{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:41:03Z","timestamp":1776750063906,"version":"3.51.2"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroimmune Pharmacol"],"DOI":"10.1007\/s11481-026-10287-w","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T03:48:15Z","timestamp":1776743295000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting Neuroinflammation in the Piriform Cortex-Amygdala: Enhanced Efficacy of Niosome-Based Sodium Butyrate in Ischemic Stroke"],"prefix":"10.1007","volume":"21","author":[{"given":"Nasim","family":"Naseri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Reza","family":"Bigdeli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh Mortazavi","family":"Moghadam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahram","family":"Kazemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"10287_CR1","doi-asserted-by":"publisher","first-page":"149308","DOI":"10.1016\/j.brainres.2024.149308","volume":"1847","author":"W Akhtar","year":"2025","unstructured":"Akhtar W, Khan MM, Kumar S, Ahmad U, Husen A, Avirmed S (2025) Pathophysiology of cerebral ischemia-reperfusion injury: An overview of oxidative stress and plant-based therapeutic approaches. Brain Res 1847:149308","journal-title":"Brain Res"},{"key":"10287_CR2","doi-asserted-by":"publisher","first-page":"100095","DOI":"10.1016\/j.onano.2022.100095","volume":"8","author":"A Al-Jammal","year":"2022","unstructured":"Al-Jammal A, Bigdeli MR, Moghadam FM (2022) pH-sensitive oleuropein-loaded niosome: efficient treatment for metastatic brain tumors in initial steps in-vivo. OpenNano 8:100095","journal-title":"OpenNano"},{"issue":"1","key":"10287_CR3","first-page":"17","volume":"9","author":"HA Awooda","year":"2015","unstructured":"Awooda HA, Lutfi MF, Saeed AM (2015) Oxidative\/nitrosative stress in rats subjected to focal cerebral ischemia\/reperfusion. Int J health Sci 9(1):17","journal-title":"Int J health Sci"},{"issue":"2","key":"10287_CR4","doi-asserted-by":"publisher","first-page":"159","DOI":"10.5853\/jos.2019.02978","volume":"22","author":"MH Balch","year":"2020","unstructured":"Balch MH, Nimjee SM, Rink C, Hannawi Y (2020) Beyond the brain: the systemic pathophysiological response to acute ischemic stroke. J stroke 22(2):159","journal-title":"J stroke"},{"key":"10287_CR5","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.conb.2020.03.001","volume":"64","author":"RM Blazing","year":"2020","unstructured":"Blazing RM, Franks KM (2020) Odor coding in piriform cortex: mechanistic insights into distributed coding. Curr Opin Neurobiol 64:96\u2013102","journal-title":"Curr Opin Neurobiol"},{"issue":"12","key":"10287_CR6","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.3748\/wjg.v17.i12.1519","volume":"17","author":"RB Canani","year":"2011","unstructured":"Canani RB, Di Costanzo M, Leone L, Pedata M, Meli R, Calignano A (2011) Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World J gastroenterology: WJG 17(12):1519","journal-title":"World J gastroenterology: WJG"},{"issue":"4","key":"10287_CR8","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1161\/01.STR.32.4.1005","volume":"32","author":"J Chen","year":"2001","unstructured":"Chen J, Li Y, Wang L, Zhang Z, Lu D, Lu M, Chopp M (2001) Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke 32(4):1005\u20131011","journal-title":"Stroke"},{"issue":"2","key":"10287_CR7","first-page":"166984","volume":"1870","author":"H Chen","year":"2024","unstructured":"Chen H, Qian Y, Jiang C, Tang L, Yu J, Zhang L, Dai Y, Jiang G (2024) Butyrate ameliorated ferroptosis in ulcerative colitis through modulating Nrf2\/GPX4 signal pathway and improving intestinal barrier. Biochim et Biophys Acta (BBA)-Molecular Basis Disease 1870(2):166984","journal-title":"Biochim et Biophys Acta (BBA)-Molecular Basis Disease"},{"issue":"1","key":"10287_CR9","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/1742-2094-5-46","volume":"5","author":"BH Clausen","year":"2008","unstructured":"Clausen BH, Lambertsen KL, Babcock AA, Holm TH, Dagnaes-Hansen F, Finsen B (2008) Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice. J Neuroinflamm 5(1):46","journal-title":"J Neuroinflamm"},{"issue":"3","key":"10287_CR10","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1002\/(SICI)1097-0215(19990505)81:3<411::AID-IJC15>3.0.CO;2-F","volume":"81","author":"D Coradini","year":"1999","unstructured":"Coradini D, Pellizzaro C, Miglierini G, Daidone MG, Perbellini A (1999) Hyaluronic acid as drug delivery for sodium butyrate: Improvement of the anti-proliferative activity on a breast\u2010cancer cell line. Int J Cancer 81(3):411\u2013416","journal-title":"Int J Cancer"},{"issue":"2","key":"10287_CR11","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3390\/pharmaceutics10020057","volume":"10","author":"M Danaei","year":"2018","unstructured":"Danaei M, Dehghankhold M, Ataei S, Hasanzadeh Davarani F, Javanmard R, Dokhani A, Khorasani S, Mozafari yM (2018) Impact of particle size and polydispersity index on the clinical applications of lipidic nanocarrier systems. Pharmaceutics 10(2):57","journal-title":"Pharmaceutics"},{"issue":"9","key":"10287_CR12","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.2174\/1570159X16666180222155833","volume":"16","author":"K Duris","year":"2018","unstructured":"Duris K, Splichal Z, Jurajda M (2018) The role of inflammatory response in stroke associated programmed cell death. Curr Neuropharmacol 16(9):1365\u20131374","journal-title":"Curr Neuropharmacol"},{"issue":"1","key":"10287_CR13","doi-asserted-by":"publisher","first-page":"21746","DOI":"10.1038\/s41598-021-01320-4","volume":"11","author":"BS East","year":"2021","unstructured":"East BS, Fleming G, Vervoordt S, Shah P, Sullivan RM, Wilson DA (2021) Basolateral amygdala to posterior piriform cortex connectivity ensures precision in learned odor threat. Sci Rep 11(1):21746","journal-title":"Sci Rep"},{"key":"10287_CR14","first-page":"212","volume":"23","author":"MS Fadaei","year":"2024","unstructured":"Fadaei MS, Fadaei MR, Kheirieh AE, Rahmanian-Devin P, Dabbaghi MM, Tavallaei KN, Shafaghi A, Hatami H, Rahimi VB, Nokhodchi A (2024) Niosome as a promising tool for increasing the effectiveness of anti-inflammatory compounds. EXCLI J 23:212","journal-title":"EXCLI J"},{"issue":"1","key":"10287_CR15","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3233\/JAD-190120","volume":"74","author":"WB Fernando","year":"2020","unstructured":"Fernando WB, Martins IJ, Morici M, Bharadwaj P, Rainey-Smith SR, Lim WLF, Martins RN (2020) Sodium butyrate reduces brain amyloid-\u03b2 levels and improves cognitive memory performance in an Alzheimer\u2019s disease transgenic mouse model at an early disease stage. J Alzheimer\u2019s Disease 74(1):91\u201399","journal-title":"J Alzheimer\u2019s Disease"},{"key":"10287_CR16","doi-asserted-by":"crossref","unstructured":"Fingerova H, Novotny J, Barborik J, Brezinova J, Svobodova M, Krskova M, Oborna I (2007) Antioxidant capacity of seminal plasma measured by TAS Randox. Biomedical Papers Med Fac Palacky Univ Olomouc, 151(1):37\u201340","DOI":"10.5507\/bp.2007.006"},{"key":"10287_CR17","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.neuropharm.2013.10.031","volume":"79","author":"H Gagliano","year":"2014","unstructured":"Gagliano H, Delgado-Morales R, Sanz-Garcia A, Armario A (2014) High doses of the histone deacetylase inhibitor sodium butyrate trigger a stress-like response. Neuropharmacology 79:75\u201382","journal-title":"Neuropharmacology"},{"issue":"11","key":"10287_CR18","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.6026\/9732063002001588","volume":"20","author":"KAB Ganesh","year":"2024","unstructured":"Ganesh KAB, Panda P, Makwana AH, Gopalakrishna PK, Rani KP, Vishnumukkala T (2024) Unraveling the amygdala: A review of its anatomy and functions. Bioinformation 20(11):1588","journal-title":"Bioinformation"},{"issue":"5","key":"10287_CR19","doi-asserted-by":"publisher","first-page":"542","DOI":"10.3390\/antiox14050542","volume":"14","author":"A Golenia","year":"2025","unstructured":"Golenia A, Olejnik P (2025) The Role of Oxidative Stress in Ischaemic Stroke and the Influence of Gut Microbiota. Antioxidants 14(5):542","journal-title":"Antioxidants"},{"issue":"4","key":"10287_CR20","doi-asserted-by":"publisher","first-page":"e70154","DOI":"10.1111\/ene.70154","volume":"32","author":"J Gruber","year":"2025","unstructured":"Gruber J, Ropele S, Pinter D, Enzinger C, Helbok R, Deutschmann H, Sonnberger M, Kneihsl M, von Oertzen TJ, Gattringer T (2025) Voxel-Based Lesion Symptom Mapping to Predict Poststroke Epilepsy After Mechanical Thrombectomy. Eur J Neurol 32(4):e70154","journal-title":"Eur J Neurol"},{"issue":"1","key":"10287_CR21","doi-asserted-by":"publisher","first-page":"13362","DOI":"10.1038\/s41598-024-64416-7","volume":"14","author":"J Hemmati","year":"2024","unstructured":"Hemmati J, Chiani M, Chegini Z, Seifalian A, Arabestani MR (2024) Surface modified niosomal quercetin with cationic lipid: an appropriate drug delivery system against Pseudomonas aeruginosa Infections. Sci Rep 14(1):13362","journal-title":"Sci Rep"},{"issue":"8","key":"10287_CR22","doi-asserted-by":"publisher","first-page":"4153","DOI":"10.3390\/ijms23084153","volume":"23","author":"AM Hersh","year":"2022","unstructured":"Hersh AM, Alomari S, Tyler BM (2022) Crossing the blood-brain barrier: advances in nanoparticle technology for drug delivery in neuro-oncology. Int J Mol Sci 23(8):4153","journal-title":"Int J Mol Sci"},{"issue":"25","key":"10287_CR24","doi-asserted-by":"publisher","first-page":"3235","DOI":"10.1016\/j.lfs.2003.06.014","volume":"73","author":"M Kaya","year":"2003","unstructured":"Kaya M, Kalayci R, K\u00fc\u00e7\u00fck M, Arican N, Elmas I, Kudat H, Korkut F (2003) Effect of losartan on the blood\u2013brain barrier permeability in diabetic hypertensive rats. Life Sci 73(25):3235\u20133244","journal-title":"Life Sci"},{"issue":"10","key":"10287_CR23","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1055\/s-2004-826018","volume":"36","author":"H Kaya","year":"2004","unstructured":"Kaya H, Sezik M, Ozkaya O, Dittrich R, Siebzehnrubl E, Wildt L (2004) Lipid peroxidation at various estradiol concentrations in human circulation during ovarian stimulation with exogenous gonadotropins. Horm Metab Res 36(10):693\u2013695","journal-title":"Horm Metab Res"},{"issue":"1","key":"10287_CR25","first-page":"150693","volume":"2013","author":"F Khajehnasiri","year":"2013","unstructured":"Khajehnasiri F, Mortazavi SB, Allameh A, Akhondzadeh S, Hashemi H (2013) Total antioxidant capacity and malondialdehyde in depressive rotational shift workers. J Environ public health 2013(1):150693","journal-title":"J Environ public health"},{"issue":"9","key":"10287_CR26","doi-asserted-by":"publisher","first-page":"6754","DOI":"10.1002\/jcp.30337","volume":"236","author":"R Kumar","year":"2021","unstructured":"Kumar R, Jain V, Kushwah N, Dheer A, Mishra KP, Prasad D, Singh SB (2021) HDAC inhibition prevents hypobaric hypoxia-induced spatial memory impairment through P\u03993K\/GSK3\u03b2\/CREB pathway. J Cell Physiol 236(9):6754\u20136771","journal-title":"J Cell Physiol"},{"issue":"20","key":"10287_CR27","doi-asserted-by":"publisher","first-page":"7609","DOI":"10.3390\/ijms21207609","volume":"21","author":"D Kuriakose","year":"2020","unstructured":"Kuriakose D, Xiao Z (2020) Pathophysiology and treatment of stroke: present status and future perspectives. Int J Mol Sci 21(20):7609","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10287_CR28","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1523\/JNEUROSCI.3200-07.2008","volume":"28","author":"B Langley","year":"2008","unstructured":"Langley B, D\u2019Annibale MA, Suh K, Ayoub I, Tolhurst A, Bastan B, Yang L, Ko B, Fisher M, Cho S (2008) Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21waf1\/cip1 in cell cycle-independent neuroprotection. J Neurosci 28(1):163\u2013176","journal-title":"J Neurosci"},{"issue":"2","key":"10287_CR29","doi-asserted-by":"publisher","first-page":"162","DOI":"10.3831\/KPI.2024.27.2.162","volume":"27","author":"HJ Lee","year":"2024","unstructured":"Lee HJ, Shin HK, Kim J-H, Choi BT (2024) Transcriptome analysis of the striatum of electroacupuncture-treated na\u00efve and ischemic stroke mice. J Pharmacopunct 27(2):162","journal-title":"J Pharmacopunct"},{"key":"10287_CR30","doi-asserted-by":"publisher","first-page":"1501359","DOI":"10.3389\/fsurg.2025.1501359","volume":"12","author":"S Levinson","year":"2025","unstructured":"Levinson S, Pulli B, Heit JJ (2025) Neuroinflammation and acute ischemic stroke: impact on translational research and clinical care. Front Surg 12:1501359","journal-title":"Front Surg"},{"issue":"2","key":"10287_CR31","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3390\/pharmaceutics16020223","volume":"16","author":"S Liga","year":"2024","unstructured":"Liga S, Paul C, Moac\u0103 E-A, Peter F (2024) Niosomes: Composition, formulation techniques, and recent progress as delivery systems in cancer therapy. Pharmaceutics 16(2):223","journal-title":"Pharmaceutics"},{"key":"10287_CR32","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.jns.2017.08.3235","volume":"381","author":"J Liu","year":"2017","unstructured":"Liu J, Wang F, Liu S, Du J, Hu X, Xiong J, Fang R, Chen W, Sun J (2017) Sodium butyrate exerts protective effect against Parkinson\u2019s disease in mice via stimulation of glucagon like peptide-1. J Neurol Sci 381:176\u2013181","journal-title":"J Neurol Sci"},{"key":"10287_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12974-020-01946-7","volume":"17","author":"M Liu","year":"2020","unstructured":"Liu M, Xu Z, Wang L, Zhang L, Liu Y, Cao J, Fu Q, Liu Y, Li H, Lou J (2020) Cottonseed oil alleviates ischemic stroke injury by inhibiting the inflammatory activation of microglia and astrocyte. J Neuroinflamm 17:1\u201315","journal-title":"J Neuroinflamm"},{"issue":"1","key":"10287_CR33","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/s43856-025-00939-y","volume":"5","author":"J Liu","year":"2025","unstructured":"Liu J, Xu A, Zhao Z, Ren B, Gao Z, Fang D, Hei B, Sun J, Bao X, Ma L (2025) Epidemiology and future trend predictions of ischemic stroke based on the global burden of disease study 1990\u20132021. Commun Med 5(1):273","journal-title":"Commun Med"},{"key":"10287_CR35","doi-asserted-by":"crossref","unstructured":"Longa EZ, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. stroke, 20(1), 84\u201391","DOI":"10.1161\/01.STR.20.1.84"},{"issue":"5","key":"10287_CR36","doi-asserted-by":"publisher","first-page":"e0125893","DOI":"10.1371\/journal.pone.0125893","volume":"10","author":"L Lorente","year":"2015","unstructured":"Lorente L, Mart\u00edn MM, Abreu-Gonz\u00e1lez P, Ramos L, Argueso M, Sol\u00e9-Viol\u00e1n J, Ria\u00f1o-Ruiz M, Jim\u00e9nez A (2015) Serum malondialdehyde levels in patients with malignant middle cerebral artery infarction are associated with mortality. PLoS ONE 10(5):e0125893","journal-title":"PLoS ONE"},{"issue":"8","key":"10287_CR37","doi-asserted-by":"publisher","first-page":"3136","DOI":"10.1093\/ndt\/gfr807","volume":"27","author":"RA Machado","year":"2012","unstructured":"Machado RA, Constantino LdS, Tomasi CD, Rojas HA, Vuolo FS, Vitto MF, Cesconetto PA, de Souza CT, Ritter C, Dal-Pizzol F (2012) Sodium butyrate decreases the activation of NF-\u03baB reducing inflammation and oxidative damage in the kidney of rats subjected to contrast-induced nephropathy. Nephrol Dialysis Transplantation 27(8):3136\u20133140","journal-title":"Nephrol Dialysis Transplantation"},{"key":"10287_CR38","doi-asserted-by":"publisher","first-page":"147191","DOI":"10.1016\/j.brainres.2020.147191","volume":"1751","author":"H Maejima","year":"2021","unstructured":"Maejima H, Kitahara M, Takamatsu Y, Mani H, Inoue T (2021) Effects of exercise and pharmacological inhibition of histone deacetylases (HDACs) on epigenetic regulations and gene expressions crucial for neuronal plasticity in the motor cortex. Brain Res 1751:147191","journal-title":"Brain Res"},{"issue":"5","key":"10287_CR39","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s00508-015-0742-6","volume":"128","author":"A Milanlioglu","year":"2016","unstructured":"Milanlioglu A, Aslan M, Ozkol H, \u00c7ilingir V, Nuri Ayd\u0131n M, Karadas S (2016) Serum antioxidant enzymes activities and oxidative stress levels in patients with acute ischemic stroke: influence on neurological status and outcome. Wiener klinische Wochenschrift 128(5):169\u2013174","journal-title":"Wiener klinische Wochenschrift"},{"key":"10287_CR40","unstructured":"MILLER A (1985) CLINICAL-PHARMACOLOGY OF SODIUM-BUTYRATE IN PATIENTS WITH ACUTE-LEUKEMIA. BRITISH JOURNAL OF CANCER"},{"issue":"2","key":"10287_CR41","first-page":"639","volume":"5","author":"S Mohammadi","year":"2013","unstructured":"Mohammadi S, Haghir H, Fazel AR, Vafaei A (2013) Analysis of amygdala nucleus in the rat brain: a review study. Electron Physician 5(2):639","journal-title":"Electron Physician"},{"issue":"1","key":"10287_CR42","first-page":"158","volume":"70","author":"DE Paglia","year":"1967","unstructured":"Paglia DE, Valentine WN (1967) Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70(1):158\u2013169","journal-title":"J Lab Clin Med"},{"issue":"1","key":"10287_CR43","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1186\/s12974-016-0765-6","volume":"13","author":"MJ Park","year":"2016","unstructured":"Park MJ, Sohrabji F (2016) The histone deacetylase inhibitor, sodium butyrate, exhibits neuroprotective effects for ischemic stroke in middle-aged female rats. J Neuroinflamm 13(1):300","journal-title":"J Neuroinflamm"},{"issue":"1","key":"10287_CR44","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.1038\/s41598-020-59624-w","volume":"10","author":"X Pei","year":"2020","unstructured":"Pei X, Zhu Z, Gan Z, Chen J, Zhang X, Cheng X, Wan Q, Wang J (2020) PEGylated nano-graphene oxide as a nanocarrier for delivering mixed anticancer drugs to improve anticancer activity. Sci Rep 10(1):2717","journal-title":"Sci Rep"},{"issue":"9","key":"10287_CR45","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1177\/0271678X20943823","volume":"40","author":"N Percie du Sert","year":"2020","unstructured":"Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U (2020) The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. J Cereb Blood Flow Metabolism 40(9):1769\u20131777","journal-title":"J Cereb Blood Flow Metabolism"},{"issue":"9","key":"10287_CR46","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","volume":"29","author":"MW Pfaffl","year":"2001","unstructured":"Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT\u2013PCR. Nucleic Acids Res 29(9):e45\u2013e45","journal-title":"Nucleic Acids Res"},{"key":"10287_CR47","doi-asserted-by":"publisher","first-page":"772286","DOI":"10.3389\/fnsys.2021.772286","volume":"15","author":"CL Samuelsen","year":"2021","unstructured":"Samuelsen CL, Vincis R (2021) Cortical hub for flavor sensation in rodents. Front Syst Neurosci 15:772286","journal-title":"Front Syst Neurosci"},{"issue":"3","key":"10287_CR48","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1002\/jcsm.12400","volume":"10","author":"N Scherbakov","year":"2019","unstructured":"Scherbakov N, Pietrock C, Sandek A, Ebner N, Valentova M, Springer J, Schefold JC, von Haehling S, Anker SD, Norman K (2019) Body weight changes and incidence of cachexia after stroke. J cachexia sarcopenia muscle 10(3):611\u2013620","journal-title":"J cachexia sarcopenia muscle"},{"issue":"5","key":"10287_CR49","doi-asserted-by":"publisher","first-page":"e00387","DOI":"10.1016\/j.neurot.2024.e00387","volume":"21","author":"Z Shen","year":"2024","unstructured":"Shen Z, Lu Y, Ren Y, Wang Z, Deng J, Nan D, Jia J, Yu W, Jin Y, Sun W (2024) The relationship between ischemic penumbra progression and the oxygen content of cortex microcirculation in acute ischemic stroke. Neurotherapeutics 21(5):e00387","journal-title":"Neurotherapeutics"},{"key":"10287_CR50","doi-asserted-by":"publisher","first-page":"109179","DOI":"10.1016\/j.jneumeth.2021.109179","volume":"358","author":"M Shvedova","year":"2021","unstructured":"Shvedova M, Islam MR, Armoundas AA, Anfinogenova ND, Wrann CD, Atochin DN (2021) Modified middle cerebral artery occlusion model provides detailed intraoperative cerebral blood flow registration and improves neurobehavioral evaluation. J Neurosci Methods 358:109179","journal-title":"J Neurosci Methods"},{"issue":"9","key":"10287_CR51","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.3390\/v12091008","volume":"12","author":"M Strycharz-Dudziak","year":"2020","unstructured":"Strycharz-Dudziak M, Fo\u0142tyn S, Dworza\u0144ski J, Kie\u0142czykowska M, Malm M, Drop B, Polz-Dacewicz M (2020) Glutathione peroxidase (GPx) and superoxide dismutase (SOD) in oropharyngeal cancer associated with EBV and HPV coinfection. Viruses 12(9):1008","journal-title":"Viruses"},{"issue":"1","key":"10287_CR52","doi-asserted-by":"publisher","first-page":"2892","DOI":"10.1038\/s41598-023-29894-1","volume":"13","author":"S Sugiyama","year":"2023","unstructured":"Sugiyama S, Sasaki T, Tanaka H, Yan H, Ikegami T, Kanki H, Nishiyama K, Beck G, Gon Y, Okazaki S (2023) The tight junction protein occludin modulates blood\u2013brain barrier integrity and neurological function after ischemic stroke in mice. Sci Rep 13(1):2892","journal-title":"Sci Rep"},{"issue":"1","key":"10287_CR53","first-page":"395895","volume":"2015","author":"J Sun","year":"2015","unstructured":"Sun J, Wang F, Li H, Zhang H, Jin J, Chen W, Pang M, Yu J, He Y, Liu J (2015) Neuroprotective effect of sodium butyrate against cerebral ischemia\/reperfusion injury in mice. Biomed Res Int 2015(1):395895","journal-title":"Biomed Res Int"},{"issue":"21","key":"10287_CR54","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1136\/vr.119.21.519","volume":"119","author":"N Suttle","year":"1986","unstructured":"Suttle N (1986) Copper deficiency in ruminants; recent developments. Vet Rec 119(21):519\u2013522","journal-title":"Vet Rec"},{"issue":"2","key":"10287_CR55","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/jcbfm.1990.47","volume":"10","author":"RA Swanson","year":"1990","unstructured":"Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson C, Sharp FR (1990) A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metabolism 10(2):290\u2013293","journal-title":"J Cereb Blood Flow Metabolism"},{"key":"10287_CR56","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3389\/fneur.2014.00259","volume":"5","author":"DN Vaughan","year":"2014","unstructured":"Vaughan DN, Jackson GD (2014) The piriform cortex and human focal epilepsy. Front Neurol 5:259","journal-title":"Front Neurol"},{"key":"10287_CR57","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3389\/fnana.2014.00167","volume":"8","author":"T-F Yuan","year":"2015","unstructured":"Yuan T-F, Liang Y-X, So K-F (2015) Occurrence of new neurons in the piriform cortex. Front Neuroanat 8:167","journal-title":"Front Neuroanat"},{"issue":"3","key":"10287_CR58","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1177\/0964528420921190","volume":"39","author":"Q Zhang","year":"2021","unstructured":"Zhang Q, Li J, Huang S, Yang M, Liang S, Liu W, Chen L, Tao J (2021) Functional connectivity of the retrosplenial cortex in rats with ischemic stroke is improved by electroacupuncture. Acupunct Med 39(3):200\u2013207","journal-title":"Acupunct Med"},{"key":"10287_CR59","doi-asserted-by":"publisher","first-page":"101665","DOI":"10.1016\/j.mtbio.2025.101665","volume":"32","author":"J Zhao","year":"2025","unstructured":"Zhao J, Zhang J, Hou L, Yang C, Jiang L, Liang D (2025) Nanoparticle-mediated sodium butyrate delivery for repairing hypoxic-ischemic brain injury in premature infants. Mater Today Bio 32:101665","journal-title":"Mater Today Bio"},{"key":"10287_CR60","doi-asserted-by":"publisher","first-page":"115272","DOI":"10.1016\/j.biopha.2023.115272","volume":"165","author":"X Zheng","year":"2023","unstructured":"Zheng X, Ren B, Gao Y (2023) Tight junction proteins related to blood-brain barrier and their regulatory signaling pathways in ischemic stroke. Biomed Pharmacother 165:115272","journal-title":"Biomed Pharmacother"}],"container-title":["Journal of Neuroimmune Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11481-026-10287-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11481-026-10287-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11481-026-10287-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:02:30Z","timestamp":1776747750000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11481-026-10287-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["10287"],"URL":"https:\/\/doi.org\/10.1007\/s11481-026-10287-w","relation":{},"ISSN":["1557-1904"],"issn-type":[{"value":"1557-1904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]},"assertion":[{"value":"22 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"In this study, all animal procedures and experiments were conducted based on ARRIVE guidelines 2.0. The research protocols received approval from the ethics committee at Shahid Beheshti University (approval code: IR.SBU.REC.1402.056).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"22"}}