{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T09:42:38Z","timestamp":1793785358316,"version":"4.6.1"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiol med"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1007\/s11547-020-01283-y","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T21:23:04Z","timestamp":1600809784000},"page":"1102-1113","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["CCTA in the diagnosis of coronary artery disease"],"prefix":"10.1007","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2710-2093","authenticated-orcid":false,"given":"Riccardo","family":"Marano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Rovere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Savino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco Ciriaco","family":"Flammia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rachele Pia","family":"Carafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Steri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biagio","family":"Merlino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Natale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,22]]},"reference":[{"key":"1283_CR1","first-page":"e139","volume":"14","author":"SS Virani","year":"2020","unstructured":"Virani SS, Alonso A, Benjamin EJ et al (2020) heart disease and stroke statistics-2020 update: a report from the American heart association. Circulation 14:e139\u2013e596","journal-title":"Circulation"},{"key":"1283_CR2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/eurheartj\/ehz425","volume":"41","author":"J Knuuti","year":"2020","unstructured":"Knuuti J, Wijns W, Saraste A et al (2020) 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. Eur Heart J 41:407\u2013477","journal-title":"Eur Heart J"},{"key":"1283_CR3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s11547-018-0943-y","volume":"124","author":"R La Russa","year":"2019","unstructured":"La Russa R, Catalano C, Di Sanzo M et al (2019) Postmortem computed tomography angiography (PMCTA) and traditional autopsy in cases of sudden cardiac death due to coronary artery disease: a systematic review and meta-analysis. Radiol Med 124:109\u2013117","journal-title":"Radiol Med"},{"key":"1283_CR4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ahj.2003.10.022","volume":"148","author":"WB Kannel","year":"2004","unstructured":"Kannel WB, D\u2019Agostino RB, Sullivan L, Wilson PW (2004) Concept and usefulness of cardiovascular risk profiles. Am Heart J 148:16\u201326","journal-title":"Am Heart J"},{"key":"1283_CR5","doi-asserted-by":"crossref","unstructured":"Lee UW, Ahn S, Shin YS et al (2020) Comparison of the CAD consortium and updated Diamond-Forrester scores for predicting obstructive coronary artery disease. Am J Emerg Med [Epub ahead of print]","DOI":"10.1016\/j.ajem.2020.02.056"},{"key":"1283_CR6","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1056\/NEJMoa0907272","volume":"362","author":"MR Patel","year":"2010","unstructured":"Patel MR, Peterson ED, Dai D et al (2010) Low diagnostic yield of elective coronary angiography. N Engl J Med 362:886\u2013895","journal-title":"N Engl J Med"},{"key":"1283_CR7","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1161\/CIRCULATIONAHA.116.023396","volume":"134","author":"MS Bittencourt","year":"2016","unstructured":"Bittencourt MS, Hulten E, Polonsky TS et al (2016) European society of cardiology-recommended coronary artery disease consortium pretest probability scores more accurately predict obstructive coronary disease and cardiovascular events than the diamond and Forrester score: the partners registry. CAD Consortium Scores. Circulation 134:201\u2013211","journal-title":"Circulation"},{"key":"1283_CR8","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s11547-019-01036-6","volume":"124","author":"G Agliata","year":"2019","unstructured":"Agliata G, Schicchi N, Agostini A et al (2019) Radiation exposure related to cardiovascular CT examination: comparison between conventional 64-MDCT and third-generation dual-source MDCT. Radiol Med 124:753\u2013761","journal-title":"Radiol Med"},{"key":"1283_CR9","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jacc.2006.07.070","volume":"49","author":"G Pundziute","year":"2007","unstructured":"Pundziute G, Schuijf JD, Jukema JW et al (2007) Prognostic value of multislice computed tomography coronary angiography in patients with known or suspected coronary artery disease. J Am Coll Cardiol 49:62\u201370","journal-title":"J Am Coll Cardiol"},{"key":"1283_CR10","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/ehjci\/jew167","volume":"18","author":"G Feuchtner","year":"2017","unstructured":"Feuchtner G, Kerber J, Burghard P et al (2017) The high-risk criteria low-attenuation plaque\u2009<\u200960 HU and the napkin-ring sign are the most powerful predictors of MACE: a long-term follow-up study. Eur Heart J Cardiovasc Imaging 18:772\u2013779","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"1283_CR11","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1056\/NEJMoa0806576","volume":"359","author":"JM Miller","year":"2008","unstructured":"Miller JM, Rochitte CE, Dewey M et al (2008) Diagnostic performance of coronary angiography by 64-row CT. N Engl J Med 359:2324\u20132336","journal-title":"N Engl J Med"},{"key":"1283_CR12","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/j.jacc.2008.07.031","volume":"52","author":"MJ Budoff","year":"2008","unstructured":"Budoff MJ, Dowe D, Jollis JG et al (2008) Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY (Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive Coronary Angiography) trial. J Am Coll Cardiol 52:1724\u20131732","journal-title":"J Am Coll Cardiol"},{"key":"1283_CR13","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/j.jacc.2008.08.058","volume":"52","author":"WB Meijboom","year":"2008","unstructured":"Meijboom WB, Meijs MF, Schuijf JD et al (2008) Diagnostic accuracy of 64-slice computed tomography coronary angiography: a prospective, multicenter, multivendor study. J Am Coll Cardiol 52:2135\u20132144","journal-title":"J Am Coll Cardiol"},{"key":"1283_CR14","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1007\/s00330-008-1239-8","volume":"19","author":"R Marano","year":"2009","unstructured":"Marano R, De Cobelli F, Floriani I et al (2009) Italian multicenter, prospective study to evaluate the negative predictive value of 16- and 64-slice MDCT imaging in patients scheduled for coronary angiography (NIMISCAD-Non Invasive Multicenter Italian Study for Coronary Artery Disease). Eur Radiol 19:1114\u20131123","journal-title":"Eur Radiol"},{"key":"1283_CR15","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1258\/ar.2012.120205","volume":"54","author":"R Marano","year":"2013","unstructured":"Marano R, Savino G, Merlino B et al (2013) MDCT coronary angiography- postprocessing, reading, and reporting: last but not least. Acta Radiol 54:249\u2013258","journal-title":"Acta Radiol"},{"key":"1283_CR16","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.jcmg.2008.05.006","volume":"1","author":"V Cheng","year":"2008","unstructured":"Cheng V, Gutstein A, Wolak A et al (2008) Moving beyond binary grading of coronary arterial stenoses on coronary computed tomographic angiography: insights for the imager and referring clinician. JACC Cardiovasc Imaging 1:460\u2013471","journal-title":"JACC Cardiovasc Imaging"},{"key":"1283_CR17","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jcct.2016.04.005","volume":"10","author":"RC Cury","year":"2016","unstructured":"Cury RC, Abbara S, Achenbach S et al (2016) CAD-RADS coronary artery disease e reporting and data system. An expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT), the American College of Radiology (ACR) and the North American Society for Cardiovascular Imaging (NASCI). Endorsed by the American College of Cardiology. J Cardiovasc Comput Tomogr 10:269\u2013281","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"1283_CR18","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1161\/CIRCULATIONAHA.113.001952","volume":"127","author":"BK Nallamothu","year":"2013","unstructured":"Nallamothu BK, Spertus JA, Lansky AJ et al (2013) Comparison of clinical interpretation with visual assessment and quantitative coronary angiography in patients undergoing percutaneous coronary intervention in contemporary practice: the Assessing Angiography (A2) project. Circulation 127:1793\u20131800","journal-title":"Circulation"},{"key":"1283_CR19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jacc.2009.02.068","volume":"54","author":"S Motoyama","year":"2009","unstructured":"Motoyama S, Sarai M, Harigaya H et al (2009) Computed tomographic angiography characteristics of atherosclerotic plaques subsequently resulting in acute coronary syndrome. J Am Coll Cardiol 54:49\u201357","journal-title":"J Am Coll Cardiol"},{"key":"1283_CR20","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1253\/circj.72.1276","volume":"72","author":"A Tanaka","year":"2008","unstructured":"Tanaka A, Shimada K, Yoshida K et al (2008) Non-invasive assessment of plaque rupture by 64-slice multidetector computed tomography\u2013comparison with intravascular ultrasound. Circ J 72:1276\u20131281","journal-title":"Circ J"},{"key":"1283_CR21","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s10554-010-9695-z","volume":"27","author":"MG Dalager","year":"2011","unstructured":"Dalager MG, Bttcher M, Andersen G et al (2011) Impact of luminal density on plaque classification by CT coronary angiography. Int J Cardiovasc Imaging 27:593\u2013600","journal-title":"Int J Cardiovasc Imaging"},{"key":"1283_CR22","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/S0140-6736(15)60291-4","volume":"385","author":"SCOT-HEART investigators","year":"2015","unstructured":"SCOT-HEART investigators (2015) CT coronary angiography in patients with suspected angina due to coronary heart disease (SCOT-HEART): an open-label, parallel-group, multicentre trial. Lancet 385:2383\u20132391","journal-title":"Lancet"},{"key":"1283_CR23","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1056\/NEJMoa1805971","volume":"379","author":"SCOT-HEART Investigators","year":"2018","unstructured":"Investigators SCOT-HEART (2018) Coronary CT angiography and 5-year risk of myocardial infarction. N Engl J Med 379:924\u2013933","journal-title":"N Engl J Med"},{"key":"1283_CR24","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1016\/j.jacc.2012.05.062","volume":"60","author":"LJ Shaw","year":"2012","unstructured":"Shaw LJ, Hausleiter J, Achenbach S et al (2012) Coronary computed tomographic angiography as a gatekeeper to invasive diagnostic and surgical procedures: results from the multicenter CONFIRM (Coronary CT Angiography Evaluation for Clinical Outcomes: an International Multicenter) registry. J Am Coll Cardiol 60:2103\u20132114","journal-title":"J Am Coll Cardiol"},{"key":"1283_CR25","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1093\/eurheartj\/ehv444","volume":"36","author":"PS Douglas","year":"2015","unstructured":"Douglas PS, Pontone G, Hlatky MA et al (2015) Clinical outcomes of fractional flow reserve by computed tomographic angiography-guided diagnostic strategies versus usual care in patients with suspected coronary artery disease: the prospective longitudinal trial of FFR(CT): outcome and resource impacts study. Eur Heart J 36:3359\u20133367","journal-title":"Eur Heart J"},{"key":"1283_CR26","doi-asserted-by":"crossref","first-page":"i5441","DOI":"10.1136\/bmj.i5441","volume":"355","author":"M Dewey","year":"2016","unstructured":"Dewey M, Rief M, Martus P et al (2016) Evaluation of computed tomography in patients with atypical angina or chest pain clinically referred for invasive coronary angiography: randomised controlled trial. BMJ 355:i5441","journal-title":"BMJ"},{"key":"1283_CR27","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.jcmg.2018.09.018","volume":"12","author":"HJ Chang","year":"2019","unstructured":"Chang HJ, Lin FY, Gebow D et al (2019) Selective referral using CCTA versus direct referral for individuals referred to invasive coronary angiography for suspected CAD: a randomized, controlled, open-label trial. JACC Cardiovas Imaging 12:1303\u20131312","journal-title":"JACC Cardiovas Imaging"},{"key":"1283_CR28","unstructured":"https:\/\/www.nice.org.uk\/guidance\/cg95"},{"key":"1283_CR29","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.jacc.2011.06.066","volume":"58","author":"BK Koo","year":"2011","unstructured":"Koo BK, Erglis A, Doh JH et al (2011) Diagnosis of ischemia-causing coronary stenoses by noninvasive fractional flow reserve computed from coronary computed tomographic angiograms. Results from the prospective multicenter DISCOVER-FLOW (Diagnosis of Ischemia-Causing Stenoses Obtained Via Noninvasive Fractional Flow Reserve) study. J Am Coll Cardiol 58:1989\u20131997","journal-title":"J Am Coll Cardiol"},{"key":"1283_CR30","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1001\/2012.jama.11274","volume":"308","author":"JK Min","year":"2012","unstructured":"Min JK, Leipsic J, Pencina MJ et al (2012) Diagnostic accuracy of fractional flow reserve from anatomic CT angiography. JAMA 308:1237\u20131245","journal-title":"JAMA"},{"key":"1283_CR31","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.jacc.2013.11.043","volume":"63","author":"BL N\u00f8rgaard","year":"2014","unstructured":"N\u00f8rgaard BL, Leipsic J, Gaur S et al (2014) Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease: the NXT trial (Analysis of Coronary Blood Flow Using CT Angiography: next Steps). J Am Coll Cardiol 63:1145\u20131155","journal-title":"J Am Coll Cardiol"},{"key":"1283_CR32","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1148\/radiol.11110638","volume":"260","author":"F Bamberg","year":"2011","unstructured":"Bamberg F, Becker A, Schwarz F et al (2011) Detection of hemodynamically significant coronary artery stenosis: incremental diagnostic value of dynamic CT-based myocardial perfusion imaging. Radiology 260:689\u2013698","journal-title":"Radiology"},{"key":"1283_CR33","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.amjcard.2015.07.078","volume":"116","author":"JA Gonzalez","year":"2015","unstructured":"Gonzalez JA, Lipinski MJ, Flors L, Shaw PW, Kramer CM, Salerno M (2015) Meta-analysis of diagnostic performance of coronary computed tomography angiography, computed tomography perfusion, and computed tomography-fractional flow reserve in functional myocardial ischemia assessment versus invasive fractional flow reserve. Am J Cardiol 116:1469\u20131478","journal-title":"Am J Cardiol"},{"key":"1283_CR34","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.crad.2014.12.013","volume":"70","author":"S Li","year":"2015","unstructured":"Li S, Tang X, Peng L, Luo Y, Dong R, Liu J (2015) The diagnostic performance of CT-derived fractional flow reserve for evaluation of myocardial ischaemia confirmed by invasive fractional flow reserve: a meta-analysis. Clin Radiol 70:476\u2013486","journal-title":"Clin Radiol"},{"key":"1283_CR35","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1016\/j.jacc.2009.11.096","volume":"55","author":"PA Tonino","year":"2010","unstructured":"Tonino PA, Fearon WF, De Bruyne B et al (2010) Angiographic versus functional severity of coronary artery stenoses in the FAME study fractional flow reserve versus angiography in multivessel evaluation. J Am Coll Cardiol 55:2816\u20132821","journal-title":"J Am Coll Cardiol"},{"key":"1283_CR36","first-page":"991","volume":"38","author":"I Danad","year":"2017","unstructured":"Danad I, Szymonifka J, Twisk JWR et al (2017) Diagnostic performance of cardiac imaging methods to diagnose ischaemia-causing coronary artery disease when directly compared with fractional flow reserve as a reference standard: a meta-analysis. Eur Heart J 38:991\u2013998","journal-title":"Eur Heart J"},{"key":"1283_CR37","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.jacc.2011.09.077","volume":"59","author":"NH Pijls","year":"2012","unstructured":"Pijls NH, Sels JW (2012) Functional measurement of coronary stenosis. J Am Coll Cardiol 59:1045\u20131057","journal-title":"J Am Coll Cardiol"},{"key":"1283_CR38","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jcmg.2015.11.025","volume":"10","author":"BL N\u00f8rgaard","year":"2017","unstructured":"N\u00f8rgaard BL, Hjort J, Gaur S, Hansson N et al (2017) Clinical use of coronary CTA-derived FFR\u00a0for decision-making in stable CAD. JACC Cardiovasc Imaging 10:541\u2013550","journal-title":"JACC Cardiovasc Imaging"},{"key":"1283_CR39","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1093\/eurheartj\/ehy530","volume":"39","author":"TA Fairbairn","year":"2018","unstructured":"Fairbairn TA, Nieman K, Akasaka T et al (2018) Real-world clinical utility and impact on clinical decision-making of coronary computed tomography angiography-derived fractional flow reserve: lessons from the ADVANCE Registry. Eur Heart J 39:3701\u20133711","journal-title":"Eur Heart J"},{"key":"1283_CR40","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1148\/radiol.2019182264","volume":"292","author":"AR Ihdayhid","year":"2019","unstructured":"Ihdayhid AR, Norgaard BL, Gaur S et al (2019) Prognostic value and risk continuum of noninvasive fractional flow reserve derived from coronary CT angiography. Radiology 292:343\u2013351","journal-title":"Radiology"},{"key":"1283_CR41","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.jcmg.2015.06.003","volume":"8","author":"BL N\u00f8rgaard","year":"2015","unstructured":"N\u00f8rgaard BL, Gaur S, Leipsic J et al (2015) Influence of coronary calcification on the\u00a0diagnostic performance of CT angiography derived FFR in coronary\u00a0artery disease: a substudy of the NXT trial. JACC Cardiovasc Imaging 8:1045\u20131055","journal-title":"JACC Cardiovasc Imaging"},{"key":"1283_CR42","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/ehjci\/jew148","volume":"18","author":"RR Packard","year":"2017","unstructured":"Packard RR, Li D, Budoff MJ, Karlsberg RP et al (2017) Fractional flow reserve by computerized tomography and subsequent coronary revascularization. Eur Heart J Cardiovasc Imaging 18:145\u2013152","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"1283_CR43","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/clc.22205","volume":"36","author":"MA Hlatky","year":"2013","unstructured":"Hlatky MA, Saxena A, Koo BK, Erglis A, Zarins CK, Min JK et al (2013) Projected costs and consequences of computed tomography-determined fractional flow reserve. Clin Cardiol 36:743\u2013748","journal-title":"Clin Cardiol"},{"key":"1283_CR44","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s12928-014-0285-1","volume":"30","author":"T Kimura","year":"2015","unstructured":"Kimura T, Shiomi H, Kuribayashi S et al (2015) Cost analysis of non-invasive fractional flow reserve derived from coronary computed tomographic angiography in Japan. Cardiovasc Interv Ther 30:38\u201344","journal-title":"Cardiovasc Interv Ther"},{"key":"1283_CR45","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1161\/01.CIR.92.3.657","volume":"92","author":"E Falk","year":"1995","unstructured":"Falk E, Shah PK, Fuster V (1995) Coronary plaque disruption. Circulation 92:657\u2013671","journal-title":"Circulation"},{"key":"1283_CR46","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1161\/01.CIR.78.5.1157","volume":"78","author":"WC Little","year":"1988","unstructured":"Little WC, Constantinescu M, Applegate RJ et al (1988) Can coronary angiography predict the site of a subsequent myocardial infarction in patients with mild-to-moderate coronary artery disease? Circulation 78:1157\u20131166","journal-title":"Circulation"},{"key":"1283_CR47","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1161\/01.CIR.0000133317.49796.0E","volume":"110","author":"SM Grundy","year":"2004","unstructured":"Grundy SM, Cleeman JI, Merz CN et al (2004) Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 110:227\u2013239","journal-title":"Circulation"},{"key":"1283_CR48","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.amjcard.2008.05.039","volume":"102","author":"R Karim","year":"2008","unstructured":"Karim R, Hodis HN, Detrano R, Liu CR, Liu CH, Mack WJ (2008) Relation of Framingham risk score to subclinical atherosclerosis evaluated across three arterial sites. Am J Cardiol 102:825\u2013830","journal-title":"Am J Cardiol"},{"key":"1283_CR49","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1001\/jama.297.6.611","volume":"297","author":"PM Ridker","year":"2007","unstructured":"Ridker PM, Buring JE, Rifai N, Cook NR (2007) Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score. JAMA 297:611\u2013619","journal-title":"JAMA"},{"key":"1283_CR50","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1161\/CIRCULATIONAHA.108.814251","volume":"118","author":"PM Ridker","year":"2008","unstructured":"Ridker PM, Paynter NP, Rifai N, Gaziano JM, Cook NR (2008) C-reactive protein and parental history improve global cardiovascular risk prediction: the Reynolds Risk Score for men. Circulation 118:2243\u20132251","journal-title":"Circulation"},{"key":"1283_CR51","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.atherosclerosis.2004.02.013","volume":"173","author":"G De Backer","year":"2004","unstructured":"De Backer G, Ambrosioni E, Borch-Johnsen K et al (2004) European guidelines on cardiovascular disease prevention in clinical practice. Third Joint Task Force of European and other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of eight societies and by invited experts). Atherosclerosis 173:381\u2013391","journal-title":"Atherosclerosis"},{"key":"1283_CR52","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","volume":"285","author":"Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults","year":"2001","unstructured":"Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 285:2486\u20132497","journal-title":"JAMA"},{"key":"1283_CR53","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nrcardio.2010.3","volume":"7","author":"AS Adabag","year":"2010","unstructured":"Adabag AS, Luepker RV, Roger VL, Gersh BJ (2010) Sudden cardiac death: epidemiology and risk factors. Nat Rev Cardiol 7:216\u2013225","journal-title":"Nat Rev Cardiol"},{"issue":"Suppl 2","key":"1283_CR54","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1038\/ncpcardio1247","volume":"5","author":"J Narula","year":"2008","unstructured":"Narula J, Garg P, Achenbach S, Motoyama S, Virmani R, Strauss HW (2008) Arithmetic of vulnerable plaques for noninvasive imaging. Nat Clin Pract Cardiovasc Med 5(Suppl 2):S2\u2013S10","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"1283_CR55","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1161\/01.CIR.0000087480.94275.97","volume":"108","author":"M Naghavi","year":"2003","unstructured":"Naghavi M, Libby P, Falk E, Casscells SW et al (2003) From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part I. Circulation 108:1664\u20131672","journal-title":"Circulation"},{"key":"1283_CR56","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1161\/01.CIR.0000159354.43778.69","volume":"111","author":"IK Jang","year":"2005","unstructured":"Jang IK, Tearney GJ, MacNeill B et al (2005) In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography. Circulation 111:1551\u20131555","journal-title":"Circulation"},{"key":"1283_CR57","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/ehjci\/jeu188","volume":"16","author":"R Nakazato","year":"2015","unstructured":"Nakazato R, Otake H, Konishi A et al (2015) Atherosclerotic plaque characterization by CT angiography for identification of high-risk coronary artery lesions: a comparison to optical coherence tomography. Eur Heart J Cardiovasc Imaging 16:373\u2013379","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"1283_CR58","first-page":"e563","volume":"140","author":"DK Arnett","year":"2019","unstructured":"Arnett DK, Blumenthal RS, Albert MA et al (2019) 2019 ACC\/AHA guideline on the primary prevention of cardiovascular disease: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. Circulation 140:e563\u2013e595","journal-title":"Circulation"},{"key":"1283_CR59","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1007\/s11547-018-0898-z","volume":"123","author":"E Di Cesare","year":"2018","unstructured":"Di Cesare E, Patriarca L, Panebianco L et al (2018) Coronary computed tomography angiography in the evaluation of intermediate risk asymptomatic individuals. Radiol Med 123:686\u2013694","journal-title":"Radiol Med"},{"key":"1283_CR60","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1093\/eurheartj\/ehv690","volume":"37","author":"S Gaur","year":"2016","unstructured":"Gaur S, \u00d8vrehus KA, Dey D et al (2016) Coronary plaque quantification and fractional flow reserve by coronary computed tomography angiography identify ischaemia-causing lesions. Eur Heart J 37:1220\u20131227","journal-title":"Eur Heart J"},{"key":"1283_CR61","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jcct.2018.04.008","volume":"12","author":"KA \u00d8vrehus","year":"2018","unstructured":"\u00d8vrehus KA, Gaur S, Leipsic J et al (2018) CT-based total vessel plaque analyses improves prediction of hemodynamic significance lesions as assessed by fractional flow reserve in patients with stable angina pectoris. J Cardiovasc Comput Tomogr 12:344\u2013349","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"1283_CR62","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1007\/s00330-017-5223-z","volume":"28","author":"D Dey","year":"2018","unstructured":"Dey D, Gaur S, Ovrehus KA et al (2018) Integrated prediction of lesion-specific ischaemia from quantitative coronary CT angiography using machine learning: a multicentre study. Eur Radiol 28:2655\u20132664","journal-title":"Eur Radiol"},{"key":"1283_CR63","doi-asserted-by":"crossref","first-page":"32B","DOI":"10.1016\/S0002-9149(00)00783-9","volume":"85","author":"MC Kontos","year":"2000","unstructured":"Kontos MC, Jesse RL (2000) Evaluation of the emergency department chest pain patient. Am J Cardiol 85:32B\u201339B","journal-title":"Am J Cardiol"},{"key":"1283_CR64","first-page":"e525","volume":"122","author":"AJ Taylor","year":"2010","unstructured":"Taylor AJ, Cerqueira M, Hodgson JM et al (2010) ACCF\/SCCT\/ACR\/AHA\/ASE\/ASNC\/NASCI\/SCAI\/SCMR\u00a02010\u00a0appropriateuse\u00a0criteria\u00a0for\u00a0cardiac\u00a0computed\u00a0tomography. a report of the American college of cardiology foundation\u00a0appropriate\u00a0use\u00a0criteria\u00a0task force, the society of cardiovascular\u00a0computed\u00a0tomography, the American college of radiology, the American\u00a0heart\u00a0association, the American society of echocardiography, the American society of nuclear cardiology, the north American society for cardiovascular imaging, the society for Cardiovascular Angiography and interventions, and the society for cardiovascular magnetic resonance. Circulation 122:e525\u2013e555","journal-title":"Circulation"},{"key":"1283_CR65","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.jacc.2015.09.011","volume":"67","author":"FJ Rybicki","year":"2016","unstructured":"Rybicki FJ, Udelson JE, Peacock WF et al (2016) 2015 ACR\/ACC\/AHA\/AATS\/ACEP\/ASNC\/NASCI\/SAEM\/SCCT\/SCMR\/SCPC\/SNMMI\/STR\/STS appropriate utilization of cardiovascular imaging in emergency department patients with chest pain: a joint document of the American College of Radiology Appropriateness Criteria Committee and the American College of Cardiology Appropriate Use Criteria TaskForce. J Am Coll Cardiol 67:853\u2013879","journal-title":"J Am Coll Cardiol"},{"key":"1283_CR66","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/eurheartj\/ehv320","volume":"37","author":"M Roffi","year":"2016","unstructured":"Roffi M, Patrono C, Collet JP et al (2016) 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J 37:267\u2013315","journal-title":"Eur Heart J"},{"key":"1283_CR67","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1016\/j.jacc.2009.01.052","volume":"53","author":"U Hoffmann","year":"2009","unstructured":"Hoffmann U, Bamberg F, Chae CU et al (2009) Coronary Computed Tomography Angiography For Early Triage of Patients with Acute Chest Pain - The Rule Out Myocardial Infarction Using Computer Assisted Tomography (ROMICAT) Trial. J Am Coll Cardiol 53:1642\u20131650","journal-title":"J Am Coll Cardiol"},{"key":"1283_CR68","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.jacc.2011.03.068","volume":"58","author":"JA Goldstein","year":"2011","unstructured":"Goldstein JA, Chinnaiyan KM, Abidov A et al (2011) The CT-STAT (Coronary Computed Tomographic Angiography for Systematic Triage of Acute Chest Pain Patients to Treatment) trial. J Am Coll Cardiol 58:1414\u20131422","journal-title":"J Am Coll Cardiol"},{"key":"1283_CR69","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1056\/NEJMoa1201163","volume":"366","author":"HI Litt","year":"2012","unstructured":"Litt HI, Gatsonis C, Snyder B et al (2012) CT angiography for safe discharge of patients with possible acute coronary syndromes. N Engl J Med 366:1393\u20131403","journal-title":"N Engl J Med"},{"key":"1283_CR70","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1056\/NEJMoa1201161","volume":"367","author":"U Hoffmann","year":"2012","unstructured":"Hoffmann U, Truong QA, Schoenfeld DA et al (2012) Coronary CT angiography versus standard evaluation in acute chest pain. N Engl J Med 367:299\u2013308","journal-title":"N Engl J Med"},{"key":"1283_CR71","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.jcmg.2015.06.016","volume":"8","author":"M Ferencik","year":"2015","unstructured":"Ferencik M, Liu T, Mayrhofer T et al (2015) highly sensitive troponin I followed by advanced coronary artery disease assessment using computed tomography angiography improves acute coronary syndrome risk stratification accuracy and work-up in acute chest pain patients: results from ROMICAT II trial. JACC Cardiovasc Imaging 8:1272\u20131281","journal-title":"JACC Cardiovasc Imaging"},{"key":"1283_CR72","doi-asserted-by":"crossref","first-page":"174","DOI":"10.7326\/M14-2948","volume":"163","author":"JM Levsky","year":"2015","unstructured":"Levsky JM, Spevack DM, Travin MI et al (2015) Coronary computed tomography angiography versus radionuclide myocardial perfusion imaging in patients with chest pain admitted to telemetry: a randomized trial. Ann Intern Med 163:174\u2013183","journal-title":"Ann Intern Med"},{"key":"1283_CR73","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/j.jcmg.2015.07.015","volume":"8","author":"JJ Linde","year":"2015","unstructured":"Linde JJ, Hove JD, S\u00f8rgaard M et al (2015) Long-term clinical impact of coronary CT angiography in patients with recent acute-onset chest pain: the randomized controlled CATCH trial. JACC Cardiovasc Imaging 8:1404\u20131413","journal-title":"JACC Cardiovasc Imaging"},{"key":"1283_CR74","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/eurheartj\/eht218","volume":"35","author":"P Haaf","year":"2014","unstructured":"Haaf P, Reichlin T, Twerenbold R et al (2014) Risk stratification in patients with acute chest pain using three high-sensitivity cardiac troponin assays. Eur Heart J 35:365\u2013375","journal-title":"Eur Heart J"},{"key":"1283_CR75","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jacc.2015.10.045","volume":"67","author":"A Dedic","year":"2016","unstructured":"Dedic A, Lubbers MM, Schaap J et al (2016) Coronary CT angiography for suspected ACS in the era of high-sensitivity troponins: randomized multicenter study. J Am Coll Cardiol 67:16\u201326","journal-title":"J Am Coll Cardiol"},{"key":"1283_CR76","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1007\/s00330-017-5097-0","volume":"28","author":"T Dai","year":"2018","unstructured":"Dai T, Wang HuPF (2018) Diagnostic performance of computed tomography angiography in the detection of coronary artery in-stent restenosis: evidence from an updated meta-analysis. Eur Radiol 28:1373\u20131382","journal-title":"Eur Radiol"},{"key":"1283_CR77","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1007\/s00330-007-0722-y","volume":"17","author":"R Marano","year":"2007","unstructured":"Marano R, Liguori C, Rinaldi P et al (2007) Coronary artery bypass grafts and MDCT imaging: what to know and what to look for. Eur Radiol 17:3166\u20133178","journal-title":"Eur Radiol"},{"key":"1283_CR78","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1055\/s-0043-120528","volume":"190","author":"F Jungmann","year":"2018","unstructured":"Jungmann F, Emrich T, Mildenberger P et al (2018) Multidetector computed tomography angiography (MD-CTA) of coronary artery bypass grafts\u2014update 2017. Rofo 190:237\u2013249","journal-title":"Rofo"}],"container-title":["La radiologia medica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11547-020-01283-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11547-020-01283-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11547-020-01283-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T01:08:30Z","timestamp":1632272910000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11547-020-01283-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,22]]},"references-count":78,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["1283"],"URL":"https:\/\/doi.org\/10.1007\/s11547-020-01283-y","relation":{},"ISSN":["0033-8362","1826-6983"],"issn-type":[{"value":"0033-8362","type":"print"},{"value":"1826-6983","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,22]]},"assertion":[{"value":"8 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}}]}}