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This study aimed to examine the association between physical function measures and geolocated social determinants of health (SDOH) in two geographically distinct groups of older sedentary PWH. We conducted a cross-sectional analysis using baseline data from a randomized exercise trial (the High-Intensity Exercise Study to Attenuate Limitations and Train Habits in Older Adults with HIV; HEALTH) of 120 sedentary PWH aged\u2009\u2265\u200950\u00a0years from two sites (Aurora\/Denver, Colorado [CO], and Seattle, Washington [WA]). Geolocated SDOH (neighborhood socioeconomic status, mobility infrastructure, environmental amenities and hazards, and access to healthcare) were derived from residential addresses and linked with physical function indicators (400-m walk time, chair rise time, PROMIS function, steps per day, and frailty). Spearman\u2019s correlations were used to quantify the associations between the study variables. For CO, a higher Area Deprivation Index (ADI) was significantly associated with slower chair rise times. In WA, a higher Social Vulnerability Index (SVI) correlated with slower 400-m walk times, and a greater distance to parks was observed among pre-frail\/frail participants. Pooled analyses revealed that participants classified as pre-frail\/frail resided in neighborhoods with significantly higher SVI scores. Higher neighborhood deprivation, greater social vulnerability, and increased distance to parks were significantly associated with poorer physical function, with site-specific patterns. These findings suggest that the neighborhood context may influence functional health and highlight the need for larger studies to inform place-based interventions.<\/jats:p>","DOI":"10.1007\/s11524-026-01116-9","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T17:16:02Z","timestamp":1784913362000},"page":"872-882","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Context Matters: Mapping Social Determinants of Health and Physical Function in Older People with HIV Using Geolocation Data"],"prefix":"10.1007","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9618-7898","authenticated-orcid":false,"given":"Evelyn","family":"Iriarte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa P.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranav","family":"Padmanabhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua A.","family":"Barocas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace L.","family":"Kulik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Webel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor H. 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This study was supported by the National Institutes of Health, National Institute on Aging R01AG066562 (to KME and AW) and K24AG082527 (to KME), the National Center for Advancing Translational Sciences (NCATS) Colorado CTSA Grant Number UM1 TR004399, and the Colorado Nutrition and Obesity Research Core (P30 DK048520). This research was also supported by the Prevention Center Shared Resource,\u00a0RRID:SCR_026631 of the Fred Hutch\/University of Washington\/Seattle Children\u2019s Cancer Consortium (P30 CA015704) and by the National Institute on Drug Abuse grant number R01DA061228. Contents are the authors\u2019 sole responsibility and do not necessarily represent official NIH views.","order":1,"name":"Ethics","label":"Conflicts of Interest and Source of Funding","group":{"name":"EthicsHeading","label":"Declarations"}}]}}