{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:51:27Z","timestamp":1786981887568,"version":"build-2736575974"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T00:00:00Z","timestamp":1726876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T00:00:00Z","timestamp":1726876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001198"],"award-info":[{"award-number":["82001198"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101310"],"award-info":[{"award-number":["82101310"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271291 and 82071556"],"award-info":[{"award-number":["82271291 and 82071556"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroimmune Pharmacol"],"DOI":"10.1007\/s11481-024-10150-w","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T02:02:05Z","timestamp":1726884125000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["MFG-E8 Ameliorates Nerve Injury-Induced Neuropathic Pain by Regulating Microglial Polarization and Neuroinflammation via Integrin \u03b23\/SOCS3\/STAT3 Pathway in Mice"],"prefix":"10.1007","volume":"19","author":[{"given":"Longqing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanhe","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiqiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,21]]},"reference":[{"key":"10150_CR1","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.bbi.2021.04.007","volume":"95","author":"KA Ahmad","year":"2021","unstructured":"Ahmad KA, Shoaib RM, Ahsan MZ, Deng MY, Ma L, Apryani E, Li XY, Wang YX (2021) Microglial IL-10 and beta-endorphin expression mediates gabapentinoids antineuropathic pain. Brain Behav Immun 95:344\u2013361","journal-title":"Brain Behav Immun"},{"key":"10150_CR2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s13311-022-01303-x","volume":"20","author":"N Andre-Obadia","year":"2023","unstructured":"Andre-Obadia N, Hodaj H, Hodaj E, Simon E, Delon-Martin C, Garcia-Larrea L (2023) Better Fields or currents? A Head-to-Head comparison of Transcranial magnetic (rTMS) Versus Direct Current Stimulation (tDCS) for Neuropathic Pain. Neurotherapeutics 20:207\u2013219","journal-title":"Neurotherapeutics"},{"key":"10150_CR3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/s12974-023-02904-9","volume":"20","author":"W Bi","year":"2023","unstructured":"Bi W, Bao K, Zhou X, Deng Y, Li X, Zhang J, Lan X, Zhao J, Lu D, Xu Y, Cen Y, Cao R, Xu M, Zhong W, Zhu L (2023) PSMC5 regulates microglial polarization and activation in LPS-induced cognitive deficits and motor impairments by interacting with TLR4. J Neuroinflammation 20:277","journal-title":"J Neuroinflammation"},{"key":"10150_CR4","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.neuron.2018.11.009","volume":"100","author":"G Chen","year":"2018","unstructured":"Chen G, Zhang YQ, Qadri YJ, Serhan CN, Ji RR (2018) Microglia in Pain: detrimental and protective roles in Pathogenesis and Resolution of Pain. Neuron 100:1292\u20131311","journal-title":"Neuron"},{"key":"10150_CR5","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1007\/s12035-023-03656-6","volume":"61","author":"W Chen","year":"2023","unstructured":"Chen W, Gao X, Yang W, Xiao X, Pan X, Li H (2023) Htr2b promotes M1 Microglia polarization and neuroinflammation after spinal cord Injury via Inhibition of Neuregulin-1\/ErbB signaling. Mol Neurobiol 61:1643\u20131654","journal-title":"Mol Neurobiol"},{"key":"10150_CR6","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.neuropharm.2011.09.018","volume":"62","author":"C Cheyuo","year":"2012","unstructured":"Cheyuo C, Jacob A, Wu R, Zhou M, Qi L, Dong W, Ji Y, Chaung WW, Wang H, Nicastro J, Coppa GF, Wang P (2012) Recombinant human MFG-E8 attenuates cerebral ischemic injury: its role in anti-inflammation and anti-apoptosis. Neuropharmacology 62:890\u2013900","journal-title":"Neuropharmacology"},{"key":"10150_CR7","doi-asserted-by":"crossref","first-page":"5754","DOI":"10.1523\/JNEUROSCI.5007-09.2010","volume":"30","author":"E Dominguez","year":"2010","unstructured":"Dominguez E, Mauborgne A, Mallet J, Desclaux M, Pohl M (2010) SOCS3-mediated blockade of JAK\/STAT3 signaling pathway reveals its major contribution to spinal cord neuroinflammation and mechanical allodynia after peripheral nerve injury. J Neurosci 30:5754\u20135766","journal-title":"J Neurosci"},{"key":"10150_CR8","first-page":"199","volume":"19","author":"NT Fiore","year":"2023","unstructured":"Fiore NT, Debs SR, Hayes JP, Duffy SS, Moalem-Taylor G (2023) Pain-resolving immune mechanisms in neuropathic pain. Nat Rev Neurol 19:199\u2013220","journal-title":"Nat Rev Neurol"},{"key":"10150_CR9","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/s41419-018-0939-5","volume":"9","author":"YY Gao","year":"2018","unstructured":"Gao YY, Zhang ZH, Zhuang Z, Lu Y, Wu LY, Ye ZN, Zhang XS, Chen CL, Li W, Hang CH (2018) Recombinant milk fat globule-EGF factor-8 reduces apoptosis via integrin beta3\/FAK\/PI3K\/AKT signaling pathway in rats after traumatic brain injury. Cell Death Dis 9:845","journal-title":"Cell Death Dis"},{"key":"10150_CR10","doi-asserted-by":"crossref","first-page":"113532","DOI":"10.1016\/j.expneurol.2020.113532","volume":"336","author":"YY Gao","year":"2021","unstructured":"Gao YY, Tao T, Wu D, Zhuang Z, Lu Y, Wu LY, Liu GJ, Zhou Y, Zhang DD, Wang H, Dai W, Li W, Hang CH (2021) MFG-E8 attenuates inflammation in subarachnoid hemorrhage by driving microglial M2 polarization. Exp Neurol 336:113532","journal-title":"Exp Neurol"},{"key":"10150_CR11","first-page":"461","volume":"165","author":"I Gilron","year":"2024","unstructured":"Gilron I, Robb S, Tu D, Holden RR, Jackson AC, Duggan S, Milev R (2024) Randomized, double-blind, controlled trial of a combination of alpha-lipoic acid and Pregabalin for neuropathic pain: the PAIN-CARE trial. Pain 165:461\u2013469","journal-title":"Pain"},{"key":"10150_CR12","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.celrep.2016.06.018","volume":"16","author":"N Gu","year":"2016","unstructured":"Gu N, Peng J, Murugan M, Wang X, Eyo UB, Sun D, Ren Y, DiCicco-Bloom E, Young W, Dong H, Wu LJ (2016) Spinal microgliosis due to Resident Microglial Proliferation is required for Pain Hypersensitivity after Peripheral nerve Injury. Cell Rep 16:605\u2013614","journal-title":"Cell Rep"},{"key":"10150_CR13","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nn.4189","volume":"19","author":"Z Guan","year":"2015","unstructured":"Guan Z, Kuhn JA, Wang X, Colquitt B, Solorzano C, Vaman S, Guan AK, Evans-Reinsch Z, Braz J, Devor M, Abboud-Werner SL, Lanier LL, Lomvardas S, Basbaum AI (2015) Injured sensory neuron\u2013derived CSF1 induces microglial proliferation and DAP12-dependent pain. Nat Neurosci 19:94\u2013101","journal-title":"Nat Neurosci"},{"key":"10150_CR14","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12964-024-01539-4","volume":"22","author":"J Guo","year":"2024","unstructured":"Guo J, Tang X, Deng P, Hui H, Chen B, An J, Zhang G, Shi K, Wang J, He Y, Hao D, Yang H (2024) Interleukin-4 from curcumin-activated OECs emerges as a central modulator for increasing M2 polarization of microglia\/macrophage in OEC anti-inflammatory activity for functional repair of spinal cord injury. Cell Commun Signal 22:162","journal-title":"Cell Commun Signal"},{"key":"10150_CR15","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00011-022-01550-w","volume":"71","author":"W Huang","year":"2022","unstructured":"Huang W et al (2022) Cavin-1 promotes M2 macrophages\/microglia polarization via SOCS3. Inflamm Res 71:397\u2013407","journal-title":"Inflamm Res"},{"key":"10150_CR16","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/nrn.2018.2","volume":"19","author":"K Inoue","year":"2018","unstructured":"Inoue K, Tsuda M (2018) Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential. Nat Rev Neurosci 19:138\u2013152","journal-title":"Nat Rev Neurosci"},{"key":"10150_CR17","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.tins.2023.05.008","volume":"46","author":"HW Kim","year":"2023","unstructured":"Kim HW, Wang S, Davies AJ, Oh SB (2023) The therapeutic potential of natural killer cells in neuropathic pain. Trends Neurosci 46:617\u2013627","journal-title":"Trends Neurosci"},{"key":"10150_CR18","first-page":"148","volume":"9","author":"E Li","year":"2012","unstructured":"Li E, Noda M, Doi Y, Parajuli B, Kawanokuchi J, Sonobe Y, Takeuchi H, Mizuno T, Suzumura A (2012) The neuroprotective effects of milk fat globule-EGF factor 8 against oligomeric amyloid beta toxicity. J Neuroinflammation 9:148","journal-title":"J Neuroinflammation"},{"key":"10150_CR21","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/s12974-018-1279-1","volume":"15","author":"R Li","year":"2018","unstructured":"Li R, Liu W, Yin J, Chen Y, Guo S, Fan H, Li X, Zhang X, He X, Duan C (2018) TSG-6 attenuates inflammation-induced brain injury via modulation of microglial polarization in SAH rats through the SOCS3\/STAT3 pathway. J Neuroinflammation 15:231","journal-title":"J Neuroinflammation"},{"key":"10150_CR20","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.neuron.2023.04.010","volume":"111","author":"L Li","year":"2023","unstructured":"Li L, Ru Q, Lu Y, Fang X, Chen G, Saifullah AB, Yao C, Tolias KF (2023a) Tiam1 coordinates synaptic structural and functional plasticity underpinning the pathophysiology of neuropathic pain. Neuron 111:2038\u20132050 e2036","journal-title":"Neuron"},{"key":"10150_CR22","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1111\/cns.14211","volume":"29","author":"X Li","year":"2023","unstructured":"Li X, Shi H, Zhang D, Jing B, Chen Z, Zheng Y, Chang S, Gao L, Zhao G (2023b) Paeonol alleviates neuropathic pain by modulating microglial M1 and M2 polarization via the RhoA\/p38MAPK signaling pathway. CNS Neurosci Ther 29:2666\u20132679","journal-title":"CNS Neurosci Ther"},{"key":"10150_CR19","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.4103\/1673-5374.389302","volume":"19","author":"F Li","year":"2024","unstructured":"Li F, Sun X, Sun K, Kong F, Jiang X, Kong Q (2024) Lupenone improves motor dysfunction in spinal cord injury mice through inhibiting the inflammasome activation and pyroptosis in microglia via the nuclear factor kappa B pathway. Neural Regeneration Res 19:1802\u20131811","journal-title":"Neural Regeneration Res"},{"key":"10150_CR23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12974-020-1726-7","volume":"17","author":"W Liu","year":"2020","unstructured":"Liu W, Rong Y, Wang J, Zhou Z, Ge X, Ji C, Jiang D, Gong F, Li L, Chen J, Zhao S, Kong F, Gu C, Fan J, Cai W (2020) Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1\/M2 polarization. J Neuroinflammation 17:47","journal-title":"J Neuroinflammation"},{"key":"10150_CR24","doi-asserted-by":"crossref","first-page":"102160","DOI":"10.1016\/j.arr.2023.102160","volume":"93","author":"Y Long","year":"2024","unstructured":"Long Y, Li XQ, Deng J, Ye QB, Li D, Ma Y, Wu YY, Hu Y, He XF, Wen J, Shi A, Yu S, Shen L, Ye Z, Zheng C, Li N (2024) Modulating the polarization phenotype of microglia - a valuable strategy for central nervous system diseases. Ageing Res Rev 93:102160","journal-title":"Ageing Res Rev"},{"key":"10150_CR25","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbi.2022.09.017","volume":"107","author":"C Qian","year":"2023","unstructured":"Qian C, Fan Y, Zong L, Miao C, Ji LL, Wan L, Jia R, Qin X, Wang Y, Wu Q, Tao XY, Hao L, Hu L, Liu WT (2023) Opening K(ATP) channels induces inflammatory tolerance and prevents chronic pain. Brain Behav Immun 107:76\u201386","journal-title":"Brain Behav Immun"},{"key":"10150_CR26","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41419-023-05607-4","volume":"14","author":"J Ren","year":"2023","unstructured":"Ren J, Zhu B, Gu G, Zhang W, Li J, Wang H, Wang M, Song X, Wei Z, Feng S (2023) Schwann cell-derived exosomes containing MFG-E8 modify macrophage\/microglial polarization for attenuating inflammation via the SOCS3\/STAT3 pathway after spinal cord injury. Cell Death Dis 14:70","journal-title":"Cell Death Dis"},{"key":"10150_CR27","doi-asserted-by":"crossref","first-page":"7777","DOI":"10.1007\/s12035-016-0255-y","volume":"54","author":"X Shi","year":"2017","unstructured":"Shi X, Cai X, Di W, Li J, Xu X, Zhang A, Qi W, Zhou Z, Fang Y (2017) MFG-E8 selectively inhibited Abeta-Induced Microglial M1 polarization via NF-kappaB and PI3K-Akt pathways. Mol Neurobiol 54:7777\u20137788","journal-title":"Mol Neurobiol"},{"key":"10150_CR28","doi-asserted-by":"crossref","unstructured":"Sun M, Sun Y, Ma J, Li K (2021) YY1 promotes SOCS3 expression to inhibit STAT3\u2013mediated neuroinflammation and neuropathic pain. Mol Med Rep 23","DOI":"10.3892\/mmr.2020.11742"},{"key":"10150_CR29","doi-asserted-by":"crossref","first-page":"108546","DOI":"10.1016\/j.pharmthera.2023.108546","volume":"251","author":"M Thouaye","year":"2023","unstructured":"Thouaye M, Yalcin I (2023) Neuropathic pain: from actual pharmacological treatments to new therapeutic horizons. Pharmacol Ther 251:108546","journal-title":"Pharmacol Ther"},{"key":"10150_CR30","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.tins.2023.05.001","volume":"46","author":"M Tsuda","year":"2023","unstructured":"Tsuda M, Masuda T, Kohno K (2023) Microglial diversity in neuropathic pain. Trends Neurosci 46:597\u2013610","journal-title":"Trends Neurosci"},{"key":"10150_CR31","doi-asserted-by":"crossref","first-page":"eade7002","DOI":"10.1126\/sciadv.ade7002","volume":"9","author":"S Tsujikawa","year":"2023","unstructured":"Tsujikawa S, DeMeulenaere KE, Centeno MV, Ghazisaeidi S, Martin ME, Tapies MR, Maneshi MM, Yamashita M, Stauderman KA, Apkarian AV, Salter MW, Prakriya M (2023) Regulation of neuropathic pain by microglial Orai1 channels. Sci Adv 9:eade7002","journal-title":"Sci Adv"},{"key":"10150_CR32","doi-asserted-by":"crossref","unstructured":"Wan L, Jia R-M, Ji L-L, Qin X-M, Hu L, Hu F, Han Y, Pan Y-B, Jiang C-Y, Liu W-T (2022) AMPK-autophagy-mediated inhibition of microRNA-30a-5p alleviates morphine tolerance via SOCS3-dependent neuroinflammation suppression. J Neuroinflamm 19","DOI":"10.1186\/s12974-022-02384-3"},{"key":"10150_CR33","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12974-020-01754-z","volume":"17","author":"L Wang","year":"2020","unstructured":"Wang L, Yin C, Liu T, Abdul M, Zhou Y, Cao JL, Lu C (2020) Pellino1 regulates neuropathic pain as well as microglial activation through the regulation of MAPK\/NF-kappaB signaling in the spinal cord. J Neuroinflammation 17:83","journal-title":"J Neuroinflammation"},{"key":"10150_CR35","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4196\/kjpp.2023.27.1.39","volume":"27","author":"Q Wang","year":"2023","unstructured":"Wang Q, Zhang Y, Du Q, Zhao X, Wang W, Zhai Q, Xiang M (2023) SKF96365 impedes spinal glutamatergic transmission-mediated neuropathic allodynia. Korean J Physiol Pharmacol 27:39\u201348","journal-title":"Korean J Physiol Pharmacol"},{"key":"10150_CR34","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11064-023-04025-4","volume":"49","author":"MJ Wang","year":"2024","unstructured":"Wang MJ, Jing XY, Wang YZ, Yang BR, Lu Q, Hu H, Kang L (2024) Exercise, spinal Microglia and Neuropathic Pain: potential molecular mechanisms. Neurochem Res 49:29\u201337","journal-title":"Neurochem Res"},{"key":"10150_CR36","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12974-020-02041-7","volume":"18","author":"H Wu","year":"2021","unstructured":"Wu H, Zheng J, Xu S, Fang Y, Wu Y, Zeng J, Shao A, Shi L, Lu J, Mei S, Wang X, Guo X, Wang Y, Zhao Z, Zhang J (2021) Mer regulates microglial\/macrophage M1\/M2 polarization and alleviates neuroinflammation following traumatic brain injury. J Neuroinflammation 18:2","journal-title":"J Neuroinflammation"},{"key":"10150_CR38","doi-asserted-by":"crossref","unstructured":"Wu W, Zhang X, Wang S, Li T, Hao Q, Li S, Yao W, Sun R (2022) Pharmacological inhibition of the cGAS-STING signaling pathway suppresses microglial M1-polarization in the spinal cord and attenuates neuropathic pain. Neuropharmacology 217.","DOI":"10.1016\/j.neuropharm.2022.109206"},{"key":"10150_CR37","doi-asserted-by":"crossref","first-page":"110764","DOI":"10.1016\/j.intimp.2023.110764","volume":"123","author":"Q Wu","year":"2023","unstructured":"Wu Q, Zheng Y, Yu J, Ying X, Gu X, Tan Q, Tu W, Lou X, Yang G, Li M, Jiang S (2023) Electroacupuncture alleviates neuropathic pain caused by SNL by promoting M2 microglia polarization through PD-L1. Int Immunopharmacol 123:110764","journal-title":"Int Immunopharmacol"},{"key":"10150_CR39","doi-asserted-by":"crossref","first-page":"109120","DOI":"10.1016\/j.intimp.2022.109120","volume":"111","author":"M Xia","year":"2022","unstructured":"Xia M, Zhang Y, Wu H, Zhang Q, Liu Q, Li G, Zhao T, Liu X, Zheng S, Qian Z, Li H (2022a) Forsythoside B attenuates neuro-inflammation and neuronal apoptosis by inhibition of NF-kappaB and p38-MAPK signaling pathways through activating Nrf2 post spinal cord injury. Int Immunopharmacol 111:109120","journal-title":"Int Immunopharmacol"},{"key":"10150_CR40","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13578-022-00816-4","volume":"12","author":"M Xia","year":"2022","unstructured":"Xia M, Li X, Ye S, Zhang Q, Zhao T, Li R, Zhang Y, Xian M, Li T, Li H, Hong X, Zheng S, Qian Z, Yang L (2022b) FANCC deficiency mediates microglial pyroptosis and secondary neuronal apoptosis in spinal cord contusion. Cell Biosci 12:82","journal-title":"Cell Biosci"},{"key":"10150_CR42","doi-asserted-by":"crossref","unstructured":"Yang H, Wu L, Deng H, Chen Y, Zhou H, Liu M, Wang S, Zheng L, Zhu L, Lv X (2020) Anti-inflammatory protein TSG-6 secreted by bone marrow mesenchymal stem cells attenuates neuropathic pain by inhibiting the TLR2\/MyD88\/NF-\u03baB signaling pathway in spinal microglia. J Neuroinflamm 17","DOI":"10.1186\/s12974-020-1731-x"},{"key":"10150_CR41","doi-asserted-by":"crossref","first-page":"856","DOI":"10.4103\/1673-5374.347739","volume":"18","author":"GC Yang","year":"2023","unstructured":"Yang GC, Shi Y, Fan CN, Li Y, Yuan MQ, Pei J, Wu Y, Wu HT (2023) Spliceosomal GTPase Eftud2 regulates microglial activation and polarization. Neural Regen Res 18:856\u2013862","journal-title":"Neural Regen Res"},{"key":"10150_CR43","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/nri2093","volume":"7","author":"A Yoshimura","year":"2007","unstructured":"Yoshimura A, Naka T, Kubo M (2007) SOCS proteins, cytokine signalling and immune regulation. Nat Rev Immunol 7:454\u2013465","journal-title":"Nat Rev Immunol"},{"key":"10150_CR44","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s10571-020-00878-3","volume":"41","author":"L Zhang","year":"2021","unstructured":"Zhang L, Lu X, Gong L, Cui L, Zhang H, Zhao W, Jiang P, Hou G, Hou Y (2021a) Tetramethylpyrazine protects blood-spinal cord Barrier Integrity by modulating Microglia polarization through activation of STAT3\/SOCS3 and inhibition of NF-small ka, CyrillicB Signaling pathways in Experimental Autoimmune Encephalomyelitis mice. Cell Mol Neurobiol 41:717\u2013731","journal-title":"Cell Mol Neurobiol"},{"key":"10150_CR49","doi-asserted-by":"crossref","first-page":"107463","DOI":"10.1016\/j.nlm.2021.107463","volume":"182","author":"LQ Zhang","year":"2021","unstructured":"Zhang LQ, Zhang W, Li T, Yang T, Yuan X, Zhou Y, Zou Q, Yang H, Gao F, Tian Y, Mei W, Tian XB (2021b) GLP-1R activation ameliorated novel-object recognition memory dysfunction via regulating hippocampal AMPK\/NF-kappaB pathway in neuropathic pain mice. Neurobiol Learn Mem 182:107463","journal-title":"Neurobiol Learn Mem"},{"key":"10150_CR47","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12974-022-02495-x","volume":"19","author":"LQ Zhang","year":"2022","unstructured":"Zhang LQ, Gao SJ, Sun J, Li DY, Wu JY, Song FH, Liu DQ, Zhou YQ, Mei W (2022a) DKK3 ameliorates neuropathic pain via inhibiting ASK-1\/JNK\/p-38-mediated microglia polarization and neuroinflammation. J Neuroinflammation 19:129","journal-title":"J Neuroinflammation"},{"key":"10150_CR48","doi-asserted-by":"crossref","first-page":"834570","DOI":"10.3389\/fphar.2022.834570","volume":"13","author":"LQ Zhang","year":"2022","unstructured":"Zhang LQ, Zhou YQ, Li JY, Sun J, Zhang S, Wu JY, Gao SJ, Tian XB, Mei W (2022b) 5-HT(1F) receptor agonist ameliorates mechanical Allodynia in Neuropathic Pain via induction of mitochondrial Biogenesis and suppression of Neuroinflammation. Front Pharmacol 13:834570","journal-title":"Front Pharmacol"},{"key":"10150_CR45","doi-asserted-by":"crossref","unstructured":"Zhang L, Liu L, Li D, Wu J, Gao S, Song F, Zhou Y, Liu D, Mei W (2024a) Heat shock protein 22 attenuates nerve Injury-induced Neuropathic Pain Via improving mitochondrial Biogenesis and reducing oxidative stress mediated by spinal AMPK\/PGC-1\u03b1 pathway in male rats. J Neuroimmune Pharmacol 19","DOI":"10.1007\/s11481-024-10100-6"},{"key":"10150_CR46","doi-asserted-by":"crossref","first-page":"687","DOI":"10.4103\/1673-5374.380905","volume":"19","author":"L Zhang","year":"2024","unstructured":"Zhang L, Tan X, Song F, Li D, Wu J, Gao S, Sun J, Liu D, Zhou Y, Mei W (2024b) Activation of G-protein-coupled receptor 39 reduces neuropathic pain in a rat model. Neural Regen Res 19:687\u2013696","journal-title":"Neural Regen Res"},{"key":"10150_CR50","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s10571-019-00703-6","volume":"39","author":"Y Zheng","year":"2019","unstructured":"Zheng Y, Hou X, Yang S (2019) Lidocaine Potentiates SOCS3 to attenuate inflammation in Microglia and suppress Neuropathic Pain. Cell Mol Neurobiol 39:1081\u20131092","journal-title":"Cell Mol Neurobiol"}],"updated-by":[{"DOI":"10.1007\/s11481-024-10166-2","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000}}],"container-title":["Journal of Neuroimmune Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11481-024-10150-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11481-024-10150-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11481-024-10150-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T14:44:00Z","timestamp":1736865840000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11481-024-10150-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,21]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["10150"],"URL":"https:\/\/doi.org\/10.1007\/s11481-024-10150-w","relation":{},"ISSN":["1557-1904"],"issn-type":[{"value":"1557-1904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,21]]},"assertion":[{"value":"29 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised: In this article Danyang Li and Jiayi Wu were incorrectly denoted as the corresponding authors.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2024","order":7,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":8,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":9,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s11481-024-10166-2","URL":"https:\/\/doi.org\/10.1007\/s11481-024-10166-2","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experiments were approved by the Experimental Animal Care and Use Committee of Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology. All experiments were conducted in accordance with the National Institutes of Health Guidelines for the Care and Use of Laboratory Animals, and the ARRIVE Guidelines for Reporting Animal Research.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"49"}}