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The biopsy sample of human synovial tissue used to generate the illustration in Fig.  was consented for and used in accordance with the ethical standards of the institutional (Cardiff Medical school, UK) and with the 1964 Helsinki declaration and its later amendments. Thus, synovial tissues were kindly obtained from Dr. Anwen S. Williams (Rheumatology department, Cardiff University and collected from diseased joints of OA and RA patients during routine surgical intervention. Ethical approval was granted by the Bro Taf Health Authority (LREC 02\/4692).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}