{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:25:38Z","timestamp":1793319938878,"version":"4.5.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroimmune Pharmacol"],"DOI":"10.1007\/s11481-024-10156-4","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T09:54:45Z","timestamp":1730109285000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Vitamin K2 Ameliorates Diabetes-Associated Cognitive Decline by Reducing Oxidative Stress and Neuroinflammation"],"prefix":"10.1007","volume":"19","author":[{"given":"Kaberi","family":"Chatterjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anubroto","family":"Pal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dibya Sundar","family":"Padhy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajdeep","family":"Saha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrita","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Bharadwaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biswatrish","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Papiya Mitra","family":"Mazumder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sugato","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"10156_CR151","doi-asserted-by":"crossref","unstructured":"Abbas N, Bednar I, Mix E, Marie S, Paterson D, Ljungberg A, Morris C, Winblad B, Nordberg A, Zhu J (2022) Upregulation of the inflammatory cytokines IFN-\u0393 and IL-12 and down-regulation of IL-4 in cerebral cortex regions of APPSWE transgenic mice. J Neuroimmunol. 126(1\u20132):50\u201357","DOI":"10.1016\/S0165-5728(02)00050-4"},{"key":"10156_CR1","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s10787-019-00681-7","volume":"28","author":"A Akhtar","year":"2020","unstructured":"Akhtar A, Dhaliwal J, Saroj P, Uniyal A, Bishnoi M, Sah SP (2020) Chromium picolinate attenuates cognitive deficit in ICV-STZ rat paradigm of sporadic Alzheimer\u2019s-like dementia via targeting neuroinflammatory and IRS-1\/PI3K\/AKT\/GSK-3\u03b2 pathway. Inflammopharmacology 28:385\u2013400","journal-title":"Inflammopharmacology"},{"key":"10156_CR2","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s10339-011-0430-z","volume":"13","author":"M Antunes","year":"2012","unstructured":"Antunes M, Biala G (2012) The novel object recognition memory: Neurobiology, test procedure, and its modifications. Cogn Process 13:93\u2013110","journal-title":"Cogn Process"},{"issue":"3","key":"10156_CR5","doi-asserted-by":"publisher","first-page":"245","DOI":"10.21307\/ane-2020-022","volume":"80","author":"H Caliskan","year":"2020","unstructured":"Caliskan H, Akat F, Omercioglu G, Bastug G, Ficicilar H, Bastug M (2020) Aerobic exercise has an anxiolytic effect on streptozotocininduced diabetic rats. Acta Neurobiol Exp (Wars) 80(3):245\u2013255","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"10156_CR3","first-page":"1","volume":"1","author":"K Chatterjee","year":"2023","unstructured":"Chatterjee K, Mazumder PM, Banerjee S (2023a) Vitamin K2 protects against aluminium chloride-mediated neurodegeneration. Inflammopharmacology 1:1\u201310","journal-title":"Inflammopharmacology"},{"key":"10156_CR4","doi-asserted-by":"crossref","unstructured":"Chatterjee K, Mazumder PM, Sarkar SR, Saha R, Chatterjee A, Sarkar B, Banerjee S (2023b) Neuroprotective effect of vitamin K2 against gut dysbiosis associated cognitive decline. Physiol Behav 269:114252","DOI":"10.1016\/j.physbeh.2023.114252"},{"key":"10156_CR6","doi-asserted-by":"publisher","first-page":"3331","DOI":"10.1007\/s11064-022-03684-z","volume":"47","author":"B Dan\u0131\u015fman","year":"2022","unstructured":"Dan\u0131\u015fman B, Ak\u00e7ay G, G\u00f6k\u00e7ek-Sara\u00e7 \u00c7, Kantar D, Aslan M, Derin N (2022) The role of Acetylcholine on the effects of different doses of Sulfite in Learning and Memory. Neurochem Res 47:3331\u20133343","journal-title":"Neurochem Res"},{"key":"10156_CR7","first-page":"815","volume":"501 50","author":"E Emekli-Alturfan","year":"2022","unstructured":"Emekli-Alturfan E, Alturfan AA (2022) The emerging relationship between vitamin K and neurodegenerative diseases: a review of current evidence. Mol Biol Rep 501 50:815\u2013828","journal-title":"Mol Biol Rep"},{"key":"10156_CR8","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.bbr.2009.12.036","volume":"215","author":"A Ennaceur","year":"2010","unstructured":"Ennaceur A (2010) One-trial object recognition in rats and mice: methodological and theoretical issues. Behav Brain Res 215:244\u2013254","journal-title":"Behav Brain Res"},{"issue":"3","key":"10156_CR9","doi-asserted-by":"publisher","first-page":"e0229769","DOI":"10.1371\/journal.pone.0229769","volume":"15","author":"B Farhadi Moghadam","year":"2020","unstructured":"Farhadi Moghadam B, Fereidoni M (2020) Neuroprotective effect of menaquinone-4 (MK-4) on transient global cerebral ischemia\/reperfusion injury in rat. PLoS ONE 15(3):e0229769","journal-title":"PLoS ONE"},{"key":"10156_CR153","doi-asserted-by":"crossref","unstructured":"Gareau MG, Wine E, Rodrigues DM, Cho JH, Whary MT, Philpott DJ, MacQueen G, Sherman PM (2011) Bacterial infection causes stress-induced memory dysfunction in mice. Gut 60(3):307\u2013317","DOI":"10.1136\/gut.2009.202515"},{"issue":"1","key":"10156_CR10","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.biopha.2018.07.157","volume":"107","author":"B Giri","year":"2018","unstructured":"Giri B, Dey S, Das T, Sarkar M, Banerjee J, Dash SK (2018) Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: an update on glucose toxicity. Biomed Pharmacother 107(1):306\u2013328","journal-title":"Biomed Pharmacother"},{"key":"10156_CR11","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1080\/1028415X.2018.1504428","volume":"23","author":"E Hadipour","year":"2018","unstructured":"Hadipour E, Tayarani-Najaran Z, Fereidoni M (2018) Vitamin K2 protects PC12 cells against A\u03b2 (1\u201342) and H2O2-induced apoptosis via p38 MAP kinase pathway. Nutr Neurosci 23:343\u2013352","journal-title":"Nutr Neurosci"},{"key":"10156_CR152","doi-asserted-by":"crossref","unstructured":"Heijtz RD, Wang S, Anuar F, Qian Y, Bj\u00f6rkholm B, Samuelsson A, Hibberd ML, Forssberg H, Pettersson S (2011) Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci 108(7):3047\u20133052","DOI":"10.1073\/pnas.1010529108"},{"issue":"3","key":"10156_CR12","doi-asserted-by":"publisher","first-page":"423","DOI":"10.3390\/biom11030423","volume":"11","author":"SH Huang","year":"2021","unstructured":"Huang SH, Fang ST, Chen YC (2021) Molecular mechanism of vitamin K2 protection against amyloid-\u03b2-induced cytotoxicity. Biomolecules 11(3):423","journal-title":"Biomolecules"},{"key":"10156_CR13","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.nut.2017.09.016","volume":"47","author":"AG Hussein","year":"2018","unstructured":"Hussein AG, Mohamed RH, Shalaby SM, Abd El Motteleb DM (2018) Vitamin K2 alleviates type 2 diabetes in rats by induction of osteocalcin gene expression. Nutrition 47:33\u201338","journal-title":"Nutrition"},{"key":"10156_CR14","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1007\/s00223-010-9441-5","volume":"88","author":"J Iwamoto","year":"2011","unstructured":"Iwamoto J, Seki A, Sato Y, Matsumoto H, Takeda T, Yeh JK (2011) Vitamin K 2 prevents hyperglycemia and cancellous osteopenia in rats with streptozotocin-induced type 1 diabetes. Calcif Tissue Int 88:162\u2013168","journal-title":"Calcif Tissue Int"},{"issue":"7","key":"10156_CR15","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.4239\/wjd.v12.i7.1102","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin S, Chang XC, Wen J, Yang J, Ao N, Zhang KY, Suo LN, Du J (2021) Decarboxylated osteocalcin, a possible drug for type 2 diabetes, triggers glucose uptake in MG63 cells. World J Diabetes 12(7):1102","journal-title":"World J Diabetes"},{"key":"10156_CR16","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1111\/j.1476-5381.2012.01911.x","volume":"166","author":"AJ King","year":"2012","unstructured":"King AJ (2012) The use of animal models in diabetes research. Br J Pharmacol 166:877\u2013894","journal-title":"Br J Pharmacol"},{"key":"10156_CR17","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1210\/er.2007-0034","volume":"29","author":"CT Kodl","year":"2008","unstructured":"Kodl CT, Seaquist ER (2008) Cognitive dysfunction and diabetes Mellitus. Endocr Rev 29:494\u2013511","journal-title":"Endocr Rev"},{"issue":"22","key":"10156_CR18","first-page":"1088","volume":"22","author":"M Komada","year":"2008","unstructured":"Komada M, Takao K, Miyakawa T (2008) Elevated plus maze for mice. J Vis Exp 22(22):1088","journal-title":"J Vis Exp"},{"key":"10156_CR19","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.diabres.2017.11.020","volume":"136","author":"Y Li","year":"2018","unstructured":"Li Y, Chen J, Peng Duan L, Li S (2018) Effect of vitamin K2 on type 2 diabetes mellitus: a review. Diabetes Res Clin Pract 136:39\u201351","journal-title":"Diabetes Res Clin Pract"},{"key":"10156_CR20","doi-asserted-by":"publisher","first-page":"515","DOI":"10.3892\/mmr.2013.1843","volume":"9","author":"S Li Yawen, Xu","year":"2014","unstructured":"Li Yawen, Xu S, Zhang Q, Li L, Lai L, Zheng T, Su J, Yang N, Li Y (2014) Cytotoxicity study on SH-SY5Y cells cultured at high glucose levels and treated with bupivacaine. Mol Med Rep 9:515\u2013520","journal-title":"Mol Med Rep"},{"key":"10156_CR21","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1113\/jphysiol.2007.135871","volume":"583","author":"P Newsholme","year":"2007","unstructured":"Newsholme P, Haber EP, Hirabara SM, Rebelato ELO, Procopio J, Morgan D, Oliveira-Emilio HC, Carpinelli AR, Curi R (2007) Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity. J Physiol 583:9\u201324","journal-title":"J Physiol"},{"key":"10156_CR22","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1002\/ptr.6853","volume":"35","author":"EL Peter","year":"2021","unstructured":"Peter EL, Nagendrappa PB, Kaligirwa A, Ogwang PE, Sesaazi CD (2021) The safety and efficacy of Momordica charantia L. in animal models of type 2 diabetes mellitus: a systematic review and meta-analysis. Phyther Res 35:637\u2013656","journal-title":"Phyther Res"},{"issue":"6","key":"10156_CR23","doi-asserted-by":"publisher","first-page":"983","DOI":"10.3390\/antiox10060983","volume":"10","author":"S Shandilya","year":"2021","unstructured":"Shandilya S, Kesari KK, Ruokolainen J (2021) Vitamin K2 modulates organelle damage and tauopathy induced by streptozotocin and menadione in SH-SY5Y cells. Antioxidants 10(6):983","journal-title":"Antioxidants"},{"key":"10156_CR24","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.phrs.2005.05.004","volume":"52","author":"K Srinivasan","year":"2005","unstructured":"Srinivasan K, Viswanad B, Asrat L, Kaul CL, Ramarao P (2005) Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening. Pharmacol Res 52:313\u2013320","journal-title":"Pharmacol Res"},{"key":"10156_CR25","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/S0006-2952(97)00254-2","volume":"54","author":"LM Vervoort","year":"1997","unstructured":"Vervoort LM, Ronden JE, Thijssen HHW (1997) The potent antioxidant activity of the vitamin K cycle in microsomal lipid peroxidation. Biochem Pharmacol 54:871\u2013876","journal-title":"Biochem Pharmacol"},{"key":"10156_CR27","doi-asserted-by":"crossref","unstructured":"Wang T, Hu X, Liang S, Li W, Wu X, Wang L, Jin F (2015) Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats. 6(5):707\u2013717","DOI":"10.3920\/BM2014.0177"},{"key":"10156_CR26","first-page":"1040","volume":"19","author":"F Wang","year":"2019","unstructured":"Wang F, Shang Y, Zhang R, Gao X, Zeng Q (2019) A SIRT1 agonist reduces cognitive decline in type 2 diabetic rats through antioxidative and anti-inflammatory mechanisms. Mol Med Rep 19:1040\u20131048","journal-title":"Mol Med Rep"},{"issue":"1","key":"10156_CR28","doi-asserted-by":"publisher","first-page":"3940","DOI":"10.1038\/s41598-023-28163-5","volume":"13","author":"J Wu","year":"2023","unstructured":"Wu J, Fang Y, Tan X, Kang S, Yue X, Rao Y, Huang H, Liu M, Qiu S, Yap PT (2023) Detecting type 2 diabetes mellitus cognitive impairment using whole-brain functional connectivity. Sci Rep 13(1):3940","journal-title":"Sci Rep"},{"key":"10156_CR29","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1007\/s00592-020-01648-9","volume":"58","author":"Y You","year":"2021","unstructured":"You Y, Liu Z, Chen Y, Xu Y, Qin J, Guo S, Huang J, Tao J (2021) The prevalence of mild cognitive impairment in type 2 diabetes mellitus patients: a systematic review and meta-analysis. Acta Diabetol 58:671\u2013685","journal-title":"Acta Diabetol"},{"issue":"4","key":"10156_CR31","doi-asserted-by":"publisher","first-page":"597","DOI":"10.3390\/biom12040597","volume":"12","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Chu JM, Wong GT (2022a) Cerebral glutamate regulation and receptor changes in perioperative neuroinflammation and cognitive dysfunction. Biomolecules 12(4):597","journal-title":"Biomolecules"},{"key":"10156_CR33","doi-asserted-by":"crossref","unstructured":"Zhang Y, Liu L, Wei C, Wang X, Li R, Xu X, Zhang Y, Geng G, Dang K, Ming Z, Tao X (2023) Vitamin K2 supplementation improves impaired glycemic homeostasis and insulin sensitivity for type 2 diabetes through gut microbiome and fecal metabolites. BMC medicine 5;21(1):174","DOI":"10.1186\/s12916-023-02880-0"},{"key":"10156_CR32","doi-asserted-by":"publisher","first-page":"1004557","DOI":"10.3389\/fnagi.2022.1004557","volume":"14","author":"Y Zhang Yaxuan, Yuan","year":"2022","unstructured":"Zhang Y, Yuan Y, Zhang J, Zhao Y, Zhang Y, Fu J (2022b) Astragaloside IV supplementation attenuates cognitive impairment by inhibiting neuroinflammation and oxidative stress in type 2 diabetic mice. Front Aging Neurosci 14:1004557","journal-title":"Front Aging Neurosci"},{"key":"10156_CR30","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.fct.2017.09.050","volume":"109","author":"B Zhao","year":"2017","unstructured":"Zhao B, Ren B, Guo R, Zhang W, Ma S, Yao Y, Yuan T, Liu Z, Liu X (2017) Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2\/NF-\u03baB transcriptional pathway. Food Chem Toxicol 109:505\u2013516","journal-title":"Food Chem Toxicol"},{"key":"10156_CR34","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.3389\/fphar.2020.01325","volume":"11","author":"X Zhu","year":"2020","unstructured":"Zhu X, Liu H, Liu Y, Chen Y, Liu Y, Yin X (2020) The antidepressant-like effects of Hesperidin in Streptozotocin-Induced Diabetic rats by activating Nrf2\/ARE\/Glyoxalase 1 pathway. Front Pharmacol 11:1325","journal-title":"Front Pharmacol"}],"container-title":["Journal of Neuroimmune Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11481-024-10156-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11481-024-10156-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11481-024-10156-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T19:43:46Z","timestamp":1736883826000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11481-024-10156-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,28]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["10156"],"URL":"https:\/\/doi.org\/10.1007\/s11481-024-10156-4","relation":{},"ISSN":["1557-1904"],"issn-type":[{"value":"1557-1904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,28]]},"assertion":[{"value":"2 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"1972\/PH\/BIT\/110\/20\/IAEC approved in 2022.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Animal Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"56"}}