holt AC, Medzhitov R, Flavell RA (2001) Recognition of double-stranded RNA and activation of NF-kappaB by toll-like receptor 3. Nature 413:732\u2013738","journal-title":"Nature"},{"key":"9845_CR3","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1001\/archinte.164.20.2206","volume":"164","author":"L Arcavi","year":"2004","unstructured":"Arcavi L, Benowitz NL (2004) Cigarette smoking and infection. Arch Intern Med 164:2206\u20132216","journal-title":"Arch Intern Med"},{"key":"9845_CR4","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1101\/gad.7.5.812","volume":"7","author":"V Baldin","year":"1993","unstructured":"Baldin V, Lukas J, Marcote MJ, Pagano M, Draetta G (1993) Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev 7:812\u2013821","journal-title":"Genes Dev"},{"key":"9845_CR5","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nri2587","volume":"9","author":"GM Barton","year":"2009","unstructured":"Barton GM, Kagan JC (2009) A cell biological view of toll-like receptor function: regulation through compartmentalization. Nat Rev Immunol 9:535\u2013542","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"9845_CR6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1089\/jir.2007.0054","volume":"28","author":"Carla M.T. Bauer","year":"2008","unstructured":"Bauer CM, Dewitte-Orr SJ, Hornby KR, Zavitz CC, Lichty BD, Stampfli MR, Mossman KL (2008) Cigarette smoke suppresses type I interferon-mediated antiviral immunity in lung fibroblast and epithelial cells. J Interferon Cytokine Res 28:167\u2013179","journal-title":"Journal of Interferon & Cytokine Research"},{"key":"9845_CR7","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12864-016-2405-z","volume":"17","author":"A Bosco","year":"2016","unstructured":"Bosco A, Wiehler S, Proud D (2016) Interferon regulatory factor 7 regulates airway epithelial cell responses to human rhinovirus infection. BMC Genomics 17:76","journal-title":"BMC Genomics"},{"key":"9845_CR8","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1056\/NEJMsa1407211","volume":"372","author":"BD Carter","year":"2015","unstructured":"Carter BD, Abnet CC, Feskanich D, Freedman ND, Hartge P, Lewis CE, Ockene JK, Prentice RL, Speizer FE, Thun MJ, Jacobs EJ (2015) Smoking and mortality--beyond established causes. N Engl J Med 372:631\u2013640","journal-title":"N Engl J Med"},{"key":"9845_CR9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125116","volume":"10","author":"A Chatzidaki","year":"2015","unstructured":"Chatzidaki A, Fouillet A, Li J, Dage J, Millar NS, Sher E, Ursu D (2015) Pharmacological characterisation of nicotinic acetylcholine receptors expressed in human iPSC-derived neurons. PLoS One 10:e0125116","journal-title":"PLoS One"},{"key":"9845_CR10","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1126\/science.aaa1578","volume":"348","author":"MJ Ciancanelli","year":"2015","unstructured":"Ciancanelli MJ, Huang SXL, Luthra P, Garner H, Itan Y, Volpi S, Lafaille FG, Trouillet C, Schmolke M, Albrecht RA, Israelsson E, Lim HK, Casadio M, Hermesh T, Lorenzo L, Leung LW, Pedergnana V, Boisson B, Okada S, Picard C, Ringuier B, Troussier F, Chaussabel D, Abel L, Pellier I, Notarangelo LD, Garcia-Sastre A, Basler CF, Geissmann F, Zhang SY, Snoeck HW, Casanova JL (2015) Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency. Science 348:448\u2013453","journal-title":"Science"},{"key":"9845_CR11","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1231143","volume":"339","author":"L Cong","year":"2013","unstructured":"Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N, Hsu PD, Wu X, Jiang W, Marraffini LA, Zhang F (2013) Multiplex genome engineering using CRISPR\/Cas systems. Science 339:819\u2013823","journal-title":"Science"},{"key":"9845_CR12","first-page":"4415","volume":"37","author":"Y Cui","year":"2017","unstructured":"Cui Y, Wu BO, Flamini V, Evans BAJ, Zhou D, Jiang WG (2017) Knockdown of EPHA1 using CRISPR\/CAS9 suppresses aggressive properties of ovarian cancer cells. Anticancer Res 37:4415\u20134424","journal-title":"Anticancer Res"},{"key":"9845_CR13","doi-asserted-by":"crossref","first-page":"e1000607","DOI":"10.1371\/journal.ppat.1000607","volume":"5","author":"S Daffis","year":"2009","unstructured":"Daffis S, Suthar MS, Szretter KJ, Gale M Jr, Diamond MS (2009) Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7. PLoS Pathog 5:e1000607","journal-title":"PLoS Pathog"},{"key":"9845_CR14","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1126\/science.8197455","volume":"264","author":"JE Darnell Jr","year":"1994","unstructured":"Darnell JE Jr, Kerr IM, Stark GR (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415\u20131421","journal-title":"Science"},{"key":"9845_CR15","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.neuropharm.2014.01.021","volume":"79","author":"B Dash","year":"2014","unstructured":"Dash B, Lukas RJ, Li MD (2014) A signal peptide missense mutation associated with nicotine dependence alters alpha2*-nicotinic acetylcholine receptor function. Neuropharmacology 79:715\u2013725","journal-title":"Neuropharmacology"},{"key":"9845_CR16","doi-asserted-by":"crossref","first-page":"1258096","DOI":"10.1126\/science.1258096","volume":"346","author":"JA Doudna","year":"2014","unstructured":"Doudna JA, Charpentier E (2014) Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Science 346:1258096","journal-title":"Science"},{"key":"9845_CR17","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1165\/rcmb.2009-0266OC","volume":"44","author":"J Eddleston","year":"2011","unstructured":"Eddleston J, Lee RU, Doerner AM, Herschbach J, Zuraw BL (2011) Cigarette smoke decreases innate responses of epithelial cells to rhinovirus infection. Am J Respir Cell Mol Biol 44:118\u2013126","journal-title":"Am J Respir Cell Mol Biol"},{"key":"9845_CR18","doi-asserted-by":"crossref","first-page":"13500","DOI":"10.1073\/pnas.93.24.13500","volume":"93","author":"H Eichenbaum","year":"1996","unstructured":"Eichenbaum H, Schoenbaum G, Young B, Bunsey M (1996) Functional organization of the hippocampal memory system. Proc Natl Acad Sci U S A 93:13500\u201313507","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9845_CR19","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1073\/pnas.051622798","volume":"98","author":"AB Elgoyhen","year":"2001","unstructured":"Elgoyhen AB, Vetter DE, Katz E, Rothlin CV, Heinemann SF, Boulter J (2001) alpha10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells. Proc Natl Acad Sci U S A 98:3501\u20133506","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"9845_CR20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1089\/jir.2010.0101","volume":"31","author":"Volker Fensterl","year":"2011","unstructured":"Fensterl V, Sen GC (2011) The ISG56\/IFIT1 gene family. J Interferon Cytokine Res 31:71\u201378","journal-title":"Journal of Interferon & Cytokine Research"},{"key":"9845_CR21","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0306-4522(02)00223-3","volume":"113","author":"A Graham","year":"2002","unstructured":"Graham A, Court JA, Martin-Ruiz CM, Jaros E, Perry R, Volsen SG, Bose S, Evans N, Ince P, Kuryatov A, Lindstrom J, Gotti C, Perry EK (2002) Immunohistochemical localisation of nicotinic acetylcholine receptor subunits in human cerebellum. Neuroscience 113:493\u2013507","journal-title":"Neuroscience"},{"issue":"4","key":"9845_CR22","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s11481-018-9806-5","volume":"13","author":"Haijun Han","year":"2018","unstructured":"Han H, Yang Z, Chang SL, Li MD (2018) Modulatory Effects of Nicotine on neuroHIV\/neuroAIDS. J Neuroimmune Pharmacol 13:467\u2013478","journal-title":"Journal of Neuroimmune Pharmacology"},{"key":"9845_CR23","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000450705","volume":"9","author":"B Hatesuer","year":"2017","unstructured":"Hatesuer B, Hoang HT, Riese P, Trittel S, Gerhauser I, Elbahesh H, Geffers R, Wilk E, Schughart K (2017) Deletion of Irf3 and Irf7 genes in mice results in altered interferon pathway activation and granulocyte-dominated inflammatory responses to influenza a infection. J Innate Immun 9:145\u2013161","journal-title":"J Innate Immun"},{"issue":"8","key":"9845_CR24","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1177\/1352458512471879","volume":"19","author":"AK Hedstr\u00f6m","year":"2013","unstructured":"Hedstrom AK, Hillert J, Olsson T, Alfredsson L (2013) Nicotine might have a protective effect in the etiology of multiple sclerosis. Mult Scler 19:1009\u20131013","journal-title":"Multiple Sclerosis Journal"},{"key":"9845_CR25","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nri1900","volume":"6","author":"K Honda","year":"2006","unstructured":"Honda K, Taniguchi T (2006) IRFs: master regulators of signalling by toll-like receptors and cytosolic pattern-recognition receptors. Nat Rev Immunol 6:644\u2013658","journal-title":"Nat Rev Immunol"},{"key":"9845_CR26","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nature03464","volume":"434","author":"K Honda","year":"2005","unstructured":"Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, Shimada N, Ohba Y, Takaoka A, Yoshida N, Taniguchi T (2005) IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434:772\u2013777","journal-title":"Nature"},{"key":"9845_CR27","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.immuni.2006.08.009","volume":"25","author":"K Honda","year":"2006","unstructured":"Honda K, Takaoka A, Taniguchi T (2006) Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors. Immunity 25:349\u2013360","journal-title":"Immunity"},{"key":"9845_CR28","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.cell.2014.05.010","volume":"157","author":"PD Hsu","year":"2014","unstructured":"Hsu PD, Lander ES, Zhang F (2014) Development and applications of CRISPR-Cas9 for genome engineering. Cell 157:1262\u20131278","journal-title":"Cell"},{"key":"9845_CR29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1101\/sqb.2013.78.020321","volume":"78","author":"H Ikushima","year":"2013","unstructured":"Ikushima H, Negishi H, Taniguchi T (2013) The IRF family transcription factors at the interface of innate and adaptive immune responses. Cold Spring Harb Symp Quant Biol 78:105\u2013116","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"9845_CR30","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1136\/pgmj.2008.073577","volume":"85","author":"JR Ingram","year":"2009","unstructured":"Ingram JR (2009) Nicotine: does it have a role in the treatment of skin disease? Postgrad Med J 85:196\u2013201","journal-title":"Postgrad Med J"},{"key":"9845_CR31","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1159\/000356678","volume":"33","author":"Y Jiang","year":"2014","unstructured":"Jiang Y, Dai A, Zhou Y, Peng G, Hu G, Li B, Sham JS, Ran P (2014) Nicotine elevated intracellular Ca(2)(+) in rat airway smooth muscle cells via activating and up-regulating alpha7-nicotinic acetylcholine receptor. Cell Physiol Biochem 33:389\u2013401","journal-title":"Cell Physiol Biochem"},{"key":"9845_CR32","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature04734","volume":"441","author":"H Kato","year":"2006","unstructured":"Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K, Tsujimura T, Koh CS, Reis e Sousa C, Matsuura Y, Fujita T, Akira S (2006) Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441:101\u2013105","journal-title":"Nature"},{"key":"9845_CR33","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","volume":"11","author":"T Kawai","year":"2010","unstructured":"Kawai T, Akira S (2010) The role of pattern-recognition receptors in innate immunity: update on toll-like receptors. Nat Immunol 11:373\u2013384","journal-title":"Nat Immunol"},{"key":"9845_CR34","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0014-4827(86)90520-3","volume":"166","author":"P Kurki","year":"1986","unstructured":"Kurki P, Vanderlaan M, Dolbeare F, Gray J, Tan EM (1986) Expression of proliferating cell nuclear antigen (PCNA)\/cyclin during the cell cycle. Exp Cell Res 166:209\u2013219","journal-title":"Exp Cell Res"},{"key":"9845_CR35","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1093\/jnci\/djq300","volume":"102","author":"CH Lee","year":"2010","unstructured":"Lee CH, Huang CS, Chen CS, Tu SH, Wang YJ, Chang YJ, Tam KW, Wei PL, Cheng TC, Chu JS, Chen LC, Wu CH, Ho YS (2010) Overexpression and activation of the alpha9-nicotinic receptor during tumorigenesis in human breast epithelial cells. J Natl Cancer Inst 102:1322\u20131335","journal-title":"J Natl Cancer Inst"},{"key":"9845_CR36","volume-title":"Tobacco Smoking Addiction: Epidemiology, Genetics, Mechanisms, and Treatment","author":"Ming D. Li","year":"2018","unstructured":"Li MD (2018) Tobacco smoking addiction: epidemiology, Genetics, Mechanisms, and Treatment. Springer, Singapore"},{"key":"9845_CR37","volume":"8","author":"MD Li","year":"2013","unstructured":"Li MD, Cao J, Wang S, Wang J, Sarkar S, Vigorito M, Ma JZ, Chang SL (2013) Transcriptome sequencing of gene expression in the brain of the HIV-1 transgenic rat. PLoS One 8:e59582","journal-title":"PLoS One"},{"key":"9845_CR38","doi-asserted-by":"crossref","first-page":"207","DOI":"10.7150\/jca.16415","volume":"8","author":"Z Li","year":"2017","unstructured":"Li Z, Huang Q, Chen H, Lin Z, Zhao M, Jiang Z (2017) Interferon regulatory factor 7 promoted glioblastoma progression and stemness by modulating IL-6 expression in microglia. J Cancer 8:207\u2013219","journal-title":"J Cancer"},{"key":"9845_CR39","doi-asserted-by":"crossref","first-page":"15895","DOI":"10.1038\/srep15895","volume":"5","author":"G Li-Sha","year":"2015","unstructured":"Li-Sha G, Jing-Lin Z, Guang-Yi C, Li L, De-Pu Z, Yue-Chun L (2015) Dose-dependent protective effect of nicotine in a murine model of viral myocarditis induced by coxsackievirus B3. Sci Rep 5:15895","journal-title":"Sci Rep"},{"key":"9845_CR40","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/j.1460-2075.1995.tb07036.x","volume":"14","author":"A Maity","year":"1995","unstructured":"Maity A, McKenna WG, Muschel RJ (1995) Evidence for post-transcriptional regulation of cyclin B1 mRNA in the cell cycle and following irradiation in HeLa cells. EMBO J 14:603\u2013609","journal-title":"EMBO J"},{"key":"9845_CR41","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00213-006-0516-y","volume":"189","author":"FJ McClernon","year":"2006","unstructured":"McClernon FJ, Hiott FB, Westman EC, Rose JE, Levin ED (2006) Transdermal nicotine attenuates depression symptoms in nonsmokers: a double-blind, placebo-controlled trial. Psychopharmacology 189:125\u2013133","journal-title":"Psychopharmacology"},{"key":"9845_CR42","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/35100529","volume":"1","author":"R Medzhitov","year":"2001","unstructured":"Medzhitov R (2001) Toll-like receptors and innate immunity. Nat Rev Immunol 1:135\u2013145","journal-title":"Nat Rev Immunol"},{"key":"9845_CR43","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.molimm.2008.09.007","volume":"46","author":"MF Mian","year":"2009","unstructured":"Mian MF, Stampfli MR, Mossman KL, Ashkar AA (2009) Cigarette smoke attenuation of poly I:C-induced innate antiviral responses in human PBMC is mainly due to inhibition of IFN-beta production. Mol Immunol 46:821\u2013829","journal-title":"Mol Immunol"},{"key":"9845_CR44","unstructured":"National Center for Chronic Disease P, Health Promotion Office on S, Health (2014) Reports of the surgeon general. In: The health consequences of smoking-50 years of progress: a report of the surgeon general. Centers for Disease Control and Prevention (US), Atlanta"},{"key":"9845_CR45","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/gene.2011.21","volume":"12","author":"S Ning","year":"2011","unstructured":"Ning S, Pagano JS, Barber GN (2011) IRF7: activation, regulation, modification and function. Genes Immun 12:399\u2013414","journal-title":"Genes Immun"},{"key":"9845_CR46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.55782\/ane-2013-1918","volume":"73","author":"A Nowakowski","year":"2013","unstructured":"Nowakowski A, Andrzejewska A, Janowski M, Walczak P, Lukomska B (2013) Genetic engineering of stem cells for enhanced therapy. Acta Neurobiol Exp 73:1\u201318","journal-title":"Acta Neurobiol Exp"},{"key":"9845_CR47","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0092-8674(93)90509-O","volume":"74","author":"ZN Oltvai","year":"1993","unstructured":"Oltvai ZN, Milliman CL, Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609\u2013619","journal-title":"Cell"},{"key":"9845_CR48","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev.neuro.25.112701.142937","volume":"25","author":"MG Packard","year":"2002","unstructured":"Packard MG, Knowlton BJ (2002) Learning and memory functions of the Basal Ganglia. Annu Rev Neurosci 25:563\u2013593","journal-title":"Annu Rev Neurosci"},{"key":"9845_CR49","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41579-018-0020-5","volume":"16","author":"YC Perng","year":"2018","unstructured":"Perng YC, Lenschow DJ (2018) ISG15 in antiviral immunity and beyond. Nat Rev Microbiol 16:423\u2013439","journal-title":"Nat Rev Microbiol"},{"issue":"13","key":"9845_CR50","doi-asserted-by":"crossref","first-page":"492","DOI":"10.2741\/2695","volume":"13","author":"Marina, R. Picciotto","year":"2008","unstructured":"Picciotto MR, Zoli M (2008) Neuroprotection via nAChRs: the role of nAChRs in neurodegenerative disorders such as Alzheimer\u2019s and Parkinson\u2019s disease. Front Biosci 13:492\u2013504","journal-title":"Frontiers in Bioscience"},{"key":"9845_CR51","volume":"11","author":"J Qian","year":"2016","unstructured":"Qian J, Mummalaneni SK, Alkahtani RM, Mahavadi S, Murthy KS, Grider JR, Lyall V (2016) Nicotine-induced effects on nicotinic acetylcholine receptors (nAChRs), Ca2+ and brain-derived neurotrophic factor (BDNF) in STC-1 cells. PLoS One 11:e0166565","journal-title":"PLoS One"},{"issue":"8","key":"9845_CR52","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1002\/mds.25028","volume":"27","author":"Maryka Quik","year":"2012","unstructured":"Quik M, Perez XA, Bordia T (2012) Nicotine as a potential neuroprotective agent for Parkinson\u2019s disease. Mov Disord 27:947\u2013957","journal-title":"Movement Disorders"},{"key":"9845_CR53","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/nprot.2013.143","volume":"8","author":"FA Ran","year":"2013","unstructured":"Ran FA, Hsu PD, Wright J, Agarwala V, Scott DA, Zhang F (2013) Genome engineering using the CRISPR-Cas9 system. Nat Protoc 8:2281\u20132308","journal-title":"Nat Protoc"},{"issue":"9","key":"9845_CR54","doi-asserted-by":"publisher","first-page":"14507","DOI":"10.1002\/jcp.27728","volume":"234","author":"Anmin Ren","year":"2018","unstructured":"Ren A, Wu H, Liu L, Guo Z, Cao Q, Dai Q (2018) Nicotine promotes atherosclerosis development in apolipoprotein E-deficient mice through alpha1-nAChR. J Cell Physiol. https:\/\/doi.org\/10.1002\/jcp.27728","journal-title":"Journal of Cellular Physiology"},{"key":"9845_CR55","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nri2314","volume":"8","author":"AJ Sadler","year":"2008","unstructured":"Sadler AJ, Williams BR (2008) Interferon-inducible antiviral effectors. Nat Rev Immunol 8:559\u2013568","journal-title":"Nat Rev Immunol"},{"key":"9845_CR56","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0014-5793(98)01514-2","volume":"441","author":"M Sato","year":"1998","unstructured":"Sato M, Hata N, Asagiri M, Nakaya T, Taniguchi T, Tanaka N (1998) Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7. FEBS Lett 441:106\u2013110","journal-title":"FEBS Lett"},{"key":"9845_CR57","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S1074-7613(00)00053-4","volume":"13","author":"M Sato","year":"2000","unstructured":"Sato M, Suemori H, Hata N, Asagiri M, Ogasawara K, Nakao K, Nakaya T, Katsuki M, Noguchi S, Tanaka N, Taniguchi T (2000) Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha\/beta gene induction. Immunity 13:539\u2013548","journal-title":"Immunity"},{"key":"9845_CR58","doi-asserted-by":"crossref","first-page":"42013","DOI":"10.1074\/jbc.M110.165936","volume":"285","author":"S Schmid","year":"2010","unstructured":"Schmid S, Mordstein M, Kochs G, Garcia-Sastre A, Tenoever BR (2010) Transcription factor redundancy ensures induction of the antiviral state. J Biol Chem 285:42013\u201342022","journal-title":"J Biol Chem"},{"key":"9845_CR59","doi-asserted-by":"crossref","unstructured":"Servant MJ, Tenoever B, Lin R (2002) Overlapping and distinct mechanisms regulating IRF-3 and IRF-7 function. J Interferon Cytokine Res 22:49\u201358","DOI":"10.1089\/107999002753452656"},{"key":"9845_CR60","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/sj.cr.7310019","volume":"16","author":"RB Seth","year":"2006","unstructured":"Seth RB, Sun L, Chen ZJ (2006) Antiviral innate immunity pathways. Cell Res 16:141\u2013147","journal-title":"Cell Res"},{"key":"9845_CR61","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nri803","volume":"2","author":"M Sopori","year":"2002","unstructured":"Sopori M (2002) Effects of cigarette smoke on the immune system. Nat Rev Immunol 2:372\u2013377","journal-title":"Nat Rev Immunol"},{"key":"9845_CR62","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nri2530","volume":"9","author":"MR Stampfli","year":"2009","unstructured":"Stampfli MR, Anderson GP (2009) How cigarette smoke skews immune responses to promote infection, lung disease and cancer. Nat Rev Immunol 9:377\u2013384","journal-title":"Nat Rev Immunol"},{"key":"9845_CR63","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.gene.2015.05.065","volume":"569","author":"AA Stepanenko","year":"2015","unstructured":"Stepanenko AA, Dmitrenko VV (2015) HEK293 in cell biology and cancer research: phenotype, karyotype, tumorigenicity, and stress-induced genome-phenotype evolution. Gene 569:182\u2013190","journal-title":"Gene"},{"key":"9845_CR64","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev.immunol.26.021607.090400","volume":"26","author":"T Tamura","year":"2008","unstructured":"Tamura T, Yanai H, Savitsky D, Taniguchi T (2008) The IRF family transcription factors in immunity and oncogenesis. Annu Rev Immunol 26:535\u2013584","journal-title":"Annu Rev Immunol"},{"key":"9845_CR65","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1146\/annurev.immunol.19.1.623","volume":"19","author":"T Taniguchi","year":"2001","unstructured":"Taniguchi T, Ogasawara K, Takaoka A, Tanaka N (2001) IRF family of transcription factors as regulators of host defense. Annu Rev Immunol 19:623\u2013655","journal-title":"Annu Rev Immunol"},{"key":"9845_CR66","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.vascn.2004.08.014","volume":"51","author":"P Thomas","year":"2005","unstructured":"Thomas P, Smart TG (2005) HEK293 cell line: a vehicle for the expression of recombinant proteins. J Pharmacol Toxicol Methods 51:187\u2013200","journal-title":"J Pharmacol Toxicol Methods"},{"key":"9845_CR67","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s002130050879","volume":"142","author":"Y Tizabi","year":"1999","unstructured":"Tizabi Y, Overstreet DH, Rezvani AH, Louis VA, Clark E Jr, Janowsky DS, Kling MA (1999) Antidepressant effects of nicotine in an animal model of depression. Psychopharmacology 142:193\u2013199","journal-title":"Psychopharmacology"},{"key":"9845_CR68","unstructured":"World Health Organization (WHO) (2013) WHO report on the global tobacco epidemic, 2013: enforcing bans on tobacco advertising, promotion and sponsorship. World Health Organization, Geneva"},{"key":"9845_CR69","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0079-6123(00)26018-4","volume":"126","author":"RA Wise","year":"2000","unstructured":"Wise RA (2000) Interactions between medial prefrontal cortex and meso-limbic components of brain reward circuitry. Prog Brain Res 126:255\u2013262","journal-title":"Prog Brain Res"},{"key":"9845_CR70","doi-asserted-by":"crossref","first-page":"L848","DOI":"10.1152\/ajplung.00158.2014","volume":"307","author":"W Wu","year":"2014","unstructured":"Wu W, Zhang W, More S, Booth JL, Duggan ES, Liu L, Zhao YD, Metcalf JP (2014) Cigarette smoke attenuates the RIG-I-initiated innate antiviral response to influenza infection in two murine models. Am J Physiol Lung Cell Mol Physiol 307:L848\u2013L858","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"9845_CR71","doi-asserted-by":"crossref","first-page":"5746","DOI":"10.1073\/pnas.96.10.5746","volume":"96","author":"W Xu","year":"1999","unstructured":"Xu W, Gelber S, Orr-Urtreger A, Armstrong D, Lewis RA, Ou CN, Patrick J, Role L, De Biasi M, Beaudet AL (1999) Megacystis, mydriasis, and ion channel defect in mice lacking the alpha3 neuronal nicotinic acetylcholine receptor. Proc Natl Acad Sci U S A 96:5746\u20135751","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9845_CR72","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.virusres.2014.09.005","volume":"195","author":"D Xu","year":"2015","unstructured":"Xu D, Zhang Y, Zhao L, Cao M, Lingel A, Zhang L (2015) Interferon regulatory factor 7 is involved in the growth of Epstein-Barr virus-transformed human B lymphocytes. Virus Res 195:112\u2013118","journal-title":"Virus Res"},{"issue":"3","key":"9845_CR73","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1007\/s11481-016-9679-4","volume":"11","author":"Zhongli Yang","year":"2016","unstructured":"Yang Z, Nesil T, Connaghan KP, Li MD, Chang SL (2016) Modulation effect of HIV-1 viral proteins and nicotine on expression of the immune-related genes in brain of the HIV-1 transgenic Rats. J Neuroimmune Pharmacol 11:562\u2013571","journal-title":"Journal of Neuroimmune Pharmacology"},{"key":"9845_CR74","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1038\/onc.2016.448","volume":"36","author":"Q Yang","year":"2017","unstructured":"Yang Q, Li X, Chen H, Cao Y, Xiao Q, He Y, Wei J, Zhou J (2017) IRF7 regulates the development of granulocytic myeloid-derived suppressor cells through S100A9 transrepression in cancer. Oncogene 36:2969\u20132980","journal-title":"Oncogene"},{"key":"9845_CR75","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/ni1087","volume":"5","author":"M Yoneyama","year":"2004","unstructured":"Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T (2004) The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol 5:730\u2013737","journal-title":"Nat Immunol"},{"key":"9845_CR76","doi-asserted-by":"crossref","unstructured":"Yu W, Mookherjee S, Chaitankar V, Hiriyanna S, Kim JW, Brooks M, Ataeijannati Y, Sun X, Dong L, Li T (2017) Nrl knockdown by AAV-delivered CRISPR\/Cas9 prevents retinal degeneration in mice. Nat Commun 8:14716","DOI":"10.1038\/ncomms14716"},{"key":"9845_CR77","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3727\/096504016X14756226781802","volume":"25","author":"Y Zhao","year":"2017","unstructured":"Zhao Y, Chen W, Zhu W, Meng H, Chen J, Zhang J (2017) Overexpression of interferon regulatory factor 7 (IRF7) reduces bone metastasis of prostate cancer cells in mice. Oncol Res 25:511\u2013522","journal-title":"Oncol Res"}],"container-title":["Journal of Neuroimmune Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11481-019-09845-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11481-019-09845-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11481-019-09845-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:20:48Z","timestamp":1721348448000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11481-019-09845-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,1]]},"references-count":77,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["9845"],"URL":"https:\/\/doi.org\/10.1007\/s11481-019-09845-2","relation":{},"ISSN":["1557-1890","1557-1904"],"issn-type":[{"value":"1557-1890","type":"print"},{"value":"1557-1904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,1]]},"assertion":[{"value":"10 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"All authors declare no conflict of interest on this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}