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Cozzi\u2014acts as Scientific Advisor to Varian Medical Systems outside the scope of the submitted work. Carlo Stella\u2014received speaker honoraria from MSD, BMS, Amgen, Janssen, AstraZeneca; acted as scientific advisor for Genenta Science, ADC Therapeutics, Sanofi, Boehringer Ingelheim; benefited from an unrestricted Grant from Rhizen Pharmaceuticals. These honoraria and Grants are outside the scope of the submitted work. Zucali\u2014received speaker honoraria from Astellas, Pfizer, Sanofi, Janssen, BMS, Ipsen, and Novartis; acted as scientific advisor for Astellas, Pfizer, BMS, Janssen, MSD and Novartis. All honoraria and Grants are outside the scope of the submitted work. Chiti\u2014received speaker honoraria from General Electric and Blue Earth Diagnostics, acted as scientific advisor for Blue Earth Diagnostics and Advanced Accelerator Applications, and benefited from an unconditional Grant from Sanofi to Humanitas University. All honoraria and Grants are outside the scope of the submitted work. As above mentioned, all declared honoraria and Grants are outside the scope of the submitted work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee (Humanitas Clinical and Research Center Review Board approval was obtained, authorization number 3\/18, April 17, 2018) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was waived by the institutional review board.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}