{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:49:56Z","timestamp":1790812196810,"version":"4.1.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2021ZD0203105"],"award-info":[{"award-number":["2021ZD0203105"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171218"],"award-info":[{"award-number":["82171218"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703524"],"award-info":[{"award-number":["81703524"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroimmune Pharmacol"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s11481-022-10054-7","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:03:45Z","timestamp":1670198625000},"page":"41-57","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Angiotensin Type 2 Receptor Pharmacological Agonist Relieves Neurocognitive Deficits via Reducing Neuroinflammation and Microglial Engulfment of Dendritic Spines"],"prefix":"10.1007","volume":"18","author":[{"given":"Liang","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian-qian","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0058-4750","authenticated-orcid":false,"given":"Shan-shan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,5]]},"reference":[{"key":"10054_CR1","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1097\/HJH.0000000000000364","volume":"33","author":"A Alhusban","year":"2015","unstructured":"Alhusban A, Fouda AY, Bindu P, Ishrat T, Soliman S, Fagan SC (2015) Compound 21 is pro-angiogenic in the brain and results in sustained recovery after ischemic stroke. J Hypertens 33:170\u2013180","journal-title":"J Hypertens"},{"key":"10054_CR2","doi-asserted-by":"publisher","first-page":"3005","DOI":"10.1007\/s12035-018-1272-9","volume":"56","author":"SA Bhat","year":"2019","unstructured":"Bhat SA, Sood A, Shukla R, Hanif K (2019) AT2R activation prevents microglia pro-inflammatory activation in a NOX-Dependent manner: inhibition of PKC activation and p47(phox) phosphorylation by PP2A. Mol Neurobiol 56:3005\u20133023","journal-title":"Mol Neurobiol"},{"key":"10054_CR3","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1007\/s12640-021-00403-4","volume":"39","author":"SA Bhat","year":"2021","unstructured":"Bhat SA, Fatima Z, Sood A, Shukla R, Hanif K (2021) The protective effects of AT2R agonist, CGP42112A, against angiotensin ii-induced oxidative stress and inflammatory response in astrocytes: role of AT2R\/PP2A\/NFkappaB\/ROS signaling. Neurotox Res 39:1991\u20132006","journal-title":"Neurotox Res"},{"issue":"2573\u20132589","key":"10054_CR4","volume":"109","author":"P Cao","year":"2021","unstructured":"Cao P et al (2021) Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines. Neuron 109(2573\u20132589):e2579","journal-title":"Neuron"},{"key":"10054_CR5","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s13054-015-0882-0","volume":"19","author":"C Chen","year":"2015","unstructured":"Chen C, Zhang Z, Chen T, Peng M, Xu X, Wang Y (2015) Prolonged mechanical ventilation-induced neuroinflammation affects postoperative memory dysfunction in surgical mice. Crit Care 19:159","journal-title":"Crit Care"},{"key":"10054_CR6","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.bbi.2016.04.004","volume":"56","author":"T Chen","year":"2016","unstructured":"Chen T, Chen C, Zhang Z, Zou Y, Peng M, Wang Y (2016) Toll-like receptor 4 knockout ameliorates neuroinflammation due to lung-brain interaction in mechanically ventilated mice. Brain Behav Immun 56:42\u201355","journal-title":"Brain Behav Immun"},{"key":"10054_CR7","doi-asserted-by":"publisher","first-page":"11706","DOI":"10.1523\/JNEUROSCI.0730-12.2012","volume":"32","author":"Z Chen","year":"2012","unstructured":"Chen Z, Jalabi W, Shpargel KB, Farabaugh KT, Dutta R, Yin X, Kidd GJ, Bergmann CC, Stohlman SA, Trapp BD (2012) Lipopolysaccharide-induced microglial activation and neuroprotection against experimental brain injury is independent of hematogenous TLR4. J Neurosci 32:11706\u201311715","journal-title":"J Neurosci"},{"key":"10054_CR8","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.freeradbiomed.2009.12.022","volume":"48","author":"ML Circu","year":"2010","unstructured":"Circu ML, Aw TY (2010) Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 48:749\u2013762","journal-title":"Free Radic Biol Med"},{"key":"10054_CR9","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.redox.2018.01.008","volume":"15","author":"JN Cobley","year":"2018","unstructured":"Cobley JN, Fiorello ML, Bailey DM (2018) 13 reasons why the brain is susceptible to oxidative stress. Redox Biol 15:490\u2013503","journal-title":"Redox Biol"},{"key":"10054_CR10","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1007\/s00429-014-0943-1","volume":"221","author":"AD de Kloet","year":"2016","unstructured":"de Kloet AD, Wang L, Ludin JA, Smith JA, Pioquinto DJ, Hiller H, Steckelings UM, Scheuer DA, Sumners C, Krause EG (2016) Reporter mouse strain provides a novel look at angiotensin type-2 receptor distribution in the central nervous system. Brain Struct Funct 221:891\u2013912","journal-title":"Brain Struct Funct"},{"key":"10054_CR11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074633","volume":"8","author":"N Ding","year":"2013","unstructured":"Ding N, Wang F, Xiao H, Xu L, She S (2013) Mechanical ventilation enhances HMGB1 expression in an LPS-induced lung injury model. PLoS ONE 8:e74633","journal-title":"PLoS ONE"},{"key":"10054_CR12","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1186\/s13054-018-2237-0","volume":"22","author":"X Ding","year":"2018","unstructured":"Ding X, Tong Y, Jin S, Chen Z, Li T, Billiar TR, Pitt BR, Li Q, Zhang LM (2018) Mechanical ventilation enhances extrapulmonary sepsis-induced lung injury: role of WISP1-alphavbeta5 integrin pathway in TLR4-mediated inflammation and injury. Crit Care 22:302","journal-title":"Crit Care"},{"key":"10054_CR13","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/1742-2094-7-41","volume":"7","author":"K Dohi","year":"2010","unstructured":"Dohi K, Ohtaki H, Nakamachi T, Yofu S, Satoh K, Miyamoto K, Song D, Tsunawaki S, Shioda S, Aruga T (2010) Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury. J Neuroinflammation 7:41","journal-title":"J Neuroinflammation"},{"key":"10054_CR14","doi-asserted-by":"publisher","first-page":"H1192","DOI":"10.1152\/ajpheart.00446.2018","volume":"316","author":"W Eldahshan","year":"2019","unstructured":"Eldahshan W, Ishrat T, Pillai B, Sayed MA, Alwhaibi A, Fouda AY, Ergul A, Fagan SC (2019) Angiotensin II type 2 receptor stimulation with compound 21 improves neurological function after stroke in female rats: a pilot study. Am J Physiol Heart Circ Physiol 316:H1192\u2013H1201","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10054_CR15","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1001\/jama.291.14.1753","volume":"291","author":"EW Ely","year":"2004","unstructured":"Ely EW, Shintani A, Truman B, Speroff T, Gordon SM, Harrell FE Jr, Inouye SK, Bernard GR, Dittus RS (2004) Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA 291:1753\u20131762","journal-title":"JAMA"},{"key":"10054_CR16","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1038\/s41598-018-20643-3","volume":"8","author":"E Furube","year":"2018","unstructured":"Furube E, Kawai S, Inagaki H, Takagi S, Miyata S (2018) Brain Region-dependent Heterogeneity and Dose-dependent Difference in Transient Microglia Population Increase during Lipopolysaccharide-induced Inflammation. Sci Rep 8:2203","journal-title":"Sci Rep"},{"key":"10054_CR17","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.jcrc.2020.12.017","volume":"62","author":"G Giordano","year":"2021","unstructured":"Giordano G, Pugliese F, Bilotta F (2021) Neuroinflammation, neuronal damage or cognitive impairment associated with mechanical ventilation: a systematic review of evidence from animal studies. J Crit Care 62:246\u2013255","journal-title":"J Crit Care"},{"key":"10054_CR18","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/nrneurol.2012.183","volume":"8","author":"TE Gofton","year":"2012","unstructured":"Gofton TE, Young GB (2012) Sepsis-associated encephalopathy. Nat Rev Neurol 8:557\u2013566","journal-title":"Nat Rev Neurol"},{"key":"10054_CR19","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.1056\/NEJMc2008597","volume":"382","author":"J Helms","year":"2020","unstructured":"Helms J, Kremer S, Merdji H, Clere-Jehl R, Schenck M, Kummerlen C, Collange O, Boulay C, Fafi-Kremer S, Ohana M, Anheim M, Meziani F (2020) Neurologic features in severe SARS-CoV-2 infection. N Engl J Med 382:2268\u20132270","journal-title":"N Engl J Med"},{"key":"10054_CR20","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/s12974-015-0332-6","volume":"12","author":"IC Hoogland","year":"2015","unstructured":"Hoogland IC, Houbolt C, van Westerloo DJ, van Gool WA, van de Beek D (2015) Systemic inflammation and microglial activation: systematic review of animal experiments. J Neuroinflammation 12:114","journal-title":"J Neuroinflammation"},{"key":"10054_CR21","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.bbi.2019.12.006","volume":"84","author":"WY Huang","year":"2020","unstructured":"Huang WY, Liu KH, Lin S, Chen TY, Tseng CY, Chen HY, Wu HM, Hsu KS (2020) NADPH oxidase 2 as a potential therapeutic target for protection against cognitive deficits following systemic inflammation in mice. Brain Behav Immun 84:242\u2013252","journal-title":"Brain Behav Immun"},{"key":"10054_CR22","doi-asserted-by":"crossref","unstructured":"Jackson-Cowan L, Eldahshan W, Dumanli S, Dong G, Jamil S, Abdul Y, Althomali W, Baban B, Fagan SC, Ergul A (2021) Delayed Administration of Angiotensin Receptor (AT2R) agonist C21 improves survival and preserves sensorimotor outcomes in female diabetic rats post-stroke through modulation of microglial activation. Int J Mol Sci 22:1356","DOI":"10.3390\/ijms22031356"},{"key":"10054_CR23","doi-asserted-by":"crossref","unstructured":"Jackson L, Eldahshan W, Fagan SC, Ergul A (2018) Within the Brain: The Renin Angiotensin System. Int J Mol Sci 19:876","DOI":"10.3390\/ijms19030876"},{"key":"10054_CR24","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1007\/s12975-019-00752-5","volume":"11","author":"L Jackson","year":"2020","unstructured":"Jackson L, Dong G, Althomali W, Sayed MA, Eldahshan W, Baban B, Johnson MH, Filosa J, Fagan SC, Ergul A (2020) Delayed administration of angiotensin II type 2 receptor (AT2R) agonist compound 21 prevents the development of post-stroke cognitive impairment in diabetes through the modulation of microglia polarization. Transl Stroke Res 11:762\u2013775","journal-title":"Transl Stroke Res"},{"key":"10054_CR25","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.bbi.2021.09.017","volume":"99","author":"J Jiang","year":"2022","unstructured":"Jiang J, Tang B, Wang L, Huo Q, Tan S, Misrani A, Han Y, Li H, Hu H, Wang J, Cheng T, Tabassum S, Chen M, Xie W, Long C, Yang L (2022) Systemic LPS-induced microglial activation results in increased GABAergic tone: a mechanism of protection against neuroinflammation in the medial prefrontal cortex in mice. Brain Behav Immun 99:53\u201369","journal-title":"Brain Behav Immun"},{"key":"10054_CR26","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/jcbfm.2011.133","volume":"32","author":"F Jing","year":"2012","unstructured":"Jing F, Mogi M, Sakata A, Iwanami J, Tsukuda K, Ohshima K, Min LJ, Steckelings UM, Unger T, Dahlof B, Horiuchi M (2012) Direct stimulation of angiotensin II type 2 receptor enhances spatial memory. J Cereb Blood Flow Metab 32:248\u2013255","journal-title":"J Cereb Blood Flow Metab"},{"key":"10054_CR27","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1038\/nm.2886","volume":"18","author":"HJ Kang","year":"2012","unstructured":"Kang HJ, Voleti B, Hajszan T, Rajkowska G, Stockmeier CA, Licznerski P, Lepack A, Majik MS, Jeong LS, Banasr M, Son H, Duman RS (2012) Decreased expression of synapse-related genes and loss of synapses in major depressive disorder. Nat Med 18:1413\u20131417","journal-title":"Nat Med"},{"key":"10054_CR28","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.bbi.2016.07.158","volume":"58","author":"A Kumar","year":"2016","unstructured":"Kumar A, Barrett JP, Alvarez-Croda DM, Stoica BA, Faden AI, Loane DJ (2016) NOX2 drives M1-like microglial\/macrophage activation and neurodegeneration following experimental traumatic brain injury. Brain Behav Immun 58:291\u2013309","journal-title":"Brain Behav Immun"},{"key":"10054_CR29","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1002\/(SICI)1096-9861(19960923)373:3<322::AID-CNE2>3.0.CO;2-4","volume":"373","author":"Z Lenkei","year":"1996","unstructured":"Lenkei Z, Palkovits M, Corvol P, Llorens-Cortes C (1996) Distribution of angiotensin II type-2 receptor (AT2) mRNA expression in the adult rat brain. J Comp Neurol 373:322\u2013339","journal-title":"J Comp Neurol"},{"key":"10054_CR30","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s12974-020-01751-2","volume":"17","author":"Z Liu","year":"2020","unstructured":"Liu Z, Yao X, Jiang W, Li W, Zhu S, Liao C, Zou L, Ding R, Chen J (2020) Advanced oxidation protein products induce microglia-mediated neuroinflammation via MAPKs-NF-kappaB signaling pathway and pyroptosis after secondary spinal cord injury. J Neuroinflammation 17:90","journal-title":"J Neuroinflammation"},{"key":"10054_CR31","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/s41577-021-00643-7","volume":"22","author":"T Manabe","year":"2022","unstructured":"Manabe T, Heneka MT (2022) Cerebral dysfunctions caused by sepsis during ageing. Nat Rev Immunol 22:444\u2013458","journal-title":"Nat Rev Immunol"},{"key":"10054_CR32","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.bbi.2020.10.008","volume":"91","author":"B Mei","year":"2021","unstructured":"Mei B, Li J, Zuo Z (2021) Dexmedetomidine attenuates sepsis-associated inflammation and encephalopathy via central alpha2A adrenoceptor. Brain Behav Immun 91:296\u2013314","journal-title":"Brain Behav Immun"},{"key":"10054_CR33","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1093\/brain\/awv379","volume":"139","author":"A Olmos-Alonso","year":"2016","unstructured":"Olmos-Alonso A, Schetters ST, Sri S, Askew K, Mancuso R, Vargas-Caballero M, Holscher C, Perry VH, Gomez-Nicola D (2016) Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer\u2019s-like pathology. Brain 139:891\u2013907","journal-title":"Brain"},{"key":"10054_CR34","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.bbi.2021.12.021","volume":"101","author":"TT Pan","year":"2022","unstructured":"Pan TT, Gao W, Song ZH, Long DD, Cao P, Hu R, Chen DY, Zhou WJ, Jin Y, Hu SS, Wei W, Chai XQ, Zhang Z, Wang D (2022) Glutamatergic neurons and myeloid cells in the anterior cingulate cortex mediate secondary hyperalgesia in chronic joint inflammatory pain. Brain Behav Immun 101:62\u201377","journal-title":"Brain Behav Immun"},{"key":"10054_CR35","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1056\/NEJMoa1301372","volume":"369","author":"PP Pandharipande","year":"2013","unstructured":"Pandharipande PP, Girard TD, Jackson JC, Morandi A, Thompson JL, Pun BT, Brummel NE, Hughes CG, Vasilevskis EE, Shintani AK, Moons KG, Geevarghese SK, Canonico A, Hopkins RO, Bernard GR, Dittus RS, Ely EW, Investigators B-IS (2013) Long-term cognitive impairment after critical illness. N Engl J Med 369:1306\u20131316","journal-title":"N Engl J Med"},{"key":"10054_CR36","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S2213-2600(20)30552-X","volume":"9","author":"BT Pun","year":"2021","unstructured":"Pun BT et al (2021) Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study. Lancet Respir Med 9:239\u2013250","journal-title":"Lancet Respir Med"},{"key":"10054_CR37","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.bbi.2015.08.002","volume":"51","author":"LL Qiu","year":"2016","unstructured":"Qiu LL, Ji MH, Zhang H, Yang JJ, Sun XR, Tang H, Wang J, Liu WX, Yang JJ (2016) NADPH oxidase 2-derived reactive oxygen species in the hippocampus might contribute to microglial activation in postoperative cognitive dysfunction in aged mice. Brain Behav Immun 51:109\u2013118","journal-title":"Brain Behav Immun"},{"key":"10054_CR38","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1007\/s13311-020-00986-4","volume":"18","author":"R Rivas-Santisteban","year":"2021","unstructured":"Rivas-Santisteban R, Lillo J, Munoz A, Rodriguez-Perez AI, Labandeira-Garcia JL, Navarro G, Franco R (2021) Novel interactions involving the mas receptor show potential of the renin-angiotensin system in the regulation of microglia activation: altered expression in parkinsonism and dyskinesia. Neurotherapeutics 18:998\u20131016","journal-title":"Neurotherapeutics"},{"key":"10054_CR39","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1161\/HYPERTENSIONAHA.119.14431","volume":"75","author":"J Royea","year":"2020","unstructured":"Royea J, Lacalle-Aurioles M, Trigiani LJ, Fermigier A, Hamel E (2020) AT2R\u2019s (Angiotensin II Type 2 Receptor\u2019s) role in cognitive and cerebrovascular deficits in a mouse model of Alzheimer disease. Hypertension 75:1464\u20131474","journal-title":"Hypertension"},{"key":"10054_CR40","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.bbi.2020.11.010","volume":"92","author":"M Saito","year":"2021","unstructured":"Saito M, Fujinami Y, Ono Y, Ohyama S, Fujioka K, Yamashita K, Inoue S, Kotani J (2021) Infiltrated regulatory T cells and Th2 cells in the brain contribute to attenuation of sepsis-associated encephalopathy and alleviation of mental impairments in mice with polymicrobial sepsis. Brain Behav Immun 92:25\u201338","journal-title":"Brain Behav Immun"},{"key":"10054_CR41","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1186\/s13054-019-2626-z","volume":"23","author":"C Sasannejad","year":"2019","unstructured":"Sasannejad C, Ely EW, Lahiri S (2019) Long-term cognitive impairment after acute respiratory distress syndrome: a review of clinical impact and pathophysiological mechanisms. Crit Care 23:352","journal-title":"Crit Care"},{"key":"10054_CR42","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1007\/s00109-016-1406-3","volume":"94","author":"K Schwengel","year":"2016","unstructured":"Schwengel K, Namsolleck P, Lucht K, Clausen BH, Lambertsen KL, Valero-Esquitino V, Thone-Reineke C, Muller S, Widdop RE, Denton KM, Horiuchi M, Iwai M, Boato F, Dahlof B, Hallberg A, Unger T, Steckelings UM (2016) Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice. J Mol Med (berl) 94:957\u2013966","journal-title":"J Mol Med (berl)"},{"key":"10054_CR43","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1164\/ajrccm.157.6.9709092","volume":"157","author":"AS Slutsky","year":"1998","unstructured":"Slutsky AS, Tremblay LN (1998) Multiple system organ failure. Is mechanical ventilation a contributing factor? Am J Respir Crit Care Med 157:1721\u20131725","journal-title":"Am J Respir Crit Care Med"},{"key":"10054_CR44","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1165\/rcmb.2021-0072OC","volume":"65","author":"NA Sparrow","year":"2021","unstructured":"Sparrow NA, Anwar F, Covarrubias AE, Rajput PS, Rashid MH, Nisson PL, Gezalian MM, Toossi S, Ayodele MO, Karumanchi SA, Ely EW, Lahiri S (2021) IL-6 inhibition reduces neuronal injury in a murine model of ventilator-induced lung injury. Am J Respir Cell Mol Biol 65:403\u2013412","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10054_CR45","doi-asserted-by":"publisher","first-page":"R88","DOI":"10.1186\/cc9019","volume":"14","author":"N Terrando","year":"2010","unstructured":"Terrando N, Rei Fidalgo A, Vizcaychipi M, Cibelli M, Ma D, Monaco C, Feldmann M, Maze M (2010) The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction. Crit Care 14:R88","journal-title":"Crit Care"},{"key":"10054_CR46","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.3233\/JAD-161088","volume":"57","author":"E Tonnies","year":"2017","unstructured":"Tonnies E, Trushina E (2017) Oxidative stress, synaptic dysfunction, and Alzheimer\u2019s disease. J Alzheimers Dis 57:1105\u20131121","journal-title":"J Alzheimers Dis"},{"key":"10054_CR47","doi-asserted-by":"publisher","first-page":"30","DOI":"10.21037\/atm.2017.12.10","volume":"6","author":"M Turon","year":"2018","unstructured":"Turon M, Fernandez-Gonzalo S, de Haro C, Magrans R, Lopez-Aguilar J, Blanch L (2018) Mechanisms involved in brain dysfunction in mechanically ventilated critically ill patients: implications and therapeutics. Ann Transl Med 6:30","journal-title":"Ann Transl Med"},{"key":"10054_CR48","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1126\/science.aaz2288","volume":"367","author":"C Wang","year":"2020","unstructured":"Wang C, Yue H, Hu Z, Shen Y, Ma J, Li J, Wang XD, Wang L, Sun B, Shi P, Wang L, Gu Y (2020) Microglia mediate forgetting via complement-dependent synaptic elimination. Science 367:688\u2013694","journal-title":"Science"},{"key":"10054_CR49","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/1742-2094-8-38","volume":"8","author":"J Wen","year":"2011","unstructured":"Wen J, Ribeiro R, Zhang Y (2011) Specific PKC isoforms regulate LPS-stimulated iNOS induction in murine microglial cells. J Neuroinflammation 8:38","journal-title":"J Neuroinflammation"},{"issue":"167\u2013182","key":"10054_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.12.004","volume":"52","author":"S Werneburg","year":"2020","unstructured":"Werneburg S, Jung J, Kunjamma RB, Ha SK, Luciano NJ, Willis CM, Gao G, Biscola NP, Havton LA, Crocker SJ, Popko B, Reich DS, Schafer DP (2020) Targeted complement inhibition at synapses prevents microglial synaptic engulfment and synapse loss in demyelinating disease. Immunity 52(167\u2013182):e167","journal-title":"Immunity"},{"key":"10054_CR51","doi-asserted-by":"publisher","first-page":"S81","DOI":"10.1097\/CCM.0b013e3182a16946","volume":"41","author":"ME Wilcox","year":"2013","unstructured":"Wilcox ME, Brummel NE, Archer K, Ely EW, Jackson JC, Hopkins RO (2013) Cognitive dysfunction in ICU patients: risk factors, predictors, and rehabilitation interventions. Crit Care Med 41:S81-98","journal-title":"Crit Care Med"},{"key":"10054_CR52","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.bbi.2018.11.013","volume":"76","author":"B Zhang","year":"2019","unstructured":"Zhang B, Bailey WM, McVicar AL, Stewart AN, Veldhorst AK, Gensel JC (2019) Reducing age-dependent monocyte-derived macrophage activation contributes to the therapeutic efficacy of NADPH oxidase inhibition in spinal cord injury. Brain Behav Immun 76:139\u2013150","journal-title":"Brain Behav Immun"},{"key":"10054_CR53","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1097\/SHK.0000000000001591","volume":"55","author":"C Zhang","year":"2021","unstructured":"Zhang C, Hu S, Zosky GR, Wei X, Shu S, Wang D, Chai X (2021) Paracoxib alleviates ventilator-induced lung injury through functional modulation of lung-recruited CD11bloLy6Chi monocytes. Shock 55:236\u2013243","journal-title":"Shock"}],"container-title":["Journal of Neuroimmune Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11481-022-10054-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11481-022-10054-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11481-022-10054-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T14:32:12Z","timestamp":1744209132000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11481-022-10054-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,5]]},"references-count":53,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10054"],"URL":"https:\/\/doi.org\/10.1007\/s11481-022-10054-7","relation":{},"ISSN":["1557-1890","1557-1904"],"issn-type":[{"value":"1557-1890","type":"print"},{"value":"1557-1904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,5]]},"assertion":[{"value":"14 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by experimental Animal Ethics Committee of Anhui Medical University (No. LLSC20160121), and all experiment protocols were approved by the Institutional Animal Care and Use Committee of Anhui Medical University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}