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Mathematical models to describe the transmission dynamics of <jats:italic>P. vivax<\/jats:italic> have been developed, but most of them fail to capture realistic dynamics of hypnozoites. Models that do capture the complexity tend to involve many governing equations, making them difficult to extend to incorporate other important factors for <jats:italic>P. vivax<\/jats:italic>, such as treatment status, age and pregnancy. In this paper, we have developed a multiscale model (a system of integro-differential equations) that involves a minimal set of equations at the population scale, with an embedded within-host model that can capture the dynamics of the hypnozoite reservoir. In this way, we can gain key insights into dynamics of <jats:italic>P. vivax<\/jats:italic> transmission with a minimum number of equations at the population scale, making this framework readily scalable to incorporate more complexity. We performed a sensitivity analysis of our multiscale model over key parameters and found that prevalence of <jats:italic>P. vivax<\/jats:italic> blood-stage infection increases with both bite rate and number of mosquitoes but decreases with hypnozoite death rate. Since our mathematical model captures the complex dynamics of <jats:italic>P. vivax<\/jats:italic> and the hypnozoite reservoir, it has the potential to become a key tool to inform elimination strategies for <jats:italic>P. vivax<\/jats:italic>.<\/jats:p>","DOI":"10.1007\/s11538-022-01036-0","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T21:10:34Z","timestamp":1656709834000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A Multiscale Mathematical Model of Plasmodium Vivax Transmission"],"prefix":"10.1007","volume":"84","author":[{"given":"Md Nurul","family":"Anwar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roslyn I.","family":"Hickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somya","family":"Mehra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"McCaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8809-726X","authenticated-orcid":false,"given":"Jennifer A.","family":"Flegg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,1]]},"reference":[{"issue":"3","key":"1036_CR1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001767","volume":"3","author":"R \u00c1guas","year":"2008","unstructured":"\u00c1guas R et al (2008) Prospects for malaria eradication in sub-Saharan Africa. 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