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The final population included only patients who underwent blood sampling for KL-6 within 5 days from CT scan (<jats:italic>n<\/jats:italic> =\u00a063), including <jats:italic>n<\/jats:italic>\u00a0=\u00a037 COVID-19-positive patients and <jats:italic>n<\/jats:italic>\u00a0=\u00a026 with negative RT-PCR testing for SARS-CoV-2 (control group). A semi-quantitative CT score was calculated based on the extent of lobar involvement (0:0%; 1, &lt; 5%; 2:5\u201325%; 3:26\u201350%; 4:51\u201375%; 5, &gt; 75%; range 0\u20135; global score 0\u201325).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>CT score was significantly correlated with serum value of KL-6 (<jats:italic>r<\/jats:italic>\u00a0= 27, <jats:italic>p<\/jats:italic>\u00a0= 0.035). This correlation was also present in COVID-19 positive patients (<jats:italic>r<\/jats:italic>\u00a0= 0.423, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.009) and CT score median value was significantly higher in patients with high KL-6 value (&gt; 400 U\/mL; 12.00, IQR 5.00-18.00, p-value 0.027). In control group, no statistically significant correlation was found between CT score and KL-6 value and CT score was higher in patients with high KL-6, although this difference was not statistically significant (5.00, IQR:1.75\u20138.00 versus 3.50, IQR:2.00\u20136.50). \"Crazy paving\" at the right upper (<jats:italic>n<\/jats:italic>\u00a0=\u00a08; 61.5%) and middle lobe (<jats:italic>n<\/jats:italic>\u00a0=\u00a04; 30.8%) and \"consolidation\" at the middle lobe (n=5; 38.5%) were observed in COVID-19 group with a significant difference between patients with high KL-6 value.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>CT score is highly correlated with KL-6 value in COVID-19 patients and might be beneficial to speed-up diagnostic workflow in symptomatic cases.\n<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11547-022-01504-6","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T14:02:56Z","timestamp":1655301776000},"page":"725-732","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association\u00a0of serum Krebs von den Lungen-6 and chest CT as potential prognostic factors in\u00a0severe acute respiratory syndrome SARS-CoV-2: a preliminary experience"],"prefix":"10.1007","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5124-3219","authenticated-orcid":false,"given":"Emanuela","family":"Anastasi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9037-9904","authenticated-orcid":false,"given":"Lucia","family":"Manganaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5470-3148","authenticated-orcid":false,"given":"Elisa","family":"Guiducci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9432-481X","authenticated-orcid":false,"given":"Simone","family":"Ciaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8322-8435","authenticated-orcid":false,"given":"Miriam","family":"Dolciami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7772-3130","authenticated-orcid":false,"given":"Alessandra","family":"Spagnoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3989-4964","authenticated-orcid":false,"given":"Francesco","family":"Alessandri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4969-9548","authenticated-orcid":false,"given":"Antonio","family":"Angeloni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6139-7174","authenticated-orcid":false,"given":"Annarita","family":"Vestri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4208-9691","authenticated-orcid":false,"given":"Carlo","family":"Catalano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5212-0678","authenticated-orcid":false,"given":"Paolo","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"1504_CR1","doi-asserted-by":"publisher","unstructured":"Mahase E (2020) China coronavirus: WHO declares international emergency as death toll exceeds 200. 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The procedures used in this study adhere to tenets of the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was waived because it is not required for images (CT).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Informed consent was waived because of the use of anonymous clinical data.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}