{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:53:26Z","timestamp":1786982006701,"version":"build-2736575974"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004702","name":"Universit\u00e0 degli Studi di Genova","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004702","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiol med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Breast magnetic resonance imaging (MRI) can detect some malignant lesions that are not visible on mammography (MX) or ultrasound (US). If a targeted, second-look fails, MRI-guided breast biopsy is the only available tool to obtain a tissue sample and pathological proof of these \u201cMRI-only lesions\u201d. The aim of this study is to report the performance and underestimation rate of 9G MRI-guided vacuum-assisted breast biopsy (VABB) over 12\u00a0years at a single center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>All 9G MRI-VABB procedures performed from January 2010 to December 2021 were retrospectively reviewed. Two MRI scanners (1.5\u00a0T and 3\u00a0T) were used with the same image resolution and contrast media. All suspicious lesions detected only by breast MRI underwent biopsy. Reference standard was histological diagnosis or at least 1-year negative follow-up. All malignant and atypical lesions underwent surgery, which was used as the reference standard.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 293 biopsies were retrospectively reviewed. Histopathological VABB results revealed 142\/293 (48.4%) benign lesions, 77\/293 (26.2%) high-risk lesions, and 74\/293 (25.2%) malignant lesions. No significant complications were observed. Surgical pathology results allowed for the reclassification of n\u2009=\u20097\/48 B3b lesions: n\u2009=\u20094 were ductal carcinoma in situ, while n\u2009=\u20093 presented invasive features at surgical histology (2 IDC; 1 ILC). B3b underestimation occurred overall in 14.6% of B3 cases. Breast follow-up was achieved for all benign VABB results, and only one false-negative case was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results confirm that 1.5\u00a0T and 3\u00a0T MRI-guided VABB is an accurate and safe procedure for histopathologic final diagnosis of MRI-only lesions. Critical issues remain the potential high-risk underestimation rate of B3b VABB results and management of follow-up of benign lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11547-024-01808-9","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T08:02:07Z","timestamp":1711008127000},"page":"767-775","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Long-term outcome of 9G MRI-guided vacuum-assisted breast biopsy: results of 293 single-center procedures and underestimation rate of high-risk lesions over 12\u00a0years"],"prefix":"10.1007","volume":"129","author":[{"given":"Giuseppe","family":"Rescinito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2487-248X","authenticated-orcid":false,"given":"Nicole","family":"Brunetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Garlaschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Tosto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licia","family":"Gristina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Conti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diletta","family":"Pieroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Calabrese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto Stefano","family":"Tagliafico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"issue":"3","key":"1808_CR1","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1148\/radiol.2333031484","volume":"233","author":"WA Berg","year":"2004","unstructured":"Berg WA et al (2004) Diagnostic accuracy of mammography, clinical examination, US, and MR imaging in preoperative assessment of breast cancer. Radiology 233(3):830\u2013849. https:\/\/doi.org\/10.1148\/radiol.2333031484","journal-title":"Radiology"},{"key":"1808_CR2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019182947","author":"RM Mann","year":"2019","unstructured":"Mann RM, Cho N, Moy L (2019) Breast MRI: state of the art. Radiology. https:\/\/doi.org\/10.1148\/radiol.2019182947","journal-title":"Radiology"},{"issue":"3","key":"1808_CR3","doi-asserted-by":"publisher","first-page":"624","DOI":"10.14366\/usg.21219","volume":"14","author":"T Jeon","year":"2022","unstructured":"Jeon T, Kim YS, Son HM, Lee SE (2022) Tips for finding magnetic resonance imaging-detected suspicious breast lesions using second-look ultrasonography: a pictorial essay. Ultrasonography 14(3):624\u2013632. https:\/\/doi.org\/10.14366\/usg.21219","journal-title":"Ultrasonography"},{"issue":"3","key":"1808_CR4","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.ejrad.2013.12.017","volume":"83","author":"MM Aracava","year":"2014","unstructured":"Aracava MM, Chojniak R, Souza JA, Bitencourt AG, Marques EF (2014) Identification of occult breast lesions detected by magnetic resonance imaging with targeted ultrasound: a prospective study. Eur J Radiol 83(3):516\u2013519. https:\/\/doi.org\/10.1016\/j.ejrad.2013.12.017","journal-title":"Eur J Radiol"},{"key":"1808_CR5","doi-asserted-by":"publisher","first-page":"901757","DOI":"10.3389\/fonc.2022.901757","volume":"12","author":"L Ma","year":"2022","unstructured":"Ma L, Qin J, Kong L, Zhao J, Xiao M, Wang H, Zhang J, Jiang Y, Li J, Liu H, Zhu Q (2022) Can pre-biopsy second-look breast ultrasound affect clinical management? experience from a single tertiary hospital. Front Oncol 12:901757. https:\/\/doi.org\/10.3389\/fonc.2022.901757","journal-title":"Front Oncol"},{"key":"1808_CR6","doi-asserted-by":"publisher","first-page":"3669","DOI":"10.1007\/s00330-015-3807-z","volume":"25","author":"RM Mann","year":"2015","unstructured":"Mann RM, Balleyguier C, Baltzer PA, Bick U, Colin C, Cornford E, Evans AN, Fallenberg EM, Forrai G, Fuchsj\u00e4ger MH et al (2015) Breast MRI: EUSOBI recommendations for women\u2019s information. Eur Radiol 25:3669\u20133678. https:\/\/doi.org\/10.1007\/s00330-015-3807-z","journal-title":"Eur Radiol"},{"key":"1808_CR7","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/tbj.12519","volume":"22","author":"Ferre\u00b4 R, Ianculescu V, Ciolovan L,","year":"2016","unstructured":"Ferre\u00b4 R, Ianculescu V, Ciolovan L, et al (2016) Diagnostic performance of MR- guided vacuum-assisted breast biopsy: 8 years of experience. Breast J 22:83\u201389. https:\/\/doi.org\/10.1111\/tbj.12519","journal-title":"Breast J"},{"key":"1808_CR8","doi-asserted-by":"publisher","first-page":"4886","DOI":"10.1007\/s00330-020-07392-6","volume":"31","author":"J Lambert","year":"2021","unstructured":"Lambert J, Steelandt T, Heywang-K\u00f6brunner SH, Gieraerts K, Van Den Berghe I, Van Ongeval C, Casselman JW (2021) Long-term MRI-guided vacuum-assisted breast biopsy results of 600 single-center procedures. Eur Radiol 31:4886\u20134897","journal-title":"Eur Radiol"},{"issue":"5","key":"1808_CR9","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/s12032-020-01358-w","volume":"37","author":"S Penco","year":"2020","unstructured":"Penco S, Rotili A, Pesapane F, Trentin C, Dominelli V, Faggian A, Farina M, Marinucci I, Bozzini A, Pizzamiglio M, Ierardi AM, Cassano E (2020) MRI-guided vacuum-assisted breast biopsy: experience of a single tertiary referral cancer centre and prospects for the future. Med Oncol 37(5):36","journal-title":"Med Oncol"},{"key":"1808_CR10","volume-title":"ACR BI-RADS\u00ae atlas, breast imaging reporting and data system","author":"EA Morris","year":"2013","unstructured":"Morris EA, Comstock CE, Lee CH (2013) ACR BI-RADS\u00ae magnetic resonance imaging. In: ACR BI-RADS\u00ae atlas, breast imaging reporting and data system. American College of Radiology, Reston, VA"},{"key":"1808_CR11","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.20.23040","author":"AY Michaels","year":"2021","unstructured":"Michaels AY, Ginter PS, Dodelzon K, Naunheim MR, Abbey GN (2021) High-risk lesions detected by MRI-guided core biopsy: upgrade rates at surgical excision and implications for management. AJR Am J Roentgenol. https:\/\/doi.org\/10.2214\/AJR.20.23040","journal-title":"AJR Am J Roentgenol"},{"issue":"8","key":"1808_CR12","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1016\/j.ejca.2010.02.015","volume":"46","author":"F Sardanelli","year":"2010","unstructured":"Sardanelli F, Boetes C, Borisch B, Decker T, Federico M, Gilbert FJ, Helbich T, Heywang-K\u00f6brunner SH, Kaiser WA, Kerin MJ et al (2010) Magnetic resonance imaging of the breast: recommendations from the EUSOMA working group. Eur J Cancer 46(8):1296\u20131316","journal-title":"Eur J Cancer"},{"issue":"5","key":"1808_CR13","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1177\/0284185117730102","volume":"59","author":"L Gristina","year":"2017","unstructured":"Gristina L, Rescinito G, Garlaschi A, Tosto S, Cevasco L, Calabrese M (2017) Freehand 3T MR-guided vacuum-assisted breast biopsy (VAB): a five-year experience. Acta Radiol 59(5):540\u2013545. https:\/\/doi.org\/10.1177\/0284185117730102","journal-title":"Acta Radiol"},{"key":"1808_CR14","doi-asserted-by":"publisher","first-page":"151563","DOI":"10.1016\/j.anndiagpath.2020.151563","volume":"48","author":"AJ Lilly","year":"2020","unstructured":"Lilly AJ, Johnson M, Kuzmiak CM, Ollila DW, O\u2019Connor SM, Hertel JD, Calhoun BC (2020) MRI-guided core needle biopsy of the breast: Radiology-pathology correlation and impact on clinical management. Ann Diagn Pathol 48:151563. https:\/\/doi.org\/10.1016\/j.anndiagpath.2020.151563","journal-title":"Ann Diagn Pathol"},{"key":"1808_CR15","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/s00330-013-2989-5","volume":"24","author":"T Imschweiler","year":"2014","unstructured":"Imschweiler T, Haueisen H, Kampmann G, Rageth L, Seifert B, Rageth C, Freiwald B, Kubik-Huch RA (2014) MRI-guided vacuum-assisted breast biopsy: comparison with stereotactically guided and ultrasound-guided techniques. Eur Radiol 24:128\u2013135. https:\/\/doi.org\/10.1007\/s00330-013-2989-5","journal-title":"Eur Radiol"},{"issue":"8","key":"1808_CR16","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.3390\/diagnostics12081985","volume":"12","author":"C Niketa","year":"2022","unstructured":"Niketa C, Pang KA, Lim JW (2022) Challenges in MRI-guided breast biopsy and some suggested strategies: case based review. Diagnostics (Basel). 12(8):1985. https:\/\/doi.org\/10.3390\/diagnostics12081985","journal-title":"Diagnostics (Basel)."},{"key":"1808_CR17","first-page":"35","volume":"50","author":"O Ellis","year":"2001","unstructured":"Ellis O, Humphreys S, Michell M, Pinder SE, Wells CA, Zakhour HD (2001) Guidelines for non-operative diagnostic procedures and reporting in cancer screening. NHSBSP Publ 50:35\u201340","journal-title":"NHSBSP Publ"},{"key":"1808_CR18","volume-title":"WHO Classification Of Tumours Editorial Board Breast Tumours","author":"IARC","year":"2019","unstructured":"IARC (2019) WHO Classification Of Tumours Editorial Board Breast Tumours. International Agency for Research on Cancer, Lyon"},{"key":"1808_CR19","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1002\/ijc.25801","volume":"129","author":"EA Rakha","year":"2011","unstructured":"Rakha EA, Lee AHS, Jenkins JA, Murphy AE, Hamilton LJ, Ellis IO (2011) Characterization and outcome of breast needle core biopsy diagnoses of lesions of uncertain malignant potential (B3) in abnormalities detected by mammographic screening. Int J Cancer 129:1417\u20131424. https:\/\/doi.org\/10.1002\/ijc.25801","journal-title":"Int J Cancer"},{"key":"1808_CR20","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1055\/s-0034-1399278","volume":"36","author":"G Mostbeck","year":"2015","unstructured":"Mostbeck G (2015) Second look US after breast MRI. Ultraschall Med 36:101\u2013103. https:\/\/doi.org\/10.1055\/s-0034-1399278","journal-title":"Ultraschall Med"},{"issue":"1","key":"1808_CR21","doi-asserted-by":"publisher","first-page":"W17","DOI":"10.2214\/AJR.16.16404","volume":"208","author":"AA Lewin","year":"2017","unstructured":"Lewin AA, Heller SL, Jaglan S, Elias K, Newburg A, Melsaether A, Moy L (2017) Radiologic-pathologic discordance and outcome after MRI-guided vacuum-assisted biopsy. AJR Am J Roentgenol 208(1):W17\u2013W22. https:\/\/doi.org\/10.2214\/AJR.16.16404","journal-title":"AJR Am J Roentgenol"},{"key":"1808_CR22","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1007\/s00330-014-3125-x","volume":"24","author":"SD Shaylor","year":"2014","unstructured":"Shaylor SD, Heller SL, Melsaether AN et al (2014) Short interval follow-up after a benign concordant MR-guided vacuum assisted breast biopsy - is it worthwhile? Eur Radiol 24:1176\u20131185. https:\/\/doi.org\/10.1007\/s00330-014-3125-x","journal-title":"Eur Radiol"},{"key":"1808_CR23","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.clinimag.2019.05.007","volume":"57","author":"D Pinkney","year":"2019","unstructured":"Pinkney D, Chikarmane S, Giess C (2019) Do benign-concordant breast MRI biopsy results require short interval follow-up imaging? Report of longitudinal study and review of the literature. Clin Imaging 57:50\u201355. https:\/\/doi.org\/10.1016\/j.clinimag.2019.05.007","journal-title":"Clin Imaging"},{"key":"1808_CR24","unstructured":"Programme NBS. (2016) Clinical guidance for breast cancer screening assessment. NHSBSP publication number 49. Fourth edition"},{"key":"1808_CR25","doi-asserted-by":"crossref","unstructured":"Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, et al. (2023) Third international consensus conference on lesions of uncertain malignant potential in the breast (B3 lesions), Virchows Arch, 483(1), pp 5\u201320","DOI":"10.1007\/s00428-023-03566-x"},{"key":"1808_CR26","doi-asserted-by":"publisher","first-page":"682","DOI":"10.2214\/AJR.13.11905","volume":"203","author":"AP Lourenco","year":"2014","unstructured":"Lourenco AP, Khalil H, Sanford M, Donegan L (2014) High-risk lesions at MRI-guided breast biopsy: frequency and rate of underestimation. Am J Roentgenol AJR 203:682\u2013686. https:\/\/doi.org\/10.2214\/AJR.13.11905","journal-title":"Am J Roentgenol AJR"},{"issue":"3","key":"1808_CR27","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s12282-019-01032-8","volume":"27","author":"S Okamoto","year":"2020","unstructured":"Okamoto S, Chen ST, Covelli JD, DeMartini WB, Daniel BL, Ikeda DM (2020) High-risk lesions diagnosed at MRI-guided vacuum-assisted breast biopsy: imaging characteristics, outcome of surgical excision or imaging follow-up. Breast Cancer 27(3):405\u2013414. https:\/\/doi.org\/10.1007\/s12282-019-01032-8","journal-title":"Breast Cancer"},{"key":"1808_CR28","doi-asserted-by":"publisher","first-page":"20180300","DOI":"10.1259\/bjr.20180300","volume":"91","author":"ME Speer","year":"2018","unstructured":"Speer ME, Huang ML, Dogan BE et al (2018) High risk breast lesions identified on MRI-guided vacuum-assisted needle biopsy: outcome of surgical excision and imaging follow-up. Br J Radiol 91:20180300. https:\/\/doi.org\/10.1259\/bjr.20180300","journal-title":"Br J Radiol"},{"key":"1808_CR29","doi-asserted-by":"publisher","first-page":"622","DOI":"10.2214\/AJR.20.23040","volume":"216","author":"A Michaels","year":"2021","unstructured":"Michaels A, Ginter PS, Dodelzon K, Naunheim MR, Abbey GN (2021) High-risk lesions detected by MRI-guided core biopsy: upgrade rates at surgical excision and implications for management. Am J Roentgenol AJR 216:622\u2013632","journal-title":"Am J Roentgenol AJR"},{"key":"1808_CR30","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1007\/s00330-010-1949-6","volume":"21","author":"P Crystal","year":"2011","unstructured":"Crystal P, Sadaf A, Bukhanov K, McCready D, O\u2019Malley F, Helbich TH (2011) High-risk lesions diagnosed at MRI-guided vacuum-assisted breast biopsy: can underestimation be predicted? Eur Radiol 21:582\u2013589. https:\/\/doi.org\/10.1007\/s00330-010-1949-6","journal-title":"Eur Radiol"},{"issue":"3","key":"1808_CR31","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s10549-022-06761-7","volume":"196","author":"E Cha","year":"2022","unstructured":"Cha E, Ambinder EB, Oluyemi ET, Mullen LA, Panigrahi B, Rossi J, Di Carlo PA, Myers KS (2022) High-risk lesions in the breast diagnosed by MRI-guided core biopsy: upgrade rates and features associated with malignancy. Breast Cancer Res Treat 196(3):517\u2013525. https:\/\/doi.org\/10.1007\/s10549-022-06761-7","journal-title":"Breast Cancer Res Treat"},{"key":"1808_CR32","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s10549-022-06761-7","volume":"196","author":"E Cha","year":"2022","unstructured":"Cha E, Ambinder EB, Oluyemi ET et al (2022) High risk lesions in the breast diagnosed by MRI guided core biopsy: upgrade rates and features associated with malignancy. Breast Cancer Res Treat 196:517\u2013525. https:\/\/doi.org\/10.1007\/s10549-022-06761-7","journal-title":"Breast Cancer Res Treat"},{"key":"1808_CR33","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1148\/radiol.2016151947","volume":"281","author":"C Verheyden","year":"2016","unstructured":"Verheyden C, Pages-Bouic E, Balleyguier C et al (2016) Underestimation rate at MR imaging-guided vacuumassisted breast biopsy: a multi-institutional retrospective study of 1509 breast biopsies. Radiology 281:708\u2013719","journal-title":"Radiology"},{"issue":"3","key":"1808_CR34","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s10549-020-05977-9","volume":"185","author":"X Li","year":"2021","unstructured":"Li X, Ma Z, Styblo TM, Arciero CA, Wang H, Cohen MA (2021) Management of high-risk breast lesions diagnosed on core biopsies and experiences from prospective high-risk breast lesion conferences at an academic institution. Breast Cancer Res Treat 185(3):573\u2013581. https:\/\/doi.org\/10.1007\/s10549-020-05977-9","journal-title":"Breast Cancer Res Treat"}],"container-title":["La radiologia medica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11547-024-01808-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11547-024-01808-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11547-024-01808-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T06:14:46Z","timestamp":1715408086000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11547-024-01808-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,21]]},"references-count":34,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["1808"],"URL":"https:\/\/doi.org\/10.1007\/s11547-024-01808-9","relation":{},"ISSN":["1826-6983"],"issn-type":[{"value":"1826-6983","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,21]]},"assertion":[{"value":"17 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no personal, financial, or institutional interest with regards to the authorship and\/or publication of this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the local Ethics Committee. Due to the retrospective nature of the study, the requirement for patients\u2019 informed consent was waived.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}