{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T11:40:34Z","timestamp":1792928434207,"version":"4.5.0"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T00:00:00Z","timestamp":1559520000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T00:00:00Z","timestamp":1559520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bull Math Biol"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1007\/s11538-019-00621-0","type":"journal-article","created":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T17:49:38Z","timestamp":1559584178000},"page":"2625-2648","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Modeling HIV Dynamics Under Combination Therapy with Inducers and Antibodies"],"prefix":"10.1007","volume":"81","author":[{"given":"Chao","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4741-7789","authenticated-orcid":false,"given":"Wendi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,3]]},"reference":[{"key":"621_CR1","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1126\/science.1255512","volume":"345","author":"DH Barouch","year":"2014","unstructured":"Barouch DH, Deeks SG (2014) Immunologic strategies for HIV-1 remission and eradication. Science 345:169\u2013174","journal-title":"Science"},{"key":"621_CR2","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s00285-006-0015-0","volume":"53","author":"N Baca\u00ebr","year":"2006","unstructured":"Baca\u00ebr N, Guernaoui S (2006) The epidemic threshold of vector-borne diseases with seasonality. J Math Biol 53:421\u2013436","journal-title":"J Math Biol"},{"key":"621_CR3","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1111\/j.1744-7348.1939.tb06990.x","volume":"26","author":"CI Bliss","year":"1939","unstructured":"Bliss CI (1939) The toxicity of poisons applied jointly. Ann Appl Biol 26:585\u2013615","journal-title":"Ann Appl Biol"},{"key":"621_CR4","doi-asserted-by":"publisher","first-page":"10844","DOI":"10.1038\/ncomms10844","volume":"7","author":"T Bruel","year":"2016","unstructured":"Bruel T, Guivel-Benhassine F, Amraoui S et al (2016) Elimination of HIV-1-infected cells by broadly neutralizing antibodies. Nat Commun 7:10844","journal-title":"Nat Commun"},{"key":"621_CR5","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/nm.2109","volume":"16","author":"CC Carter","year":"2010","unstructured":"Carter CC, Onafuwa-Nuga A, McNamara LA, Riddell J IV, Bixby D, Savona MR, Collins KL (2010) HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs. Nat Med 16:446\u2013451","journal-title":"Nat Med"},{"key":"621_CR6","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1038\/nm.1972","volume":"15","author":"N Chomont","year":"2009","unstructured":"Chomont N, El-Far M, Ancuta P et al (2009) HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nat Med 15:893\u2013900","journal-title":"Nat Med"},{"key":"621_CR7","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/0022-5193(76)90169-7","volume":"59","author":"TC Chou","year":"1976","unstructured":"Chou TC (1976) Derivation and properties of Michaelis\u2013Menten type and Hill type equations for reference ligands. J Theor Biol 59:253\u2013276","journal-title":"J Theor Biol"},{"key":"621_CR8","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1038\/nm1295-1284","volume":"1","author":"TW Chun","year":"1995","unstructured":"Chun TW, Finzi D, Margolick J, Chadwick K, Schwartz D, Siliciano RF (1995) In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency. Nat Med 1:1284\u20131290","journal-title":"Nat Med"},{"key":"621_CR9","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/ni.3152","volume":"16","author":"TW Chun","year":"2015","unstructured":"Chun TW, Moir S, Fauci AS (2015) HIV reservoirs as obstacles and opportunities for an HIV cure. Nat Immunol 16:584\u2013589","journal-title":"Nat Immunol"},{"key":"621_CR10","doi-asserted-by":"publisher","first-page":"e1002033","DOI":"10.1371\/journal.pcbi.1002033","volume":"7","author":"JM Conway","year":"2011","unstructured":"Conway JM, Coombs D (2011) A stochastic model of latently infected cell reactivation and viral blip generation in treated HIV patients. PLoS Comput Biol 7:e1002033","journal-title":"PLoS Comput Biol"},{"key":"621_CR11","doi-asserted-by":"publisher","first-page":"5467","DOI":"10.1073\/pnas.1419162112","volume":"112","author":"JM Conway","year":"2015","unstructured":"Conway JM, Perelson AS (2015) Post-treatment control of HIV infection. Proc Natl Acad Sci USA 112:5467\u20135472","journal-title":"Proc Natl Acad Sci USA"},{"key":"621_CR12","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.coisb.2018.10.006","volume":"12","author":"JM Conway","year":"2018","unstructured":"Conway JM, Ribeiro RM (2018) Modeling the immune response to HIV infection. Curr Opinion Syst Biol 12:61\u201369","journal-title":"Curr Opinion Syst Biol"},{"key":"621_CR13","doi-asserted-by":"publisher","first-page":"e01395-17","DOI":"10.1128\/JVI.01395-17","volume":"91","author":"D Cromer","year":"2017","unstructured":"Cromer D, Pinkevych M, Rasmussen TA et al (2017) Modeling of antilatency treatment in HIV: what is the optimal duration of antiretroviral therapy-free HIV remission? J Virol 91:e01395-17","journal-title":"J Virol"},{"key":"621_CR14","doi-asserted-by":"publisher","first-page":"15109","DOI":"10.1073\/pnas.96.26.15109","volume":"96","author":"RT Davey","year":"1999","unstructured":"Davey RT, Bhat N, Yoder C, Chun TW et al (1999) HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression. Proc Natl Acad Sci USA 96:15109\u201315114","journal-title":"Proc Natl Acad Sci USA"},{"key":"621_CR15","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/nature10509","volume":"478","author":"MA Dawson","year":"2011","unstructured":"Dawson MA, Prinjha RK, Dittmann A et al (2011) Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature 478:529\u2013533","journal-title":"Nature"},{"key":"621_CR16","doi-asserted-by":"publisher","first-page":"3928","DOI":"10.4049\/jimmunol.171.8.3928","volume":"171","author":"RJ De Boer","year":"2003","unstructured":"De Boer RJ, Homann D, Perelson AS (2003) Different dynamics of CD4+ and CD8+ T cell responses during and after acute lymphocytic choriomeningitis virus infection. J Immunol 171:3928\u20133935","journal-title":"J Immunol"},{"key":"621_CR17","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1742-4690-10-11","volume":"10","author":"DA Donahue","year":"2013","unstructured":"Donahue DA, Wainberg MA (2013) Cellular and molecular mechanisms involved in the establishment of HIV-1 latency. Retrovirology 10:11","journal-title":"Retrovirology"},{"key":"621_CR18","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.it.2012.07.001","volume":"33","author":"CM Durand","year":"2012","unstructured":"Durand CM, Blankson JN, Siliciano RF (2012) Developing strategies for HIV-1 eardication. Trends Immunol 33:554\u2013562","journal-title":"Trends Immunol"},{"key":"621_CR19","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.matcom.2011.10.007","volume":"82","author":"T Gao","year":"2011","unstructured":"Gao T, Wang W, Liu X (2011) Mathematical analysis of an HIV model with impulsive antiretroviral drug doses. Math Comput Simul 82:653\u2013665","journal-title":"Math Comput Simul"},{"key":"621_CR20","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.tiv.2007.03.003","volume":"21","author":"M Goldoni","year":"2007","unstructured":"Goldoni M, Johansson C (2007) A mathematical approach to study combined effects of toxicants in vitro: evaluation of the Bliss independence criterion and the Loewe additivity model. Toxicol Vitro 21:759\u2013769","journal-title":"Toxicol Vitro"},{"key":"621_CR21","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1126\/science.274.5289.985","volume":"274","author":"AT Haase","year":"1996","unstructured":"Haase AT, Henry K, Zupancic M et al (1996) Quantitative image analysis of HIV-1 infection in lymphoid tissue. Science 274:985\u2013989","journal-title":"Science"},{"key":"621_CR22","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1172\/JCI80561","volume":"126","author":"A Halper-Stromberg","year":"2016","unstructured":"Halper-Stromberg A, Nussenzweig MC (2016) Towards HIV-1 remission: potential roles for broadly neutralizing antibodies. J Clin Investig 126:415\u2013423","journal-title":"J Clin Investig"},{"key":"621_CR23","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.cell.2014.07.043","volume":"158","author":"A Halper-Stromberg","year":"2014","unstructured":"Halper-Stromberg A, Lu CL, Klein F, Horwitz JA, Bournazos S, Nogueira L, Eisenreich TR, Liu C, Gazumyan A, Schaefer U et al (2014) Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice. Cell 158:989\u2013999","journal-title":"Cell"},{"key":"621_CR24","volume-title":"HIV-1 latency, current topics in microbiology and immunology","author":"AL Hill","year":"2017","unstructured":"Hill AL (2017) Mathematical models of HIV latency. In: Silvestri G, Lichterfeld M (eds) HIV-1 latency, current topics in microbiology and immunology, vol 417. Springer, Cham"},{"key":"621_CR25","doi-asserted-by":"publisher","first-page":"13475","DOI":"10.1073\/pnas.1406663111","volume":"111","author":"AL Hill","year":"2014","unstructured":"Hill AL, Rosenbloom DI, Fu F, Nowak MA, Siliciano RF (2014) Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1. Proc Natl Acad Sci USA 111:13475\u201313480","journal-title":"Proc Natl Acad Sci USA"},{"key":"621_CR26","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1084\/jem.189.10.1545","volume":"189","author":"RD Hockett","year":"1999","unstructured":"Hockett RD, Kilby JM, Derdeyn CA, Saag MS et al (1999) Constant mean viral copy number per infected cell in tissues regardless of high, low, or undetectable plasma HIV RNA. J Exper Med 189:1545\u20131554","journal-title":"J Exper Med"},{"key":"621_CR27","doi-asserted-by":"publisher","first-page":"16538","DOI":"10.1073\/pnas.1315295110","volume":"110","author":"JA Horwitz","year":"2013","unstructured":"Horwitz JA, Halper-Stromberg A, Mouquet H et al (2013) HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice. Proc Natl Acad Sci USA 110:16538\u201316543","journal-title":"Proc Natl Acad Sci USA"},{"key":"621_CR28","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.3934\/dcdsb.2014.19.1801","volume":"19","author":"C Jiang","year":"2014","unstructured":"Jiang C, Wang W (2014) Complete classification of global dynamics of a virus model with immune responses. Discrete Contin Dyn Syst Ser B 19:1087\u20131103","journal-title":"Discrete Contin Dyn Syst Ser B"},{"key":"621_CR29","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1097\/QAI.0b013e3180654836","volume":"45","author":"LE Jones","year":"2007","unstructured":"Jones LE, Perelson AS (2007) Transient viremia, plasma viral load, and reservoir replenishment in HIV-infected patients on antiretroviral therapy. J Acquir Immune Defic Syndr 45:483\u2013493","journal-title":"J Acquir Immune Defic Syndr"},{"key":"621_CR30","doi-asserted-by":"publisher","first-page":"e1005237","DOI":"10.1371\/journal.ppat.1005237","volume":"11","author":"R Ke","year":"2015","unstructured":"Ke R, Lewin SR, Elliott JH, Perelson AS (2015) Modeling the effects of vorinostat in vivo reveals both transient and delayed HIV transcriptional activation and minimal killing of latently infected cells. PLoS Pathog 11:e1005237","journal-title":"PLoS Pathog"},{"key":"621_CR31","doi-asserted-by":"publisher","first-page":"e123052","DOI":"10.1172\/jci.insight.123052","volume":"3","author":"R Ke","year":"2017","unstructured":"Ke R, Conway JM et al (2017) Determinants of the efficacy of HIV latency-reversing agents and implications for drug and treatment design. JCI Insight 3:e123052","journal-title":"JCI Insight"},{"key":"621_CR32","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/nature11604","volume":"492","author":"F Klein","year":"2012","unstructured":"Klein F, Halper-Stromberg A, Horwitz JA, Gruell H, Scheid JF, Bournazos S, Mouquet H, Spatz LA, Diskin R, Abadir A et al (2012) HIV therapy by a combination of broadly neutralizing antibodies in humanized mice. Nature 492:118\u2013122","journal-title":"Nature"},{"key":"621_CR33","doi-asserted-by":"publisher","first-page":"15323","DOI":"10.1073\/pnas.93.26.15323","volume":"93","author":"P Klenerman","year":"1996","unstructured":"Klenerman P, Phillips RE, Rinaldo CR et al (1996) Cytotoxic T lymphocytes and viral turnover in HIV type 1 infection. Proc Natl Acad Sci USA 93:15323\u201315328","journal-title":"Proc Natl Acad Sci USA"},{"key":"621_CR34","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/1742-4682-11-41","volume":"11","author":"Y Koizumi","year":"2014","unstructured":"Koizumi Y, Iwami S (2014) Mathematical modeling of multi-drugs therapy: a challenge for determining the optimal combinations of antiviral drugs. Theor Biol Med Modell 11:41","journal-title":"Theor Biol Med Modell"},{"key":"621_CR35","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.jtbi.2006.12.038","volume":"246","author":"O Krakovska","year":"2007","unstructured":"Krakovska O, Wahl L (2007) Optimal drug treatment regimens for HIV depend on adherence. J Theor Biol 246:499\u2013509","journal-title":"J Theor Biol"},{"key":"621_CR36","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/nri3516","volume":"13","author":"PD Kwong","year":"2013","unstructured":"Kwong PD, Mascola JR, Nabel GJ (2013) Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning. Nat Rev Immunol 13:693\u2013701","journal-title":"Nat Rev Immunol"},{"key":"621_CR37","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1172\/JCI80142","volume":"125","author":"GM Laird","year":"2015","unstructured":"Laird GM, Bullen CK, Rosenbloom DI et al (2015) Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations. J Clin Investig 125:1901\u20131912","journal-title":"J Clin Investig"},{"key":"621_CR38","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1097\/00002030-200405210-00008","volume":"18","author":"O Lambotte","year":"2004","unstructured":"Lambotte O, Chaix ML, Gubler B, Nasreddine N, Wallon C, Goujard C, Rouzioux C, Taoufik Y, Delfraissy JF (2004) The lymphocyte HIV reservoir in patients on long-term HAART is a memory of virus evolution. AIDS 18:1147\u20131158","journal-title":"AIDS"},{"key":"621_CR39","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1007\/s00285-011-0474-9","volume":"65","author":"J Lou","year":"2012","unstructured":"Lou J, Lou Y, Wu J (2012) Threshold virus dynamics with impulsive antiretroviral drug effects. J Math Biol 65:623\u2013652","journal-title":"J Math Biol"},{"key":"621_CR40","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1126\/science.aaf1279","volume":"352","author":"CL Lu","year":"2016","unstructured":"Lu CL, Murakowski DK, Bournazos S et al (2016) Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo. Science 352:1001\u20131004","journal-title":"Science"},{"key":"621_CR41","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.jmaa.2015.09.048","volume":"434","author":"J Luo","year":"2016","unstructured":"Luo J, Wang W, Chen H, Fu R (2016) Bifurcations of a mathematical model for HIV dynamics. J Math Anal Appl 434:837\u2013857","journal-title":"J Math Anal Appl"},{"key":"621_CR42","doi-asserted-by":"publisher","first-page":"5037","DOI":"10.1128\/JVI.77.8.5037-5038.2003","volume":"77","author":"M Markowitz","year":"2003","unstructured":"Markowitz M, Louie M, Hurley A, Sun E et al (2003) A novel antiviral intervention results in more accurate assessment of human immunodeficiency virus type 1 replication dynamics and T-cell decay in vivo. J Virol 77:5037\u20135038","journal-title":"J Virol"},{"key":"621_CR43","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.cell.2014.08.010","volume":"158","author":"MD Marsden","year":"2014","unstructured":"Marsden MD, Zack JA (2014) Neutralizing the HIV reservoir. Cell 158:971\u2013972","journal-title":"Cell"},{"key":"621_CR44","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1097\/COH.0000000000000136","volume":"10","author":"P Mohammadi","year":"2015","unstructured":"Mohammadi P, Ciuffi A, Beerenwinkel N (2015) Dynamic models of viral replication and latency. Curr Opinion HIV AIDS 10:90\u201395","journal-title":"Curr Opinion HIV AIDS"},{"key":"621_CR45","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1137\/S0036144598335107","volume":"41","author":"AS Perelson","year":"1999","unstructured":"Perelson AS, Nelson PW (1999) Mathematical analysis of HIV-1 dynamics in vivo. SIAM Rev 41:3\u201344","journal-title":"SIAM Rev"},{"key":"621_CR46","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/1741-7007-11-96","volume":"11","author":"AS Perelson","year":"2013","unstructured":"Perelson AS, Ribeiro RM (2013) Modeling the within-host dynamics of HIV infection. BMC Biol 11:96","journal-title":"BMC Biol"},{"key":"621_CR47","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/0025-5564(93)90043-A","volume":"114","author":"AS Perelson","year":"1993","unstructured":"Perelson AS, Kirschner DE, De Boer R (1993) Dynamics of HIV infection of CD4+ T cells. Math Biosci 114:81\u2013125","journal-title":"Math Biosci"},{"key":"621_CR48","doi-asserted-by":"publisher","first-page":"e1001058","DOI":"10.1371\/journal.pcbi.1001058","volume":"7","author":"JE Pearson","year":"2011","unstructured":"Pearson JE, Krapivsky P, Perelson AS (2011) Stochastic theory of early viral infection: continuous versus burst production of virions. PLoS Comput Biol 7:e1001058","journal-title":"PLoS Comput Biol"},{"key":"621_CR49","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1016\/S0140-6736(99)02035-8","volume":"354","author":"B Ramratnam","year":"1999","unstructured":"Ramratnam B, Bonhoeffer S, Binley J, Hurley A, Zhang L et al (1999) Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis. Lancet 354:1782\u20131785","journal-title":"Lancet"},{"key":"621_CR50","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.jtbi.2009.06.011","volume":"260","author":"L Rong","year":"2009","unstructured":"Rong L, Perelson AS (2009a) Modeling HIV persistence, the latent reservoir, and viral blips. J Theor Biol 260:308\u2013331","journal-title":"J Theor Biol"},{"key":"621_CR51","doi-asserted-by":"publisher","first-page":"e1000533","DOI":"10.1371\/journal.pcbi.1000533","volume":"5","author":"L Rong","year":"2009","unstructured":"Rong L, Perelson AS (2009b) Modeling latently infected cell activation: viral and latent reservoir persistence, and viral blips in HIV-infected patients on potent therapy. PLoS Comput Biol 5:e1000533","journal-title":"PLoS Comput Biol"},{"key":"621_CR52","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1007\/s11538-007-9203-3","volume":"69","author":"L Rong","year":"2007","unstructured":"Rong L, Feng Z, Perelson AS (2007) Emergence of HIV-1 drug resistance during antiretroviral treatment. Bull Math Biol 69:2027\u20132060","journal-title":"Bull Math Biol"},{"key":"621_CR53","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.coviro.2013.06.015","volume":"3","author":"C Selinger","year":"2013","unstructured":"Selinger C, Katze MG (2013) Mathematical models of viral latency. Curr Opinion Virol 3:402\u2013407","journal-title":"Curr Opinion Virol"},{"key":"621_CR54","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.coviro.2013.06.001","volume":"3","author":"M Sgarbanti","year":"2013","unstructured":"Sgarbanti M, Battistini A (2013) Therapeutics for HIV-1 reactivation from latency. Curr Opinion Virol 3:394\u2013401","journal-title":"Curr Opinion Virol"},{"key":"621_CR55","doi-asserted-by":"publisher","first-page":"91ra63","DOI":"10.1126\/scitranslmed.3002304","volume":"3","author":"L Shen","year":"2011","unstructured":"Shen L, Alireza Rabi S, Sedaghat AR, Shan L, Lai J, Xing S, Siliciano RF (2011) A critical subset model provides a conceptual basis for the high antiviral activity of major HIV drugs. Sci Transl Med 3:91ra63","journal-title":"Sci Transl Med"},{"key":"621_CR56","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1137\/120896463","volume":"73","author":"H Shu","year":"2013","unstructured":"Shu H, Wang L, Watmough J (2013) Global stability of a nonlinear viral infection model with infinitely distributed intracellular delays and CTL immune responses. SIAM J Appl Math 73:1280\u20131302","journal-title":"SIAM J Appl Math"},{"key":"621_CR57","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jaci.2014.05.026","volume":"134","author":"JD Siliciano","year":"2014","unstructured":"Siliciano JD, Siliciano RF (2014) Recent developments in the search for a cure for HIV-1 infection: targeting the latent reservoir for HIV-1. J Allergy Clin Immunol 134:12\u201319","journal-title":"J Allergy Clin Immunol"},{"key":"621_CR58","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1016\/j.bulm.2003.12.004","volume":"66","author":"R Smith","year":"2004","unstructured":"Smith R, Wahl L (2004) Distinct effects of protease and reverse transcriptase inhibition in an immunological model of HIV-1 infection with impulsive drug effects. Bull Math Biol 66:1259\u20131283","journal-title":"Bull Math Biol"},{"key":"621_CR59","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.bulm.2004.10.004","volume":"67","author":"R Smith","year":"2005","unstructured":"Smith R, Wahl L (2005) Drug resistance in an immunological model of HIV-1 infection with impulsive drug effects. Bull Math Biol 67:783\u2013813","journal-title":"Bull Math Biol"},{"key":"621_CR60","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1137\/0524026","volume":"24","author":"HR Thieme","year":"1993","unstructured":"Thieme HR (1993) Persistence under relaxed point-dissipativity (with application to an endemic model). SIAM J Math Anal 24:407\u2013435","journal-title":"SIAM J Math Anal"},{"key":"621_CR61","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1137\/080732870","volume":"70","author":"HR Thieme","year":"2009","unstructured":"Thieme HR (2009) Spectral bound and reproduction number for infinite-dimensional population structure and time heterogeneity. SIAM J Appl Math 70:188\u2013211","journal-title":"SIAM J Appl Math"},{"key":"621_CR62","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.nonrwa.2013.09.002","volume":"16","author":"Y Tian","year":"2014","unstructured":"Tian Y, Liu X (2014) Global dynamics of a virus dynamical model with general incidence rate and cure rate. Nonlinear Anal Real World Appl 16:17\u201326","journal-title":"Nonlinear Anal Real World Appl"},{"key":"621_CR63","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1186\/s12879-017-2683-3","volume":"17","author":"K Thorlund","year":"2017","unstructured":"Thorlund K, Horwitz MS, Fife BT et al (2017) Landscape review of current HIV \u2018kick and kill\u2019 cure research-some kicking, not enough killing. BMC Infect Dis 17:595","journal-title":"BMC Infect Dis"},{"key":"621_CR64","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1137\/16M1092003","volume":"77","author":"NK Vaidya","year":"2017","unstructured":"Vaidya NK, Rong L (2017) Modeling pharmacodynamics on hiv latent infection: choice of drugs is key to successful cure via early therapy. SIAM J Appl Math 77:1781\u20131804","journal-title":"SIAM J Appl Math"},{"key":"621_CR65","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0025-5564(02)00108-6","volume":"180","author":"P van den Driessche","year":"2002","unstructured":"van den Driessche P, Watmough J (2002) Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission. Math Biosci 180:29\u201348","journal-title":"Math Biosci"},{"key":"621_CR66","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1098\/rspb.2000.1079","volume":"267","author":"LM Wahl","year":"2000","unstructured":"Wahl LM, Nowak MA (2000) Adherence and drug resistance: predictions for therapy outcome. Proc R Soc Lond B 267:835\u2013843","journal-title":"Proc R Soc Lond B"},{"key":"621_CR67","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.jtbi.2014.06.042","volume":"360","author":"S Wang","year":"2014","unstructured":"Wang S, Rong L (2014) Stochastic population switch may explain the latent reservoir stability and intermittent viral blips in HIV patients on suppressive therapy. J Theor Biol 360:137\u2013148","journal-title":"J Theor Biol"},{"key":"621_CR68","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.jtbi.2012.08.023","volume":"313","author":"X Wang","year":"2012","unstructured":"Wang X, Wang W (2012) An HIV infection model based on a vectored immunoprophylaxis experiment. J Theor Biol 313:127\u2013135","journal-title":"J Theor Biol"},{"key":"621_CR69","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.mbs.2002.11.001","volume":"190","author":"W Wang","year":"2004","unstructured":"Wang W, Zhao X (2004) An epidemic model in a patchy environment. Math Biosci 190:97\u2013112","journal-title":"Math Biosci"},{"key":"621_CR70","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1137\/S0036139903431245","volume":"65","author":"W Wang","year":"2005","unstructured":"Wang W, Zhao X (2005) An age-structured epidemic model in a patchy environment. SIAM J Appl Math 65:1597\u20131614","journal-title":"SIAM J Appl Math"},{"key":"621_CR71","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1137\/050622948","volume":"66","author":"W Wang","year":"2006","unstructured":"Wang W, Zhao X (2006) An epidemic model with population dispersal and infection period. SIAM J Appl Math 66:1454\u20131472","journal-title":"SIAM J Appl Math"},{"key":"621_CR72","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1007\/s10884-008-9111-8","volume":"20","author":"W Wang","year":"2008","unstructured":"Wang W, Zhao XQ (2008) Threshold dynamics for compartmental epidemic models in periodic environments. J Dyn Differ Equ 20:699\u2013717","journal-title":"J Dyn Differ Equ"},{"key":"621_CR73","doi-asserted-by":"publisher","first-page":"8443","DOI":"10.1038\/ncomms9443","volume":"6","author":"NE Webb","year":"2015","unstructured":"Webb NE, Montefiori DC, Lee B (2015) Dose-response curve slope helps predict therapeutic potency and breadth of HIV broadly neutralizing antibodies. Nat Commun 6:8443","journal-title":"Nat Commun"},{"key":"621_CR74","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/nature13594","volume":"512","author":"JB Whitney","year":"2014","unstructured":"Whitney JB, Hill AL, Sanisetty S, Penaloza-MacMaster P, Liu J, Shetty M, Parenteau L, Cabral C, Shields J, Blackmore S et al (2014) Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys. Nature 512:74\u201377","journal-title":"Nature"},{"key":"621_CR75","doi-asserted-by":"publisher","first-page":"401","DOI":"10.3934\/dcdsb.2012.17.401","volume":"17","author":"Y Yan","year":"2012","unstructured":"Yan Y, Wang W (2012) Global stability of a five-dimensional model with immune responses and delay. Discrete Contin Dyn Syst Ser B 17:401\u2013416","journal-title":"Discrete Contin Dyn Syst Ser B"},{"key":"621_CR76","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1002\/bmc.734","volume":"21","author":"P Yeo","year":"2007","unstructured":"Yeo P, Xin L, Goh E et al (2007) Development and validation of high-performance liquid chromatography-tandem mass spectrometry assay for 6-(3-benzoyl-ureido)-hexanoic acid hydroxyamide, a novel HDAC inhibitor, in mouse plasma for pharmacokinetic studies. Biomed Chromatogr 21:184\u2013189","journal-title":"Biomed Chromatogr"},{"key":"621_CR77","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1137\/130937421","volume":"56","author":"W Zhang","year":"2014","unstructured":"Zhang W, Wahl L, Yu P (2014) Viral blips may not need a trigger: how transient viremia can arise in deterministic in-host models. SIAM Rev 56:127\u2013155","journal-title":"SIAM Rev"},{"key":"621_CR78","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-56433-3","volume-title":"Dynamical systems in population biology","author":"XQ Zhao","year":"2017","unstructured":"Zhao XQ (2017) Dynamical systems in population biology. Springer, London"}],"container-title":["Bulletin of Mathematical Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11538-019-00621-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11538-019-00621-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11538-019-00621-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T01:28:58Z","timestamp":1591061338000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11538-019-00621-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,3]]},"references-count":78,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["621"],"URL":"https:\/\/doi.org\/10.1007\/s11538-019-00621-0","relation":{},"ISSN":["0092-8240","1522-9602"],"issn-type":[{"value":"0092-8240","type":"print"},{"value":"1522-9602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,3]]},"assertion":[{"value":"1 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}