{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:12:20Z","timestamp":1780377140486,"version":"3.54.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871124"],"award-info":[{"award-number":["81871124"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471403"],"award-info":[{"award-number":["81471403"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30973024"],"award-info":[{"award-number":["30973024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61773223"],"award-info":[{"award-number":["61773223"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiol med"],"DOI":"10.1007\/s11547-024-01776-0","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T17:02:15Z","timestamp":1706806935000},"page":"280-290","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Systematic investigation of cerebellar functional alterations and their association with surgical outcomes in patients with degenerative cervical myelopathy: a resting-state fMRI study"],"prefix":"10.1007","volume":"129","author":[{"given":"Yuqi","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4232-8146","authenticated-orcid":false,"given":"Yuan","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"issue":"12","key":"1776_CR1","doi-asserted-by":"publisher","first-page":"E675","DOI":"10.1097\/BRS.0000000000000913","volume":"40","author":"A Nouri","year":"2015","unstructured":"Nouri A et al (2015) Degenerative cervical myelopathy: epidemiology, genetics, and pathogenesis. Spine (Philadelphia PA 1976) 40(12):E675\u2013E693","journal-title":"Spine (Philadelphia PA 1976)"},{"issue":"4","key":"1776_CR2","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1177\/1073858412467377","volume":"19","author":"S Kalsi-Ryan","year":"2013","unstructured":"Kalsi-Ryan S, Karadimas SK, Fehlings MG (2013) Cervical spondylotic myelopathy: the clinical phenomenon and the current pathobiology of an increasingly prevalent and devastating disorder. Neuroscientist 19(4):409\u2013421","journal-title":"Neuroscientist"},{"issue":"18","key":"1776_CR3","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.2106\/JBJS.L.00589","volume":"95","author":"MG Fehlings","year":"2013","unstructured":"Fehlings MG et al (2013) Efficacy and safety of surgical decompression in patients with cervical spondylotic myelopathy: results of the AOSpine North America prospective multi-center study. J Bone Joint Surg Am 95(18):1651\u20131658","journal-title":"J Bone Joint Surg Am"},{"issue":"17","key":"1776_CR4","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1097\/BRS.0000000000000988","volume":"40","author":"MG Fehlings","year":"2015","unstructured":"Fehlings MG et al (2015) A global perspective on the outcomes of surgical decompression in patients with cervical spondylotic myelopathy: results from the prospective multicenter AOSpine international study on 479 patients. Spine (Philadelphia PA 1976) 40(17):1322\u20131328","journal-title":"Spine (Philadelphia PA 1976)"},{"issue":"7","key":"1776_CR5","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1302\/0301-620X.95B7.31363","volume":"95-b","author":"M Pumberger","year":"2013","unstructured":"Pumberger M et al (2013) Clinical predictors of surgical outcome in cervical spondylotic myelopathy: an analysis of 248 patients. Bone Joint J 95-b(7):966\u2013971","journal-title":"Bone Joint J"},{"issue":"5","key":"1776_CR6","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1097\/BRS.0000000000001289","volume":"41","author":"GD Chen","year":"2016","unstructured":"Chen GD et al (2016) Effect and prognostic factors of laminoplasty for cervical myelopathy with an occupying ratio greater than 50%. Spine (Philadelphia PA 1976) 41(5):378\u2013383","journal-title":"Spine (Philadelphia PA 1976)"},{"issue":"5","key":"1776_CR7","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1097\/BRS.0b013e3182715bc3","volume":"38","author":"A Karpova","year":"2013","unstructured":"Karpova A et al (2013) Predictors of surgical outcome in cervical spondylotic myelopathy. Spine (Philadelphia PA 1976) 38(5):392\u2013400","journal-title":"Spine (Philadelphia PA 1976)"},{"issue":"1","key":"1776_CR8","doi-asserted-by":"publisher","first-page":"10456","DOI":"10.1038\/s41598-019-46859-5","volume":"9","author":"S Takenaka","year":"2019","unstructured":"Takenaka S et al (2019) Towards prognostic functional brain biomarkers for cervical myelopathy: a resting-state fMRI study. Sci Rep 9(1):10456","journal-title":"Sci Rep"},{"key":"1776_CR9","doi-asserted-by":"publisher","first-page":"632829","DOI":"10.3389\/fnhum.2021.632829","volume":"15","author":"R Zhao","year":"2021","unstructured":"Zhao R et al (2021) Enhanced information flow from cerebellum to secondary visual cortices leads to better surgery outcome in degenerative cervical myelopathy patients: a stochastic dynamic causal modeling study with functional magnetic resonance imaging. Front Hum Neurosci 15:632829","journal-title":"Front Hum Neurosci"},{"issue":"6","key":"1776_CR10","doi-asserted-by":"publisher","first-page":"3693","DOI":"10.1007\/s00330-021-08488-3","volume":"32","author":"R Zhao","year":"2022","unstructured":"Zhao R et al (2022) Functional MRI evidence for primary motor cortex plasticity contributes to the disease\u2019s severity and prognosis of cervical spondylotic myelopathy patients. Eur Radiol 32(6):3693\u20133704","journal-title":"Eur Radiol"},{"issue":"9","key":"1776_CR11","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1007\/s00234-018-2061-x","volume":"60","author":"Z Chen","year":"2018","unstructured":"Chen Z et al (2018) Visual cortex neural activity alteration in cervical spondylotic myelopathy patients: a resting-state fMRI study. Neuroradiology 60(9):921\u2013932","journal-title":"Neuroradiology"},{"issue":"7","key":"1776_CR12","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1097\/CORR.0000000000001157","volume":"478","author":"S Takenaka","year":"2020","unstructured":"Takenaka S et al (2020) Resting-state amplitude of low-frequency fluctuation is a potentially useful prognostic functional biomarker in cervical myelopathy. Clin Orthop Relat Res 478(7):1667\u20131680","journal-title":"Clin Orthop Relat Res"},{"key":"1776_CR13","doi-asserted-by":"publisher","first-page":"829714","DOI":"10.3389\/fneur.2022.829714","volume":"13","author":"N Fan","year":"2022","unstructured":"Fan N et al (2022) Dynamic and static amplitude of low-frequency fluctuation is a potential biomarker for predicting prognosis of degenerative cervical myelopathy patients: a preliminary resting-state fMRI study. Front Neurol 13:829714","journal-title":"Front Neurol"},{"key":"1776_CR14","doi-asserted-by":"publisher","first-page":"1003578","DOI":"10.3389\/fneur.2022.1003578","volume":"13","author":"R Zhao","year":"2022","unstructured":"Zhao R et al (2022) Brain connectivity markers in degenerative cervical myelopathy patients with depression for predicting the prognosis following decompression surgery. Front Neurol 13:1003578","journal-title":"Front Neurol"},{"issue":"6","key":"1776_CR15","doi-asserted-by":"publisher","first-page":"E14","DOI":"10.3171\/2016.3.FOCUS1665","volume":"40","author":"L Tetreault","year":"2016","unstructured":"Tetreault L et al (2016) Predicting the minimum clinically important difference in patients undergoing surgery for the treatment of degenerative cervical myelopathy. Neurosurg Focus 40(6):E14","journal-title":"Neurosurg Focus"},{"issue":"18","key":"1776_CR16","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.2106\/JBJS.L.01323","volume":"95","author":"LA Tetreault","year":"2013","unstructured":"Tetreault LA et al (2013) A clinical prediction model to determine outcomes in patients with cervical spondylotic myelopathy undergoing surgical treatment: data from the prospective, multi-center AOSpine North America study. J Bone Joint Surg Am 95(18):1659\u20131666","journal-title":"J Bone Joint Surg Am"},{"issue":"22 Suppl 1","key":"1776_CR17","doi-asserted-by":"publisher","first-page":"S89","DOI":"10.1097\/BRS.0b013e3182a7eae0","volume":"38","author":"LA Tetreault","year":"2013","unstructured":"Tetreault LA et al (2013) Systematic review of magnetic resonance imaging characteristics that affect treatment decision making and predict clinical outcome in patients with cervical spondylotic myelopathy. Spine (Philadelphia PA 1976) 38(22 Suppl 1):S89-110","journal-title":"Spine (Philadelphia PA 1976)"},{"issue":"6","key":"1776_CR18","doi-asserted-by":"publisher","first-page":"631","DOI":"10.3171\/2014.10.SPINE14222","volume":"22","author":"BM Ellingson","year":"2015","unstructured":"Ellingson BM et al (2015) Correlation between degree of subvoxel spinal cord compression measured with super-resolution tract density imaging and neurological impairment in cervical spondylotic myelopathy. J Neurosurg Spine 22(6):631\u2013638","journal-title":"J Neurosurg Spine"},{"issue":"1","key":"1776_CR19","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1097\/BRS.0b013e31820e6c35","volume":"37","author":"M Kerkovsk\u00fd","year":"2012","unstructured":"Kerkovsk\u00fd M et al (2012) Magnetic resonance diffusion tensor imaging in patients with cervical spondylotic spinal cord compression: correlations between clinical and electrophysiological findings. Spine (Philadelphia PA 1976) 37(1):48\u201356","journal-title":"Spine (Philadelphia PA 1976)"},{"issue":"2","key":"1776_CR20","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/s41582-019-0303-0","volume":"16","author":"JH Badhiwala","year":"2020","unstructured":"Badhiwala JH et al (2020) Degenerative cervical myelopathy: update and future directions. Nat Rev Neurol 16(2):108\u2013124","journal-title":"Nat Rev Neurol"},{"issue":"21","key":"1776_CR21","doi-asserted-by":"publisher","first-page":"2978","DOI":"10.1089\/neu.2021.0148","volume":"38","author":"K Vallotton","year":"2021","unstructured":"Vallotton K et al (2021) Tracking white and gray matter degeneration along the spinal cord axis in degenerative cervical myelopathy. J Neurotrauma 38(21):2978\u20132987","journal-title":"J Neurotrauma"},{"issue":"1","key":"1776_CR22","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s00586-016-4646-6","volume":"26","author":"XP Zhong","year":"2017","unstructured":"Zhong XP et al (2017) Cervical spinal functional magnetic resonance imaging of the spinal cord injured patient during electrical stimulation. Eur Spine J 26(1):71\u201377","journal-title":"Eur Spine J"},{"key":"1776_CR23","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.neuroimage.2016.09.065","volume":"154","author":"F Eippert","year":"2017","unstructured":"Eippert F et al (2017) Denoising spinal cord fMRI data: approaches to acquisition and analysis. Neuroimage 154:255\u2013266","journal-title":"Neuroimage"},{"key":"1776_CR24","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.neuroimage.2016.12.072","volume":"147","author":"F Eippert","year":"2017","unstructured":"Eippert F et al (2017) Investigating resting-state functional connectivity in the cervical spinal cord at 3T. Neuroimage 147:589\u2013601","journal-title":"Neuroimage"},{"issue":"50","key":"1776_CR25","doi-asserted-by":"publisher","first-page":"18067","DOI":"10.1073\/pnas.1414293111","volume":"111","author":"Y Kong","year":"2014","unstructured":"Kong Y et al (2014) Intrinsically organized resting state networks in the human spinal cord. Proc Natl Acad Sci USA 111(50):18067\u201318072","journal-title":"Proc Natl Acad Sci USA"},{"issue":"Pt 2","key":"1776_CR26","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1093\/brain\/awr328","volume":"135","author":"I Kowalczyk","year":"2012","unstructured":"Kowalczyk I, Duggal N, Bartha R (2012) Proton magnetic resonance spectroscopy of the motor cortex in cervical myelopathy. Brain 135(Pt 2):461\u2013468","journal-title":"Brain"},{"issue":"6","key":"1776_CR27","doi-asserted-by":"publisher","first-page":"668","DOI":"10.3171\/2016.10.SPINE16479","volume":"26","author":"SC Craciunas","year":"2017","unstructured":"Craciunas SC et al (2017) Remote motor system metabolic profile and surgery outcome in cervical spondylotic myelopathy. J Neurosurg Spine 26(6):668\u2013678","journal-title":"J Neurosurg Spine"},{"issue":"Pt 5","key":"1776_CR28","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1093\/brain\/awr054","volume":"134","author":"WR Yu","year":"2011","unstructured":"Yu WR et al (2011) Human neuropathological and animal model evidence supporting a role for Fas-mediated apoptosis and inflammation in cervical spondylotic myelopathy. Brain 134(Pt 5):1277\u20131292","journal-title":"Brain"},{"key":"1776_CR29","doi-asserted-by":"publisher","first-page":"104255","DOI":"10.1016\/j.ebiom.2022.104255","volume":"84","author":"C Wang","year":"2022","unstructured":"Wang C et al (2022) Evolution of brain functional plasticity associated with increasing symptom severity in degenerative cervical myelopathy. EBioMedicine 84:104255","journal-title":"EBioMedicine"},{"key":"1776_CR30","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/B978-0-444-63956-1.00004-7","volume":"154","author":"CJ Stoodley","year":"2018","unstructured":"Stoodley CJ, Schmahmann JD (2018) Functional topography of the human cerebellum. Handb Clin Neurol 154:59\u201370","journal-title":"Handb Clin Neurol"},{"key":"1776_CR31","doi-asserted-by":"publisher","first-page":"784263","DOI":"10.3389\/fnagi.2022.784263","volume":"14","author":"S Chen","year":"2022","unstructured":"Chen S et al (2022) Degeneration of the sensorimotor tract in degenerative cervical myelopathy and compensatory structural changes in the brain. Front Aging Neurosci 14:784263","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"1776_CR32","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s00330-019-06352-z","volume":"30","author":"\u00c1 Bernab\u00e9u-Sanz","year":"2020","unstructured":"Bernab\u00e9u-Sanz \u00c1 et al (2020) MRI evidence of brain atrophy, white matter damage, and functional adaptive changes in patients with cervical spondylosis and prolonged spinal cord compression. Eur Radiol 30(1):357\u2013369","journal-title":"Eur Radiol"},{"issue":"6","key":"1776_CR33","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.amjmed.2017.11.051","volume":"131","author":"JM Baker","year":"2018","unstructured":"Baker JM (2018) Gait disorders. Am J Med 131(6):602\u2013607","journal-title":"Am J Med"},{"key":"1776_CR34","doi-asserted-by":"publisher","first-page":"102624","DOI":"10.1016\/j.nicl.2021.102624","volume":"30","author":"K J\u00fctten","year":"2021","unstructured":"J\u00fctten K et al (2021) Cortical volume reductions as a sign of secondary cerebral and cerebellar impairment in patients with degenerative cervical myelopathy. Neuroimage Clin 30:102624","journal-title":"Neuroimage Clin"},{"key":"1776_CR35","doi-asserted-by":"publisher","first-page":"895348","DOI":"10.3389\/fneur.2022.895348","volume":"13","author":"Y Zhou","year":"2022","unstructured":"Zhou Y, Shi J (2022) Brain structural and functional dissociated patterns in degenerative cervical myelopathy: a case-controlled retrospective resting-state fMRI study. Front Neurol 13:895348","journal-title":"Front Neurol"},{"key":"1776_CR36","doi-asserted-by":"publisher","first-page":"596795","DOI":"10.3389\/fneur.2020.596795","volume":"11","author":"R Zhao","year":"2020","unstructured":"Zhao R et al (2020) Neural correlates of cognitive dysfunctions in cervical spondylotic myelopathy patients: a resting-state fMRI study. Front Neurol 11:596795","journal-title":"Front Neurol"},{"issue":"7","key":"1776_CR37","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.cortex.2009.11.008","volume":"46","author":"CJ Stoodley","year":"2010","unstructured":"Stoodley CJ, Schmahmann JD (2010) Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing. Cortex 46(7):831\u2013844","journal-title":"Cortex"},{"key":"1776_CR38","doi-asserted-by":"publisher","first-page":"119015","DOI":"10.1016\/j.neuroimage.2022.119015","volume":"251","author":"Z Chen","year":"2022","unstructured":"Chen Z et al (2022) Functional connectome of human cerebellum. Neuroimage 251:119015","journal-title":"Neuroimage"},{"issue":"5","key":"1776_CR39","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1080\/10790268.2020.1786321","volume":"44","author":"EJ Richardson","year":"2021","unstructured":"Richardson EJ et al (2021) Differences in resting cerebellar and prefrontal cortical blood flow in spinal cord injury-related neuropathic pain: a brief report. J Spinal Cord Med 44(5):794\u2013799","journal-title":"J Spinal Cord Med"},{"issue":"3","key":"1776_CR40","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1007\/s00415-022-11531-y","volume":"270","author":"A Gardoni","year":"2023","unstructured":"Gardoni A et al (2023) Cerebellar alterations in Parkinson\u2019s disease with postural instability and gait disorders. J Neurol 270(3):1735\u20131744","journal-title":"J Neurol"},{"issue":"15","key":"1776_CR41","doi-asserted-by":"publisher","first-page":"6333","DOI":"10.1523\/JNEUROSCI.4837-12.2013","volume":"33","author":"CJ Keller","year":"2013","unstructured":"Keller CJ et al (2013) Neurophysiological investigation of spontaneous correlated and anticorrelated fluctuations of the BOLD signal. J Neurosci 33(15):6333\u20136342","journal-title":"J Neurosci"}],"container-title":["La radiologia medica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11547-024-01776-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11547-024-01776-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11547-024-01776-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T13:15:58Z","timestamp":1708434958000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11547-024-01776-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,1]]},"references-count":41,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["1776"],"URL":"https:\/\/doi.org\/10.1007\/s11547-024-01776-0","relation":{},"ISSN":["1826-6983"],"issn-type":[{"value":"1826-6983","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,1]]},"assertion":[{"value":"23 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Institutional Review Board of Tianjin Medical University General Hospital approval was obtained.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human or animal rights"}},{"value":"Written informed consent was obtained from all subjects (patients) in this study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}