{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:51:41Z","timestamp":1786981901672,"version":"build-2736575974"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"The National Key R&D Program of China","award":["2023YFC2414200"],"award-info":[{"award-number":["2023YFC2414200"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82371934"],"award-info":[{"award-number":["82371934"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Zhongyuan Thousand Talents Plan Project - Basic Research Leader Talent","award":["No. ZYQR201810117"],"award-info":[{"award-number":["No. ZYQR201810117"]}]},{"name":"the Zhengzhou Collaborative Innovation Major Project","award":["No. 20XTZX05015"],"award-info":[{"award-number":["No. 20XTZX05015"]}]},{"name":"the Joint Fund of Henan Province Science and Technology R&D Program","award":["225200810062"],"award-info":[{"award-number":["225200810062"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiol med"],"DOI":"10.1007\/s11547-025-01992-2","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T08:25:00Z","timestamp":1744705500000},"page":"1003-1012","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multiparametric 18F-FDG PET\/MRI based on restrictive spectrum imaging and amide proton transfer-weighted imaging facilitates the assessment of lymph node metastases in non-small cell lung cancer"],"prefix":"10.1007","volume":"130","author":[{"given":"Nan","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"1992_CR1","first-page":"17","volume":"73","author":"RL Siegel","year":"2023","unstructured":"Siegel RL, Miller KD, Wagle NS, Jemal A (2023) Cancer statistics, 2023. CA Cancer J Clin 73:17\u201348","journal-title":"CA Cancer J Clin"},{"key":"1992_CR2","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.suc.2021.12.001","volume":"102","author":"AL Oliver","year":"2022","unstructured":"Oliver AL (2022) Lung cancer: epidemiology and screening. Surg Clin North Am 102:335\u2013344","journal-title":"Surg Clin North Am"},{"key":"1992_CR3","doi-asserted-by":"crossref","unstructured":"Remon J, Soria JC, Peters S, ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org (2021) Early and locally advanced non-small-cell lung cancer: an update of the ESMO clinical practice guidelines focusing on diagnosis, staging, systemic and local therapy. Ann Oncol. 32:1637\u20131642","DOI":"10.1016\/j.annonc.2021.08.1994"},{"key":"1992_CR4","doi-asserted-by":"publisher","first-page":"497","DOI":"10.6004\/jnccn.2022.0025","volume":"20","author":"DS Ettinger","year":"2022","unstructured":"Ettinger DS, Wood DE, Aisner DL et al (2022) Non-small cell lung cancer, version 3.2022, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw 20:497\u2013530","journal-title":"J Natl Compr Canc Netw"},{"key":"1992_CR5","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.jtcvs.2010.11.008","volume":"141","author":"GE Darling","year":"2011","unstructured":"Darling GE, Allen MS, Decker PA et al (2011) Randomized trial of mediastinal lymph node sampling versus complete lymphadenectomy during pulmonary resection in the patient with N0 or N1 (less than hilar) non-small cell carcinoma: results of the American College of Surgery Oncology Group Z0030 Trial. J Thorac Cardiovasc Surg 141:662\u2013670","journal-title":"J Thorac Cardiovasc Surg"},{"key":"1992_CR6","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1183\/09031936.00126714","volume":"46","author":"G Stamatis","year":"2015","unstructured":"Stamatis G (2015) Staging of lung cancer: the role of noninvasive, minimally invasive and invasive techniques. Eur Respir J 46:521\u2013531","journal-title":"Eur Respir J"},{"key":"1992_CR7","doi-asserted-by":"publisher","first-page":"561","DOI":"10.3390\/diagnostics10080561","volume":"10","author":"K Kaseda","year":"2020","unstructured":"Kaseda K (2020) Recent and current advances in FDG-PET imaging within the field of clinical oncology in NSCLC: a review of the literature. Diagnostics (Basel) 10:561","journal-title":"Diagnostics (Basel)"},{"key":"1992_CR8","doi-asserted-by":"publisher","first-page":"e220138","DOI":"10.1148\/rg.220138","volume":"43","author":"J Broncano","year":"2023","unstructured":"Broncano J, Steinbrecher K, Marquis KM et al (2023) Diffusion-weighted imaging of the chest: a primer for radiologists. Radiographics 43:e220138","journal-title":"Radiographics"},{"key":"1992_CR9","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/hbm.21454","volume":"34","author":"NS White","year":"2013","unstructured":"White NS, Leergaard TB, D\u2019Arceuil H, Bjaalie JG, Dale AM (2013) Probing tissue microstructure with restriction spectrum imaging: histological and theoretical validation. Hum Brain Mapp 34:327\u2013346","journal-title":"Hum Brain Mapp"},{"key":"1992_CR10","doi-asserted-by":"publisher","first-page":"4638","DOI":"10.1158\/0008-5472.CAN-13-3534","volume":"74","author":"NS White","year":"2014","unstructured":"White NS, McDonald C, Farid N et al (2014) Diffusion-weighted imaging in cancer: physical foundations and applications of restriction spectrum imaging. Cancer Res 74:4638\u20134652","journal-title":"Cancer Res"},{"key":"1992_CR11","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1002\/mrm.10651","volume":"50","author":"J Zhou","year":"2003","unstructured":"Zhou J, Lal B, Wilson DA, Laterra J, van Zijl PC (2003) Amide proton transfer (APT) contrast for imaging of brain tumors. Magn Reson Med 50:1120\u20131126","journal-title":"Magn Reson Med"},{"key":"1992_CR12","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1038\/nm907","volume":"9","author":"J Zhou","year":"2003","unstructured":"Zhou J, Payen JF, Wilson DA, Traystman RJ, van Zijl PC (2003) Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI. Nat Med 9:1085\u20131090","journal-title":"Nat Med"},{"key":"1992_CR13","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/s41391-022-00591-w","volume":"27","author":"SE Eng","year":"2024","unstructured":"Eng SE, Basasie B, Lam A et al (2024) Prospective comparison of restriction spectrum imaging and non-invasive biomarkers to predict upgrading on active surveillance prostate biopsy. Prostate Cancer Prostatic Dis 27:65\u201372","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"1992_CR14","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1002\/jmri.28468","volume":"57","author":"Y Qin","year":"2023","unstructured":"Qin Y, Tang C, Hu Q et al (2023) Quantitative assessment of restriction spectrum MR imaging for the diagnosis of breast cancer and association with prognostic factors. J Magn Reson Imaging 57:1832\u20131841","journal-title":"J Magn Reson Imaging"},{"key":"1992_CR15","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1007\/s00261-022-03500-w","volume":"47","author":"Z Xiong","year":"2022","unstructured":"Xiong Z, Geng Z, Lian S et al (2022) Discriminating rectal cancer grades using restriction spectrum imaging. Abdom Radiol (NY) 47:2014\u20132022","journal-title":"Abdom Radiol (NY)"},{"key":"1992_CR16","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s40644-024-00677-9","volume":"24","author":"N Meng","year":"2024","unstructured":"Meng N, Song C, Sun J et al (2024) Amide proton transfer-weighted imaging and stretch-exponential model DWI based 18F-FDG PET\/MRI for differentiation of benign and malignant solitary pulmonary lesions. Cancer Imaging 24:33","journal-title":"Cancer Imaging"},{"key":"1992_CR17","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1148\/radiol.2015151161","volume":"279","author":"Y Ohno","year":"2016","unstructured":"Ohno Y, Yui M, Koyama H et al (2016) Chemical exchange saturation transfer MR imaging: preliminary results for differentiation of malignant and benign thoracic lesions. Radiology 279:578\u2013589","journal-title":"Radiology"},{"key":"1992_CR18","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1002\/jmri.28135","volume":"56","author":"N Meng","year":"2022","unstructured":"Meng N, Fu F, Feng P et al (2022) Evaluation of amide proton transfer-weighted imaging for lung cancer subtype and epidermal growth factor receptor: a comparative study with diffusion and metabolic parameters. J Magn Reson Imaging 56:1118\u20131129","journal-title":"J Magn Reson Imaging"},{"key":"1992_CR19","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1002\/jmri.28691","volume":"58","author":"Y Ohno","year":"2023","unstructured":"Ohno Y, Yui M, Yamamoto K et al (2023) Chemical exchange saturation transfer MRI: capability for predicting therapeutic effect of chemoradiotherapy on non-small cell lung cancer patients. J Magn Reson Imaging 58:174\u2013186","journal-title":"J Magn Reson Imaging"},{"key":"1992_CR20","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1007\/s00259-020-05135-9","volume":"48","author":"S Chen","year":"2021","unstructured":"Chen S, Gu Y, Yu H et al (2021) NEMA NU2-2012 performance measurements of the United Imaging uPMR790: an integrated PET\/MR system. Eur J Nucl Med Mol Imaging 48:1726\u20131735","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1992_CR21","doi-asserted-by":"publisher","first-page":"8213215","DOI":"10.1155\/2019\/8213215","volume":"2019","author":"G Liu","year":"2019","unstructured":"Liu G, Cao T, Hu L et al (2019) Validation of MR-based attenuation correction of a newly released whole-body simultaneous PET\/MR system. Biomed Res Int 2019:8213215","journal-title":"Biomed Res Int"},{"key":"1992_CR22","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1002\/jmri.27393","volume":"53","author":"CC Conlin","year":"2021","unstructured":"Conlin CC, Feng CH, Rodriguez-Soto AE et al (2021) Improved characterization of diffusion in normal and cancerous prostate tissue through optimization of multicompartmental signal models. J Magn Reson Imaging 53:628\u2013639","journal-title":"J Magn Reson Imaging"},{"key":"1992_CR23","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jtho.2015.09.009","volume":"11","author":"P Goldstraw","year":"2016","unstructured":"Goldstraw P, Chansky K, Crowley J et al (2016) The IASLC lung cancer staging project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer. J Thorac Oncol 11:39\u201351","journal-title":"J Thorac Oncol"},{"key":"1992_CR24","doi-asserted-by":"publisher","first-page":"994","DOI":"10.3758\/s13428-015-0623-y","volume":"48","author":"G Shieh","year":"2016","unstructured":"Shieh G (2016) Choosing the best index for the average score intraclass correlation coefficient. Behav Res Methods 48:994\u20131003","journal-title":"Behav Res Methods"},{"key":"1992_CR25","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s12880-023-01004-7","volume":"23","author":"X Liao","year":"2023","unstructured":"Liao X, Liu M, Li S et al (2023) The value on SUV-derived parameters assessed on 18F-FDG PET\/CT for predicting mediastinal lymph node metastasis in non-small cell lung cancer. BMC Med Imaging 23:49","journal-title":"BMC Med Imaging"},{"key":"1992_CR26","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1093\/ejcts\/ezw109","volume":"50","author":"JT Lin","year":"2016","unstructured":"Lin JT, Yang XN, Zhong WZ et al (2016) Association of maximum standardized uptake value with occult mediastinal lymph node metastases in cN0 non-small cell lung cancer. Eur J Cardiothorac Surg 50:914\u2013919","journal-title":"Eur J Cardiothorac Surg"},{"key":"1992_CR27","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1148\/radiol.221376","volume":"305","author":"L Milot","year":"2022","unstructured":"Milot L (2022) Amide proton transfer-weighted MRI: insight into cancer cell biology. Radiology 305:135\u2013136","journal-title":"Radiology"},{"key":"1992_CR28","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.mri.2023.12.001","volume":"106","author":"Q Xu","year":"2024","unstructured":"Xu Q, Song Q, Wang Y et al (2024) Amide proton transfer weighted combined with diffusion kurtosis imaging for predicting lymph node metastasis in cervical cancer. Magn Reson Imaging 106:85\u201390","journal-title":"Magn Reson Imaging"},{"key":"1992_CR29","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1093\/neuonc\/not158","volume":"16","author":"O Togao","year":"2014","unstructured":"Togao O, Yoshiura T, Keupp J et al (2014) Amide proton transfer imaging of adult diffuse gliomas: correlation with histopathological grades. Neuro Oncol 16:441\u2013448","journal-title":"Neuro Oncol"},{"key":"1992_CR30","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1002\/mrm.24770","volume":"71","author":"S Zheng","year":"2014","unstructured":"Zheng S, van der Bom IM, Zu Z, Lin G, Zhao Y, Gounis MJ (2014) Chemical exchange saturation transfer effect in blood. Magn Reson Med 71:1082\u20131092","journal-title":"Magn Reson Med"},{"key":"1992_CR31","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1007\/s00330-020-07101-3","volume":"31","author":"Y Yuan","year":"2021","unstructured":"Yuan Y, Pu H, Chen GW et al (2021) Diffusion-weighted MR volume and apparent diffusion coefficient for discriminating lymph node metastases and good response after chemoradiation therapy in locally advanced rectal cancer. Eur Radiol 31:200\u2013211","journal-title":"Eur Radiol"},{"key":"1992_CR32","doi-asserted-by":"publisher","first-page":"110504","DOI":"10.1016\/j.ejrad.2022.110504","volume":"156","author":"J Ren","year":"2022","unstructured":"Ren J, Li Y, Liu XY et al (2022) Diagnostic performance of ADC values and MRI-based radiomics analysis for detecting lymph node metastasis in patients with cervical cancer: a systematic review and meta-analysis. Eur J Radiol 156:110504","journal-title":"Eur J Radiol"},{"key":"1992_CR33","doi-asserted-by":"publisher","first-page":"4052","DOI":"10.1007\/s00261-020-02504-8","volume":"45","author":"A Chatterjee","year":"2020","unstructured":"Chatterjee A, Harmath C, Oto A (2020) New prostate MRI techniques and sequences. Abdom Radiol (NY) 45:4052\u20134062","journal-title":"Abdom Radiol (NY)"},{"key":"1992_CR34","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.2214\/AJR.18.20564","volume":"212","author":"XL Chen","year":"2019","unstructured":"Chen XL, Chen GW, Pu H et al (2019) DWI and T2-weighted MRI volumetry in resectable rectal cancer: correlation with lymphovascular invasion and lymph node metastases. AJR Am J Roentgenol 212:1271\u20131278","journal-title":"AJR Am J Roentgenol"},{"key":"1992_CR35","doi-asserted-by":"publisher","first-page":"e463","DOI":"10.1016\/j.cllc.2019.03.006","volume":"20","author":"W Lutfi","year":"2019","unstructured":"Lutfi W, Schuchert MJ, Dhupar R et al (2019) Node-positive segmentectomy for non-small-cell lung cancer: risk factors and outcomes. Clin Lung Cancer 20:e463\u2013e469","journal-title":"Clin Lung Cancer"},{"key":"1992_CR36","first-page":"172","volume":"30","author":"M Kuzucuoglu","year":"2020","unstructured":"Kuzucuoglu M, Gokyer A, Kula O et al (2020) Relationship between the size and location of the mass and hilar and mediastinal lymph node metastasis in early and locally advanced non-small cell lung cancer. J Coll Phys Surg Pak 30:172\u2013176","journal-title":"J Coll Phys Surg Pak"}],"container-title":["La radiologia medica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11547-025-01992-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11547-025-01992-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11547-025-01992-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T10:51:56Z","timestamp":1757155916000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11547-025-01992-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,15]]},"references-count":36,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["1992"],"URL":"https:\/\/doi.org\/10.1007\/s11547-025-01992-2","relation":{},"ISSN":["1826-6983"],"issn-type":[{"value":"1826-6983","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,15]]},"assertion":[{"value":"30 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"JN Y, YY, and ZW are employees of United Imaging Healthcare. The remaining authors declare no relationships with any companies whose products or services may be related to the subject matter of the article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Ethics Committee of Henan Provincial People\u2019s Hospital (number: 2020119).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from all participants in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors affirm that the human research participants provided informed consent for the publication of the studied data and the images.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}