{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T08:39:13Z","timestamp":1786523953611,"version":"build-2736575974"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Shanghai Pujiang Program","award":["23PJ1411100"],"award-info":[{"award-number":["23PJ1411100"]}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["20214Y0026"],"award-info":[{"award-number":["20214Y0026"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Biol Eng Comput"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s11517-026-03609-w","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:02:05Z","timestamp":1782788525000},"page":"2807-2819","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A robot-assisted eye positioning method with high precision and repeatability for ocular particle therapy: mechanical and geometric assessment"],"prefix":"10.1007","volume":"64","author":[{"given":"Dequan","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kundong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinxiangzi","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Ming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuze","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"issue":"5","key":"3609_CR1","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/s0190-9622(98)70201-4","volume":"38","author":"JM Grin","year":"1998","unstructured":"Grin JM, Grant-Kels JM, Grin CM, Berke A, Kels BD (1998) Ocular melanomas and melanocytic lesions of the eye. J Am Acad Dermatol 38(5):716\u2013730. https:\/\/doi.org\/10.1016\/s0190-9622(98)70201-4","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"3609_CR2","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/s0008-4182(04)80004-8","volume":"39","author":"IW McLean","year":"2004","unstructured":"McLean IW, Saraiva VS, Burnier MN Jr. (2004) Pathological and prognostic features of uveal melanomas. Can J Ophthalmol 39(4):343\u2013350. https:\/\/doi.org\/10.1016\/s0008-4182(04)80004-8","journal-title":"Can J Ophthalmol"},{"issue":"12","key":"3609_CR3","doi-asserted-by":"publisher","first-page":"6541","DOI":"10.21873\/anticanres.12110","volume":"37","author":"T Berus","year":"2017","unstructured":"Berus T, Halon A, Markiewicz A et al (2017) Clinical, histopathological and cytogenetic prognosticators in uveal melanoma \u2013 a comprehensive review. AR 37(12):6541\u20136549. https:\/\/doi.org\/10.21873\/anticanres.12110","journal-title":"AR"},{"key":"3609_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.975565","author":"Y Cui","year":"2022","unstructured":"Cui Y, Yin S, Qin X et al (2022) Advances in the treatment of intraocular malignancies: a literature review. Front Med. https:\/\/doi.org\/10.3389\/fmed.2022.975565","journal-title":"Front Med"},{"issue":"4","key":"3609_CR5","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.ophtha.2017.10.009","volume":"125","author":"J Thariat","year":"2018","unstructured":"Thariat J, Rahmi A, Salleron J et al (2018) Proton beam therapy for iris melanomas in 107 patients. Ophthalmology 125(4):606\u2013614. https:\/\/doi.org\/10.1016\/j.ophtha.2017.10.009","journal-title":"Ophthalmology"},{"issue":"7","key":"3609_CR6","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1001\/jamaophthalmol.2015.0887","volume":"133","author":"AM Lane","year":"2015","unstructured":"Lane AM, Kim IK, Gragoudas ES (2015) Long-term risk of melanoma-related mortality for patients with uveal melanoma treated with proton beam therapy. JAMA Ophthalmol 133(7):792\u2013796. https:\/\/doi.org\/10.1001\/jamaophthalmol.2015.0887","journal-title":"JAMA Ophthalmol"},{"issue":"2","key":"3609_CR7","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3390\/cancers15020333","volume":"15","author":"M Zemba","year":"2023","unstructured":"Zemba M, Dumitrescu OM, Gheorghe AG, Radu M, Ionescu MA, Vatafu A, Dinu V (2023) Ocular complications of radiotherapy in uveal melanoma. Cancers 15(2):333. https:\/\/doi.org\/10.3390\/cancers15020333","journal-title":"Cancers"},{"issue":"2","key":"3609_CR8","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/eye.2012.241","volume":"27","author":"C Stannard","year":"2012","unstructured":"Stannard C, Sauerwein W, Maree G, Lecuona K (2012) Radiotherapy for ocular tumours. Eye (Lond) 27(2):119\u2013127. https:\/\/doi.org\/10.1038\/eye.2012.241","journal-title":"Eye (Lond)"},{"issue":"872","key":"3609_CR9","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1259\/bjr.73.872.11026853","volume":"73","author":"B Jones","year":"2000","unstructured":"Jones B, Errington RD (2000) Proton beam radiotherapy. Br J Radiol 73(872):802\u2013805. https:\/\/doi.org\/10.1259\/bjr.73.872.11026853","journal-title":"Br J Radiol"},{"key":"3609_CR10","doi-asserted-by":"publisher","DOI":"10.1186\/s13244-021-01000-x","author":"PV Foti","year":"2021","unstructured":"Foti PV, Travali M, Farina R et al (2021) Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging\u2014Part I: MR imaging with pathologic correlation and technical considerations. Insights Imaging. https:\/\/doi.org\/10.1186\/s13244-021-01000-x","journal-title":"Insights Imaging"},{"issue":"9","key":"3609_CR11","doi-asserted-by":"publisher","first-page":"2555","DOI":"10.3390\/cancers15092555","volume":"15","author":"SA Lane","year":"2023","unstructured":"Lane SA, Slater JM, Yang GY (2023) Image-guided proton therapy: a comprehensive review. Cancers 15(9):2555. https:\/\/doi.org\/10.3390\/cancers15092555","journal-title":"Cancers"},{"issue":"11","key":"3609_CR12","doi-asserted-by":"publisher","first-page":"7093","DOI":"10.1002\/mp.16767","volume":"50","author":"KW Jee","year":"2023","unstructured":"Jee KW, Verburg JM, Ruggieri TA, Bussi\u00e8re M, Trofimov AV (2023) Modernization of safety environment for a dedicated beamline for proton ocular therapy. Med Phys 50(11):7093\u20137103. https:\/\/doi.org\/10.1002\/mp.16767","journal-title":"Med Phys"},{"issue":"1","key":"3609_CR13","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s13014-021-01902-6","volume":"16","author":"J Gollrad","year":"2021","unstructured":"Gollrad J, Rabsahl C, Riechardt AI, Heufelder J, Stroux A, Goerling U et al (2021) Quality of life and treatment-related burden during ocular proton therapy: a prospective trial of 131 patients with uveal melanoma. Radiat Oncol 16(1):174. https:\/\/doi.org\/10.1186\/s13014-021-01902-6","journal-title":"Radiat Oncol"},{"issue":"12","key":"3609_CR14","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1007\/s00066-005-1395-6","volume":"181","author":"S H\u00f6cht","year":"2005","unstructured":"H\u00f6cht S, Stark R, Seiler F, Heufelder J, Bechrakis NE, Cordini D et al (2005) Proton or stereotactic photon irradiation for posterior uveal melanoma? Strahlenther Onkol 181(12):783\u2013788. https:\/\/doi.org\/10.1007\/s00066-005-1395-6","journal-title":"Strahlenther Onkol"},{"issue":"12","key":"3609_CR15","doi-asserted-by":"publisher","first-page":"4649","DOI":"10.1118\/1.2804750","volume":"34","author":"M Buchgeister","year":"2007","unstructured":"Buchgeister M, Grisanti S, S\u00fcsskind D, Bamberg M, Paulsen F (2007) A new fixation aid for the radiotherapy of eye tumors. Med Phys 34(12):4649\u20134653. https:\/\/doi.org\/10.1118\/1.2804750","journal-title":"Med Phys"},{"issue":"4","key":"3609_CR16","doi-asserted-by":"publisher","first-page":"E455","DOI":"10.1016\/j.ijrobp.2011.05.012","volume":"81","author":"R Al-Wassia","year":"2011","unstructured":"Al-Wassia R, Dal Pra A, Shun K, Shaban A, Corriveau C, Edelstein C et al (2011) Stereotactic fractionated radiotherapy in the treatment of juxtapapillary choroidal melanoma: the Mcgill University experience. Int J Radiat Oncol Biol Phys 81(4):E455\u2013E462. https:\/\/doi.org\/10.1016\/j.ijrobp.2011.05.012","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"3609_CR17","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/978-981-10-9023-3_89","volume":"68","author":"F Souza","year":"2019","unstructured":"Souza F, Valani J, Gon\u00e7alves OD, Batista DVS, Cardoso SC, Pereira DD (2019) Stereotactic radiotherapy for choroidal melanoma: analysis of eye movement during treatment, eye simulator design and automated monitoring system development. IFMBE Proc 68(3):493\u2013497. https:\/\/doi.org\/10.1007\/978-981-10-9023-3_89","journal-title":"IFMBE Proc"},{"key":"3609_CR18","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.radonc.2020.08.023","volume":"154","author":"R Via","year":"2020","unstructured":"Via R, Hennings F, Pica A, Fattori G, Beer J, Peroni M et al (2020) Potential and pitfalls of 1.5T MRI imaging for target volume definition in ocular proton therapy. Radiother Oncol 154:53\u201359. https:\/\/doi.org\/10.1016\/j.radonc.2020.08.023","journal-title":"Radiother Oncol"},{"issue":"8","key":"3609_CR19","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1118\/1.4885975","volume":"41","author":"MB R\u00fcegsegger","year":"2014","unstructured":"R\u00fcegsegger MB, Geiser D, Steiner P, Pica A, Aebersold DM, Kowal JH (2014) Noninvasive referencing of intraocular tumors for external beam radiation therapy using optical coherence tomography: a proof of a concept. Med Phys 41(8):79\u201387. https:\/\/doi.org\/10.1118\/1.4885975","journal-title":"Med Phys"},{"issue":"5","key":"3609_CR20","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.1118\/1.4915921","volume":"42","author":"R Via","year":"2015","unstructured":"Via R, Fassi A, Fattori G et al (2015) Optical eye tracking system for real-time noninvasive tumor localization in external beam radiotherapy. Med Phys 42(5):2194\u20132202. https:\/\/doi.org\/10.1118\/1.4915921","journal-title":"Med Phys"},{"issue":"13","key":"3609_CR21","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1364\/ao.51.002441","volume":"51","author":"A Fassi","year":"2012","unstructured":"Fassi A, Riboldi M, Forlani CF, Baroni G (2012) Optical eye tracking system for noninvasive and automatic monitoring of eye position and movements in radiotherapy treatments of ocular tumors. Appl Opt 51(13):2441. https:\/\/doi.org\/10.1364\/ao.51.002441","journal-title":"Appl Opt"},{"key":"3609_CR22","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ejmp.2019.02.020","volume":"59","author":"R Via","year":"2019","unstructured":"Via R, Pella A, Roman\u00f2 F, Fassi A, Ricotti R, Tagaste B, Vai A, Mastella E, Fiore MR, Valvo F, Ciocca M, Baroni G (2019) A platform for patient positioning and motion monitoring in ocular proton therapy with a non-dedicated beamline. Phys Med 59:55\u201363. https:\/\/doi.org\/10.1016\/j.ejmp.2019.02.020","journal-title":"Phys Med"},{"key":"3609_CR23","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ejmp.2021.01.070","volume":"82","author":"G Elisei","year":"2021","unstructured":"Elisei G, Pella A, Ricotti R et al (2021) Development and validation of a new set-up simulator dedicated to ocular proton therapy at CNAO. Phys Med 82:228\u2013239. https:\/\/doi.org\/10.1016\/j.ejmp.2021.01.070","journal-title":"Phys Med"},{"issue":"4","key":"3609_CR24","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.3390\/app14041537","volume":"14","author":"G Sellaro","year":"2024","unstructured":"Sellaro G, Pella A, Pepa M et al (2024) Setup optimization in ocular proton therapy at the national centre for oncological hadrontherapy: comparison of two approaches to refine the position of an eye-tracking device. Appl Sci 14(4):1537. https:\/\/doi.org\/10.3390\/app14041537","journal-title":"Appl Sci"},{"key":"3609_CR25","doi-asserted-by":"publisher","DOI":"10.1007\/s13246-024-01453-6","author":"D Shi","year":"2024","unstructured":"Shi D, Ming X, Wang K, Wang X, Sheng Y, Jia S, Zhang J (2024) Robot-assisted system for non-invasive wide-range flexible eye positioning and tracking in particle radiotherapy. Phys Eng Sci Med. https:\/\/doi.org\/10.1007\/s13246-024-01453-6","journal-title":"Phys Eng Sci Med"},{"key":"3609_CR26","doi-asserted-by":"publisher","DOI":"10.1002\/rcs.2668","author":"X Wang","year":"2024","unstructured":"Wang X, Shi D, Wang K, Ming X, Shengyin X, Jia S (2024) Robot\u2010assisted ocular tumour radiotherapy positioning and tracking system. Int J Med Robot. https:\/\/doi.org\/10.1002\/rcs.2668","journal-title":"Int J Med Robot"}],"container-title":["Medical & Biological Engineering & Computing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-026-03609-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11517-026-03609-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11517-026-03609-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T08:23:33Z","timestamp":1786523013000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11517-026-03609-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["3609"],"URL":"https:\/\/doi.org\/10.1007\/s11517-026-03609-w","relation":{},"ISSN":["0140-0118","1741-0444"],"issn-type":[{"value":"0140-0118","type":"print"},{"value":"1741-0444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]},"assertion":[{"value":"5 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study did not involve any human participants, animal subjects, or biological samples. Therefore, ethical approval from an institutional review board or ethics committee was not required for this work. The authors have nothing to report.","order":1,"name":"Ethics","label":"Ethics Statement","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","label":"Competing interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that no generative AI tools were used in the preparation of this manuscript.","order":3,"name":"Ethics","label":"Generative AI use","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study did not involve any human participants, animal subjects, or biological samples. Therefore, the authors have nothing to report.","order":4,"name":"Ethics","label":"Clinical trial registration","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study did not involve any human participants, animal subjects, or biological samples. Therefore, the authors have nothing to report.","order":5,"name":"Ethics","label":"Patient consent statement","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No material from other sources requiring permission was used.","order":6,"name":"Ethics","label":"Permission to reproduce material from other sources","group":{"name":"EthicsHeading","label":"Declarations"}}]}}