{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:01:30Z","timestamp":1779112890346,"version":"3.51.4"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T00:00:00Z","timestamp":1408579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiol med"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1007\/s11547-014-0455-3","type":"journal-article","created":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T11:17:09Z","timestamp":1408533429000},"page":"3-11","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["The role of CEUS in the assessment of haemodynamically stable patients with blunt abdominal trauma"],"prefix":"10.1007","volume":"120","author":[{"given":"Fabio","family":"Pinto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Valentino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Romanini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Basilico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Miele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,8,21]]},"reference":[{"key":"455_CR1","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1097\/00005373-199903000-00022","volume":"46","author":"TM Scalea","year":"1999","unstructured":"Scalea TM, Rodriguez A, Chiu WC et al (1999) Focused Assessment with Sonography for Trauma (FAST): results from an international consensus conference. J Trauma 46:466\u2013472","journal-title":"J Trauma"},{"key":"455_CR2","doi-asserted-by":"crossref","first-page":"905","DOI":"10.2214\/ajr.172.4.10587119","volume":"172","author":"PJ Bode","year":"1999","unstructured":"Bode PJ, Edwards MJ, Kruit MC et al (1999) Sonography in a clinical algorithm for early evaluation of 1671 patients with blunt abdominal trauma. Am J Roentgenol 172:905\u2013911","journal-title":"Am J Roentgenol"},{"key":"455_CR3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1148\/rg.281075047","volume":"28","author":"M Korner","year":"2008","unstructured":"Korner M, Krotz MM, Degenhart C et al (2008) Current role of emergency US in patients with major trauma. Radiographics 28:225\u2013242","journal-title":"Radiographics"},{"key":"455_CR4","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1148\/radiology.217.2.r00nv23426","volume":"217","author":"SS Lingawi","year":"2000","unstructured":"Lingawi SS, Buckley AR (2000) Focused abdominal US in patients with trauma. Radiology 217:426\u2013429","journal-title":"Radiology"},{"key":"455_CR5","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1053\/j.sult.2007.01.008","volume":"28","author":"M Valentino","year":"2007","unstructured":"Valentino M, Serra C, Pavlica P et al (2007) Contrast-enhanced ultrasound for blunt abdominal trauma. Semin Ultrasound CT MR 28:130\u2013140","journal-title":"Semin Ultrasound CT MR"},{"key":"455_CR6","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1097\/00005373-199904000-00003","volume":"46","author":"SR Shackford","year":"1999","unstructured":"Shackford SR, Rogers FB, Osler TM et al (1999) Focused abdominal sonogram for trauma: the learning curve of nonradiologist clinicians in detecting hemoperitoneum. J Trauma 46:553\u2013564","journal-title":"J Trauma"},{"key":"455_CR7","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s00330-002-1353-y","volume":"12","author":"PA Poletti","year":"2002","unstructured":"Poletti PA, Wintermark M, Schnyder P, Becker CD (2002) Traumatic injuries: role of imaging in the management of polytrauma victim (conservative expectation). Eur Radiol 12:969\u2013978","journal-title":"Eur Radiol"},{"key":"455_CR8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1148\/radiol.10091210","volume":"257","author":"SR Wilson","year":"2010","unstructured":"Wilson SR, Burns PN (2010) Microbubble-enhanced US in body imaging: what role? Radiology 257:24\u201339","journal-title":"Radiology"},{"key":"455_CR9","first-page":"5","volume":"22","author":"PN Burns","year":"2006","unstructured":"Burns PN, Wilson SR (2006) Microbubble contrast for radiological imaging: 1 Principles. Ultrasound Q 22:5\u201313","journal-title":"Ultrasound Q"},{"key":"455_CR10","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cult.2009.10.011","volume":"4","author":"M Bertolotto","year":"2009","unstructured":"Bertolotto M, Catalano O (2009) Contrast-enhanced ultrasound: past, present, and future. Ultrasound Clin 4:339\u2013367","journal-title":"Ultrasound Clin"},{"issue":"Suppl 8","key":"455_CR11","first-page":"P16","volume":"14","author":"E Leen","year":"2004","unstructured":"Leen E, Moug SJ, Horgan P (2004) Potential impact and utilization of ultrasound contrast media. Eur Radiol 14(Suppl 8):P16\u2013P24","journal-title":"Eur Radiol"},{"issue":"Suppl 6","key":"455_CR12","doi-asserted-by":"crossref","first-page":"F107","DOI":"10.1007\/s10406-007-0235-4","volume":"17","author":"L Thorelius","year":"2007","unstructured":"Thorelius L (2007) Emergency real-time contrast-enhanced ultrasonography for detection of solid organ injuries. Eur Radiol 17(Suppl 6):F107\u2013F111","journal-title":"Eur Radiol"},{"key":"455_CR13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s13244-012-0209-5","volume":"4","author":"D Cokkinos","year":"2013","unstructured":"Cokkinos D, Antypa E, Kalogeropuolos I et al (2013) Contrast-enhanced ultrasound performed under urgent condition. Indications, review of the technique, clinical examples and limitations. Insights Imaging 4:185\u2013198","journal-title":"Insights Imaging"},{"key":"455_CR14","first-page":"15","volume":"22","author":"SR Wilson","year":"2006","unstructured":"Wilson SR, Burns PN (2006) Microbubble contrast for radiological imaging: 2 Applications. Ultrasound Q 22:15\u201318","journal-title":"Ultrasound Q"},{"key":"455_CR15","doi-asserted-by":"crossref","unstructured":"Pinto F, Miele V, Scaglione M, Pinto A (2013) The use of contrast-enhanced ultrasound in blunt abdominal trauma: advantages and limitations. Acta Radiol [Epub ahead of print]","DOI":"10.1177\/0284185113505517"},{"key":"455_CR16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/02841850801961647","volume":"49","author":"HHT Madsen","year":"2008","unstructured":"Madsen HHT (2008) Ultrasound contrast: the most important innovation in ultrasound in recent decades. Acta Radiol 49:247\u2013248","journal-title":"Acta Radiol"},{"issue":"Suppl 2","key":"455_CR17","doi-asserted-by":"crossref","first-page":"S282","DOI":"10.1016\/S1076-6332(03)80204-0","volume":"9","author":"A Bauer","year":"2002","unstructured":"Bauer A, Solbiati L, Weissman N (2002) Ultrasound imaging with SonoVue: low mechanical index real-time imaging. Acad Radiol 9(Suppl 2):S282\u2013S284","journal-title":"Acad Radiol"},{"key":"455_CR18","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1097\/TA.0b013e31825a74b5","volume":"73","author":"JE Mihalik","year":"2012","unstructured":"Mihalik JE, Smith RS, Toevs CC et al (2012) The use of contrast-enhanced ultrasound for the evaluation of solid abdominal organ injury in patients with blunt abdominal trauma. J Trauma Acute Care Surg 73:1100\u20131105","journal-title":"J Trauma Acute Care Surg"},{"key":"455_CR19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2214\/AJR.09.2553","volume":"193","author":"SR Wilson","year":"2009","unstructured":"Wilson SR, Greenbaum LD, Goldberg BB (2009) Contrast-enhanced ultrasound: what is the evidence and what are the obstacles? AJR Am J Roentgenol 193:55\u201360","journal-title":"AJR Am J Roentgenol"},{"key":"455_CR20","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.ultrasmedbio.2006.05.031","volume":"32","author":"F Piscaglia","year":"2006","unstructured":"Piscaglia F, Bolondi L (2006) The safety of Sonovue in abdominal applications: retrospective analysis of 23,188 investigations. Ultrasound Med Biol 32:1369\u20131375","journal-title":"Ultrasound Med Biol"},{"key":"455_CR21","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/00004424-200102000-00006","volume":"36","author":"D Bokor","year":"2001","unstructured":"Bokor D, Chambers JB, Rees PJ et al (2001) Clinical safety of SonoVue, a new contrast agent for ultrasound imaging, in healthy volunteers and in patients with chronic obstructive pulmonary disease. Invest Radiol 36:104\u2013109","journal-title":"Invest Radiol"},{"key":"455_CR22","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1007\/s11547-010-0573-5","volume":"115","author":"W Li","year":"2010","unstructured":"Li W, Tang J, Lv F et al (2010) Effectiveness and safety of CEUS-guided haemostatic injection for blunt splenic trauma: an animal experiment. Radiol Med 115:1080\u20131086","journal-title":"Radiol Med"},{"key":"455_CR23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-0029-1245948","volume":"32","author":"F Piscaglia","year":"2011","unstructured":"Piscaglia F, Nols\u00f8e C, Dietrich CF et al (2011) The EFSUMB guidelines and recommendations on the clinical practice of contrast enhanced ultrasound (CEUS). Update 2011 on non-hepatic applications. Ultraschall Med 32:1\u201327","journal-title":"Ultraschall Med"},{"key":"455_CR24","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.dld.2006.08.008","volume":"39","author":"L Bolondi","year":"2007","unstructured":"Bolondi L, Correas JM, Lencioni R et al (2007) New perspectives for the use of contrast-enhanced liver ultrasound in clinical practice. Dig Liv Dis 39:187\u2013195","journal-title":"Dig Liv Dis"},{"key":"455_CR25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00261-005-0369-6","volume":"31","author":"O Catalano","year":"2006","unstructured":"Catalano O, Cusati B, Nunziata A et al (2006) Active abdominal bleeding: contrast-enhanced sonography. Abdom Imaging 31:9\u201316","journal-title":"Abdom Imaging"},{"key":"455_CR26","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1259\/bjr\/73325367","volume":"77","author":"P Glen","year":"2004","unstructured":"Glen P, MacQuarrie J, Imrie CW, Leen E (2004) A novel application of ultrasound contrast: demonstration of splenic arterial bleeding. Br J Radiol 77:333\u2013334","journal-title":"Br J Radiol"},{"key":"455_CR27","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1007\/s11547-011-0680-y","volume":"116","author":"F Lv","year":"2011","unstructured":"Lv F, Tang J, Luo Y et al (2011) Contrast-enhanced ultrasound imaging of active bleeding associated with hepatic and splenic trauma. Radiol Med 116:1076\u20131082","journal-title":"Radiol Med"},{"key":"455_CR28","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.2214\/ajr.183.5.1831293","volume":"183","author":"PA Poletti","year":"2004","unstructured":"Poletti PA, Platon A, Becker CD et al (2004) Blunt abdominal trauma: does the use of a second-generation sonographic contrast agent help to detect solid organ injuries? AJR Am J Roentgenol 183:1293\u20131301","journal-title":"AJR Am J Roentgenol"},{"key":"455_CR29","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.2214\/AJR.05.0027","volume":"186","author":"M Valentino","year":"2006","unstructured":"Valentino M, Serra C, Zironi G et al (2006) Blunt abdominal trauma: emergency contrast-enhanced sonography for detection of solid organ injuries. AJR Am J Roentgenol 186:1361\u20131367","journal-title":"AJR Am J Roentgenol"},{"key":"455_CR30","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1148\/radiol.2463070652","volume":"246","author":"M Valentino","year":"2008","unstructured":"Valentino M, Serra C, Pavlica P et al (2008) Blunt abdominal trauma: diagnostic performance of contrast-enhanced US in children: initial experience. Radiology 246:903\u2013909","journal-title":"Radiology"},{"key":"455_CR31","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s11547-007-0164-2","volume":"112","author":"G Regine","year":"2007","unstructured":"Regine G, Atzori M, Miele V et al (2007) Second-generation sonographic contrast agents in the evaluation of renal trauma. Radiol Med 112:581\u2013587","journal-title":"Radiol Med"},{"key":"455_CR32","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.crad.2012.01.017","volume":"67","author":"C McArthur","year":"2012","unstructured":"McArthur C, Baxter GM (2012) Current and potential renal applications of contrast-enhanced ultrasound. Clin Radiol 67:909\u2013922","journal-title":"Clin Radiol"},{"key":"455_CR33","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.cult.2010.08.005","volume":"5","author":"CJ Harvey","year":"2010","unstructured":"Harvey CJ, Sidhu PS (2010) Ultrasound contrast agents in genitourinary imaging. Ultrasound Clin 5:489\u2013506","journal-title":"Ultrasound Clin"},{"key":"455_CR34","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ejrad.2006.04.021","volume":"59","author":"F Pinto","year":"2006","unstructured":"Pinto F, Bode PJ, Tonerini M et al (2006) The role of the radiologist in the management of politrauma patients. Eur J Radiol 59:315\u2013316","journal-title":"Eur J Radiol"},{"key":"455_CR35","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0160-9963(00)80191-0","volume":"29","author":"SE Mirvis","year":"2000","unstructured":"Mirvis SE (2000) Role of CT in diagnosis and management of spleen injury. Appl Radiol 29:7\u201312","journal-title":"Appl Radiol"},{"key":"455_CR36","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.cult.2013.04.002","volume":"8","author":"Z Harkanyi","year":"2013","unstructured":"Harkanyi Z (2013) Potential applications of contrast-enhanced ultrasound in pediatric patients. Ultrasound Clin 8:403\u2013422","journal-title":"Ultrasound Clin"},{"key":"455_CR37","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1055\/s-0031-1281936","volume":"33","author":"M Piskunowicz","year":"2012","unstructured":"Piskunowicz M, Kosiak W, Batko T (2012) Intravenous application of second-generation ultrasound contrast agents in children: a review of the literature. Ultraschall Med 33:135\u2013140","journal-title":"Ultraschall Med"},{"key":"455_CR38","doi-asserted-by":"crossref","first-page":"966","DOI":"10.2214\/AJR.13.12010","volume":"202","author":"JL Coleman","year":"2014","unstructured":"Coleman JL, Navid F, Furman WL, McCarville MB (2014) Safety of ultrasound contrast agents in the pediatric oncologic population: a single-institution experience. AJR Am J Roentgenol 202:966\u2013970","journal-title":"AJR Am J Roentgenol"},{"key":"455_CR39","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1055\/s-0034-1366567","volume":"35","author":"ME Sellars","year":"2014","unstructured":"Sellars ME, Deganello A, Sidhu PS (2014) Paediatric contrast-enhanced ultrasound (CEUS): a technique that requires co-operation for rapid implementation into clinical practice. Ultrascall Med 35:203\u2013206","journal-title":"Ultrascall Med"},{"key":"455_CR40","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s00247-013-2746-6","volume":"43","author":"K Darge","year":"2013","unstructured":"Darge K, Papadopoulou F, Ntoulia A et al (2013) Safety of contrast-enhanced ultrasound in children for non-cardiac applications: a review by the Society for Pediatric Radiology (SPR) and the International Contrast Ultrasound Society (ICUS). Pediatr Radiol 43:1063\u20131073","journal-title":"Pediatr Radiol"},{"issue":"Suppl 6","key":"455_CR41","doi-asserted-by":"crossref","first-page":"F99","DOI":"10.1007\/s10406-007-0234-5","volume":"17","author":"L Romanini","year":"2007","unstructured":"Romanini L, Passamonti M, Aiani L et al (2007) Economic assessment of contrast-enhanced ultrasonography for evaluation of focal liver lesions: a multicenter Italian experience. Eur Radiol 17(Suppl 6):F99\u2013F106","journal-title":"Eur Radiol"},{"issue":"1 Pt 2","key":"455_CR42","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0221-0363(09)70089-7","volume":"90","author":"F Tranquart","year":"2009","unstructured":"Tranquart F, Correas JM, Ladam Marcus V et al (2009) Real-time contrast-enhanced ultrasound in the evaluation of focal liver lesions: diagnostic efficacy and economical issues from a French multicentric study. J Radiol 90(1 Pt 2):109\u2013122","journal-title":"J Radiol"},{"key":"455_CR43","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00261-008-9452-0","volume":"34","author":"O Catalano","year":"2009","unstructured":"Catalano O, Aiani L, Barozzi L et al (2009) CEUS in abdominal trauma: multi-center study. Abdom Imaging 34:225\u2013234","journal-title":"Abdom Imaging"},{"key":"455_CR44","first-page":"454","volume":"108","author":"O Catalano","year":"2004","unstructured":"Catalano O, Lobianco R, Sandomenico F et al (2004) Real-time, contrast-enhanced sonographic imaging in emergency radiology. Radiol Med 108:454\u2013469","journal-title":"Radiol Med"},{"key":"455_CR45","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1007\/s11547-009-0444-0","volume":"114","author":"M Valentino","year":"2009","unstructured":"Valentino M, Ansaloni L, Catena F et al (2009) Contrast-enhanced ultrasonography in blunt abdominal trauma: considerations after 5\u00a0years of experience. Radiol Med 114:1080\u20131093","journal-title":"Radiol Med"},{"key":"455_CR46","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1007\/s00330-007-0623-0","volume":"17","author":"E Quaia","year":"2007","unstructured":"Quaia E (2007) Microbubble ultrasound contrast agents: an update. Eur Radiol 17:1995\u20132008","journal-title":"Eur Radiol"},{"key":"455_CR47","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/00005373-199503000-00001","volume":"38","author":"EE Moore","year":"1995","unstructured":"Moore EE, Cogbill TH, Jurkovich GJ et al (1995) Organ injury scaling: spleen and liver (1994 revision). J Trauma 38:323\u2013324","journal-title":"J Trauma"},{"key":"455_CR48","first-page":"82","volume":"108","author":"V Miele","year":"2004","unstructured":"Miele V, Buffa V, Stasolla A et al (2004) Contrast enhanced ultrasound with second generation contrast agent in traumatic liver lesions. Radiol Med 108:82\u201391","journal-title":"Radiol Med"},{"key":"455_CR49","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.ultrasmedbio.2008.09.028","volume":"35","author":"J Tang","year":"2009","unstructured":"Tang J, Li W, Lv F et al (2009) Comparison of gray-scale contrast-enhanced ultrasonography with contrast-enhanced computed tomography in different grading of blunt hepatic and splenic trauma: an animal experiment. Ultrasound Med Biol 35:566\u2013575","journal-title":"Ultrasound Med Biol"},{"key":"455_CR50","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s11547-009-0406-6","volume":"114","author":"R Manetta","year":"2009","unstructured":"Manetta R, Pistoia ML, Bultrini C et al (2009) Ultrasound enhanced with sulphur-hexafluoride-filled microbubbles agent (SonoVue) in the follow-up of mild liver and spleen trauma. Radiol Med 114:771\u2013779","journal-title":"Radiol Med"}],"container-title":["La radiologia medica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11547-014-0455-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11547-014-0455-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11547-014-0455-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T00:27:59Z","timestamp":1565742479000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11547-014-0455-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,21]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["455"],"URL":"https:\/\/doi.org\/10.1007\/s11547-014-0455-3","relation":{},"ISSN":["0033-8362","1826-6983"],"issn-type":[{"value":"0033-8362","type":"print"},{"value":"1826-6983","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,21]]}}}