{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:47:07Z","timestamp":1785332827251,"version":"3.55.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T00:00:00Z","timestamp":1624838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T00:00:00Z","timestamp":1624838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiol med"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s11547-021-01376-2","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T09:03:12Z","timestamp":1624870992000},"page":"1345-1355","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Imaging biomarkers in the diagnosis of salivary gland tumors: the value of lesion\/parenchyma ratio of perfusion-MR pharmacokinetic parameters"],"prefix":"10.1007","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5212-2136","authenticated-orcid":false,"given":"Francesco","family":"Mungai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Battista","family":"Verrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Bonasera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Bicci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Pietragalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosimo","family":"Nardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Berti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo Nicola","family":"Mazzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Miele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,28]]},"reference":[{"key":"1376_CR1","doi-asserted-by":"publisher","first-page":"S142","DOI":"10.1017\/s0022215116000566","volume":"130","author":"S Sood","year":"2016","unstructured":"Sood S, McGurk M, Vaz F (2016) Management of salivary gland tumours: United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol 130:S142\u2013S149. https:\/\/doi.org\/10.1017\/s0022215116000566","journal-title":"J Laryngol Otol"},{"key":"1376_CR2","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.nic.2018.01.009","volume":"28","author":"AAK Abdel Razek","year":"2018","unstructured":"Abdel Razek AAK, Mukherji SK (2018) State-of-the-art imaging of salivary gland tumors. Neuroimaging Clin N Am 28:303\u2013317. https:\/\/doi.org\/10.1016\/j.nic.2018.01.009","journal-title":"Neuroimaging Clin N Am"},{"key":"1376_CR3","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.crad.2017.05.020","volume":"73","author":"YL Dai","year":"2018","unstructured":"Dai YL, King AD (2018) State of the art MRI in head and neck cancer. Clin Radiol 73:45\u201359. https:\/\/doi.org\/10.1016\/j.crad.2017.05.020","journal-title":"Clin Radiol"},{"key":"1376_CR4","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.otc.2015.10.003","volume":"49","author":"RS Prasad","year":"2016","unstructured":"Prasad RS (2016) Parotid gland imaging. Otolaryngol Clin North Am 49:285\u2013312. https:\/\/doi.org\/10.1016\/j.otc.2015.10.003","journal-title":"Otolaryngol Clin North Am"},{"key":"1376_CR5","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.nic.2018.01.008","volume":"28","author":"AAK Abdel Razek","year":"2018","unstructured":"Abdel Razek AAK, Mukherji SK (2018) Imaging of minor salivary glands. Neuroimaging Clin N Am 28:295\u2013302. https:\/\/doi.org\/10.1016\/j.nic.2018.01.008","journal-title":"Neuroimaging Clin N Am"},{"issue":"2","key":"1376_CR6","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s11547-017-0813-z","volume":"123","author":"TJ Vogl","year":"2018","unstructured":"Vogl TJ, Albrecht MH, Nour-Eldin NA et al (2018) Assessment of salivary gland tumors using MRI and CT: impact of experience on diagnostic accuracy. Radiol Med 123(2):105\u2013116. https:\/\/doi.org\/10.1007\/s11547-017-0813-z","journal-title":"Radiol Med"},{"key":"1376_CR7","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jasc.2014.11.003","volume":"4","author":"EN Consamus","year":"2015","unstructured":"Consamus EN, Smith D, Pina Oviedo S, Mody DR, Takei H (2015) Diagnostic accuracy of fine-needle aspiration cytology of salivary gland lesions: a 6-year retrospective review. J Am Soc Cytopathol 4:63\u201373. https:\/\/doi.org\/10.1016\/j.jasc.2014.11.003","journal-title":"J Am Soc Cytopathol"},{"key":"1376_CR8","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1002\/lary.26764","volume":"128","author":"HJ Kim","year":"2018","unstructured":"Kim HJ, Kim JS (2018) Ultrasound-guided core needle biopsy in salivary glands: a meta-analysis. Laryngoscope 128:118\u2013125. https:\/\/doi.org\/10.1002\/lary.26764","journal-title":"Laryngoscope"},{"key":"1376_CR9","doi-asserted-by":"publisher","first-page":"501","DOI":"10.4329\/wjr.v8.i5.501","volume":"8","author":"S Haldar","year":"2016","unstructured":"Haldar S, Sinnott JD, Tekeli KM, Turner SS, Howlett DC (2016) Biopsy of parotid masses: review of current techniques. World J Radiol 8:501\u2013505. https:\/\/doi.org\/10.4329\/wjr.v8.i5.501","journal-title":"World J Radiol"},{"key":"1376_CR10","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s00330-013-3002-z","volume":"24","author":"M Sumi","year":"2014","unstructured":"Sumi M, Nakamura T (2014) Head and neck tumours: combined MRI assessment based on IVIM and TIC analyses for the differentiation of tumors of different histological types. Eur Radiol 24:223\u2013231. https:\/\/doi.org\/10.1007\/s00330-013-3002-z","journal-title":"Eur Radiol"},{"key":"1376_CR11","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s00234-018-2046-9","volume":"60","author":"T Yamamoto","year":"2018","unstructured":"Yamamoto T, Kimura H, Hayashi K, Imamura Y, Mori M (2018) Pseudo-continuous arterial spin labeling MR images in Warthin tumors and pleomorphic adenomas of the parotid gland: qualitative and quantitative analyses and their correlation with histopathologic and DWI and dynamic contrast enhanced MRI findings. Neuroradiology 60:803\u2013812. https:\/\/doi.org\/10.1007\/s00234-018-2046-9","journal-title":"Neuroradiology"},{"key":"1376_CR12","doi-asserted-by":"publisher","first-page":"e0178002","DOI":"10.1371\/journal.pone.0178002","volume":"12","author":"I Katayama","year":"2017","unstructured":"Katayama I, Eida S, Fujita S, Hotokezaka Y, Sumi M, Nakamura T (2017) Perfusion MR imaging detection of carcinoma arising from preexisting salivary gland pleomorphic adenoma by computer-Assisted analysis of time-signal intensity maps. PLoS ONE 12:e0178002. https:\/\/doi.org\/10.1371\/journal.pone.0178002","journal-title":"PLoS ONE"},{"key":"1376_CR13","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20140685","author":"PD Lam","year":"2015","unstructured":"Lam PD, Kuribayashi A, Imaizumi A, Sakamoto J, Sumi Y, Yoshino N et al (2015) Differentiating benign and malignant salivary gland tumours: diagnostic criteria and the accuracy of dynamic contrast-enhanced MRI with high temporal resolution. Br J Radiol. https:\/\/doi.org\/10.1259\/bjr.20140685","journal-title":"Br J Radiol"},{"issue":"9","key":"1376_CR14","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1007\/s11547-020-01182-2","volume":"125","author":"M Pietragalla","year":"2020","unstructured":"Pietragalla M, Nardi C, Bonasera L et al (2020) The role of diffusion-weighted and dynamic contrast enhancement perfusion-weighted imaging in the evaluation of salivary glands neoplasms. Radiol Med 125(9):851\u2013863. https:\/\/doi.org\/10.1007\/s11547-020-01182-2","journal-title":"Radiol Med"},{"key":"1376_CR15","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1148\/radiol.12111248","volume":"263","author":"M Sumi","year":"2012","unstructured":"Sumi M, Van Cauteren M, Sumi T, Obara M, Ichikawa Y, Nakamura T (2012) Salivary gland tumors: use of intravoxel incoherent motion MR imaging for assessment of diffusion and perfusion for the differentiation of benign from malignant tumors. Radiology 263:770\u2013777. https:\/\/doi.org\/10.1148\/radiol.12111248","journal-title":"Radiology"},{"key":"1376_CR16","first-page":"e484","volume":"4","author":"H Kim","year":"2018","unstructured":"Kim H (2018) Variability in quantitative DCE-MRI: sources and solutions. J Nat Sci 4:e484","journal-title":"J Nat Sci"},{"key":"1376_CR17","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1002\/(SICI)1522-2586(199909)10:3<254::AID-JMRI5>3.0.CO;2-9","volume":"10","author":"JL Evelhoch","year":"1999","unstructured":"Evelhoch JL (1999) Key factors in the acquisition of contrast kinetic data for oncology. J Magn Reson Imaging 10:254\u2013259. https:\/\/doi.org\/10.1002\/(SICI)1522-2586(199909)10:3%3c254::AID-JMRI5%3e3.0.CO;2-9","journal-title":"J Magn Reson Imaging"},{"key":"1376_CR18","unstructured":"Profile: DCE MRI quantification v.1.0. (2014) Quantitative imaging biomarkers alliance (QIBA)\u2013Radiological society of North America. Web site. https:\/\/qibawiki.rsna.org\/index.php\/Profiles. updated July 1, 2012. Accessed December"},{"key":"1376_CR19","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/(SICI)1522-2586(199909)10:3<223::AID-JMRI2>3.0.CO;2-S","volume":"10","author":"PS Tofts","year":"1999","unstructured":"Tofts PS, Brix G, Buckley DL, Evelhoch JL, Henderson E, Knopp MV et al (1999) Estimating kinetic parameters from dynamic contrast-enhanced T1-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging 10:223\u2013232. https:\/\/doi.org\/10.1002\/(SICI)1522-2586(199909)10:3%3c223::AID-JMRI2%3e3.0.CO;2-S","journal-title":"J Magn Reson Imaging"},{"key":"1376_CR20","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/j.diii.2013.10.010","volume":"94","author":"CA Cuenod","year":"2013","unstructured":"Cuenod CA, Balvay D (2013) Perfusion and vascular permeability: basic concepts and measurement in DCE-CT and DCE-MRI. Diagn Interv Imaging 94:1187\u20131204. https:\/\/doi.org\/10.1016\/j.diii.2013.10.010","journal-title":"Diagn Interv Imaging"},{"key":"1376_CR21","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1016\/B978-0-323-05355-6.00040-9","volume-title":"Head and neck imaging","author":"PM Som","year":"2011","unstructured":"Som PM, Brandwein-Gensler MS (2011) Anatomy and pathology of the salivary glands. In: Som PM, Curtin HD (eds) Head and neck imaging, 5th edn. Elsevier Mosby, St. Louis, Pa, pp 2449\u20132468","edition":"5"},{"key":"1376_CR22","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1148\/radiol.2332031110","volume":"233","author":"CS van Rijswijk","year":"2004","unstructured":"van Rijswijk CS, Geirnaerdt MJ, Hogendoorn PC et al (2004) Soft-tissue tumors: value of static and dynamic gadopentetate dimeglumine-enhanced MR imaging in prediction of malignancy. Radiology 233:493\u2013502. https:\/\/doi.org\/10.1148\/radiol.2332031110","journal-title":"Radiology"}],"container-title":["La radiologia medica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11547-021-01376-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11547-021-01376-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11547-021-01376-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T10:30:56Z","timestamp":1778495456000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11547-021-01376-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,28]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["1376"],"URL":"https:\/\/doi.org\/10.1007\/s11547-021-01376-2","relation":{},"ISSN":["0033-8362","1826-6983"],"issn-type":[{"value":"0033-8362","type":"print"},{"value":"1826-6983","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,28]]},"assertion":[{"value":"12 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors have no disclosures or conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Institutional Board Review approved this study (protocol number: 2042\/2019).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all patients included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Patients signed informed consent regarding publishing their data in anonymous form.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}