{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T19:00:36Z","timestamp":1781118036776,"version":"3.54.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,3,23]],"date-time":"2019-03-23T00:00:00Z","timestamp":1553299200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,3,23]],"date-time":"2019-03-23T00:00:00Z","timestamp":1553299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["T32DA007237-28"],"award-info":[{"award-number":["T32DA007237-28"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["P30DA013429"],"award-info":[{"award-number":["P30DA013429"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R37AA015913"],"award-info":[{"award-number":["R37AA015913"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U01AA023552"],"award-info":[{"award-number":["U01AA023552"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH115786"],"award-info":[{"award-number":["MH115786"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroimmune Pharmacol"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s11481-019-09846-1","type":"journal-article","created":{"date-parts":[[2019,3,23]],"date-time":"2019-03-23T10:02:31Z","timestamp":1553335351000},"page":"375-382","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Chronic Intrahippocampal Infusion of HIV-1 Neurotoxic Proteins: A Novel Mouse Model of HIV-1 Associated Inflammation and Neural Stem Cell Dysfunction"],"prefix":"10.1007","volume":"14","author":[{"given":"Jeremy D.","family":"Hill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Zuluaga-Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Gajghate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malika","family":"Winfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Persidsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,3,23]]},"reference":[{"key":"9846_CR1","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1111\/bph.12478","volume":"171","author":"HK Avraham","year":"2014","unstructured":"Avraham HK et al (2014) The cannabinoid CB(2) receptor agonist AM1241 enhances neurogenesis in GFAP\/Gp120 transgenic mice displaying deficits in neurogenesis. Br J Pharmacol 171:468\u2013479. \n                    https:\/\/doi.org\/10.1111\/bph.12478","journal-title":"Br J Pharmacol"},{"key":"9846_CR2","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1111\/j.1460-9568.2010.07325.x","volume":"32","author":"A Bachis","year":"2010","unstructured":"Bachis A, Cruz MI, Mocchetti I (2010) M-tropic HIV envelope protein gp120 exhibits a different neuropathological profile than T-tropic gp120 in rat striatum. Eur J Neurosci 32:570\u2013578. \n                    https:\/\/doi.org\/10.1111\/j.1460-9568.2010.07325.x","journal-title":"Eur J Neurosci"},{"key":"9846_CR3","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.stem.2018.03.015","volume":"22","author":"M Boldrini","year":"2018","unstructured":"Boldrini M et al (2018) Human hippocampal neurogenesis persists throughout aging. Cell Stem Cell 22:589\u2013599.e585. \n                    https:\/\/doi.org\/10.1016\/j.stem.2018.03.015","journal-title":"Cell Stem Cell"},{"key":"9846_CR4","doi-asserted-by":"publisher","first-page":"11362","DOI":"10.1523\/JNEUROSCI.1208-16.2016","volume":"36","author":"Y Fan","year":"2016","unstructured":"Fan Y, Gao X, Chen J, Liu Y, He JJ (2016) HIV tat impairs neurogenesis through functioning as a notch ligand and activation of notch signaling pathway. J Neurosci 36:11362\u201311373. \n                    https:\/\/doi.org\/10.1523\/jneurosci.1208-16.2016","journal-title":"J Neurosci"},{"key":"9846_CR5","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.biopsych.2012.09.026","volume":"73","author":"S Fitting","year":"2013","unstructured":"Fitting S et al (2013) Synaptic dysfunction in the hippocampus accompanies learning and memory deficits in human immunodeficiency virus type-1 tat transgenic mice. Biol Psychiatry 73:443\u2013453. \n                    https:\/\/doi.org\/10.1016\/j.biopsych.2012.09.026","journal-title":"Biol Psychiatry"},{"key":"9846_CR6","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1002\/ana.410380510","volume":"38","author":"JD Glass","year":"1995","unstructured":"Glass JD, Fedor H, Wesselingh SL, McArthur JC (1995) Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia. Ann Neurol 38:755\u2013762. \n                    https:\/\/doi.org\/10.1002\/ana.410380510","journal-title":"Ann Neurol"},{"key":"9846_CR7","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12993-014-0047-3","volume":"11","author":"R Harricharan","year":"2015","unstructured":"Harricharan R, Thaver V, Russell VA, Daniels WM (2015) Tat-induced histopathological alterations mediate hippocampus-associated behavioural impairments in rats. Behav Brain Funct: BBF 11:3. \n                    https:\/\/doi.org\/10.1186\/s12993-014-0047-3","journal-title":"Behav Brain Funct: BBF"},{"key":"9846_CR8","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/B978-0-12-801284-0.00009-9","volume":"118","author":"KF Hauser","year":"2014","unstructured":"Hauser KF, Knapp PE (2014) Interactions of HIV and drugs of abuse: the importance of glia, neural progenitors, and host genetic factors. Int Rev Neurobiol 118:231\u2013313. \n                    https:\/\/doi.org\/10.1016\/b978-0-12-801284-0.00009-9","journal-title":"Int Rev Neurobiol"},{"key":"9846_CR9","doi-asserted-by":"publisher","first-page":"3407","DOI":"10.1111\/bph.14387","volume":"175","author":"JD Hill","year":"2018","unstructured":"Hill JD, Zuluaga-Ramirez V, Gajghate S, Winfield M, Persidsky Y (2018) Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis. Br J Pharmacol 175:3407\u20133421. \n                    https:\/\/doi.org\/10.1111\/bph.14387","journal-title":"Br J Pharmacol"},{"key":"9846_CR10","doi-asserted-by":"publisher","unstructured":"Hill JD, Zuluaga-Ramirez V, Gajghate S, Winfield M, Sriram U, Rom S, Persidsky Y (2018b) Activation of GPR55 induces neuroprotection of hippocampal neurogenesis andimmune responses of neural stem cells following chronic, systemic inflammation. Brain Behav Immun (76):165\u2013181. \n                    https:\/\/doi.org\/10.1016\/j.bbi.2018.11.017","DOI":"10.1016\/j.bbi.2018.11.017"},{"key":"9846_CR11","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.bbi.2016.12.023","volume":"63","author":"L Hoeijmakers","year":"2017","unstructured":"Hoeijmakers L, Ruigrok SR, Amelianchik A, Ivan D, van Dam AM, Lucassen PJ, Korosi A (2017) Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer's disease mouse model. Brain Behav Immun 63:160\u2013175. \n                    https:\/\/doi.org\/10.1016\/j.bbi.2016.12.023","journal-title":"Brain Behav Immun"},{"key":"9846_CR12","doi-asserted-by":"publisher","unstructured":"Hsu DC et al (2018) Central nervous system inflammation and infection during early, nonaccelerated simian-human immunodeficiency virus infection in rhesus macaques. J Virol 92. \n                    https:\/\/doi.org\/10.1128\/jvi.00222-18","DOI":"10.1128\/jvi.00222-18"},{"key":"9846_CR13","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1038\/35073667","volume":"410","author":"M Kaul","year":"2001","unstructured":"Kaul M, Garden GA, Lipton SA (2001) Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature 410:988\u2013994. \n                    https:\/\/doi.org\/10.1038\/35073667","journal-title":"Nature"},{"key":"9846_CR14","first-page":"1","volume":"2","author":"JP Keblesh","year":"2008","unstructured":"Keblesh JP, Reiner BC, Liu J, Xiong H (2008) Pathogenesis of human immunodeficiency virus Type-1 (HIV-1)-associated dementia: role of voltage-gated potassium channels. Retrovirology : research and treatment 2:1\u201310","journal-title":"Retrovirology : research and treatment"},{"key":"9846_CR15","doi-asserted-by":"publisher","first-page":"e19439","DOI":"10.1371\/journal.pone.0019439","volume":"6","author":"H Peng","year":"2011","unstructured":"Peng H, Sun L, Jia B, Lan X, Zhu B, Wu Y, Zheng J (2011) HIV-1-infected and immune-activated macrophages induce astrocytic differentiation of human cortical neural progenitor cells via the STAT3 pathway. PLoS One 6:e19439. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0019439","journal-title":"PLoS One"},{"key":"9846_CR16","doi-asserted-by":"publisher","first-page":"401","DOI":"10.3109\/13550289709031186","volume":"3","author":"Y Persidsky","year":"1997","unstructured":"Persidsky Y, Buttini M, Limoges J, Bock P, Gendelman HE (1997) An analysis of HIV-1-associated inflammatory products in brain tissue of humans and SCID mice with HIV-1 encephalitis. J Neurovirol 3:401\u2013416","journal-title":"J Neurovirol"},{"key":"9846_CR17","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/S1044-7431(03)00171-4","volume":"24","author":"H Pu","year":"2003","unstructured":"Pu H, Tian J, Flora G, Lee YW, Nath A, Hennig B, Toborek M (2003) HIV-1 tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain. Mol Cell Neurosci 24:224\u2013237","journal-title":"Mol Cell Neurosci"},{"key":"9846_CR18","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1186\/s12974-018-1322-2","volume":"15","author":"R Putatunda","year":"2018","unstructured":"Putatunda R, Zhang Y, Li F, Yang XF, Barbe MF, Hu W (2018) Adult neurogenic deficits in HIV-1 Tg26 transgenic mice. J Neuroinflammation 15:287. \n                    https:\/\/doi.org\/10.1186\/s12974-018-1322-2","journal-title":"J Neuroinflammation"},{"key":"9846_CR19","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1038\/nn1969","volume":"10","author":"A Sahay","year":"2007","unstructured":"Sahay A, Hen R (2007) Adult hippocampal neurogenesis in depression. Nat Neurosci 10:1110\u20131115. \n                    https:\/\/doi.org\/10.1038\/nn1969","journal-title":"Nat Neurosci"},{"key":"9846_CR20","doi-asserted-by":"publisher","unstructured":"Snyder JS (2019) Recalibrating the relevance of adult neurogenesis. Trends Neurosci. \n                    https:\/\/doi.org\/10.1016\/j.tins.2018.12.001","DOI":"10.1016\/j.tins.2018.12.001"},{"key":"9846_CR21","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/nature25975","volume":"555","author":"SF Sorrells","year":"2018","unstructured":"Sorrells SF et al (2018) Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature 555:377\u2013381. \n                    https:\/\/doi.org\/10.1038\/nature25975","journal-title":"Nature"},{"key":"9846_CR22","doi-asserted-by":"publisher","first-page":"a007120","DOI":"10.1101\/cshperspect.a007120","volume":"2","author":"S Spudich","year":"2012","unstructured":"Spudich S, Gonzalez-Scarano F (2012) HIV-1-related central nervous system disease: current issues in pathogenesis, diagnosis, and treatment. Cold Spring Harb Perspect Med 2:a007120. \n                    https:\/\/doi.org\/10.1101\/cshperspect.a007120","journal-title":"Cold Spring Harb Perspect Med"}],"container-title":["Journal of Neuroimmune Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11481-019-09846-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11481-019-09846-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11481-019-09846-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T16:21:25Z","timestamp":1589732485000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11481-019-09846-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,23]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["9846"],"URL":"https:\/\/doi.org\/10.1007\/s11481-019-09846-1","relation":{},"ISSN":["1557-1890","1557-1904"],"issn-type":[{"value":"1557-1890","type":"print"},{"value":"1557-1904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,23]]},"assertion":[{"value":"27 January 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Authors declare no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}