{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T02:49:40Z","timestamp":1787453380139,"version":"build-2736575974"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T00:00:00Z","timestamp":1575590400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T00:00:00Z","timestamp":1575590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Biol Eng Comput"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s11517-019-02071-1","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T17:03:03Z","timestamp":1575651783000},"page":"171-186","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Nucleus and cytoplasm\u2013based segmentation and actor-critic neural network for acute lymphocytic leukaemia detection in single cell blood smear images"],"prefix":"10.1007","volume":"58","author":[{"given":"Krishna Kumar","family":"Jha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himadri Sekhar","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,6]]},"reference":[{"key":"2071_CR1","doi-asserted-by":"crossref","unstructured":"Oikonomidis I, Kyriazi N, Argyros AA (2011) Efficient model-based 3D tracking of hand articulations using Kinect. In: Proceedings of the 22nd British Machine Vision Conference on University of Dundee (BMVC), 29 August\u20132 September 2011","DOI":"10.5244\/C.25.101"},{"key":"2071_CR2","doi-asserted-by":"crossref","unstructured":"Palumbo P, Miconi G, Cinque B, Lombardi F, La Torre C, Dehcordi SR, Galzio R, Cimini A, Giordano A, Cifone MG (2017) NOS2 expression in glioma cell lines and glioma primary cell cultures: correlation with neurosphere generation and SOX-2 expression. Oncotarget 8(15)","DOI":"10.18632\/oncotarget.16106"},{"issue":"8","key":"2071_CR3","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1007\/s11517-016-1590-x","volume":"55","author":"J Zhao","year":"2017","unstructured":"Zhao J, Zhang M, Zhou Z, Chu J, Cao F (2017) Automatic detection and classification of leukocytes using convolutional neural networks. Med Biol Eng Comput 55(8):1287","journal-title":"Med Biol Eng Comput"},{"issue":"10","key":"2071_CR4","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1007\/s11517-015-1281-z","volume":"53","author":"Y Ding","year":"2015","unstructured":"Ding Y, John NW, Smith L, Sun JA, Smith M (2015) Combination of 3D skin surface texture features and 2D ABCD features for improved melanoma diagnosis. Med Biol Eng Comput 53(10):961\u2013974","journal-title":"Med Biol Eng Comput"},{"issue":"12","key":"2071_CR5","doi-asserted-by":"publisher","first-page":"3530","DOI":"10.1002\/jcp.25814","volume":"232","author":"B Cinque","year":"2017","unstructured":"Cinque B, La Torre C, Lombardi F, Palumbo P, Evtoski Z, Santini SJ, Falone S, Cimini A, Amicarelli F, Cifone MG (2017) VSL# 3 probiotic differently influences IEC-6 intestinal epithelial cell status and function. J Cell Physiol 232(12):3530\u20133539","journal-title":"J Cell Physiol"},{"issue":"5","key":"2071_CR6","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1097\/CMR.0000000000000367","volume":"27","author":"Stefano Guadagni","year":"2017","unstructured":"Guadagni S, Fiorentini G, Clementi M, Palumbo G, Masedu F, Deraco M, De Manzoni G, Chiominto A, Valenti M, Pellegrini C (2017) MGMT methylation correlates with melphalan pelvic perfusion survival in stage III melanoma patients: a pilot study. Melanoma Res 27(5)","journal-title":"Melanoma Research"},{"issue":"3","key":"2071_CR7","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.soard.2017.12.009","volume":"14","author":"F Sista","year":"2018","unstructured":"Sista F, Abruzzese V, Clementi M, Guadagni S, Montana L, Carandina S (2018) Resolution of type 2 diabetes after sleeve gastrectomy: a 2-step hypothesis. Surg Obes Relat Dis 14(3):284\u2013290","journal-title":"Surg Obes Relat Dis"},{"key":"2071_CR8","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.bspc.2016.11.021","volume":"33","author":"S Mishra","year":"2017","unstructured":"Mishra S, Majhi B, Sa PK, Sharma L (2017) Gray level co-occurrence matrix and random forest based acute lymphoblastic leukemia detection. Biomed Signal Process Control 33:272\u2013280","journal-title":"Biomed Signal Process Control"},{"key":"2071_CR9","doi-asserted-by":"crossref","unstructured":"Li Y, Zhu R, Mi L, Cao Y, Yao D (2016) Segmentation of white blood cell from acute lymphoblastic leukemia images using dual-threshold method. Comput Math Methods Med","DOI":"10.1155\/2016\/9514707"},{"issue":"1","key":"2071_CR10","doi-asserted-by":"publisher","first-page":"76","DOI":"10.20965\/jaciii.2012.p0076","volume":"16","author":"C Fatichah","year":"2012","unstructured":"Fatichah C, Tangel ML, Widyanto MR, Dong F, Hirota K (2012) Interest-based ordering for fuzzy morphology on white blood cell image segmentation. J Adv Comput Intell Intell Inform 16(1):76\u201386","journal-title":"J Adv Comput Intell Intell Inform"},{"issue":"2","key":"2071_CR11","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s11517-013-1122-x","volume":"52","author":"HQ Huang","year":"2014","unstructured":"Huang HQ, Fang XZ, Shi J, Hu J (2014) Abnormal localization of immature precursors (ALIP) detection for early prediction of acute myelocytic leukemia (AML) relapse. J Med Biol Eng Comput 52(2):121\u2013129","journal-title":"J Med Biol Eng Comput"},{"issue":"1","key":"2071_CR12","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1117\/1.1631315","volume":"13","author":"M Sezgin","year":"2004","unstructured":"Sezgin M (2004) Survey over image thresholding techniques and quantitative performance evaluation. J Electron Imaging 13(1):146\u2013168","journal-title":"J Electron Imaging"},{"key":"2071_CR13","unstructured":"Nallaperumal K, Krishnaveni K (2008) Watershed segmentation of cervical images using multiscale morphological gradient and HSI color space. Int J Imaging Sci Eng:212\u2013216"},{"issue":"3","key":"2071_CR14","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1109\/JSYST.2014.2308452","volume":"8","author":"S Agaian","year":"2014","unstructured":"Agaian S, Madhukar M, Chronopoulos AT (2014) Automated screening system for acute myelogenous leukemia detection in blood microscopic images. IEEE Syst J 8(3):995\u20131004","journal-title":"IEEE Syst J"},{"key":"2071_CR15","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.humpath.2015.09.037","volume":"48","author":"A-MK Fiehn","year":"2016","unstructured":"Fiehn A-MK, Engel U, Holck S, Munck LK, Engel PJH (2016) CD3 immunohistochemical staining in diagnosis of lymphocytic colitis. Hum Pathol 48:25\u201331","journal-title":"Hum Pathol"},{"key":"2071_CR16","unstructured":"ALL IDB Database. https:\/\/homes.di.unimi.it\/scotti\/all\/. Accessed on November 2017"},{"key":"2071_CR17","doi-asserted-by":"crossref","unstructured":"Oikonomidis I, Kyriazis N, Argyros, AA (2011) Full DOF tracking of a hand interacting with an object by modeling occlusions and physical constraints. In: Proceedings of the International Conference on Computer Vision ICCV, pp 2088\u20132095","DOI":"10.1109\/ICCV.2011.6126483"},{"key":"2071_CR18","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/978-3-642-38682-4_10","volume-title":"Advances in Computational Intelligence","author":"Adnan Khashman","year":"2013","unstructured":"Khashman A, Abbas HH (2013) Acute lymphoblastic leukemia identification using blood smear images and a neural classifier. In: Proceedings of the International Work-Conference on Artificial Neural Networks (IWANN), Advances in Computational Intelligence, pp 80\u201387"},{"issue":"18","key":"2071_CR19","doi-asserted-by":"publisher","first-page":"19057","DOI":"10.1007\/s11042-017-4478-3","volume":"76","author":"J Rawat","year":"2017","unstructured":"Rawat J, Singh A, Bhadauria HS, Virmani J, Devgun JS (2017) Classification of acute lymphoblastic leukaemia using hybrid hierarchical classifiers. Multimed Tools Appl 76(18):19057\u201319085","journal-title":"Multimed Tools Appl"},{"key":"2071_CR20","doi-asserted-by":"crossref","unstructured":"Bhattacharjee R, Saini LM (2015) Robust technique for the detection of acute lymphoblastic leukemia. In: Proceedings of the IEEE Power, Communication and Information Technology Conference (PCITC), pp 657\u2013662","DOI":"10.1109\/PCITC.2015.7438079"},{"key":"2071_CR21","unstructured":"Blood and Marrow Stem Cell Transplantation, Leukaemia and Lymphoma Society (2015) https:\/\/www.mskcc.org\/cancer-care\/diagnosis-treatment\/cancer-treatments\/blood-stem-cell-transplantation"},{"key":"2071_CR22","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.asoc.2017.03.024","volume":"56","author":"W Srisukkham","year":"2017","unstructured":"Srisukkham W, Zhang L, Neoh SC, Todryk S, Lim CP (2017) Intelligent leukaemia diagnosis with bare-bones PSO based feature optimization. Appl Soft Comput 56:405\u2013419","journal-title":"Appl Soft Comput"},{"key":"2071_CR23","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.procs.2015.08.017","volume":"58","author":"P Viswanathan","year":"2015","unstructured":"Viswanathan P (2015) Fuzzy C means detection of leukemia based on morphological contour segmentation. Procedia Comput Sci 58:84\u201390","journal-title":"Procedia Comput Sci"},{"key":"2071_CR24","unstructured":"Ali K, Nadi S (2010) An implementation of the active contours without edges model and the logic framework for active contours on multi-channel images"},{"key":"2071_CR25","doi-asserted-by":"crossref","unstructured":"Sergyan S (2008) Color histogram features based image classification in content-based image retrieval systems. In: Proceedings of the 6th International Symposium on Applied Machine Intelligence and Informatics, pp 221\u2013224","DOI":"10.1109\/SAMI.2008.4469170"},{"issue":"11","key":"2071_CR26","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1007\/s00500-013-1110-y","volume":"17","author":"D Zhao","year":"2013","unstructured":"Zhao D, Wang B, Liu D (2013) A supervised actor\u2013critic approach for adaptive cruise control. Soft Comput 17(11):2089\u20132099","journal-title":"Soft Comput"},{"key":"2071_CR27","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.knosys.2015.12.022","volume":"96","author":"S Mirjalili","year":"2016","unstructured":"Mirjalili S (2016) SCA: a Sine Cosine Algorithm for solving optimization problems. Knowl-Based Syst 96:120\u2013133","journal-title":"Knowl-Based Syst"},{"key":"2071_CR28","unstructured":"Arya M (2019) Automated detection of acute leukemia using K-means clustering algorithm"}],"container-title":["Medical &amp; Biological Engineering &amp; Computing"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-019-02071-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11517-019-02071-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-019-02071-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T00:47:13Z","timestamp":1607129233000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11517-019-02071-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,6]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["2071"],"URL":"https:\/\/doi.org\/10.1007\/s11517-019-02071-1","relation":{},"ISSN":["0140-0118","1741-0444"],"issn-type":[{"value":"0140-0118","type":"print"},{"value":"1741-0444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,6]]},"assertion":[{"value":"23 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}