{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T09:34:45Z","timestamp":1749548085551,"version":"3.37.3"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bull Math Biol"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1007\/s11538-023-01217-5","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T18:02:43Z","timestamp":1697220163000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ex Vivo Experiments Shed Light on the Innate Immune Response from Influenza Virus"],"prefix":"10.1007","volume":"85","author":[{"given":"Daniel","family":"Olmos Liceaga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro Filipe","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0723-2539","authenticated-orcid":false,"given":"Roberto A.","family":"Saenz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,10,13]]},"reference":[{"issue":"10","key":"1217_CR1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1008874","volume":"17","author":"JO Aponte-Serrano","year":"2021","unstructured":"Aponte-Serrano JO, Weaver JJA, Sego TJ et al (2021) Multicellular spatial model of RNA virus replication and interferon responses reveals factors controlling plaque growth dynamics. PLoS Comput Biol 17(10):e1008874. https:\/\/doi.org\/10.1371\/journal.pcbi.1008874","journal-title":"PLoS Comput Biol"},{"key":"1217_CR2","doi-asserted-by":"publisher","first-page":"7590","DOI":"10.1128\/JVI.01623-05","volume":"80","author":"P Baccam","year":"2006","unstructured":"Baccam P, Beauchemin C, Macken CA et al (2006) Kinetics of influenza A virus infection in humans. J Virol 80:7590\u20137599. https:\/\/doi.org\/10.1128\/JVI.01623-05","journal-title":"J Virol"},{"key":"1217_CR3","doi-asserted-by":"publisher","first-page":"A110","DOI":"10.1016\/j.antiviral.2008.12.014","volume":"82","author":"D Barnard","year":"2009","unstructured":"Barnard D (2009) Animal models for the study of influenza pathogenesis and therapy. Antivir Res 82:A110\u2013A122. https:\/\/doi.org\/10.1016\/j.antiviral.2008.12.014","journal-title":"Antivir Res"},{"issue":"Suppl 1:S7","key":"1217_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2458-11-S1-S7","volume":"11","author":"CA Beauchemin","year":"2011","unstructured":"Beauchemin CA, Handel A (2011) A review of mathematical models of influenza A infections within a host or cell culture: lessons learned and challenges ahead. BMC Public Health 11(Suppl 1:S7):1\u201315. https:\/\/doi.org\/10.1186\/1471-2458-11-S1-S7","journal-title":"BMC Public Health"},{"key":"1217_CR5","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.jtbi.2004.08.001","volume":"232","author":"C Beauchemin","year":"2005","unstructured":"Beauchemin C, Samuel J, Tuszynski J (2005) A simple cellular automaton model for influenza A viral infections. J Theor Biol 232:223\u2013234. https:\/\/doi.org\/10.1016\/j.jtbi.2004.08.001","journal-title":"J Theor Biol"},{"key":"1217_CR6","doi-asserted-by":"publisher","unstructured":"Beauchemin C, Forrest S, Koster F (2006) Modeling influenza viral dynamics in tissue. In: Bersini H, Carneiro J (eds) International conference on artificial immune systems: artificial immune systems. Springer, Berlin p 4163 (23\u201336). https:\/\/doi.org\/10.1007\/11823940_3","DOI":"10.1007\/11823940_3"},{"key":"1217_CR7","doi-asserted-by":"publisher","first-page":"5274","DOI":"10.3390\/v7102875","volume":"7","author":"A Boianelli","year":"2015","unstructured":"Boianelli A, Nguyen VK, Ebensen T et al (2015) Modeling influenza virus infection: a roadmap for influenza research. Viruses 7:5274\u20135304. https:\/\/doi.org\/10.3390\/v7102875","journal-title":"Viruses"},{"key":"1217_CR8","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.ijid.2019.08.002","volume":"88","author":"LK Borkenhagen","year":"2019","unstructured":"Borkenhagen LK, Salman MD, Ma MJ et al (2019) Animal influenza virus infections in humans: a commentary. Int J Infect Dis 88:113\u2013119. https:\/\/doi.org\/10.1016\/j.ijid.2019.08.002","journal-title":"Int J Infect Dis"},{"issue":"197","key":"1217_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/v9080197","volume":"9","author":"P Cao","year":"2017","unstructured":"Cao P, McCaw JM (2017) The mechanisms for within-host influenza virus control affect model-based assessment and prediction of antiviral treatment. Viruses 9(197):1\u201320. https:\/\/doi.org\/10.3390\/v9080197","journal-title":"Viruses"},{"issue":"7","key":"1217_CR10","doi-asserted-by":"publisher","first-page":"775","DOI":"10.3390\/mps1020012","volume":"167","author":"F Carrat","year":"2008","unstructured":"Carrat F, Vergu E, Ferguson NM et al (2008) Time lines of infection and disease in human influenza: a review of volunteer challenge studies. Am J Epidemiol 167(7):775\u2013785. https:\/\/doi.org\/10.3390\/mps1020012","journal-title":"Am J Epidemiol"},{"issue":"12","key":"1217_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/mps1020012","volume":"1","author":"RD de Vries","year":"2018","unstructured":"de Vries RD, Rennick LJ, Duprex WP et al (2018) Paramyxovirus infections in ex vivo lung slice cultures of different host species. Methods Protoc 1(12):1\u20139. https:\/\/doi.org\/10.3390\/mps1020012","journal-title":"Methods Protoc"},{"key":"1217_CR12","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/1297-9716-45-42","volume":"45","author":"M Delgado-Ortega","year":"2014","unstructured":"Delgado-Ortega M, Melo S, Punyadarsaniya D et al (2014) Innate immune response to a H3N2 subtype swine influenza virus in newborn porcine trachea cells, alveolar macrophages, and precision-cut lung slices. Vet Res 45:42. https:\/\/doi.org\/10.1186\/1297-9716-45-42","journal-title":"Vet Res"},{"issue":"10","key":"1217_CR13","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1093\/bioinformatics\/btaa969","volume":"37","author":"RW Gregg","year":"2021","unstructured":"Gregg RW, Shabnam F, Shoemaker JE (2021) Agent-based modeling reveals benefits of heterogeneous and stochastic cell populations during cGAS-mediated IFN$$\\beta $$ production. Bioinformatics 37(10):1428\u20131434. https:\/\/doi.org\/10.1093\/bioinformatics\/btaa969","journal-title":"Bioinformatics"},{"issue":"5750","key":"1217_CR14","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1126\/science.1116681","volume":"310","author":"V Grimm","year":"2005","unstructured":"Grimm V, Revilla E, Berger U et al (2005) Pattern-oriented modeling of agent-based complex systems: lessons from ecology. Science 310(5750):987\u2013991. https:\/\/doi.org\/10.1126\/science.1116681","journal-title":"Science"},{"issue":"20131","key":"1217_CR15","doi-asserted-by":"publisher","first-page":"083","DOI":"10.1098\/rsif.2013.1083","volume":"11","author":"A Handel","year":"2014","unstructured":"Handel A, Akin V, Pilyugin S et al (2014) How sticky should a virus be? The impact of virus binding and release on transmission fitness using influenza as an example. J R Soc Interface 11(20131):083. https:\/\/doi.org\/10.1098\/rsif.2013.1083","journal-title":"J R Soc Interface"},{"key":"1217_CR16","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.coisb.2018.08.009","volume":"12","author":"A Handel","year":"2018","unstructured":"Handel A, Liao L, Beauchemin C (2018) Progress and trends in mathematical modelling of influenza A virus infections. Curr Opin Syst Biol 12:30\u201336. https:\/\/doi.org\/10.1016\/j.coisb.2018.08.009","journal-title":"Curr Opin Syst Biol"},{"issue":"11","key":"1217_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003372","volume":"9","author":"FS Heldt","year":"2013","unstructured":"Heldt FS, Frensing T, Pflugmacher A et al (2013) Multiscale modeling of influenza A virus infection supports the development of direct-acting antivirals. PLOS Comp Biol 9(11):e1003372. https:\/\/doi.org\/10.1371\/journal.pcbi.1003372","journal-title":"PLOS Comp Biol"},{"key":"1217_CR18","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s00441-016-2546-z","volume":"367","author":"AC Hocke","year":"2017","unstructured":"Hocke AC, Suttorp N, Hippenstiel S (2017) Human lung ex vivo infection models. Cell Tissue Res 367:511\u2013524. https:\/\/doi.org\/10.1007\/s00441-016-2546-z","journal-title":"Cell Tissue Res"},{"issue":"3","key":"1217_CR19","doi-asserted-by":"publisher","first-page":"e14767","DOI":"10.1371\/journal.pone.0014767","volume":"6","author":"BP Holder","year":"2011","unstructured":"Holder BP, Simon P, Liao LL et al (2011) Assessing the in vitro fitness of an oseltamivir-resistant seasonal A\/H1N1 influenza strain using a mathematical model. PLoS ONE 6(3):e14767. https:\/\/doi.org\/10.1371\/journal.pone.0014767","journal-title":"PLoS ONE"},{"key":"1217_CR20","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.00459-22","author":"SS Jhutty","year":"2022","unstructured":"Jhutty SS, Boehme JD, Jeron A et al (2022) Predicting influenza A virus infection in the lung from hematological data with machine learning. mSystems. https:\/\/doi.org\/10.1128\/msystems.00459-22","journal-title":"mSystems"},{"issue":"22","key":"1217_CR21","doi-asserted-by":"publisher","first-page":"12496","DOI":"10.1128\/JVI.02499-13","volume":"87","author":"J Jones","year":"2013","unstructured":"Jones J, Baranovich T, Zaraket H et al (2013) Human H7N9 influenza A viruses replicate in swine respiratory tissue explants. J Virol 87(22):12496\u201312498. https:\/\/doi.org\/10.1128\/JVI.02499-13","journal-title":"J Virol"},{"issue":"3","key":"1217_CR22","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.jinf.2017.12.012","volume":"76","author":"Y Kang","year":"2018","unstructured":"Kang Y, Shen X, Yuan R et al (2018) Pathogenicity and transmissibility of three avian influenza A (H5N6) viruses isolated from wild birds. J Infect 76(3):286\u2013294. https:\/\/doi.org\/10.1016\/j.jinf.2017.12.012","journal-title":"J Infect"},{"key":"1217_CR23","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1099\/vir.0.014480-0","volume":"90","author":"E Lange","year":"2009","unstructured":"Lange E, Kalthoff D, Blohm U et al (2009) Pathogenesis and transmission of the novel swine-origin influenza virus A\/H1N1 after experimental infection of pigs. J Gen Virol 90:2119\u20132123. https:\/\/doi.org\/10.1099\/vir.0.014480-0","journal-title":"J Gen Virol"},{"key":"1217_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1098\/rspb.2020.3002","volume":"288","author":"GM Lavigne","year":"2021","unstructured":"Lavigne GM, Russell H, Sherry B et al (2021) Autocrine and paracrine interferon signalling as \u2018ring vaccination\u2019 and \u2018contact tracing\u2019 strategies to suppress virus infection in a host. Proc R Soc B 288:1\u20138. https:\/\/doi.org\/10.1098\/rspb.2020.3002","journal-title":"Proc R Soc B"},{"issue":"517","key":"1217_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/v10100517","volume":"10","author":"S Leviyang","year":"2018","unstructured":"Leviyang S, Griva I (2018) Investigating functional roles for positive feedback and cellular heterogeneity in the type I interferon response to viral infection. Viruses 10(517):1\u201329. https:\/\/doi.org\/10.3390\/v10100517","journal-title":"Viruses"},{"key":"1217_CR26","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1099\/vir.0.037358-0","volume":"93","author":"D Lin","year":"2012","unstructured":"Lin D, Sun S, Du L et al (2012) Natural and experimental infection of dogs with pandemic H1N1\/2009 influenza virus. J Gen Virol 93:119\u2013123. https:\/\/doi.org\/10.1099\/vir.0.037358-0","journal-title":"J Gen Virol"},{"issue":"3","key":"1217_CR27","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1111\/j.1750-2659.2012.00397.x","volume":"7","author":"B L\u00f6ndt","year":"2013","unstructured":"L\u00f6ndt B, Brookes S, Nash B et al (2013) The infectivity of pandemic 2009 H1N1 and avian influenza viruses for pigs: an assessment by ex vivo respiratory tract organ culture. Influenza Other Respir Viruses 7(3):393\u2013402. https:\/\/doi.org\/10.1111\/j.1750-2659.2012.00397.x","journal-title":"Influenza Other Respir Viruses"},{"issue":"2","key":"1217_CR28","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1128\/JVI.01722-10","volume":"85","author":"H Mitchell","year":"2011","unstructured":"Mitchell H, Levin D, Forrest S et al (2011) Higher level of replication efficiency of 2009 (H1N1) pandemic influenza virus than those of seasonal and avian strains: Kinetics from epithelial cell culture and computational modeling. J Virol 85(2):1125\u20131135. https:\/\/doi.org\/10.1128\/JVI.01722-10","journal-title":"J Virol"},{"key":"1217_CR29","doi-asserted-by":"publisher","DOI":"10.3390\/pr6090138","author":"E Mochan","year":"2018","unstructured":"Mochan E, Ackerman EE, Shoemaker JE (2018) A systems and treatment perspective of models of influenza virus-induced host responses. Processes. https:\/\/doi.org\/10.3390\/pr6090138","journal-title":"Processes"},{"issue":"3","key":"1217_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11538-020-00711-4","volume":"82","author":"JR Moore","year":"2020","unstructured":"Moore JR, Ahmed H, Manicassamy B et al (2020) Varying inoculum dose to assess the roles of the immune response and target cell depletion by the pathogen in control of acute viral infections. Bull Math Biol 82(3):1\u201335. https:\/\/doi.org\/10.1007\/s11538-020-00711-4","journal-title":"Bull Math Biol"},{"key":"1217_CR31","doi-asserted-by":"publisher","unstructured":"Nunes SF (2011) Influenza A infection dynamics in an ex vivo organ culture of pig trachea. Ph.D. Thesis, University of Cambridge, UK. https:\/\/doi.org\/10.13140\/RG.2.2.16357.58083","DOI":"10.13140\/RG.2.2.16357.58083"},{"issue":"1","key":"1217_CR32","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/j.1750-2659.2009.00119.x","volume":"4","author":"SF Nunes","year":"2009","unstructured":"Nunes SF, Murcia PR, Tiley LS et al (2009) An ex vivo swine tracheal organ culture for the study of influenza infection. Influenza Other Respir Viruses 4(1):7\u201315. https:\/\/doi.org\/10.1111\/j.1750-2659.2009.00119.x","journal-title":"Influenza Other Respir Viruses"},{"key":"1217_CR33","first-page":"633","volume-title":"Handbook in operations research and management science: simulation","author":"S \u00d3lafsson","year":"2006","unstructured":"\u00d3lafsson S (2006) Metaheuristics. In: Henderson SG, Nelson BL (eds) Handbook in operations research and management science: simulation. Elsevier, Amsterdam, pp 633\u2013654"},{"issue":"6","key":"1217_CR34","doi-asserted-by":"publisher","first-page":"2990","DOI":"10.1128\/JVI.03146-14","volume":"89","author":"CR Parrish","year":"2015","unstructured":"Parrish CR, Murcia PR, Holmes EC (2015) Influenza virus reservoirs and intermediate hosts: dogs, horses, and new possibilities for influenza virus exposure of humans. J Virol 89(6):2990\u20132994. https:\/\/doi.org\/10.1128\/JVI.03146-14","journal-title":"J Virol"},{"issue":"6","key":"1217_CR35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002588","volume":"8","author":"KA Pawelek","year":"2012","unstructured":"Pawelek KA, Huynh GT, Quinlivan M et al (2012) Modeling within-host dynamics of influenza virus infection including immune responses. PLoS Comp Biol 8(6):e1002588. https:\/\/doi.org\/10.1371\/journal.pcbi.1002588","journal-title":"PLoS Comp Biol"},{"key":"1217_CR36","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.jtbi.2015.07.003","volume":"382","author":"SM Petrie","year":"2015","unstructured":"Petrie SM, Butler J, Barr IG et al (2015) Quantifying relative within-host replication fitness in influenza virus competition experiments. J Theor Biol 382:259\u2013271. https:\/\/doi.org\/10.1016\/j.jtbi.2015.07.003","journal-title":"J Theor Biol"},{"issue":"1","key":"1217_CR37","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1093\/ilar\/ilv002","volume":"56","author":"DS Rajao","year":"2015","unstructured":"Rajao DS, Vincent AL (2015) Swine as a model for influenza A virus infection and immunity. ILAR J 56(1):44\u201352. https:\/\/doi.org\/10.1093\/ilar\/ilv002","journal-title":"ILAR J"},{"key":"1217_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1099\/vir.0.83391-0","volume":"89","author":"RE Randall","year":"2008","unstructured":"Randall RE, Goodbourn S (2008) Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J Gen Virol 89:1\u201347. https:\/\/doi.org\/10.1099\/vir.0.83391-0","journal-title":"J Gen Virol"},{"issue":"8","key":"1217_CR39","doi-asserted-by":"publisher","first-page":"3974","DOI":"10.1128\/JVI.02078-09","volume":"84","author":"RA Saenz","year":"2010","unstructured":"Saenz RA, Quinlivan M, Elton D et al (2010) Dynamics of influenza virus infection and pathology. J Virol 84(8):3974\u20133983. https:\/\/doi.org\/10.1128\/JVI.02078-09","journal-title":"J Virol"},{"issue":"3","key":"1217_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2022.152192","volume":"227","author":"S Starb\u00e6k","year":"2022","unstructured":"Starb\u00e6k S, Andersen M, Brogaard L et al (2022) Innate antiviral responses in porcine nasal mucosal explants inoculated with influenza A virus are comparable with responses in respiratory tissues after viral infection. Immunobiology 227(3):152192. https:\/\/doi.org\/10.1016\/j.imbio.2022.152192","journal-title":"Immunobiology"},{"issue":"2","key":"1217_CR41","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1128\/mr.44.2.303-330.1980","volume":"44","author":"C Sweet","year":"1980","unstructured":"Sweet C, Smith H (1980) Pathogenicity of influenza virus. Microbiol Rev 44(2):303\u2013330. https:\/\/doi.org\/10.1128\/mr.44.2.303-330.1980","journal-title":"Microbiol Rev"},{"issue":"6","key":"1217_CR42","doi-asserted-by":"crossref","first-page":"236","DOI":"10.7883\/yoken.JJID.2004.236","volume":"57","author":"S Tamura","year":"2004","unstructured":"Tamura S, Kurata T (2004) Defense mechanisms against influenza virus infection in the respiratory tract mucosa. Jpn J Infect Dis 57(6):236\u201347","journal-title":"Jpn J Infect Dis"},{"issue":"9","key":"1217_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.it.2021.07.004","volume":"42","author":"LC Van Eyndhoven","year":"2021","unstructured":"Van Eyndhoven LC, Singh A, Tel J (2021) Decoding the dynamics of multilayered stochastic antiviral IFN-I responses. Trends Immunol 42(9):1\u201316. https:\/\/doi.org\/10.1016\/j.it.2021.07.004","journal-title":"Trends Immunol"},{"key":"1217_CR44","unstructured":"World Health Organization (2017) Up to 650 000 people die of respiratory diseases linked to seasonal flu each year. https:\/\/www.who.int\/news\/item\/13-12-2017-up-to-650-000-people-die-of-respiratory-diseases-linked-to-sea\/sonal-flu-each-year. Accessed 4 Nov 2021"},{"issue":"100","key":"1217_CR45","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.epidem.2020.100406","volume":"33","author":"A Yan","year":"2020","unstructured":"Yan A, Zhou J, Beauchemin C et al (2020) Quantifying mechanistic traits of influenza viral dynamics using in vitro data. Epidemics 33(100):406. https:\/\/doi.org\/10.1016\/j.epidem.2020.100406","journal-title":"Epidemics"}],"container-title":["Bulletin of Mathematical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11538-023-01217-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11538-023-01217-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11538-023-01217-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T20:37:25Z","timestamp":1730320645000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11538-023-01217-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,13]]},"references-count":45,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["1217"],"URL":"https:\/\/doi.org\/10.1007\/s11538-023-01217-5","relation":{},"ISSN":["0092-8240","1522-9602"],"issn-type":[{"type":"print","value":"0092-8240"},{"type":"electronic","value":"1522-9602"}],"subject":[],"published":{"date-parts":[[2023,10,13]]},"assertion":[{"value":"7 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}],"article-number":"115"}}