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We propose a mathematical model for the immune response during the initial stage of Systemic Lupus Erythematosus which models the process of aberrant apoptosis and activation of macrophages and neutrophils. NETosis is a type of cell death characterised by the release of neutrophil extracellular traps, or NETs, containing material from the neutrophil\u2019s nucleus, in response to a pathogenic stimulus. This process is hypothesised to contribute to the development of autoimmunogenicity in SLE. The aim of this work is to study how NETosis contributes to the establishment of persistent autoantigen production by analysing the steady states and the asymptotic dynamics of the model by numerical experiment.<\/jats:p>","DOI":"10.1007\/s11538-024-01291-3","type":"journal-article","created":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T14:01:16Z","timestamp":1714312876000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Modelling the Impact of NETosis During the Initial Stage of Systemic Lupus Erythematosus"],"prefix":"10.1007","volume":"86","author":[{"given":"Vladimira","family":"Suvandjieva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivanka","family":"Tsacheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Kararigas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4093-7837","authenticated-orcid":false,"given":"Peter","family":"Rashkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,28]]},"reference":[{"issue":"2","key":"1291_CR1","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/0040-5809(87)90050-5","volume":"32","author":"P Abrams","year":"1987","unstructured":"Abrams P (1987) The functional responses of adaptive consumers of two resources. 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