{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:06:23Z","timestamp":1789203983468,"version":"build-2803163510"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"General Program of National Natural Science Foundation of China","award":["82272255"],"award-info":[{"award-number":["82272255"]}]},{"name":"Key Program of the National Natural Science Foundation of China","award":["11932013"],"award-info":[{"award-number":["11932013"]}]},{"name":"Independent Innovation Science Fund","award":["KYZZZCX2405"],"award-info":[{"award-number":["KYZZZCX2405"]}]},{"name":"ianjin Education Commission scientific research project","award":["2022YGYB07"],"award-info":[{"award-number":["2022YGYB07"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neuroimmune Pharmacol"],"DOI":"10.1007\/s11481-026-10314-w","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:14:14Z","timestamp":1789200854000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tamoxifen Modulates Spinal Cord Injury Repair Via CCL2\/CCR2 Axis and its Mechanisms"],"prefix":"10.1007","volume":"21","author":[{"given":"Xiangzi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuhua","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1389-2712","authenticated-orcid":false,"given":"Ziqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0420-8349","authenticated-orcid":false,"given":"Xuyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,12]]},"reference":[{"key":"10314_CR3","doi-asserted-by":"publisher","first-page":"181","DOI":"10.29252\/beat-060301","volume":"6","author":"A Azarhomayoun","year":"2018","unstructured":"Azarhomayoun A, Aghasi M, Mousavi N, Shokraneh F, Vaccaro AR, Mirzaian H, Derakhshan A, P., Rahimi-Movaghar V (2018) Mortality Rate and Predicting Factors of Traumatic Thoracolumbar Spinal Cord Injury; A Systematic Review and Meta-Analysis. Bull Emerg trauma 6:181\u2013194","journal-title":"Bull Emerg trauma"},{"key":"10314_CR23","doi-asserted-by":"crossref","unstructured":"Brennan FH, Li Y, Wang C, Ma A, Guo Q, Li Y, Pukos N, Campbell WA, Witcher KG, Guan Z, Kigerl KA, Hall JCE, Godbout JP, Fischer AJ, McTigue DM, He Z, Ma Q, Popovich PG (2022) Microglia coordinate cellular interactions during spinal cord repair in mice. Nat Commun 13:4096","DOI":"10.1038\/s41467-022-31797-0"},{"key":"10314_CR39","doi-asserted-by":"crossref","unstructured":"Cabrera-Aldana EE, Balderas-Martinez YI, Vel\u00e1zquez-Cruz R, Tovar-y-Romo LB, Sevilla-Montoya R, Mart\u00ednez-Cruz A, Martinez-Cordero C, Valdes-Flores M, Santamaria-Olmedo M, Hidalgo-Bravo A, Gu\u00edzar-Sahag\u00fan G (2023) Administration of tamoxifen can regulate changes in gene expression during the acute phase of traumatic spinal cord injury. Curr Issues Mol Biol 45:7476\u20137491","DOI":"10.3390\/cimb45090472"},{"key":"10314_CR36","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.4103\/1673-5374.189164","volume":"11","author":"JM Col\u00f3n","year":"2016","unstructured":"Col\u00f3n JM, Miranda JD (2016) Tamoxifen: an FDA approved drug with neuroprotective effects for spinal cord injury recovery. Neural Regeneration Res 11:1208\u20131211","journal-title":"Neural Regeneration Res"},{"key":"10314_CR38","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1089\/neu.2015.4111","volume":"33","author":"JM Colon","year":"2016","unstructured":"Colon JM, Torrado AI, Cajigas A, Santiago JM, Salgado IK, Arroyo Y, Miranda JD (2016) Tamoxifen Administration Immediately or 24 Hours after Spinal Cord Injury Improves Locomotor Recovery and Reduces Secondary Damage in Female Rats. J Neurotrauma 33:1696\u20131708","journal-title":"J Neurotrauma"},{"key":"10314_CR35","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.expneurol.2017.10.006","volume":"299","author":"JM Colon","year":"2018","unstructured":"Colon JM, Gonzalez PA, Cajigas A, Maldonado WI, Torrado AI, Sandago JM, Salgado IK, Miranda JD (2018) Continuous tamoxifen delivery improves locomotor recovery 6\u00a0h after spinal cord injury by neuronal and glial mechanisms in male rats. Exp Neurol 299:109\u2013121","journal-title":"Exp Neurol"},{"key":"10314_CR45","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1002\/glia.24526","volume":"72","author":"I Crisci","year":"2024","unstructured":"Crisci I, Bonzano S, Nicolas Z, Dallorto E, Peretto P, Krezel W, De Marchis S (2024) Tamoxifen exerts direct and microglia-mediated effects preventing neuroinflammatory changes in the adult mouse hippocampal neurogenic niche. GLIA 72:1273\u20131289","journal-title":"GLIA"},{"key":"10314_CR12","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s12974-021-02125-y","volume":"18","author":"MA Dansereau","year":"2021","unstructured":"Dansereau MA, Midavaine \u00c9, B\u00e9gin-Lavall\u00e9e V, Belkouch M, Beaudet N, Longpr\u00e9 JM, M\u00e9lik-Parsadaniantz S, Sarret P (2021) Mechanistic insights into the role of the chemokine CCL2\/CCR2 axis in dorsal root ganglia to peripheral inflammation and pain hypersensitivity. J Neuroinflammation 18:79","journal-title":"J Neuroinflammation"},{"key":"10314_CR37","doi-asserted-by":"publisher","first-page":"9561968","DOI":"10.1155\/2016\/9561968","volume":"2016","author":"B de la Torre Valdovinos","year":"2016","unstructured":"de la Torre Valdovinos B, Duenas Jimenez JM, Estrada IJ, Banuelos Pineda J, Franco Rodriguez NE, Lopez Ruiz JR, Osuna Carrasco LP, Candanedo Arellano A, Duenas Jimenez SH (2016) Tamoxifen Promotes Axonal Preservation and Gait Locomotion Recovery after Spinal Cord Injury in Cats. J veterinary Med 2016:9561968\u20139561968","journal-title":"J veterinary Med"},{"key":"10314_CR9","doi-asserted-by":"publisher","first-page":"113310","DOI":"10.1016\/j.expneurol.2020.113310","volume":"329","author":"NA Devanney","year":"2020","unstructured":"Devanney NA, Stewart AN, Gensel JC (2020) Microglia and macrophage metabolism in CNS injury and disease: The role of immunometabolism in neurodegeneration and neurotrauma. Exp Neurol 329:113310","journal-title":"Exp Neurol"},{"key":"10314_CR21","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1186\/s12964-024-01746-z","volume":"22","author":"Y Dong","year":"2024","unstructured":"Dong Y, Dong Y, Zhu C, Yang L, Wang H, Li J, Zheng Z, Zhao H, Xie W, Chen M, Jie Z, Li J, Zang Y, Shi J (2024) Targeting CCL2-CCR2 signaling pathway alleviates macrophage dysfunction in COPD via PI3K-AKT axis. Cell Commun Signal 22:364","journal-title":"Cell Commun Signal"},{"key":"10314_CR1","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.ncl.2021.02.004","volume":"39","author":"I Eli","year":"2021","unstructured":"Eli I, Lerner DP, Ghogawala Z (2021) Acute Traumatic Spinal Cord Injury. Neurol Clin 39:471\u2013488","journal-title":"Neurol Clin"},{"key":"10314_CR24","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1007\/s11011-023-01181-y","volume":"38","author":"S Fang","year":"2023","unstructured":"Fang S, Tang H, Li M-Z, Chu J-J, Yin Z-S, Jia Q-Y (2023) Identification of the CCL2 PI3K\/Akt axis involved in autophagy and apoptosis after spinal cord injury. Metab Brain Dis 38:1335\u20131349","journal-title":"Metab Brain Dis"},{"key":"10314_CR32","doi-asserted-by":"publisher","first-page":"8894752","DOI":"10.1155\/2021\/8894752","volume":"2021","author":"P Gao","year":"2021","unstructured":"Gao P, Wang J, Su Z, Li F, Zhang X (2021) Amorfrutins Relieve Neuropathic Pain through the PPAR\u03b3\/CCL2 Axis in CCI Rats. PPAR Res 2021:8894752","journal-title":"PPAR Res"},{"key":"10314_CR20","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1126\/science.1194637","volume":"330","author":"F Ginhoux","year":"2010","unstructured":"Ginhoux F, Greter M, Leboeuf M, Nandi S, See P, Gokhan S, Mehler MF, Conway SJ, Ng LG, Stanley ER, Samokhvalov IM, Merad M (2010) Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Sci (New York NY) 330:841\u2013845","journal-title":"Sci (New York NY)"},{"key":"10314_CR43","doi-asserted-by":"crossref","unstructured":"Gu C, Geng X, Wu Y, Dai Y, Zeng J, Wang Z, Fang H, Sun Y, Chen X (2024) Engineered macrophage membrane-coated nanoparticles with enhanced CCR2 expression promote spinal cord injury repair by suppressing neuroinflammation and neuronal death. Small 20","DOI":"10.1002\/smll.202305659"},{"key":"10314_CR7","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.jphys.2015.11.004","volume":"62","author":"LA Harvey","year":"2016","unstructured":"Harvey LA (2016) Physiotherapy rehabilitation for people with spinal cord injuries. J Physiotherapy 62:4\u201311","journal-title":"J Physiotherapy"},{"key":"10314_CR2","doi-asserted-by":"crossref","unstructured":"Hu Y, Li L, Hong B, Xie Y, Li T, Feng C, Yang F, Wang Y, Zhang J, Yu Y, Fan X (2023) Epidemiological features of traumatic spinal cord injury in China: A systematic review and meta-analysis. Front Neurol 14:1131791","DOI":"10.3389\/fneur.2023.1131791"},{"key":"10314_CR19","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/nn.3318","volume":"16","author":"K Kierdorf","year":"2013","unstructured":"Kierdorf K, Erny D, Goldmann T, Sander V, Schulz C, Perdiguero EG, Wieghofer P, Heinrich A, Riemke P, H\u00f6lscher C, M\u00fcller DN, Luckow B, Brocker T, Debowski K, Fritz G, Opdenakker G, Diefenbach A, Biber K, Heikenwalder M, Geissmann F, Rosenbauer F, Prinz M (2013) Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways. Nat Neurosci 16:273\u2013280","journal-title":"Nat Neurosci"},{"key":"10314_CR28","doi-asserted-by":"crossref","unstructured":"Krishna S, Cheng B, Sharma DR, Yadav S, Stempinski ES, Mamtani S, Shah E, Deo A, Acherjee T, Thomas T, Zhang X, Zhang J, Iacobas DA, Ballabh P (2021) PPAR-\u03b3 activation enhances myelination and neurological recovery in premature rabbits with intraventricular hemorrhage. Proc Natl Acad Sci USA 118:e2103084118","DOI":"10.1073\/pnas.2103084118"},{"key":"10314_CR33","doi-asserted-by":"crossref","unstructured":"Li B, Mei X-F (2023) Naringin may promote functional recovery following spinal cord injury by modulating microglial polarization through the PPAR-\u03b3\/NF-\u03baB signaling pathway. Brain Res 1821:148563","DOI":"10.1016\/j.brainres.2023.148563"},{"key":"10314_CR29","doi-asserted-by":"publisher","first-page":"620525","DOI":"10.3389\/fnins.2021.620525","volume":"15","author":"X Li","year":"2021","unstructured":"Li X, Guo Q, Ye Z, Wang E, Zou W, Sun Z, He Z, Zhong T, Weng Y, Pan Y (2021) PPAR \u03b3 Prevents Neuropathic Pain by Down-Regulating CX3CR1 and Attenuating M1 Activation of Microglia in the Spinal Cord of Rats Using a Sciatic Chronic Constriction Injury Model. Front NeuroSci 15:620525","journal-title":"Front NeuroSci"},{"key":"10314_CR6","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.wneu.2021.07.148","volume":"155","author":"X Liu","year":"2021","unstructured":"Liu X, Zhang Y, Wang Y, Qian T (2021) Inflammatory Response to Spinal Cord Injury and Its Treatment. World Neurosurg 155:19\u201331","journal-title":"World Neurosurg"},{"key":"10314_CR34","doi-asserted-by":"publisher","first-page":"15094","DOI":"10.1021\/acs.jmedchem.0c00913","volume":"63","author":"Y Lu","year":"2020","unstructured":"Lu Y, Liu W (2020) Selective Estrogen Receptor Degraders (SERDs): A Promising Strategy for Estrogen Receptor Positive Endocrine-Resistant Breast Cancer. J Med Chem 63:15094\u201315114","journal-title":"J Med Chem"},{"key":"10314_CR40","doi-asserted-by":"publisher","first-page":"4865","DOI":"10.7150\/ijbs.84564","volume":"19","author":"H Ma","year":"2023","unstructured":"Ma H, Wang C, Han L, Kong F, Liu Z, Zhang B, Chu W, Wang H, Wang L, Li Q, Peng W, Yang H, Han C, Lu X (2023) Tofacitinib Promotes Functional Recovery after Spinal Cord Injury by Regulating Microglial Polarization via JAK\/STAT Signaling Pathway. Int J Biol Sci 19:4865\u20134882","journal-title":"Int J Biol Sci"},{"key":"10314_CR27","doi-asserted-by":"publisher","first-page":"517162","DOI":"10.1155\/2008\/517162","volume":"2008","author":"DM McTigue","year":"2008","unstructured":"McTigue DM (2008) Potential Therapeutic Targets for PPAR\u03b3 after Spinal Cord Injury. PPAR Res 2008:517162","journal-title":"PPAR Res"},{"key":"10314_CR8","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1007\/s00401-019-02016-w","volume":"137","author":"LM Milich","year":"2019","unstructured":"Milich LM, Ryan CB, Lee JK (2019) The origin, fate, and contribution of macrophages to spinal cord injury pathology. Acta Neuropathol 137:799\u2013800","journal-title":"Acta Neuropathol"},{"key":"10314_CR11","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.joca.2016.10.008","volume":"25","author":"J Miotla Zarebska","year":"2017","unstructured":"Miotla Zarebska J, Chanalaris A, Driscoll C, Burleigh A, Miller RE, Malfait AM, Stott B, Vincent TL (2017) CCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy. Osteoarthr Cartil 25:406\u2013412","journal-title":"Osteoarthr Cartil"},{"key":"10314_CR26","doi-asserted-by":"crossref","unstructured":"Paterniti I, Impellizzeri D, Crupi R, Morabito R, Campolo M, Esposito E, Cuzzocrea S (2013) Molecular evidence for the involvement of PPAR-\u03b4 and PPAR-\u03b3 in anti-inflammatory and neuroprotective activities of palmitoylethanolamide after spinal cord trauma. J Neuroinflammation 10:20","DOI":"10.1186\/1742-2094-10-20"},{"key":"10314_CR4","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1080\/10790268.2010.11689699","volume":"33","author":"E Pickelsimer","year":"2010","unstructured":"Pickelsimer E, Shiroma EJ, Wilson DA (2010) Statewide Investigation of Medically Attended Adverse Health Conditions of Persons With Spinal Cord Injury. J Spinal Cord Med 33:221\u2013231","journal-title":"J Spinal Cord Med"},{"key":"10314_CR31","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/34178","volume":"391","author":"M Ricote","year":"1998","unstructured":"Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK (1998) The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 391:79\u201382","journal-title":"Nature"},{"key":"10314_CR18","doi-asserted-by":"crossref","unstructured":"Rogic A, Pant I, Grumolato L, Fernandez-Rodriguez R, Edwards A, Das S, Sun A, Yao S, Qiao R, Jaffer S, Sachidanandam R, Akturk G, Karlic R, Skobe M, Aaronson SA (2021) High endogenous CCL2 expression promotes the aggressive phenotype of human inflammatory breast cancer. Nat Commun. 12:6889","DOI":"10.1038\/s41467-021-27108-8"},{"key":"10314_CR16","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1186\/s12974-021-02268-y","volume":"18","author":"Y Rong","year":"2021","unstructured":"Rong Y, Ji C, Wang Z, Ge X, Wang J, Ye W, Tang P, Jiang D, Fan J, Yin G, Liu W, Cai W (2021) Small extracellular vesicles encapsulating CCL2 from activated astrocytes induce microglial activation and neuronal apoptosis after traumatic spinal cord injury. J Neuroinflam 18:196","journal-title":"J Neuroinflam"},{"key":"10314_CR5","doi-asserted-by":"publisher","first-page":"4658","DOI":"10.1523\/JNEUROSCI.0498-17.2017","volume":"37","author":"R Rust","year":"2017","unstructured":"Rust R, Kaiser J (2017) Insights into the Dual Role of Inflammation after Spinal Cord Injury. J neuroscience: official J Soc Neurosci 37:4658\u20134660","journal-title":"J neuroscience: official J Soc Neurosci"},{"key":"10314_CR42","doi-asserted-by":"publisher","first-page":"385","DOI":"10.4103\/1673-5374.153685","volume":"10","author":"IK Salgado","year":"2015","unstructured":"Salgado IK, Torrado AI, Santiago JM, Miranda JD (2015) Tamoxifen and Src kinase inhibitors as neuroprotective\/neuroregenerative drugs after spinal cord injury. NEURAL REGENERATION Res 10:385\u2013390","journal-title":"NEURAL REGENERATION Res"},{"key":"10314_CR17","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.immuni.2013.02.012","volume":"38","author":"R Shechter","year":"2013","unstructured":"Shechter R, Miller O, Yovel G, Rosenzweig N, London A, Ruckh J, Kim K-W, Klein E, Kalchenko V, Bendel P, Lira SA, Jung S, Schwartz M (2013) Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus. Immunity 38:555\u2013569","journal-title":"Immunity"},{"key":"10314_CR10","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1038\/s41401-023-01222-3","volume":"45","author":"S-c Shen","year":"2024","unstructured":"Shen S-c, Xu J, Cheng C, Xiang X-j, Hong B-y, Zhang M, Gong C, Ma L-k (2024) Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF\/CCL2\/CCR2 and phenotype switching. Acta Pharmacol Sin 45:959\u2013974","journal-title":"Acta Pharmacol Sin"},{"key":"10314_CR22","first-page":"121","volume":"27","author":"LR Shi Xu","year":"2023","unstructured":"Shi Xu LR, Bing Z, Qi C, Zuo Hua (2023) Effect of inflammatory reaction mediated by microglia polarization in spinal cord injury. Chin J Tissue Eng Res 27:121\u2013129","journal-title":"Chin J Tissue Eng Res"},{"key":"10314_CR41","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.bioactmat.2022.10.020","volume":"23","author":"R Wang","year":"2023","unstructured":"Wang R, Wu X, Tian Z, Hu T, Cai C, Wu G, Jiang GB, Liu B (2023) Sustained release of hydrogen sulfide from anisotropic ferrofluid hydrogel for the repair of spinal cord injury. Bioactive Mater 23:118\u2013128","journal-title":"Bioactive Mater"},{"key":"10314_CR13","doi-asserted-by":"crossref","unstructured":"Wang X, Niu X, Wang Y, Liu Y, Yang C, Chen X, Qi Z (2024) C-C motif chemokine ligand 2\/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury, Neural Regen Res","DOI":"10.4103\/NRR.NRR-D-24-00119"},{"key":"10314_CR14","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.4103\/NRR.NRR-D-24-00119","volume":"20","author":"X Wang","year":"2025","unstructured":"Wang X, Niu X, Wang Y, Liu Y, Yang C, Chen X, Qi Z (2025) C-C motif chemokine ligand 2\/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury. Neural Regen Res 20:2231\u20132244","journal-title":"Neural Regen Res"},{"key":"10314_CR44","first-page":"7710","volume":"20","author":"H Wei","year":"2016","unstructured":"Wei. H (2016) Neuroprotective effect of tamoxifen in a model rat with aucte spinal cord injury. Chin J Tissue Eng Res 20:7710\u20137716","journal-title":"Chin J Tissue Eng Res"},{"key":"10314_CR25","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.bbr.2017.05.066","volume":"332","author":"J Xu","year":"2017","unstructured":"Xu J, Dong H, Qian Q, Zhang X, Wang Y, Jin W, Qian Y (2017) Astrocyte-derived CCL2 participates in surgery-induced cognitive dysfunction and neuroinflammation via evoking microglia activation. Behav Brain Res 332:145\u2013153","journal-title":"Behav Brain Res"},{"key":"10314_CR30","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1002\/tox.22902","volume":"35","author":"H Zhang","year":"2020","unstructured":"Zhang H, Gong M, Luo X (2020) Methoxytetrahydro-2H-pyran-2-yl)methyl benzoate inhibits spinal cord injury in the rat model via PPAR-\u03b3\/PI3K\/p-Akt activation. Environ Toxicol 35:714\u2013721","journal-title":"Environ Toxicol"},{"key":"10314_CR15","first-page":"1802","volume":"18","author":"H Zhang","year":"2023","unstructured":"Zhang H, Hu Y-M, Wang Y-J, Zhou Y, Zhu Z-J, Chen M-H, Wang Y-J, Xu H, Wang Y-H (2023) Macrophage migration inhibitory factor facilitates astrocytic production of the CCL2 chemokine following spinal cord injury. Neural regeneration Res 18:1802\u20131808","journal-title":"Neural regeneration Res"}],"container-title":["Journal of Neuroimmune Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11481-026-10314-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11481-026-10314-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11481-026-10314-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:14:19Z","timestamp":1789200859000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11481-026-10314-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,12]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["10314"],"URL":"https:\/\/doi.org\/10.1007\/s11481-026-10314-w","relation":{},"ISSN":["1557-1904"],"issn-type":[{"value":"1557-1904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,12]]},"assertion":[{"value":"2 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were approved by the Experimental Animal Ethics Committee of Tianjin Armed Police Specialized Medical Center (Number: Animal 2024-0024), and followed the guidelines for the management and use of experimental animals and the guidelines for the handling of experimental animals issued by the Ministry of Science and Technology (2006).","order":2,"name":"Ethics","label":"Animal Ethics","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"48"}}