{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:22:13Z","timestamp":1792783333257,"version":"4.5.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000008","name":"David and Lucile Packard Foundation","doi-asserted-by":"publisher","award":["2013-39274"],"award-info":[{"award-number":["2013-39274"]}],"id":[{"id":"10.13039\/100000008","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32-HL069768"],"award-info":[{"award-number":["T32-HL069768"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL141934"],"award-info":[{"award-number":["R01HL141934"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35GM119661"],"award-info":[{"award-number":["R35GM119661"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"P.E.O. International"},{"DOI":"10.13039\/100009744","name":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009744","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008982","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DMS-1664645"],"award-info":[{"award-number":["DMS-1664645"]}],"id":[{"id":"10.13039\/501100008982","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008982","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DMS-1517274"],"award-info":[{"award-number":["DMS-1517274"]}],"id":[{"id":"10.13039\/501100008982","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008982","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DMS-1816630"],"award-info":[{"award-number":["DMS-1816630"]}],"id":[{"id":"10.13039\/501100008982","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bull Math Biol"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s11538-021-00950-z","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T03:02:36Z","timestamp":1636426956000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Experimental Data and PBPK Modeling Quantify Antibody Interference in PEGylated Drug Carrier Delivery"],"prefix":"10.1007","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6296-6754","authenticated-orcid":false,"given":"Anne M.","family":"Talkington","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8122-2016","authenticated-orcid":false,"given":"Timothy","family":"Wessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4721-528X","authenticated-orcid":false,"given":"Samuel K.","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3974-9073","authenticated-orcid":false,"given":"Yanguang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7718-4456","authenticated-orcid":false,"given":"M. Gregory","family":"Forest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"key":"950_CR1","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jconrel.2013.07.026","volume":"172","author":"AS Abu Lila","year":"2013","unstructured":"Abu Lila AS, Kiwada H, Ishida T (2013) The accelerated blood clearance (ABC) phenomenon: clinical challenge and approaches to manage. J Control Release 172:38\u201347. https:\/\/doi.org\/10.1016\/j.jconrel.2013.07.026","journal-title":"J Control Release"},{"key":"950_CR2","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1007\/s12206-013-0428-9","volume":"27","author":"D An","year":"2013","unstructured":"An D, Choi J-H (2013) Improved MCMC method for parameter estimation based on marginal probability density function. J Mech Sci Technol 27:1771\u20131779. https:\/\/doi.org\/10.1007\/s12206-013-0428-9","journal-title":"J Mech Sci Technol"},{"key":"950_CR3","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/cncr.22739","volume":"110","author":"JK Armstrong","year":"2007","unstructured":"Armstrong JK, Hempel G, Koling S, Chan LS, Fisher T, Meiselman HJ, Garratty G (2007) Antibody against poly(ethylene glycol) adversely affects PEG-asparaginase therapy in acute lymphoblastic leukemia patients. Cancer 110:103\u2013111. https:\/\/doi.org\/10.1002\/cncr.22739","journal-title":"Cancer"},{"key":"950_CR4","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1177\/074823379701300401","volume":"13","author":"RP Brown","year":"1997","unstructured":"Brown RP, Delp MD, Lindstedt SL, Rhomberg LR, Beliles RP (1997) Physiological parameter values for physiologically based pharmacokinetic models. Toxicol Ind Health 13:407\u2013484. https:\/\/doi.org\/10.1177\/074823379701300401","journal-title":"Toxicol Ind Health"},{"key":"950_CR5","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1007\/s10928-012-9280-2","volume":"39","author":"Y Cao","year":"2012","unstructured":"Cao Y, Jusko WJ (2012) Applications of minimal physiologically-based pharmacokinetic models. J Pharmacokinet Pharmacodyn 39:711\u2013723. https:\/\/doi.org\/10.1007\/s10928-012-9280-2","journal-title":"J Pharmacokinet Pharmacodyn"},{"key":"950_CR6","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1023\/A:1018943613122","volume":"10","author":"B Davies","year":"1993","unstructured":"Davies B, Morris T (1993) Physiological parameters in laboratory animals and humans. Pharm Res 10:1093\u20131095. https:\/\/doi.org\/10.1023\/A:1018943613122","journal-title":"Pharm Res"},{"key":"950_CR7","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1007\/s00280-016-3018-6","volume":"77","author":"AN Edginton","year":"2016","unstructured":"Edginton AN, Zimmerman EI, Vasilyeva A, Baker SD, Panetta JC (2016) Sorafenib metabolism, transport, and enterohepatic recycling: physiologically based modeling and simulation in mice. Cancer Chemother Pharmacol 77:1039\u20131052. https:\/\/doi.org\/10.1007\/s00280-016-3018-6","journal-title":"Cancer Chemother Pharmacol"},{"key":"950_CR8","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.yrtph.2016.03.009","volume":"77","author":"F F\u00e0brega","year":"2016","unstructured":"F\u00e0brega F, Nadal M, Schuhmacher M, Domingo JL, Kumar V (2016) Influence of the uncertainty in the validation of PBPK models: a case-study for PFOS and PFOA. Regul Toxicol Pharmacol 77:230\u2013239. https:\/\/doi.org\/10.1016\/j.yrtph.2016.03.009","journal-title":"Regul Toxicol Pharmacol"},{"key":"950_CR9","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1208\/s12248-017-0116-2","volume":"19","author":"J Fan","year":"2017","unstructured":"Fan J, Zhang X, Zhao L (2017) Utility of physiologically based pharmacokinetic absorption modeling to predict the impact of salt-to-base conversion on prasugrel HCl product bioequivalence in the presence of proton pump inhibitors. AAPS J 19:1479\u20131486. https:\/\/doi.org\/10.1208\/s12248-017-0116-2","journal-title":"AAPS J"},{"key":"950_CR10","doi-asserted-by":"publisher","first-page":"4981","DOI":"10.4049\/jimmunol.1202017","volume":"189","author":"LP Ganesan","year":"2012","unstructured":"Ganesan LP et al (2012) Fc\u03b3RIIb on liver sinusoidal endothelium clears small immune complexes. J Immunol 189:4981\u20134988. https:\/\/doi.org\/10.4049\/jimmunol.1202017","journal-title":"J Immunol"},{"key":"950_CR11","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1007\/s10928-007-9065-1","volume":"34","author":"A Garg","year":"2007","unstructured":"Garg A, Balthasar JP (2007) Physiologically-based pharmacokinetic (PBPK) model to predict IgG tissue kinetics in wild-type and FcRn-knockout mice. J Pharmacokinet Pharmacodyn 34:687\u2013709. https:\/\/doi.org\/10.1007\/s10928-007-9065-1","journal-title":"J Pharmacokinet Pharmacodyn"},{"key":"950_CR12","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1007\/s11095-018-2456-8","volume":"35","author":"H He","year":"2018","unstructured":"He H, Liu C, Wu Y, Zhang X, Fan J, Cao Y (2018) A multiscale physiologically-based pharmacokinetic model for doxorubicin to explore its mechanisms of cytotoxicity and cardiotoxicity in human physiological contexts. Pharm Res 35:174. https:\/\/doi.org\/10.1007\/s11095-018-2456-8","journal-title":"Pharm Res"},{"key":"950_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics11030110","author":"H He","year":"2019","unstructured":"He H, Yuan D, Wu Y, Cao Y (2019) Pharmacokinetics and pharmacodynamics modeling and simulation systems to support the development and regulation of liposomal drugs. Pharmaceutics. https:\/\/doi.org\/10.3390\/pharmaceutics11030110","journal-title":"Pharmaceutics"},{"key":"950_CR14","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0951-8320(03)00058-9","volume":"81","author":"JC Helton","year":"2003","unstructured":"Helton JC, Davis FJ (2003) Latin hypercube sampling and the propagation of uncertainty in analyses of complex systems. Reliab Eng Syst Saf 81:23\u201369. https:\/\/doi.org\/10.1016\/S0951-8320(03)00058-9","journal-title":"Reliab Eng Syst Saf"},{"key":"950_CR15","doi-asserted-by":"publisher","first-page":"R63","DOI":"10.1186\/ar4500","volume":"16","author":"MS Hershfield","year":"2014","unstructured":"Hershfield MS, Ganson NJ, Kelly SJ, Scarlett EL, Jaggers DA, Sundy JS (2014) Induced and pre-existing anti-polyethylene glycol antibody in a trial of every 3-week dosing of pegloticase for refractory gout, including in organ transplant recipients. Arthritis Res Ther 16:R63. https:\/\/doi.org\/10.1186\/ar4500","journal-title":"Arthritis Res Ther"},{"key":"950_CR16","doi-asserted-by":"publisher","first-page":"323","DOI":"10.13182\/NSE89-A23645","volume":"102","author":"SC Hora","year":"1989","unstructured":"Hora SC, Iman RL (1989) Expert opinion in risk analysis: the NUREG-1150 methodology. Nucl Sci Eng 102:323\u2013331. https:\/\/doi.org\/10.13182\/NSE89-A23645","journal-title":"Nucl Sci Eng"},{"key":"950_CR17","doi-asserted-by":"publisher","first-page":"588","DOI":"10.3389\/fphar.2018.00588","volume":"9","author":"NH Hsieh","year":"2018","unstructured":"Hsieh NH, Reisfeld B, Bois FY, Chiu WA (2018) Applying a global sensitivity analysis workflow to improve the computational efficiencies in physiologically-based pharmacokinetic modeling. Front Pharmacol 9:588. https:\/\/doi.org\/10.3389\/fphar.2018.00588","journal-title":"Front Pharmacol"},{"key":"950_CR18","doi-asserted-by":"publisher","first-page":"972","DOI":"10.3109\/00498254.2011.598582","volume":"41","author":"Y Huh","year":"2011","unstructured":"Huh Y, Smith DE, Rose Feng M (2011) Interspecies scaling and prediction of human clearance: comparison of small- and macro-molecule drugs. Xenobiotica 41:972\u2013987. https:\/\/doi.org\/10.3109\/00498254.2011.598582","journal-title":"Xenobiotica"},{"key":"950_CR19","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1080\/00224065.1981.11978748","volume":"13","author":"RL Iman","year":"1981","unstructured":"Iman RL, Helton JC, Campbell JE (1981) An approach to sensitivity analysis of computer models: part I\u2014introduction, input variable selection and preliminary variable assessment. J Qual Technol 13:174\u2013183. https:\/\/doi.org\/10.1080\/00224065.1981.11978748","journal-title":"J Qual Technol"},{"key":"950_CR20","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1248\/yakushi.128.233","volume":"128","author":"T Ishida","year":"2008","unstructured":"Ishida T, Kiwada H (2008) Accelerated blood clearance (ABC) phenomenon induced by administration of PEGylated liposome. Yakugaku zasshi J Pharm Soc Jpn 128:233\u2013243","journal-title":"Yakugaku zasshi J Pharm Soc Jpn"},{"key":"950_CR21","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.jconrel.2005.04.003","volume":"105","author":"T Ishida","year":"2005","unstructured":"Ishida T, Harada M, Wang XY, Ichihara M, Irimura K, Kiwada H (2005) Accelerated blood clearance of PEGylated liposomes following preceding liposome injection: effects of lipid dose and PEG surface-density and chain length of the first-dose liposomes. J Control Release 105:305\u2013317. https:\/\/doi.org\/10.1016\/j.jconrel.2005.04.003","journal-title":"J Control Release"},{"key":"950_CR22","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/psp.2013.41","volume":"2","author":"HM Jones","year":"2013","unstructured":"Jones HM, Rowland-Yeo K (2013) Basic concepts in physiologically based pharmacokinetic modeling in drug discovery and development CPT: pharmacometrics & systems. Pharmacology 2:63. https:\/\/doi.org\/10.1038\/psp.2013.41","journal-title":"Pharmacology"},{"key":"950_CR23","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3181\/00379727-75-18083","volume":"75","author":"N Kaliss","year":"1950","unstructured":"Kaliss N, Pressman D (1950) Plasma and blood volumes of mouse organs, as determined with radioactive iodoproteins. Proc Soc Exp Biol Med Soc Exp Biol Med 75:16\u201320. https:\/\/doi.org\/10.3181\/00379727-75-18083","journal-title":"Proc Soc Exp Biol Med Soc Exp Biol Med"},{"key":"950_CR24","doi-asserted-by":"publisher","first-page":"26","DOI":"10.5414\/ALX02215E","volume":"5","author":"J Kleine-Tebbe","year":"2021","unstructured":"Kleine-Tebbe J et al (2021) Severe allergic reactions to the COVID-19 vaccine: statement and practical consequences. Allergol Sel 5:26\u201328. https:\/\/doi.org\/10.5414\/ALX02215E","journal-title":"Allergol Sel"},{"key":"950_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.07.024","author":"GT Kozma","year":"2020","unstructured":"Kozma GT, Shimizu T, Ishida T, Szebeni J (2020) Anti-PEG antibodies: properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals. Adv Drug Deliv Rev. https:\/\/doi.org\/10.1016\/j.addr.2020.07.024","journal-title":"Adv Drug Deliv Rev"},{"key":"950_CR26","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/2193-9616-1-6","volume":"1","author":"M Krauss","year":"2013","unstructured":"Krauss M et al (2013) Using Bayesian-PBPK modeling for assessment of inter-individual variability and subgroup stratification. In Silico Pharmacol 1:6\u20136. https:\/\/doi.org\/10.1186\/2193-9616-1-6","journal-title":"In Silico Pharmacol"},{"key":"950_CR27","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2134","author":"J Lang","year":"2020","unstructured":"Lang J, Vincent L, Chenel M, Ogungbenro K, Galetin A (2020) Impact of hepatic CYP3A4 ontogeny functions on drug-drug interaction risk in pediatric physiologically-based pharmacokinetic\/pharmacodynamic modeling: critical literature review and ivabradine case study. Clin Pharmacol Ther. https:\/\/doi.org\/10.1002\/cpt.2134","journal-title":"Clin Pharmacol Ther"},{"key":"950_CR28","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s11095-020-02965-y","volume":"37","author":"M Le Merdy","year":"2020","unstructured":"Le Merdy M et al (2020) Ocular physiologically based pharmacokinetic modeling for ointment formulations. Pharm Res 37:245. https:\/\/doi.org\/10.1007\/s11095-020-02965-y","journal-title":"Pharm Res"},{"key":"950_CR29","doi-asserted-by":"publisher","first-page":"3187807","DOI":"10.1155\/2018\/3187807","volume":"2018","author":"C Li","year":"2018","unstructured":"Li C, Pei Y, Zhu M, Deng Y (2018) Parameter estimation on a stochastic SIR model with media coverage. Discrete Dyn Nat Soc 2018:3187807. https:\/\/doi.org\/10.1155\/2018\/3187807","journal-title":"Discrete Dyn Nat Soc"},{"key":"950_CR30","doi-asserted-by":"publisher","first-page":"R60","DOI":"10.1186\/ar4497","volume":"16","author":"PE Lipsky","year":"2014","unstructured":"Lipsky PE, Calabrese LH, Kavanaugh A, Sundy JS, Wright D, Wolfson M, Becker MA (2014) Pegloticase immunogenicity: the relationship between efficacy and antibody development in patients treated for refractory chronic gout. Arthritis Res Ther 16:R60. https:\/\/doi.org\/10.1186\/ar4497","journal-title":"Arthritis Res Ther"},{"key":"950_CR31","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2176","author":"JD Lutz","year":"2021","unstructured":"Lutz JD, Mathias A, German P, Pikora C, Reddy S, Kirby BJ (2021) Physiologically-based pharmacokinetic modeling of remdesivir and its metabolites to support dose selection for the treatment of pediatric patients with COVID-19. Clin Pharmacol Ther. https:\/\/doi.org\/10.1002\/cpt.2176","journal-title":"Clin Pharmacol Ther"},{"key":"950_CR32","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.jtbi.2008.04.011","volume":"254","author":"S Marino","year":"2008","unstructured":"Marino S, Hogue IB, Ray CJ, Kirschner DE (2008) A methodology for performing global uncertainty and sensitivity analysis in systems biology. J Theor Biol 254:178\u2013196. https:\/\/doi.org\/10.1016\/j.jtbi.2008.04.011","journal-title":"J Theor Biol"},{"key":"950_CR33","doi-asserted-by":"publisher","first-page":"239","DOI":"10.2307\/1268522","volume":"21","author":"MD McKay","year":"1979","unstructured":"McKay MD, Beckman RJ, Conover WJ (1979) A comparison of three methods for selecting values of input variables in the analysis of output from a computer code. Technometrics 21:239\u2013245. https:\/\/doi.org\/10.2307\/1268522","journal-title":"Technometrics"},{"key":"950_CR34","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.jconrel.2018.06.002","volume":"284","author":"MD McSweeney","year":"2018","unstructured":"McSweeney MD et al (2018) A minimal physiologically based pharmacokinetic model that predicts anti-PEG IgG-mediated clearance of PEGylated drugs in human and mouse. J Control Release 284:171\u2013178. https:\/\/doi.org\/10.1016\/j.jconrel.2018.06.002","journal-title":"J Control Release"},{"key":"950_CR35","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1080\/14686996.2019.1627174","volume":"20","author":"M Mohamed","year":"2019","unstructured":"Mohamed M et al (2019) PEGylated liposomes: immunological responses. Sci Technol Adv Mater 20:710\u2013724. https:\/\/doi.org\/10.1080\/14686996.2019.1627174","journal-title":"Sci Technol Adv Mater"},{"key":"950_CR36","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1023\/A:1015836720294","volume":"8","author":"J Mordenti","year":"1991","unstructured":"Mordenti J, Chen SA, Moore JA, Ferraiolo BL, Green JD (1991) Interspecies scaling of clearance and volume of distribution data for five therapeutic proteins. Pharm Res 8:1351\u20131359. https:\/\/doi.org\/10.1023\/A:1015836720294","journal-title":"Pharm Res"},{"key":"950_CR37","unstructured":"Moses (2021). spider_plot (https:\/\/github.com\/NewGuy012\/spider_plot), GitHub. Accessed 4 Feb 2021"},{"key":"950_CR38","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1124\/dmd.104.001040","volume":"33","author":"R Nasu","year":"2005","unstructured":"Nasu R, Kumagai Y, Kogetsu H, Tsujimoto M, Ohtani H, Sawada Y (2005) Physiologically based pharmacokinetic model for pralmorelin hydrochloride in rats. Drug Metab Dispos Biol Fate Chem 33:1488\u20131494. https:\/\/doi.org\/10.1124\/dmd.104.001040","journal-title":"Drug Metab Dispos Biol Fate Chem"},{"key":"950_CR39","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1016\/j.jaci.2016.04.058","volume":"138","author":"TJ Povsic","year":"2016","unstructured":"Povsic TJ et al (2016) Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer. J Allergy Clin Immunol 138:1712\u20131715. https:\/\/doi.org\/10.1016\/j.jaci.2016.04.058","journal-title":"J Allergy Clin Immunol"},{"key":"950_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01540","author":"M Pyzik","year":"2019","unstructured":"Pyzik M, Sand KMK, Hubbard JJ, Andersen JT, Sandlie I, Blumberg RS (2019) The Neonatal Fc Receptor (FcRn): a misnomer? Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2019.01540","journal-title":"Front Immunol"},{"key":"950_CR41","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/0742-8413(92)90003-P","volume":"103","author":"WA Ritschel","year":"1992","unstructured":"Ritschel WA, Vachharajani NN, Johnson RD, Hussain AS (1992) The allometric approach for interspecies scaling of pharmacokinetic parameters. Comp Biochem Physiol Part C Comp Pharmacol 103:249\u2013253. https:\/\/doi.org\/10.1016\/0742-8413(92)90003-P","journal-title":"Comp Biochem Physiol Part C Comp Pharmacol"},{"key":"950_CR42","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2221","author":"F Stader","year":"2021","unstructured":"Stader F, Battegay M, Marzolini C (2021) Physiologically based pharmacokinetic modelling to support the clinical management of drug-drug interactions with bictegravir. Clin Pharmacol Ther. https:\/\/doi.org\/10.1002\/cpt.2221","journal-title":"Clin Pharmacol Ther"},{"key":"950_CR43","first-page":"1299","volume":"12","author":"AS Talawar","year":"2016","unstructured":"Talawar AS, Aundhakar UR (2016) Parameter estimation of SIR epidemic model using MCMC methods. Glob J Pure Appl Math 12:1299\u20131306","journal-title":"Glob J Pure Appl Math"},{"key":"950_CR44","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1111\/bcp.12234","volume":"79","author":"N Tsamandouras","year":"2015","unstructured":"Tsamandouras N, Rostami-Hodjegan A, Aarons L (2015) Combining the \u2018bottom up\u2019 and \u2018top down\u2019 approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data. Br J Clin Pharmacol 79:48\u201355. https:\/\/doi.org\/10.1111\/bcp.12234","journal-title":"Br J Clin Pharmacol"},{"key":"950_CR45","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12606","author":"T Ueno","year":"2021","unstructured":"Ueno T, Miyajima Y, Landry I, Lalovic B, Schuck E (2021) Physiologically based pharmacokinetic modeling to predict drug interactions of lemborexant with CYP3A inhibitors. CPT Pharmacomet Syst Pharmacol. https:\/\/doi.org\/10.1002\/psp4.12606","journal-title":"CPT Pharmacomet Syst Pharmacol"},{"key":"950_CR46","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1111\/bcp.12878","volume":"81","author":"C Walsh","year":"2016","unstructured":"Walsh C et al (2016) Development of a physiologically based pharmacokinetic model of actinomycin D in children with cancer. Br J Clin Pharmacol 81:989\u2013998. https:\/\/doi.org\/10.1111\/bcp.12878","journal-title":"Br J Clin Pharmacol"},{"key":"950_CR47","doi-asserted-by":"publisher","first-page":"72","DOI":"10.5414\/ALX02225E","volume":"5","author":"M Worm","year":"2021","unstructured":"Worm M et al (2021) Practical recommendations for the allergological risk assessment of the COVID-19 vaccination: a harmonized statement of allergy centers in Germany. Allergol Sel 5:72\u201376. https:\/\/doi.org\/10.5414\/ALX02225E","journal-title":"Allergol Sel"},{"key":"950_CR48","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1002\/wnan.1339","volume":"7","author":"Q Yang","year":"2015","unstructured":"Yang Q, Lai SK (2015) Anti-PEG immunity: emergence, characteristics, and unaddressed questions. Wiley Interdiscip Rev Nanomed Nanobiotechnol 7:655\u2013677. https:\/\/doi.org\/10.1002\/wnan.1339","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"key":"950_CR49","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.xphs.2018.10.037","volume":"108","author":"D Yuan","year":"2019","unstructured":"Yuan D, He H, Wu Y, Fan J, Cao Y (2019) Physiologically based pharmacokinetic modeling of nanoparticles. J Pharm Sci 108:58\u201372. https:\/\/doi.org\/10.1016\/j.xphs.2018.10.037","journal-title":"J Pharm Sci"}],"container-title":["Bulletin of Mathematical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11538-021-00950-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11538-021-00950-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11538-021-00950-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T05:57:42Z","timestamp":1744178262000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11538-021-00950-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,9]]},"references-count":49,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["950"],"URL":"https:\/\/doi.org\/10.1007\/s11538-021-00950-z","relation":{},"ISSN":["0092-8240","1522-9602"],"issn-type":[{"value":"0092-8240","type":"print"},{"value":"1522-9602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,9]]},"assertion":[{"value":"21 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflict of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"123"}}