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Our aim was to describe ultrasound findings of patients with plantar forefoot pain treated with custom-made foot orthoses.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Twenty patients (15 females; mean age: 62.6\u2009\u00b1\u200911\u00a0years) affected by metatarsalgia in 27\/40 feet underwent clinical evaluation before, three months and six months after treatment with custom-made full foot insole with a support proximal and an excavation below the painful metatarsals. Ultrasound was performed before and three months after the use of orthoses to examine the presence of intermetatarsal\/submetatarsal bursitis, metatarsophalangeal joints effusion, anterior plantar fat pad oedema, flexor tendinitis\/tenosynovitis, and Morton\u2019s neuroma. Outcome measures were clinical response with Foot Function Index (FFI)\/Visual Analogue Scale (VAS) and ultrasound features changes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Median VAS and FFI before treatment were 8[5\u20138.5] and 45.85[32.4\u201359.4], respectively. After 3 and 6\u00a0months of insoles use, both median VAS (2.5 [0\u20135] and 0 [0\u20132.75], respectively) and median FFI (7.9 [3.95\u201320] and 0 [0\u20133.95], respectively) showed a significant reduction in pain and disability (p\u2009&lt;\u2009.001). Before treatment, ultrasound revealed 22 intermetatarsal bursitis, 16 submetatarsal bursitis, 10 joint effusions, 20 fat pad oedema, 3 flexor tendinitis\/tenosynovitis and 3 Morton\u2019s neuromas. After 3\u00a0months of treatment, a significant decrease of intermetatarsal bursitis (7, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) was observed. No significant changes were observed in any other ultrasound parameters.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Ultrasound might be able to detect some imaging features associated with the response of forefoot pain to custom-made foot orthoses, especially intermetatarsal bursitis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11547-021-01354-8","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T09:19:19Z","timestamp":1618996759000},"page":"963-970","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Plantar forefoot pain: ultrasound findings before and after treatment with custom-made foot orthoses"],"prefix":"10.1007","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7989-9861","authenticated-orcid":false,"given":"Domenico","family":"Albano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Bonifacini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Zannoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Bernareggi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmelo","family":"Messina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Galia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca Maria","family":"Sconfienza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"1354_CR1","unstructured":"Dockery G (2000) Evaluation and treatment of metatarsalgia and keratotic disorders. 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