{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T02:28:41Z","timestamp":1780712921573,"version":"3.54.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T00:00:00Z","timestamp":1730505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T00:00:00Z","timestamp":1730505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Natural Science Foundation of Shanghai","award":["23ZR1459500"],"award-info":[{"award-number":["23ZR1459500"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82171897"],"award-info":[{"award-number":["82171897"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82371923"],"award-info":[{"award-number":["82371923"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiol med"],"DOI":"10.1007\/s11547-024-01910-y","type":"journal-article","created":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T04:36:51Z","timestamp":1730522211000},"page":"1766-1777","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A preliminary study of developing an MRI-based model for postoperative recurrence prediction and treatment direction of intrahepatic cholangiocarcinoma"],"prefix":"10.1007","volume":"129","author":[{"given":"Ruofan","family":"Sheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beixuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0030-9254","authenticated-orcid":false,"given":"Mengsu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,2]]},"reference":[{"key":"1910_CR1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.21037\/cco.2018.07.03","volume":"7","author":"AJ Lee","year":"2018","unstructured":"Lee AJ, Chun YS (2018) Intrahepatic cholangiocarcinoma: the AJCC\/UICC 8th edition updates. Chin Clin Oncol 7:52. https:\/\/doi.org\/10.21037\/cco.2018.07.03","journal-title":"Chin Clin Oncol"},{"key":"1910_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16040739","author":"C Tsung","year":"2024","unstructured":"Tsung C, Quinn PL, Ejaz A (2024) Management of Intrahepatic Cholangiocarcinoma: A Narrative Review. Cancers. https:\/\/doi.org\/10.3390\/cancers16040739","journal-title":"Cancers"},{"key":"1910_CR3","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-022-11463-x","author":"WJ Choi","year":"2022","unstructured":"Choi WJ, Williams PJ, Claasen M et al (2022) Systematic review and meta-analysis of prognostic factors for early recurrence in intrahepatic cholangiocarcinoma after curative-intent resection. Ann Surg Oncol. https:\/\/doi.org\/10.1245\/s10434-022-11463-x","journal-title":"Ann Surg Oncol"},{"key":"1910_CR4","doi-asserted-by":"publisher","first-page":"553","DOI":"10.14218\/jcth.2021.00250","volume":"10","author":"X Chen","year":"2022","unstructured":"Chen X, Du J, Huang J, Zeng Y, Yuan K (2022) Neoadjuvant and adjuvant therapy in intrahepatic cholangiocarcinoma. J Clin Transl Hepatol 10:553\u2013563. https:\/\/doi.org\/10.14218\/jcth.2021.00250","journal-title":"J Clin Transl Hepatol"},{"key":"1910_CR5","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-051421","volume":"12","author":"Y Chen","year":"2022","unstructured":"Chen Y, Zhang B, Liu C, Cao Y, Lyu C, Qiu M (2022) Clinical efficacy of adjuvant treatments for patients with resected biliary tract cancer: a systematic review and network meta-analysis. BMJ Open 12:e051421. https:\/\/doi.org\/10.1136\/bmjopen-2021-051421","journal-title":"BMJ Open"},{"key":"1910_CR6","doi-asserted-by":"publisher","first-page":"693","DOI":"10.4254\/wjh.v12.i10.693","volume":"12","author":"C Akateh","year":"2020","unstructured":"Akateh C, Ejaz AM, Pawlik TM, Cloyd JM (2020) Neoadjuvant treatment strategies for intrahepatic cholangiocarcinoma. World J Hepatol 12:693\u2013708. https:\/\/doi.org\/10.4254\/wjh.v12.i10.693","journal-title":"World J Hepatol"},{"key":"1910_CR7","doi-asserted-by":"publisher","first-page":"6558","DOI":"10.1245\/s10434-023-13809-5","volume":"30","author":"SK Maithel","year":"2023","unstructured":"Maithel SK, Keilson JM, Cao HST et al (2023) NEO-GAP: a single-arm, phase II feasibility trial of neoadjuvant gemcitabine, cisplatin, and nab-paclitaxel for resectable, high-risk intrahepatic cholangiocarcinoma. Ann Surg Oncol 30:6558\u20136566. https:\/\/doi.org\/10.1245\/s10434-023-13809-5","journal-title":"Ann Surg Oncol"},{"key":"1910_CR8","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1245\/s10434-020-09478-3","volume":"28","author":"O Utuama","year":"2021","unstructured":"Utuama O, Permuth JB, Dagne G et al (2021) Neoadjuvant chemotherapy for intrahepatic cholangiocarcinoma: a propensity score survival analysis supporting use in patients with high-risk disease. Ann Surg Oncol 28:1939\u20131949. https:\/\/doi.org\/10.1245\/s10434-020-09478-3","journal-title":"Ann Surg Oncol"},{"key":"1910_CR9","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1245\/s10434-019-07353-4","volume":"26","author":"LS Hu","year":"2019","unstructured":"Hu LS, Zhang XF, Weiss M et al (2019) Recurrence patterns and timing courses following curative-intent resection for intrahepatic cholangiocarcinoma. Ann Surg Oncol 26:2549\u20132557. https:\/\/doi.org\/10.1245\/s10434-019-07353-4","journal-title":"Ann Surg Oncol"},{"key":"1910_CR10","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1001\/jamasurg.2020.1973","volume":"155","author":"DI Tsilimigras","year":"2020","unstructured":"Tsilimigras DI, Sahara K, Wu L et al (2020) Very early recurrence after liver resection for intrahepatic cholangiocarcinoma: considering alternative treatment approaches. JAMA Surg 155:823\u2013831. https:\/\/doi.org\/10.1001\/jamasurg.2020.1973","journal-title":"JAMA Surg"},{"key":"1910_CR11","doi-asserted-by":"publisher","first-page":"2250","DOI":"10.1007\/s11605-021-04911-8","volume":"25","author":"TL Sutton","year":"2021","unstructured":"Sutton TL, Billingsley KG, Walker BS et al (2021) Detection of tumor multifocality in resectable intrahepatic cholangiocarcinoma: defining the optimal pre-operative imaging modality. J Gastrointest Surg 25:2250\u20132257. https:\/\/doi.org\/10.1007\/s11605-021-04911-8","journal-title":"J Gastrointest Surg"},{"key":"1910_CR12","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1148\/radiol.2018180450","volume":"289","author":"A Pandey","year":"2018","unstructured":"Pandey A, Pandey P, Ghasabeh MA et al (2018) Baseline volumetric multiparametric MRI: can it be used to predict survival in patients with unresectable intrahepatic cholangiocarcinoma undergoing transcatheter arterial chemoembolization? Radiology 289:843\u2013853. https:\/\/doi.org\/10.1148\/radiol.2018180450","journal-title":"Radiology"},{"key":"1910_CR13","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.29390","author":"YJ Pan","year":"2024","unstructured":"Pan YJ, Wu SJ, Zeng Y et al (2024) Intra- and peri-tumoral radiomics based on dynamic contrast enhanced-MRI to identify lymph node metastasis and prognosis in intrahepatic cholangiocarcinoma. J Magn Reson Imaging. https:\/\/doi.org\/10.1002\/jmri.29390","journal-title":"J Magn Reson Imaging"},{"key":"1910_CR14","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1148\/radiol.2018181485","volume":"290","author":"JH Min","year":"2019","unstructured":"Min JH, Kim YK, Choi SY et al (2019) Intrahepatic mass-forming cholangiocarcinoma: arterial enhancement patterns at MRI and prognosis. Radiology 290:691\u2013699. https:\/\/doi.org\/10.1148\/radiol.2018181485","journal-title":"Radiology"},{"key":"1910_CR15","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1148\/radiol.2018181290","volume":"290","author":"SH Choi","year":"2019","unstructured":"Choi SH, Lee SS, Park SH et al (2019) LI-RADS classification and prognosis of primary liver cancers at gadoxetic acid-enhanced MRI. Radiology 290:388\u2013397. https:\/\/doi.org\/10.1148\/radiol.2018181290","journal-title":"Radiology"},{"key":"1910_CR16","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1007\/s00330-023-10002-w","volume":"34","author":"R Sheng","year":"2024","unstructured":"Sheng R, Zhang Y, Wang H et al (2024) A multi-center diagnostic system for intrahepatic mass-forming cholangiocarcinoma based on preoperative MRI and clinical features. Eur Radiol 34:548\u2013559. https:\/\/doi.org\/10.1007\/s00330-023-10002-w","journal-title":"Eur Radiol"},{"key":"1910_CR17","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1002\/jmri.28214","volume":"57","author":"R Sheng","year":"2022","unstructured":"Sheng R, Sun W, Huang X et al (2022) Apparent diffusion coefficient MRI shows association with early progression of unresectable intrahepatic cholangiocarcinoma with combined targeted-immunotherapy. J Magn Reson Imaging 57:275\u2013284. https:\/\/doi.org\/10.1002\/jmri.28214","journal-title":"J Magn Reson Imaging"},{"key":"1910_CR18","doi-asserted-by":"publisher","first-page":"698","DOI":"10.3390\/curroncol29020061","volume":"29","author":"JD Kova\u010d","year":"2022","unstructured":"Kova\u010d JD, Jankovi\u0107 A, \u0110iki\u0107-Rom A, Grubor N, Anti\u0107 A, Dugali\u0107 V (2022) Imaging spectrum of intrahepatic mass-forming cholangiocarcinoma and its mimickers: how to differentiate them using MRI. Curr Oncol 29:698\u2013723. https:\/\/doi.org\/10.3390\/curroncol29020061","journal-title":"Curr Oncol"},{"key":"1910_CR19","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1148\/radiol.2018181494","volume":"289","author":"V Chernyak","year":"2018","unstructured":"Chernyak V, Fowler KJ, Kamaya A et al (2018) Liver imaging reporting and data system (LI-RADS) version 2018: imaging of hepatocellular carcinoma in at-risk patients. Radiology 289:816\u2013830. https:\/\/doi.org\/10.1148\/radiol.2018181494","journal-title":"Radiology"},{"key":"1910_CR20","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1159\/000521747","volume":"11","author":"S Park","year":"2022","unstructured":"Park S, Lee Y, Kim H et al (2022) Subtype classification of intrahepatic cholangiocarcinoma using liver MR imaging features and its prognostic value. Liver Cancer 11:233\u2013246. https:\/\/doi.org\/10.1159\/000521747","journal-title":"Liver Cancer"},{"key":"1910_CR21","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.jhep.2017.04.024","volume":"67","author":"S Lee","year":"2017","unstructured":"Lee S, Kim SH, Lee JE, Sinn DH, Park CK (2017) Preoperative gadoxetic acid-enhanced MRI for predicting microvascular invasion in patients with single hepatocellular carcinoma. J Hepatol 67:526\u2013534. https:\/\/doi.org\/10.1016\/j.jhep.2017.04.024","journal-title":"J Hepatol"},{"key":"1910_CR22","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s40644-020-00318-x","volume":"20","author":"X Ma","year":"2020","unstructured":"Ma X, Liu L, Fang J et al (2020) MRI features predict microvascular invasion in intrahepatic cholangiocarcinoma. Cancer Imaging 20:40. https:\/\/doi.org\/10.1186\/s40644-020-00318-x","journal-title":"Cancer Imaging"},{"key":"1910_CR23","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/jmri.26768","volume":"51","author":"SS Kim","year":"2020","unstructured":"Kim SS, Kim SH, Song KD, Choi SY, Heo NH (2020) Value of gadoxetic acid-enhanced MRI and diffusion-weighted imaging in the differentiation of hypervascular hyperplastic nodule from small (<3 cm) hypervascular hepatocellular carcinoma in patients with alcoholic liver cirrhosis: a retrospective case-control study. J Magn Reson Imaging 51:70\u201380. https:\/\/doi.org\/10.1002\/jmri.26768","journal-title":"J Magn Reson Imaging"},{"key":"1910_CR24","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.diii.2020.09.001","volume":"101","author":"M Benchoufi","year":"2020","unstructured":"Benchoufi M, Matzner-Lober E, Molinari N, Jannot AS, Soyer P (2020) Interobserver agreement issues in radiology. Diagn Interv Imaging 101:639\u2013641. https:\/\/doi.org\/10.1016\/j.diii.2020.09.001","journal-title":"Diagn Interv Imaging"},{"key":"1910_CR25","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1016\/s0140-6736(14)60405-0","volume":"383","author":"M Maeng","year":"2014","unstructured":"Maeng M, Tilsted HH, Jensen LO et al (2014) Differential clinical outcomes after 1 year versus 5 years in a randomised comparison of zotarolimus-eluting and sirolimus-eluting coronary stents (the SORT OUT III study): a multicentre, open-label, randomised superiority trial. Lancet 383:2047\u20132056. https:\/\/doi.org\/10.1016\/s0140-6736(14)60405-0","journal-title":"Lancet"},{"key":"1910_CR26","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1007\/s00261-023-03847-8","volume":"48","author":"S Chen","year":"2023","unstructured":"Chen S, Wan L, Zhao R et al (2023) Predictive factors of microvascular invasion in patients with intrahepatic mass-forming cholangiocarcinoma based on magnetic resonance images. Abdom Radiol 48:1306\u20131319. https:\/\/doi.org\/10.1007\/s00261-023-03847-8","journal-title":"Abdom Radiol"},{"key":"1910_CR27","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1186\/s12885-021-09035-5","volume":"21","author":"Y Chen","year":"2021","unstructured":"Chen Y, Liu H, Zhang J et al (2021) Prognostic value and predication model of microvascular invasion in patients with intrahepatic cholangiocarcinoma: a multicenter study from China. BMC Cancer 21:1299. https:\/\/doi.org\/10.1186\/s12885-021-09035-5","journal-title":"BMC Cancer"},{"key":"1910_CR28","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1007\/s11605-018-4052-y","volume":"23","author":"P Addeo","year":"2019","unstructured":"Addeo P, Jedidi I, Locicero A et al (2019) Prognostic impact of tumor multinodularity in intrahepatic cholangiocarcinoma. J Gastrointest Surg 23:1801\u20131809. https:\/\/doi.org\/10.1007\/s11605-018-4052-y","journal-title":"J Gastrointest Surg"},{"key":"1910_CR29","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s40644-020-00323-0","volume":"20","author":"MJ King","year":"2020","unstructured":"King MJ, Hectors S, Lee KM et al (2020) Outcomes assessment in intrahepatic cholangiocarcinoma using qualitative and quantitative imaging features. Cancer Imaging 20:43. https:\/\/doi.org\/10.1186\/s40644-020-00323-0","journal-title":"Cancer Imaging"},{"key":"1910_CR30","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.acra.2021.09.004","volume":"29","author":"R Sheng","year":"2022","unstructured":"Sheng R, Zeng M, Jin K, Zhang Y, Wu D, Sun H (2022) MRI-based nomogram predicts the risk of progression of unresectable hepatocellular carcinoma after combined lenvatinib and anti-PD-1 antibody therapy. Acad Radiol 29:819\u2013829. https:\/\/doi.org\/10.1016\/j.acra.2021.09.004","journal-title":"Acad Radiol"},{"key":"1910_CR31","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1159\/000511384","volume":"10","author":"A Surov","year":"2021","unstructured":"Surov A, Pech M, Omari J et al (2021) Diffusion-weighted imaging reflects tumor grading and microvascular invasion in hepatocellular carcinoma. Liver Cancer 10:10\u201324. https:\/\/doi.org\/10.1159\/000511384","journal-title":"Liver Cancer"},{"key":"1910_CR32","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1002\/jhbp.732","volume":"27","author":"S Yamada","year":"2020","unstructured":"Yamada S, Morine Y, Imura S et al (2020) Prognostic prediction of apparent diffusion coefficient obtained by diffusion-weighted MRI in mass-forming intrahepatic cholangiocarcinoma. J Hepatobiliary Pancreat Sci 27:388\u2013395. https:\/\/doi.org\/10.1002\/jhbp.732","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"1910_CR33","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.29207","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Yang C, Qian X, Dai Y, Zeng M (2023) Evaluate the microvascular invasion of hepatocellular carcinoma (\u22645 cm) and recurrence free survival with gadoxetate disodium-enhanced mri-based habitat imaging. J Magn Reson Imaging. https:\/\/doi.org\/10.1002\/jmri.29207","journal-title":"J Magn Reson Imaging"},{"key":"1910_CR34","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1002\/jmri.22876","volume":"35","author":"KA Kim","year":"2012","unstructured":"Kim KA, Kim MJ, Jeon HM et al (2012) Prediction of microvascular invasion of hepatocellular carcinoma: usefulness of peritumoral hypointensity seen on gadoxetate disodium-enhanced hepatobiliary phase images. J Magn Reson Imaging 35:629\u2013634. https:\/\/doi.org\/10.1002\/jmri.22876","journal-title":"J Magn Reson Imaging"},{"key":"1910_CR35","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s12876-023-02754-y","volume":"23","author":"Z Yang","year":"2023","unstructured":"Yang Z, Jiang X (2023) Efficacy and safety comparison of neoadjuvant chemotherapy followed by surgery and upfront surgery for treating intrahepatic cholangiocarcinoma: a systematic review and meta-analysis. BMC Gastroenterol 23:122. https:\/\/doi.org\/10.1186\/s12876-023-02754-y","journal-title":"BMC Gastroenterol"},{"key":"1910_CR36","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14174320","author":"R Marcus","year":"2022","unstructured":"Marcus R, Christopher W, Keller J et al (2022) Systemic therapy is associated with improved oncologic outcomes in resectable stage II\/III intrahepatic cholangiocarcinoma: an examination of the national cancer database over the past decade. Cancers. https:\/\/doi.org\/10.3390\/cancers14174320","journal-title":"Cancers"},{"key":"1910_CR37","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1002\/bjs.10676","volume":"105","author":"XF Zhang","year":"2018","unstructured":"Zhang XF, Beal EW, Bagante F et al (2018) Early versus late recurrence of intrahepatic cholangiocarcinoma after resection with curative intent. Br J Surg 105:848\u2013856. https:\/\/doi.org\/10.1002\/bjs.10676","journal-title":"Br J Surg"}],"container-title":["La radiologia medica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11547-024-01910-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11547-024-01910-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11547-024-01910-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T20:04:29Z","timestamp":1734379469000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11547-024-01910-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,2]]},"references-count":37,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1910"],"URL":"https:\/\/doi.org\/10.1007\/s11547-024-01910-y","relation":{},"ISSN":["1826-6983"],"issn-type":[{"value":"1826-6983","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,2]]},"assertion":[{"value":"28 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was conducted according to the guidelines of the Declaration of Helsinki. It was approved by the Ethics Committee of Zhongshan Hospital, Fudan University, Shanghai, China (protocol code B2021-113R).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}