{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:47:35Z","timestamp":1790351255355,"version":"4.1.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Graduate Research Innovation Project Fund of Harbin Medical University","award":["YJSCX2020-41HYD"],"award-info":[{"award-number":["YJSCX2020-41HYD"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroimmune Pharmacol"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1007\/s11481-023-10071-0","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T10:02:10Z","timestamp":1686823330000},"page":"366-382","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effect and Mechanism of Sodium Butyrate on Neuronal Recovery and Prognosis in Diabetic Stroke"],"prefix":"10.1007","volume":"18","author":[{"given":"Ting-ting","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deng-ming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-ting","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-bo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-fei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-nan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-chao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4196-524X","authenticated-orcid":false,"given":"Wen-zhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,15]]},"reference":[{"key":"10071_CR1","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1007\/s12035-018-1184-8","volume":"56","author":"Y Abdul","year":"2019","unstructured":"Abdul Y, Abdelsaid M, Li W, Webb RC, Sullivan JC, Dong G, Ergul A (2019) Inhibition of Toll-Like Receptor-4 (TLR-4) Improves Neurobehavioral Outcomes After Acute Ischemic Stroke in Diabetic Rats: Possible Role of Vascular Endothelial TLR-4. Mol Neurobiol 56:1607\u20131617","journal-title":"Mol Neurobiol"},{"key":"10071_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.678360","volume":"12","author":"J Beisner","year":"2021","unstructured":"Beisner J, Filipe Rosa L, Kaden-Volynets V, Stolzer I, G\u00fcnther C, Bischoff SC (2021) Prebiotic Inulin and Sodium Butyrate Attenuate Obesity-Induced Intestinal Barrier Dysfunction by Induction of Antimicrobial Peptides. Front Immunol 12:678360","journal-title":"Front Immunol"},{"key":"10071_CR3","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/S1474-4422(20)30139-3","volume":"19","author":"GJ Biessels","year":"2020","unstructured":"Biessels GJ, Nobili F, Teunissen CE, Sim\u00f3 R, Scheltens P (2020) Understanding multifactorial brain changes in type 2 diabetes: a biomarker perspective. Lancet Neurol 19:699\u2013710","journal-title":"Lancet Neurol"},{"key":"10071_CR4","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1126\/science.abh1654","volume":"373","author":"JA Bluestone","year":"2021","unstructured":"Bluestone JA, Buckner JH, Herold KC (2021) Immunotherapy: Building a bridge to a cure for type 1 diabetes. Science 373:510\u2013516","journal-title":"Science"},{"key":"10071_CR5","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S1474-4422(19)30356-4","volume":"19","author":"JF Cryan","year":"2020","unstructured":"Cryan JF, O\u2019Riordan KJ, Sandhu K, Peterson V, Dinan TG (2020) The gut microbiome in neurological disorders. Lancet Neurol 19:179\u2013194","journal-title":"Lancet Neurol"},{"key":"10071_CR6","doi-asserted-by":"crossref","unstructured":"Duscha A et al (2020) Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism. Cell 180","DOI":"10.1016\/j.cell.2020.02.035"},{"key":"10071_CR7","doi-asserted-by":"publisher","first-page":"2458","DOI":"10.1007\/s00125-021-05522-3","volume":"64","author":"M Fang","year":"2021","unstructured":"Fang M, Ishigami J, Echouffo-Tcheugui JB, Lutsey PL, Pankow JS, Selvin E (2021) Diabetes and the risk of hospitalisation for infection: the Atherosclerosis Risk in Communities (ARIC) study. Diabetologia 64:2458\u20132465","journal-title":"Diabetologia"},{"key":"10071_CR8","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1093\/jn\/nxy324","volume":"149","author":"W Fang","year":"2019","unstructured":"Fang W, Xue H, Chen X, Chen K, Ling W (2019) Supplementation with Sodium Butyrate Modulates the Composition of the Gut Microbiota and Ameliorates High-Fat Diet-Induced Obesity in Mice. J Nutr 149:747\u2013754","journal-title":"J Nutr"},{"key":"10071_CR9","doi-asserted-by":"crossref","unstructured":"Feigin VL, Stark BA, Johnson CO, Roth GA, Bisignano C, Abady GG, Abbasifard M, Abbasi-Kangevari M, Abd-Allah F, Abedi V, Abualhasan A\u00a0(2021) Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol 20:795-820","DOI":"10.1016\/S1474-4422(21)00252-0"},{"key":"10071_CR10","doi-asserted-by":"crossref","unstructured":"Gale EA, Gillespie KM (2001) Diabetes and gender. Diabetologia 44","DOI":"10.1007\/s001250051573"},{"key":"10071_CR11","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1038\/s41467-020-15644-8","volume":"11","author":"S Garofalo","year":"2020","unstructured":"Garofalo S, Cocozza G, Porzia A, Inghilleri M, Raspa M, Scavizzi F, Aronica E, Bernardini G, Peng L, Ransohoff RM, Santoni A, Limatola C (2020) Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis. Nat Commun 11:1773","journal-title":"Nat Commun"},{"key":"10071_CR12","doi-asserted-by":"publisher","first-page":"5816","DOI":"10.1038\/s41467-019-13812-z","volume":"10","author":"K Haruwaka","year":"2019","unstructured":"Haruwaka K, Ikegami A, Tachibana Y, Ohno N, Konishi H, Hashimoto A, Matsumoto M, Kato D, Ono R, Kiyama H, Moorhouse AJ, Nabekura J, Wake H (2019) Dual microglia effects on blood brain barrier permeability induced by systemic inflammation. Nat Commun 10:5816","journal-title":"Nat Commun"},{"key":"10071_CR13","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1212\/WNL.57.4.691","volume":"57","author":"H Hassaballa","year":"2001","unstructured":"Hassaballa H, Gorelick PB, West CP, Hansen MD, Adams HP (2001) Ischemic stroke outcome: racial differences in the trial of danaparoid in acute stroke (TOAST). Neurology 57:691\u2013697","journal-title":"Neurology"},{"key":"10071_CR14","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s12974-019-1498-0","volume":"16","author":"P Hong","year":"2019","unstructured":"Hong P, Gu R-N, Li F-X, Xiong X-X, Liang W-B, You Z-J, Zhang H-F (2019) NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes. J Neuroinflamm 16:121","journal-title":"J Neuroinflamm"},{"key":"10071_CR15","doi-asserted-by":"publisher","first-page":"9163521","DOI":"10.1155\/2018\/9163521","volume":"2018","author":"P Hong","year":"2018","unstructured":"Hong P, Li F-X, Gu R-N, Fang Y-Y, Lai L-Y, Wang Y-W, Tao T, Xu S-Y, You Z-J, Zhang H-F (2018) Inhibition of NLRP3 Inflammasome Ameliorates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice. Neural Plast 2018:9163521","journal-title":"Neural Plast"},{"key":"10071_CR16","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/s41586-018-0824-5","volume":"565","author":"M Ito","year":"2019","unstructured":"Ito M, Komai K, Mise-Omata S, Iizuka-Koga M, Noguchi Y, Kondo T, Sakai R, Matsuo K, Nakayama T, Yoshie O, Nakatsukasa H, Chikuma S, Shichita T, Yoshimura A (2019) Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery. Nature 565:246\u2013250","journal-title":"Nature"},{"key":"10071_CR17","doi-asserted-by":"crossref","unstructured":"James SL, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N, Abbastabar H, Abd-Allah F, Abdela J, Abdelalim A, Abdollahpour I\u00a0(2018) Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 392:1789-1858","DOI":"10.1016\/S0140-6736(18)32279-7"},{"key":"10071_CR18","doi-asserted-by":"publisher","first-page":"4260","DOI":"10.2337\/db15-0422","volume":"64","author":"A Kalani","year":"2015","unstructured":"Kalani A, Kamat PK, Tyagi N (2015) Diabetic Stroke Severity: Epigenetic Remodeling and Neuronal, Glial, and Vascular Dysfunction. Diabetes 64:4260\u20134271","journal-title":"Diabetes"},{"key":"10071_CR19","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1182\/blood-2012-04-426734","volume":"121","author":"C Kleinschnitz","year":"2013","unstructured":"Kleinschnitz C et al (2013) Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. Blood 121:679\u2013691","journal-title":"Blood"},{"key":"10071_CR20","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/S2213-8587(20)30113-3","volume":"8","author":"S Kullmann","year":"2020","unstructured":"Kullmann S, Kleinridders A, Small DM, Fritsche A, H\u00e4ring H-U, Preissl H, Heni M (2020) Central nervous pathways of insulin action in the control of metabolism and food intake. Lancet Diabetes Endocrinol 8:524\u2013534","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10071_CR21","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/j.1365-2249.2008.03810.x","volume":"154","author":"JM Lawson","year":"2008","unstructured":"Lawson JM, Tremble J, Dayan C, Beyan H, Leslie RDG, Peakman M, Tree TIM (2008) Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes. Clin Exp Immunol 154:353\u2013359","journal-title":"Clin Exp Immunol"},{"key":"10071_CR22","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.bbi.2020.09.025","volume":"91","author":"D Levard","year":"2021","unstructured":"Levard D, Buendia I, Lanquetin A, Glavan M, Vivien D, Rubio M (2021) Filling the gaps on stroke research: Focus on inflammation and immunity. Brain Behav Immun 91:649\u2013667","journal-title":"Brain Behav Immun"},{"key":"10071_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174664","volume":"914","author":"TT Li","year":"2022","unstructured":"Li TT, Sun T, Wang YZ, Wan Q, Li WZ, Yang WC (2022a) Molecular hydrogen alleviates lung injury after traumatic brain injury: Pyroptosis and apoptosis. Eur J Pharmacol 914:174664","journal-title":"Eur J Pharmacol"},{"key":"10071_CR24","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.4103\/1673-5374.335162","volume":"17","author":"TT Li","year":"2022","unstructured":"Li TT, Wan Q, Zhang X, Xiao Y, Sun LY, Zhang YR, Liu XN, Yang WC (2022b) Stellate ganglion block reduces inflammation and improves neurological function in diabetic rats during ischemic stroke. Neural Regen Res 17:1991\u20131997","journal-title":"Neural Regen Res"},{"key":"10071_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2020.146651","volume":"1730","author":"TT Li","year":"2020","unstructured":"Li TT, Yang WC, Wang YZ, Sun T, Cao HL, Chen JF, Li WZ (2020a) Effects of a high concentration of hydrogen on neurological function after traumatic brain injury in diabetic rats. Brain Res 1730:146651","journal-title":"Brain Res"},{"key":"10071_CR26","doi-asserted-by":"crossref","unstructured":"Li Z, Li M, Shi SX, Yao N, Cheng X, Guo A, Zhu Z, Zhang X, Liu Q (2020b) Brain transforms natural killer cells that exacerbate brain edema after intracerebral hemorrhage. J Exp Med 217","DOI":"10.1084\/jem.20200213"},{"key":"10071_CR27","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1161\/STROKEAHA.119.028428","volume":"51","author":"JW Lo","year":"2020","unstructured":"Lo JW et al (2020) Association of Prediabetes and Type 2 Diabetes With Cognitive Function After Stroke: A STROKOG Collaboration Study. Stroke 51:1640\u20131646","journal-title":"Stroke"},{"key":"10071_CR28","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1038\/ni.3868","volume":"18","author":"T Maj","year":"2017","unstructured":"Maj T, Wang W, Crespo J, Zhang H, Wang W, Wei S, Zhao L, Vatan L, Shao I, Szeliga W, Lyssiotis C, Liu JR, Kryczek I, Zou W (2017) Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor. Nat Immunol 18:1332\u20131341","journal-title":"Nat Immunol"},{"key":"10071_CR29","doi-asserted-by":"crossref","unstructured":"McGinley AM, Sutton CE, Edwards SC, Leane CM, DeCourcey J, Teijeiro A, Hamilton JA, Boon L, Djouder N, Mills KHG (2020) Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1\u03b2-Producing Myeloid Cells that Promote Pathogenic T Cells. Immunity 52","DOI":"10.1016\/j.immuni.2020.01.002"},{"key":"10071_CR30","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/S0140-6736(16)30506-2","volume":"388","author":"MJ O'Donnell","year":"2016","unstructured":"O\u2019Donnell MJ et al (2016) Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study. Lancet 388:761\u2013775","journal-title":"Lancet"},{"key":"10071_CR31","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/s41590-018-0289-6","volume":"20","author":"DL Owen","year":"2019","unstructured":"Owen DL et al (2019) Thymic regulatory T cells arise via two distinct developmental programs. Nat Immunol 20:195\u2013205","journal-title":"Nat Immunol"},{"key":"10071_CR32","doi-asserted-by":"crossref","unstructured":"Proto JD, Doran AC, Gusarova G, Yurdagul A, Sozen E, Subramanian M, Islam MN, Rymond CC, Du J, Hook J, Kuriakose G, Bhattacharya J, Tabas I (2018) Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution. Immunity 49","DOI":"10.1016\/j.immuni.2018.07.015"},{"key":"10071_CR33","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1136\/jnnp-2018-318869","volume":"90","author":"C Rosso","year":"2019","unstructured":"Rosso C, Blanc R, Ly J, Samson Y, Leh\u00e9ricy S, Gory B, Marnat G, Mazighi M, Consoli A, Labreuche J, Saleme S, Costalat V, Bracard S, Desal H, Piotin M, Lapergue B (2019) Impact of infarct location on functional outcome following endovascular therapy for stroke. J Neurol Neurosurg Psychiatry 90:313\u2013319","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10071_CR34","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.jid.2016.11.014","volume":"137","author":"A Schwarz","year":"2017","unstructured":"Schwarz A, Bruhs A, Schwarz T (2017) The Short-Chain Fatty Acid Sodium Butyrate Functions as a Regulator of the Skin Immune System. J Invest Dermatol 137:855\u2013864","journal-title":"J Invest Dermatol"},{"key":"10071_CR35","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1161\/CIRCRESAHA.119.316461","volume":"127","author":"M Sharma","year":"2020","unstructured":"Sharma M, Schlegel MP, Afonso MS, Brown EJ, Rahman K, Weinstock A, Sansbury BE, Corr EM, van Solingen C, Koelwyn GJ, Shanley LC, Beckett L, Peled D, Lafaille JJ, Spite M, Pn Loke, Fisher EA, Moore KJ (2020) Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression. Circ Res 127:335\u2013353","journal-title":"Circ Res"},{"key":"10071_CR36","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1016\/S1474-4422(19)30078-X","volume":"18","author":"K Shi","year":"2019","unstructured":"Shi K, Tian D-C, Li Z-G, Ducruet AF, Lawton MT, Shi F-D (2019) Global brain inflammation in stroke. Lancet Neurol 18:1058\u20131066","journal-title":"Lancet Neurol"},{"key":"10071_CR37","doi-asserted-by":"crossref","unstructured":"Shi L, Sun Z, Su W, Xu F, Xie D, Zhang Q, Dai X, Iyer K, Hitchens TK, Foley LM, Li S, Stolz DB, Chen K, Ding Y, Thomson AW, Leak RK, Chen J, Hu X (2021) Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke. Immunity 54","DOI":"10.1016\/j.immuni.2021.04.022"},{"key":"10071_CR38","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1126\/science.1241165","volume":"341","author":"PM Smith","year":"2013","unstructured":"Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, Bohlooly-y M, Glickman JN, Garrett WS (2013) The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 341:569\u2013573","journal-title":"Science"},{"key":"10071_CR39","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1038\/mp.2017.144","volume":"22","author":"M Song","year":"2017","unstructured":"Song M, Martinowich K, Lee FS (2017) BDNF at the synapse: why location matters. Mol Psychiatry 22:1370\u20131375","journal-title":"Mol Psychiatry"},{"key":"10071_CR40","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/S2213-8587(20)30118-2","volume":"8","author":"V Srikanth","year":"2020","unstructured":"Srikanth V, Sinclair AJ, Hill-Briggs F, Moran C, Biessels GJ (2020) Type 2 diabetes and cognitive dysfunction-towards effective management of both comorbidities. Lancet Diabetes Endocrinol 8:535\u2013545","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10071_CR41","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1111\/jam.14612","volume":"128","author":"W Sun","year":"2020","unstructured":"Sun W, Sun J, Li M, Xu Q, Zhang X, Tang Z, Chen J, Zhen J, Sun Z (2020) The effects of dietary sodium butyrate supplementation on the growth performance, carcass traits and intestinal microbiota of growing-finishing pigs. J Appl Microbiol 128:1613\u20131623","journal-title":"J Appl Microbiol"},{"key":"10071_CR42","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/bph.15693","volume":"179","author":"G Tang","year":"2022","unstructured":"Tang G, Du Y, Guan H, Jia J, Zhu N, Shi Y, Rong S, Yuan W (2022) Butyrate ameliorates skeletal muscle atrophy in diabetic nephropathy by enhancing gut barrier function and FFA2-mediated PI3K\/Akt\/mTOR signals. Br J Pharmacol 179:159\u2013178","journal-title":"Br J Pharmacol"},{"key":"10071_CR43","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s00125-019-05040-3","volume":"63","author":"B Tramunt","year":"2020","unstructured":"Tramunt B, Smati S, Grandgeorge N, Lenfant F, Arnal J-F, Montagner A, Gourdy P (2020) Sex differences in metabolic regulation and diabetes susceptibility. Diabetologia 63:453\u2013461","journal-title":"Diabetologia"},{"key":"10071_CR44","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1177\/0963689718791568","volume":"27","author":"P Venkat","year":"2018","unstructured":"Venkat P, Yan T, Chopp M, Zacharek A, Ning R, Van Slyke P, Dumont D, Landschoot-Ward J, Liang L, Chen J (2018) Angiopoietin-1 Mimetic Peptide Promotes Neuroprotection after Stroke in Type 1 Diabetic Rats. Cell Transplant 27:1744\u20131752","journal-title":"Cell Transplant"},{"key":"10071_CR45","doi-asserted-by":"publisher","DOI":"10.1128\/Spectrum.00042-21","volume":"9","author":"H Wang","year":"2021","unstructured":"Wang H, Song W, Wu Q, Gao X, Li J, Tan C, Zhou H, Zhu J, He Y, Yin J (2021) Fecal Transplantation from db\/db Mice Treated with Sodium Butyrate Attenuates Ischemic Stroke Injury. Microbiol Spectr 9:e0004221","journal-title":"Microbiol Spectr"},{"key":"10071_CR46","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1161\/CIRCULATIONAHA.116.025250","volume":"135","author":"W Wang","year":"2017","unstructured":"Wang W, Jiang B, Sun H, Ru X, Sun D, Wang L, Wang L, Jiang Y, Li Y, Wang Y, Chen Z, Wu S, Zhang Y, Wang D, Wang Y, Feigin VL (2017) Prevalence, Incidence, and Mortality of Stroke in China: Results from a Nationwide Population-Based Survey of 480 687 Adults. Circulation 135:759\u2013771","journal-title":"Circulation"},{"key":"10071_CR47","doi-asserted-by":"crossref","unstructured":"Yan Y, Ramanan D, Rozenberg M, McGovern K, Rastelli D, Vijaykumar B, Yaghi O, Voisin T, Mosaheb M, Chiu I, Itzkovitz S, Rao M, Mathis D, Benoist C (2021) Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T\u00a0cells in the gut. Immunity 54","DOI":"10.1016\/j.immuni.2021.02.002"},{"key":"10071_CR48","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202050308","volume":"21","author":"J Yang","year":"2020","unstructured":"Yang J et al (2020) The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation. EMBO Rep 21:e50308","journal-title":"EMBO Rep"},{"key":"10071_CR49","doi-asserted-by":"publisher","first-page":"2172","DOI":"10.2337\/db14-1322","volume":"64","author":"A Yu","year":"2015","unstructured":"Yu A, Snowhite I, Vendrame F, Rosenzwajg M, Klatzmann D, Pugliese A, Malek TR (2015) Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes. Diabetes 64:2172\u20132183","journal-title":"Diabetes"},{"key":"10071_CR50","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.2147\/JIR.S350566","volume":"15","author":"H Zhang","year":"2022","unstructured":"Zhang H, Xu J, Wu Q, Fang H, Shao X, Ouyang X, He Z, Deng Y, Chen C (2022) Gut Microbiota Mediates the Susceptibility of Mice to Sepsis-Associated Encephalopathy by Butyric Acid. J Inflamm Res 15:2103\u20132119","journal-title":"J Inflamm Res"},{"key":"10071_CR51","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.brainresbull.2020.04.011","volume":"161","author":"J Zhao","year":"2020","unstructured":"Zhao J, Wang B, Wu X, Yang Z, Huang T, Guo X, Guo D, Liu Z, Song J (2020) TGF\u03b21 alleviates axonal injury by regulating microglia\/macrophages alternative activation in traumatic brain injury. Brain Res Bull 161:21\u201332","journal-title":"Brain Res Bull"},{"key":"10071_CR52","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1177\/0271678X20910533","volume":"41","author":"Z Zhou","year":"2021","unstructured":"Zhou Z, Xu N, Matei N, McBride DW, Ding Y, Liang H, Tang J, Zhang JH (2021) Sodium butyrate attenuated neuronal apoptosis via GPR41\/G\u03b2\u03b3\/PI3K\/Akt pathway after MCAO in rats. J Cereb Blood Flow Metab 41:267\u2013281","journal-title":"J Cereb Blood Flow Metab"}],"container-title":["Journal of Neuroimmune Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11481-023-10071-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11481-023-10071-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11481-023-10071-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T03:17:21Z","timestamp":1697426241000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11481-023-10071-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,15]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10071"],"URL":"https:\/\/doi.org\/10.1007\/s11481-023-10071-0","relation":{},"ISSN":["1557-1890","1557-1904"],"issn-type":[{"value":"1557-1890","type":"print"},{"value":"1557-1904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,15]]},"assertion":[{"value":"27 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The protocol was approved by the Institutional Medical Ethics Committee on September 22, 2020 (Ethics approval No. SYDW2020-018).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.\u00a0","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for\u00a0Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publication\u00a0"}},{"value":"The authors declare no conflicts of interest.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest"}}]}}