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Here we report the findings from a multicenter, open, pilot RCT. The intervention involved independent prescriber pharmacist from the National Health Service working on outreach in partnership with dedicated workers from Homeless Voluntary Charity or Social Enterprises (HVCSEs) (Pharmacist and third sector charity worker integrated Homeless Outreach Engagement Non-medical Independent prescriber Rx\u2019-PHOENIx) in low threshold HVCSE venues or temporary accommodation addressing PEH participants\u2019 health and wider needs through repeated outreach. The trial aimed to investigate whether sufficient numbers of participants could be recruited, retained, the intervention delivered as planned, and sufficient data collected to inform a subsequent definitive RCT. Clinical outcomes were also collected at follow-up (6\u00a0months). Participants were recruited from five community pharmacies and nearby venues in urban centers of Glasgow-Scotland and Birmingham-England, then randomized one-to-one into PHOENIx intervention in addition to usual care (UC) or UC only. A priori progression criteria were achieved: 55% of those assessed as eligible were recruited; at 6\u00a0months, 72% remained in the study, 91% had emergency department and mortality data available, and 72% completed questionnaire booklets. Fifty-three percent of participants received at least 50% of the planned PHOENIx intervention consultations (in-person or phone) at 6\u00a0months. Signs of improvement in clinical outcomes in the PHOENIx group included fewer ambulance call-outs, ED visits, and hospitalizations; higher outpatient attendances; and higher scores on self-reported health-related quality of life. A definitive RCT is merited.<\/jats:p>","DOI":"10.1007\/s11524-025-00981-0","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T16:25:50Z","timestamp":1749486350000},"page":"540-563","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pharmacy Homeless Outreach Engagement Non-medical Independent Prescribing Rx (PHOENIx) Community Pharmacy-Based Pilot Randomized Controlled Trial"],"prefix":"10.1007","volume":"102","author":[{"given":"Richard","family":"Lowrie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibhu","family":"Paudyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"McPherson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Heath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Moir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Araf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cian","family":"Lombard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Tearne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parbir","family":"Jagpal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Versha","family":"Cheed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Middleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabana","family":"Akhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Provan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Hislop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances S.","family":"Mair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"981_CR1","unstructured":"FEANTSA. ETHOS Typology of Homelessness and Housing Exclusion. https:\/\/www.feantsa.org\/en\/toolkit\/2005\/04\/01\/ethos-typology-on-homelessness-and-housing-exclusion?bcParent=27. Accessed 29 Nov 2024."},{"key":"981_CR2","unstructured":"Scottish Government. Homelessness in Scotland: 2022\u201323\/ A National Statistics publication for Scotland. 2023. https:\/\/www.gov.scot\/binaries\/content\/documents\/govscot\/publications\/statistics\/2023\/08\/homelessness-in-scotland-2022-23\/documents\/homelessness-in-scotland-2022-23\/homelessness-in-scotland-2022-23\/govscot%3Adocument\/Homelessness%2Bin%2BScotland%2B2022-23.pdf. Accessed 29 Nov 2024."},{"key":"981_CR3","unstructured":"United Kingdom Government. Department for Levelling Up, Housing & Communities. Official StatisticsRough sleeping snapshot in England: Autumn 2023. 2024.\u00a0https:\/\/www.gov.uk\/government\/statistics\/rough-sleeping-snapshot-in-england-autumn-2023\/rough-sleeping-snapshot-in-england-autumn-2023#:~:text=The%20rate%20of%20people%20sleeping,compared%20to%20the%20previous%20year. Accessed 29 Nov 2024."},{"key":"981_CR4","unstructured":"FEANTSA. Ninth overview of housing exclusion in Europe. Fondation Abb\u00e9 Pierre-FEANTSA. 2024. https:\/\/www.feantsa.org\/public\/user\/Activities\/events\/2024\/9th_overview\/Rapport-_EN.pdf. Accessed 01 Nov 2024."},{"key":"981_CR5","unstructured":"World Economic Forum Civil Society. These innovative projects are tackling homelessness around the world. 2021. https:\/\/www.weforum.org\/agenda\/2021\/10\/innovative-projects-tackling-homelessness-around-the-world\/. 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