{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:46:57Z","timestamp":1784616417445,"version":"3.55.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroimmune Pharmacol"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s11481-021-09985-4","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T20:16:31Z","timestamp":1614024991000},"page":"152-164","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Expression of Human Immunodeficiency Virus Transactivator of Transcription (HIV-Tat1-86) Protein Alters Nociceptive Processing that is Sensitive to Anti-Oxidant and Anti-Inflammatory Interventions"],"prefix":"10.1007","volume":"17","author":[{"given":"Thomas J.","family":"Cirino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy R.","family":"Alleyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariana","family":"Figueroa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe A.","family":"Simons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emet M.","family":"Anceaume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Kendrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Wallman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shainnel O.","family":"Eans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather M.","family":"Stacy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M.","family":"Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9851-9342","authenticated-orcid":false,"given":"Jay P.","family":"McLaughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,22]]},"reference":[{"key":"9985_CR1","doi-asserted-by":"publisher","first-page":"4345","DOI":"10.1096\/fj.10-162313","volume":"24","author":"S Acharjee","year":"2010","unstructured":"Acharjee S, Noorbakhsh F, Stemkowski PL, Olechowski C, Cohen EA, Ballanyi K, Kerr B, Pardo C, Smith PA, Power C (2010) HIV-1 viral protein R causes peripheral nervous system injury associated with in vivo neuropathic pain. FASEB J 24:4345\u20134353","journal-title":"FASEB J"},{"key":"9985_CR2","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.cyto.2014.11.001","volume":"71","author":"H Ahn","year":"2015","unstructured":"Ahn H, Kim J, Lee MJ, Kim YJ, Cho YW, Lee GS (2015) Methylsulfonylmethane inhibits NLRP3 inflammasome activation. Cytokine 71:223\u2013231","journal-title":"Cytokine"},{"key":"9985_CR3","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1002\/jnr.10762","volume":"74","author":"IE Andr\u00e1s","year":"2003","unstructured":"Andr\u00e1s IE, Pu H, Deli MA, Nath A, Hennig B, Toborek M (2003) HIV-1 Tat protein alters tight junction protein expression and distribution in cultured brain endothelial cells. J Neurosci Res 74:255\u2013265","journal-title":"J Neurosci Res"},{"key":"9985_CR4","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1038\/sj.jcbfm.9600115","volume":"25","author":"IE Andr\u00e1s","year":"2005","unstructured":"Andr\u00e1s IE, Pu H, Tian J, Deli MA, Nath A, Hennig B, Toborek M (2005) Signaling mechanisms of HIV-1 Tat-induced alterations of claudin-5 expression in brain endothelial cells. J Cereb Blood Flow Metab 25:1159\u20131170","journal-title":"J Cereb Blood Flow Metab"},{"key":"9985_CR5","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1186\/1743-422X-10-358","volume":"10","author":"A Bagashev","year":"2013","unstructured":"Bagashev A, Sawaya BE (2013) Roles and functions of HIV-1 Tat protein in the CNS: an overview. Virol J 10:358","journal-title":"Virol J"},{"key":"9985_CR6","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1002\/ejp.1618","volume":"24","author":"D Bagdas","year":"2020","unstructured":"Bagdas D, Paris JJ, Carper M, Wodarski R, Rice ASC, Knapp PE, Hauser KF, Damaj MI (2020) Conditional expression of HIV-1 tat in the mouse alters the onset and progression of tonic, inflammatory and neuropathic hypersensitivity in a sex-dependent manner. Eur J Pain 24:1609\u20131623","journal-title":"Eur J Pain"},{"key":"9985_CR7","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","volume":"33","author":"GJ Bennett","year":"1988","unstructured":"Bennett GJ, Xie YK (1988) A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33:87\u2013107","journal-title":"Pain"},{"key":"9985_CR8","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1177\/1756285614564152","volume":"8","author":"R Bomprezzi","year":"2015","unstructured":"Bomprezzi R (2015) Dimethyl fumarate in the treatment of relapsing-remitting multiple sclerosis: an overview. Ther Adv Neurol Disord 8:20\u201330","journal-title":"Ther Adv Neurol Disord"},{"key":"9985_CR9","doi-asserted-by":"crossref","unstructured":"Cheng HYM, Pitcher GM, Laviolette SR, Whishaw IQ, Tong KI, Kockeritz LK, Wada T, Joza NA, Crackower M, Goncalves J\u00a0(2002)\u00a0DREAM Is a Critical Transcriptional Repressor for Pain Modulation. Cell\u00a0108:31-43","DOI":"10.1016\/S0092-8674(01)00629-8"},{"key":"9985_CR10","doi-asserted-by":"publisher","first-page":"e24412","DOI":"10.1371\/journal.pone.0024412","volume":"6","author":"X Chi","year":"2011","unstructured":"Chi X, Amet T, Byrd D, Chang KH, Shah K, Hu N, Grantham A, Hu S, Duan J, Tao F et al (2011) Direct effects of HIV-1 Tat on excitability and survival of primary dorsal root ganglion neurons: possible contribution to HIV-1-associated pain. PLoS One 6:e24412","journal-title":"PLoS One"},{"key":"9985_CR11","doi-asserted-by":"publisher","first-page":"3599","DOI":"10.1523\/JNEUROSCI.3045-16.2017","volume":"37","author":"ET Chivero","year":"2017","unstructured":"Chivero ET, Guo ML, Periyasamy P, Liao K, Callen SE, Buch S (2017) HIV-1 Tat Primes and Activates Microglial NLRP3 Inflammasome-Mediated Neuroinflammation. J Neurosci 37:3599\u20133609","journal-title":"J Neurosci"},{"key":"9985_CR12","doi-asserted-by":"publisher","first-page":"678","DOI":"10.3389\/fphar.2019.00678","volume":"10","author":"TJ Cirino","year":"2019","unstructured":"Cirino TJ, Eans SO, Medina JM, Wilson LL, Mottinelli M, Intagliata S, McCurdy CR, McLaughlin JP (2019) Characterization of Sigma 1 Receptor Antagonist CM-304 and Its Analog, AZ-66: Novel Therapeutics Against Allodynia and Induced Pain. Front Pharmacol 10:678","journal-title":"Front Pharmacol"},{"key":"9985_CR13","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.neuron.2007.04.017","volume":"54","author":"RW Colburn","year":"2007","unstructured":"Colburn RW, Lubin ML, Stone DJ, Wang Y, Lawrence D, D\u2019Andrea MR, Brandt MR, Liu Y, Flores CM, Qin N (2007) Attenuated cold sensitivity in TRPM8 null mice. Neuron 54:379\u2013386","journal-title":"Neuron"},{"key":"9985_CR14","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3389\/fnmol.2017.00284","volume":"10","author":"JR Deuis","year":"2017","unstructured":"Deuis JR, Dvorakova LS, Vetter I (2017) Methods Used to Evaluate Pain Behaviors in Rodents. Front Mol Neurosci 10:284","journal-title":"Front Mol Neurosci"},{"key":"9985_CR15","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.neulet.2008.12.062","volume":"452","author":"R Deumens","year":"2009","unstructured":"Deumens R, Jaken RJ, Knaepen L, van der Meulen I, Joosten EA (2009) Inverse relation between intensity of GFAP expression in the substantia gelatinosa and degree of chronic mechanical allodynia. Neurosci Lett 452:101\u2013105","journal-title":"Neurosci Lett"},{"key":"9985_CR16","doi-asserted-by":"publisher","first-page":"302","DOI":"10.3389\/fncel.2014.00302","volume":"8","author":"MF DosSantos","year":"2014","unstructured":"DosSantos MF, Holanda-Afonso RC, Lima RL, DaSilva AF, Moura-Neto V (2014) The role of the blood-brain barrier in the development and treatment of migraine and other pain disorders. Front Cell Neurosci 8:302","journal-title":"Front Cell Neurosci"},{"key":"9985_CR17","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.ejphar.2012.05.029","volume":"689","author":"S Fitting","year":"2012","unstructured":"Fitting S, Scoggins KL, Xu R, Dever SM, Knapp PE, Dewey WL, Hauser KF (2012) Morphine efficacy is altered in conditional HIV-1 Tat transgenic mice. Eur J Pharmacol 689:96\u2013103","journal-title":"Eur J Pharmacol"},{"key":"9985_CR18","doi-asserted-by":"publisher","DOI":"10.3791\/51012","author":"BN Gaskill","year":"2013","unstructured":"Gaskill BN, Karas AZ, Garner JP, Pritchett-Corning KR (2013) Nest building as an indicator of health and welfare in laboratory mice. J Vis Exp. https:\/\/doi.org\/10.3791\/51012","journal-title":"J Vis Exp"},{"key":"9985_CR19","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1007\/s11904-007-0017-6","volume":"4","author":"A Gonzalez-Duarte","year":"2007","unstructured":"Gonzalez-Duarte A, Cikurel K, Simpson DM (2007) Managing HIV peripheral neuropathy. Curr HIV\/AIDS Rep 4:114\u2013118","journal-title":"Curr HIV\/AIDS Rep"},{"key":"9985_CR20","doi-asserted-by":"publisher","first-page":"499","DOI":"10.2174\/1570159X11311050005","volume":"11","author":"S Hao","year":"2013","unstructured":"Hao S (2013) The Molecular and Pharmacological Mechanisms of HIV-Related Neuropathic Pain. Curr Neuropharmacol 11:499\u2013512","journal-title":"Curr Neuropharmacol"},{"issue":"Suppl 2","key":"9985_CR21","doi-asserted-by":"publisher","first-page":"S145","DOI":"10.1097\/QAD.0000000000002268","volume":"33","author":"LJ Henderson","year":"2019","unstructured":"Henderson LJ, Johnson TP, Smith BR, Reoma LB, Santamaria UA, Bachani M, Demarino C, Barclay RA, Snow J, Sacktor N et al (2019) Presence of Tat and transactivation response element in spinal fluid despite antiretroviral therapy. AIDS 33(Suppl 2):S145\u2013S157","journal-title":"AIDS"},{"key":"9985_CR22","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1136\/bmj.324.7335.466","volume":"324","author":"RAC Hughes","year":"2002","unstructured":"Hughes RAC (2002) Peripheral neuropathy. BMJ 324:466\u2013469","journal-title":"BMJ"},{"key":"9985_CR23","doi-asserted-by":"publisher","first-page":"13588","DOI":"10.1073\/pnas.1308673110","volume":"110","author":"TP Johnson","year":"2013","unstructured":"Johnson TP, Patel K, Johnson KR, Maric D, Calabresi PA, Hasbun R, Nath A (2013) Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein. Proc Natl Acad Sci U S A 110:13588\u201313593","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9985_CR24","doi-asserted-by":"publisher","first-page":"8903","DOI":"10.1021\/jm500989n","volume":"57","author":"VB Journigan","year":"2014","unstructured":"Journigan VB, M\u00e9sangeau C, Vyas N, Eans SO, Cutler SJ, McLaughlin JP, Mollereau C, McCurdy CR (2014) Nonpeptide small molecule agonist and antagonist original leads for neuropeptide FF1 and FF2 receptors. J Med Chem 57:8903\u20138927","journal-title":"J Med Chem"},{"key":"9985_CR25","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s13365-014-0236-8","volume":"20","author":"JR Keltner","year":"2014","unstructured":"Keltner JR, Fennema-Notestine C, Vaida F, Wang D, Franklin DR, Dworkin RH, Sanders C, McCutchan JA, Archibald SL, Miller DJ et al (2014) HIV-associated distal neuropathic pain is associated with smaller total cerebral cortical gray matter. J Neurovirol 20:209\u2013218","journal-title":"J Neurovirol"},{"key":"9985_CR26","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1016\/S0002-9440(10)64304-0","volume":"162","author":"BO Kim","year":"2003","unstructured":"Kim BO, Liu Y, Ruan Y, Xu ZC, Schantz L, He JJ (2003) Neuropathologies in transgenic mice expressing human immunodeficiency virus type 1 Tat protein under the regulation of the astrocyte-specific glial fibrillary acidic protein promoter and doxycycline. Am J Pathol 162:1693\u20131707","journal-title":"Am J Pathol"},{"key":"9985_CR27","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1248\/bpb.32.651","volume":"32","author":"YH Kim","year":"2009","unstructured":"Kim YH, Kim DH, Lim H, Baek DY, Shin HK, Kim JK (2009) The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages. Biol Pharm Bull 32:651\u2013656","journal-title":"Biol Pharm Bull"},{"key":"9985_CR28","doi-asserted-by":"publisher","first-page":"14851","DOI":"10.1073\/pnas.1009926107","volume":"107","author":"D Kim","year":"2010","unstructured":"Kim D, You B, Jo EK, Han SK, Simon MI, Lee SJ (2010) NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain. Proc Natl Acad Sci U S A 107:14851\u201314856","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9985_CR29","doi-asserted-by":"publisher","first-page":"14851","DOI":"10.1073\/pnas.1009926107","volume":"107","author":"M Kim","year":"2010","unstructured":"Kim M, Kwak C, Yu NK, Kaang BK (2010) NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain. Proc Natl Acad Sci 107:14851\u201314856","journal-title":"Proc Natl Acad Sci"},{"issue":"2","key":"9985_CR30","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1007\/s13365-017-0598-9","volume":"24","author":"D Langford","year":"2017","unstructured":"Langford D, Oh Kim B, Zou W, Fan Y, Rahimain P, Liu Y, He JJ (2017) Doxycycline-inducible and astrocyte-specific HIV-1 Tat transgenic mice (iTat) as an HIV\/neuroAIDS model. J Neurovirol 24(2):168\u2013179","journal-title":"J Neurovirol"},{"key":"9985_CR31","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.neulet.2016.12.073","volume":"640","author":"CR Leibrand","year":"2017","unstructured":"Leibrand CR, Paris JJ, Ghandour MS, Knapp PE, Kim WK, Hauser KF, McRae M (2017) HIV-1 Tat disrupts blood-brain barrier integrity and increases phagocytic perivascular macrophages and microglia in the dorsal striatum of transgenic mice. Neurosci Lett 640:136\u2013143","journal-title":"Neurosci Lett"},{"key":"9985_CR32","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1007\/s13365-019-00757-8","volume":"25","author":"CR Leibrand","year":"2019","unstructured":"Leibrand CR, Paris JJ, Jones AM, Masuda QN, Halquist MS, Kim WK, Knapp PE, Kashuba ADM, Hauser KF, McRae M (2019) HIV-1 Tat and opioids act independently to limit antiretroviral brain concentrations and reduce blood-brain barrier integrity. J Neurovirol 25:560\u2013577","journal-title":"J Neurovirol"},{"key":"9985_CR33","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1007\/s11064-019-02824-2","volume":"44","author":"DS Luo","year":"2019","unstructured":"Luo DS, Lin R, Luo LL, Li QH, Chen T, Qiu RH, Li YQ (2019) Glial plasticity in the trigeminal root entry zone of a rat trigeminal neuralgia animal model. Neurochem Res 44:1893\u20131902","journal-title":"Neurochem Res"},{"key":"9985_CR34","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S1090-3801(02)00053-8","volume":"7","author":"C Martin","year":"2003","unstructured":"Martin C, Solders G, S\u00f6nnerborg A, Hansson P (2003) Painful and non-painful neuropathy in HIV-infected patients: an analysis of somatosensory nerve function. Eur J Pain 7:23\u201331","journal-title":"Eur J Pain"},{"key":"9985_CR35","first-page":"599","volume":"2","author":"JP McLaughlin","year":"2017","unstructured":"McLaughlin JP, Paris JJ, Mintzopoulos D, Hymel KA, Kim JK, Cirino TJ, Gillis TE, Eans SO, Vitaliano GD, Medina JM et al (2017) Conditional Human Immunodeficiency Virus Transactivator of Transcription Protein Expression Induces Depression-like Effects and Oxidative Stress. Biol Psychiatry Cogn Neurosci Neuroimaging 2:599\u2013609","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"},{"key":"9985_CR36","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/S0006-8993(00)02050-3","volume":"86","author":"ED Milligan","year":"2000","unstructured":"Milligan ED, Mehmert KK, Hinde JL, Harvey LO, Martin D, Tracey KJ, Maier SF, Watkins LR (2000) Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120. Brain Res 86:105\u2013116","journal-title":"Brain Res"},{"key":"9985_CR37","doi-asserted-by":"publisher","first-page":"2808","DOI":"10.1523\/JNEUROSCI.21-08-02808.2001","volume":"21","author":"ED Milligan","year":"2001","unstructured":"Milligan ED, O\u2019Connor KA, Nguyen KT, Armstrong CB, Twining C, Gaykema RP, Holguin A, Martin D, Maier SF, Watkins LR (2001) Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines. J Neurosci 21:2808\u20132019","journal-title":"J Neurosci"},{"key":"9985_CR38","doi-asserted-by":"publisher","first-page":"60","DOI":"10.18773\/austprescr.2018.022","volume":"41","author":"BP Murnion","year":"2018","unstructured":"Murnion BP (2018) Neuropathic pain: current definition and review of drug treatment. Aust Prescr 41:60\u201363","journal-title":"Aust Prescr"},{"key":"9985_CR39","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1097\/j.pain.0000000000000171","volume":"156","author":"SS Negus","year":"2015","unstructured":"Negus SS, Neddenriep B, Altarifi AA, Carroll FI, Leitl MD, Miller LL (2015) Effects of ketoprofen, morphine, and kappa opioids on pain-related depression of nesting in mice. Pain 156:1153\u20131160","journal-title":"Pain"},{"key":"9985_CR40","unstructured":"Oliver VL, Thurston SE, Lofgren JL (2018)\u00a0Using Cageside Measures to Evaluate Analgesic Efficacy in Mice. J Am Assoc Lab Anim Sci 57:186-201"},{"key":"9985_CR41","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.bbr.2015.05.021","volume":"291","author":"JJ Paris","year":"2015","unstructured":"Paris JJ, Singh HD, Carey AN, McLaughlin JP (2015) Exposure to HIV-1 Tat in brain impairs sensorimotor gating and activates microglia in limbic and extralimbic brain regions of male mice. Behav Brain Res 291:209\u2013218","journal-title":"Behav Brain Res"},{"key":"9985_CR42","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/0091-3057(88)90243-2","volume":"31","author":"D Paul","year":"1988","unstructured":"Paul D, Mana MJ, Pfaus JG, Pinel JP (1988) Attenuation of morphine analgesia by the S2 antagonists, pirenperone and ketanserin. Pharmacol Biochem Behav 31:641\u2013647","journal-title":"Pharmacol Biochem Behav"},{"key":"9985_CR43","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.bbi.2019.03.011","volume":"80","author":"P Periyasamy","year":"2019","unstructured":"Periyasamy P, Thangaraj A, Bendi VS, Buch S (2019) HIV-1 Tat-mediated microglial inflammation involves a novel miRNA-34a-NLRC5-NF\u03baB signaling axis. Brain Behav Immun 80:227\u2013237","journal-title":"Brain Behav Immun"},{"key":"9985_CR44","doi-asserted-by":"publisher","first-page":"e14433","DOI":"10.1371\/journal.pone.0014433","volume":"5","author":"TJC Phillips","year":"2010","unstructured":"Phillips TJC, Cherry CL, Cox S, Marshall SJ, Rice ASC (2010) Pharmacological treatment of painful HIV-associated sensory neuropathy: a systematic review and meta-analysis of randomized controlled trials. PLoS One 5:e14433","journal-title":"PLoS One"},{"key":"9985_CR45","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1016\/j.pain.2014.06.014","volume":"155","author":"TJC Phillips","year":"2014","unstructured":"Phillips TJC, Brown M, Ramirez JD, Perkins J, Woldeamanuel YW (2014) de C Williams AC, Orengo C, Bennett DLH, Bodi I, Cox S, Maier C, Krumova EK, Rice ASC: Sensory, psychological, and metabolic dysfunction in HIV-associated peripheral neuropathy: A cross-sectional deep profilng study. Pain 155:1846\u20131860","journal-title":"Pain"},{"key":"9985_CR46","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/S1044-7431(03)00171-4","volume":"24","author":"H Pu","year":"2003","unstructured":"Pu H, Tian J, Flora G, Lee YW, Nath A, Hennig B, Toborek M (2003) HIV-1 Tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain. Mol Cell Neurosci 24:224\u2013237","journal-title":"Mol Cell Neurosci"},{"key":"9985_CR47","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.brainres.2007.09.063","volume":"1184","author":"H Pu","year":"2007","unstructured":"Pu H, Hayashi K, Andras IE, Eum SY, Hennig B, Toborek M (2007) Limited role of COX-2 in HIV Tat-induced alterations of tight junction protein expression and disruption of the blood-brain barrier. Brain Res 1184:333\u2013344","journal-title":"Brain Res"},{"key":"9985_CR48","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1093\/infdis\/jix013","volume":"215","author":"E Rahimy","year":"2017","unstructured":"Rahimy E, Li FY, Hagberg L, Fuchs D, Robertson K, Meyerhoff DJ, Zetterberg H, Price RW, Gissl\u00e9n M, Spudich S (2017) Blood-Brain Barrier Disruption Is Initiated During Primary HIV Infection and Not Rapidly Altered by Antiretroviral Therapy. J Infect Dis 215:1132\u20131140","journal-title":"J Infect Dis"},{"key":"9985_CR49","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1208\/s12248-010-9191-3","volume":"12","author":"KJ Reilley","year":"2010","unstructured":"Reilley KJ, Giulianotti M, Dooley CT, Nefzi A, McLaughlin JP, Houghten RA (2010) Identification of two novel, potent, low-liability antinociceptive compounds from the direct in vivo screening of a large mixture-based combinatorial library. AAPS J 12:318\u2013329","journal-title":"AAPS J"},{"key":"9985_CR50","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1080\/13550280701200102","volume":"13","author":"B Robinson","year":"2007","unstructured":"Robinson B, Li Z, Nath A (2007) Nucleoside reverse transcriptase inhibitors and human immunodeficiency virus proteins cause axonal injury in human dorsal root ganglia cultures. J Neurovirol 13:160\u2013167","journal-title":"J Neurovirol"},{"key":"9985_CR51","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1038\/jcbfm.2011.197","volume":"32","author":"GA Rosenberg","year":"2012","unstructured":"Rosenberg GA (2012) Neurological diseases in relation to the blood-brain barrier. J Cereb Blood Flow Metab 32:1139\u20131151","journal-title":"J Cereb Blood Flow Metab"},{"key":"9985_CR52","doi-asserted-by":"publisher","first-page":"8408","DOI":"10.1523\/JNEUROSCI.2851-18.2019","volume":"39","author":"W Ru","year":"2019","unstructured":"Ru W, Liu X, Bae C, Shi Y, Walikonis R, Chung JM, Tan S-J (2019) Microglia mediate HIV-1 gp120-induced synaptic degeneration in spinal pain neural circuits. J Neurosci 39:8408\u20138421","journal-title":"J Neurosci"},{"key":"9985_CR53","doi-asserted-by":"publisher","first-page":"3102","DOI":"10.1523\/JNEUROSCI.3195-17.2018","volume":"38","author":"J Sellmeijer","year":"2018","unstructured":"Sellmeijer J, Mathis V, Hugel S, Li XH, Song Q, Chen QY, Barthas F, Lutz PE, Karatas M, Luthi A et al (2018) Hyperactivity of Anterior Cingulate Cortex Areas 24a\/24b Drives Chronic Pain-Induced Anxiodepressive-like Consequences. J Neurosci 38:3102\u20133115","journal-title":"J Neurosci"},{"key":"9985_CR54","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-020-09951-6","author":"Y Shi","year":"2020","unstructured":"Shi Y, Yuan S, Tang SJ (2020) Reactive oxygen species (ROS) are critical for morphine exacerbation of HIV-1 gp120-induced pain. J Neuroimmune Pharmacol. https:\/\/doi.org\/10.1007\/s11481-020-09951-6","journal-title":"J Neuroimmune Pharmacol"},{"key":"9985_CR55","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1038\/nn.4053","volume":"18","author":"RE Sorge","year":"2015","unstructured":"Sorge RE, Mapplebeck JC, Rosen S, Beggs S, Taves S, Alexander JK, Martin LJ, Austin JS, Sotocinal SG, Chen D et al (2015) Different immune cells mediate mechanical pain hypersensitivity in male and female mice. Nat Neurosci 18:1081\u20131083","journal-title":"Nat Neurosci"},{"key":"9985_CR56","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1002\/glia.23768","volume":"68","author":"E Trias","year":"2020","unstructured":"Trias E, Kovacs M, King PH, Si Y, Kwon Y, Varela V, Ibarburu S, Moura IC, Hermine O, Beckman JS, Barbeito L (2020) Schwann cells orchestrate peripheral nerve inflammation through the expression of CSF1, IL-34, and SCF in amyotrophic lateral sclerosis. Glia 68:1165\u20131181","journal-title":"Glia"},{"key":"9985_CR57","doi-asserted-by":"publisher","first-page":"e654","DOI":"10.1097\/PR9.0000000000000654","volume":"3","author":"R Wodarski","year":"2018","unstructured":"Wodarski R, Bagdas D, Paris JJ, Pheby T, Toma W, Xu R, Damaj MI, Knapp PE, Rice ASC, Hauser KF (2018) Reduced intraepidermal nerve fibre density, glial activation, and sensory changes in HIV type-1 Tat-expressing female mice: involvement of Tat during early stages of HIV-associated painful sensory neuropathy. Pain Rep 3:e654","journal-title":"Pain Rep"},{"key":"9985_CR58","doi-asserted-by":"publisher","first-page":"14181","DOI":"10.1038\/s41598-020-71073-z","volume":"10","author":"AX Xie","year":"2020","unstructured":"Xie AX, Madayag A, Minton SK, McCarthy KD, Malykhina AP (2020) Sensory satellite glial Gq-GPCR activation alleviates inflammatory pain via peripheral adenosine 1 receptor activation. Sci Rep 10:14181","journal-title":"Sci Rep"},{"key":"9985_CR59","doi-asserted-by":"publisher","first-page":"4576","DOI":"10.1523\/JNEUROSCI.5552-03.2004","volume":"24","author":"M Xu","year":"2004","unstructured":"Xu M, Petraschka M, McLaughlin JP, Westenbroek RE, Caron MG, Lefkowitz RJ, Czyzyk TA, Pintar JE, Terman GW, Chavkin C (2004) Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance. J Neurosci 24:4576\u20134584","journal-title":"J Neurosci"},{"key":"9985_CR60","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1002\/ana.24139","volume":"75","author":"SB Yuan","year":"2014","unstructured":"Yuan SB, Shi Y, Chen J, Zhou X, Li G, Gelman BB, Lisinicchia JG, Carlton SM, Ferguson MR, Tan A et al (2014) Gp120 in the pathogenesis of human immunodeficiency virus-associated pain. Ann Neurol 75:837\u2013850","journal-title":"Ann Neurol"}],"container-title":["Journal of Neuroimmune Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11481-021-09985-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11481-021-09985-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11481-021-09985-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T03:30:54Z","timestamp":1670383854000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11481-021-09985-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,22]]},"references-count":60,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["9985"],"URL":"https:\/\/doi.org\/10.1007\/s11481-021-09985-4","relation":{},"ISSN":["1557-1890","1557-1904"],"issn-type":[{"value":"1557-1890","type":"print"},{"value":"1557-1904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,22]]},"assertion":[{"value":"26 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experiments were conducted in accordance with the National Institutes of Health guide for the care and use of Laboratory animals (NIH Publications No. 8023, revised 1978). All procedures were preapproved and conducted in accordance with the Institutional Animal Care and Use Committee at the University of Florida as specified by the 2011 NIH Guide for the Care and Use of Laboratory Animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"The authors state they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}