{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T19:59:52Z","timestamp":1786391992378,"version":"build-2736575974"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiol med"],"DOI":"10.1007\/s11547-025-02026-7","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T01:52:03Z","timestamp":1748915523000},"page":"1275-1282","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["ADC measurement in whole-body MRI for multiple myeloma: a three b-values vs. two b-values DWI comparison"],"prefix":"10.1007","volume":"130","author":[{"given":"Marta","family":"Zerunian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Masci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominga","family":"Pugliese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Nardacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Polici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pucciarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"De Santis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damiano","family":"Caruso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacinto","family":"La Verde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3091-7819","authenticated-orcid":false,"given":"Andrea","family":"Laghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"issue":"12","key":"2026_CR1","doi-asserted-by":"publisher","first-page":"e538","DOI":"10.1016\/S1470-2045(14)70442-5","volume":"15","author":"SV Rajkumar","year":"2014","unstructured":"Rajkumar SV et al (2014) International Myeloma working group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol 15(12):e538\u2013e548","journal-title":"Lancet Oncol"},{"key":"2026_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/medsci9010003","author":"SA Padala","year":"2021","unstructured":"Padala SA et al (2021) Epidemiology, staging, and management of multiple myeloma. Med Sci. https:\/\/doi.org\/10.3390\/medsci9010003","journal-title":"Med Sci"},{"key":"2026_CR3","doi-asserted-by":"publisher","first-page":"e418","DOI":"10.1200\/EDBK_159009","volume":"35","author":"SV Rajkumar","year":"2016","unstructured":"Rajkumar SV (2016) Updated diagnostic criteria and staging system for multiple myeloma. Am Soc Clin Oncol Educ Book 35:e418\u2013e423","journal-title":"Am Soc Clin Oncol Educ Book"},{"issue":"1","key":"2026_CR4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1148\/radiol.2019181949","volume":"291","author":"C Messiou","year":"2019","unstructured":"Messiou C et al (2019) Guidelines for acquisition, interpretation, and reporting of whole-body MRI in myeloma: myeloma response assessment and diagnosis system (MY-RADS). Radiology 291(1):5\u201313","journal-title":"Radiology"},{"issue":"11","key":"2026_CR5","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1055\/a-0897-3966","volume":"191","author":"J Mosebach","year":"2019","unstructured":"Mosebach J et al (2019) Multiple myeloma guidelines and their recent updates: implications for imaging. Rofo 191(11):998\u20131009","journal-title":"Rofo"},{"issue":"1","key":"2026_CR6","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s13244-022-01253-0","volume":"13","author":"M Rata","year":"2022","unstructured":"Rata M et al (2022) Implementation of Whole-Body MRI (MY-RADS) within the OPTIMUM\/MUKnine multi-centre clinical trial for patients with myeloma. Insights Imaging 13(1):123","journal-title":"Insights Imaging"},{"issue":"1","key":"2026_CR7","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/bjh.13509","volume":"171","author":"C Messiou","year":"2015","unstructured":"Messiou C, Kaiser M (2015) Whole body diffusion weighted MRI\u2013a new view of myeloma. Br J Haematol 171(1):29\u201337","journal-title":"Br J Haematol"},{"issue":"3","key":"2026_CR8","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1148\/radiol.2021201740","volume":"299","author":"G Petralia","year":"2021","unstructured":"Petralia G et al (2021) Oncologically relevant findings reporting and data system (ONCO-RADS): guidelines for the acquisition, interpretation, and reporting of whole-body MRI for cancer screening. Radiology 299(3):494\u2013507","journal-title":"Radiology"},{"issue":"3","key":"2026_CR9","doi-asserted-by":"publisher","first-page":"W287","DOI":"10.2214\/AJR.13.11818","volume":"203","author":"SY Park","year":"2014","unstructured":"Park SY et al (2014) Comparison of apparent diffusion coefficient calculation between two-point and multipoint B value analyses in prostate cancer and benign prostate tissue at 3 T: preliminary experience. AJR Am J Roentgenol 203(3):W287\u2013W294","journal-title":"AJR Am J Roentgenol"},{"issue":"3","key":"2026_CR10","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1002\/jmri.29155","volume":"60","author":"Y Gao","year":"2024","unstructured":"Gao Y et al (2024) Treatment response assessment in multiple myeloma: histogram analysis of total Tumor apparent diffusion coefficient based on whole-body diffusion-weighted MR imaging. J Magn Reson Imag 60(3):1051\u20131060","journal-title":"J Magn Reson Imag"},{"issue":"9","key":"2026_CR11","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.3390\/diagnostics12092182","volume":"12","author":"P Torkian","year":"2022","unstructured":"Torkian P et al (2022) Advanced imaging in multiple myeloma: new frontiers for MRI. Diagnostics 12(9):2182","journal-title":"Diagnostics"},{"issue":"6","key":"2026_CR12","doi-asserted-by":"publisher","first-page":"e302","DOI":"10.1016\/S1470-2045(19)30309-2","volume":"20","author":"J Hillengass","year":"2019","unstructured":"Hillengass J et al (2019) International myeloma working group consensus recommendations on imaging in monoclonal plasma cell disorders. Lancet Oncol 20(6):e302\u2013e312","journal-title":"Lancet Oncol"},{"issue":"1","key":"2026_CR13","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.eururo.2012.02.020","volume":"62","author":"FE Lecouvet","year":"2012","unstructured":"Lecouvet FE et al (2012) Can whole-body magnetic resonance imaging with diffusion-weighted imaging replace Tc 99m bone scanning and computed tomography for single-step detection of metastases in patients with high-risk prostate cancer? Eur Urol 62(1):68\u201375","journal-title":"Eur Urol"},{"issue":"9","key":"2026_CR14","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1200\/JCO.2009.25.5356","volume":"28","author":"J Hillengass","year":"2010","unstructured":"Hillengass J et al (2010) Prognostic significance of focal lesions in whole-body magnetic resonance imaging in patients with asymptomatic multiple myeloma. J Clin Oncol 28(9):1606\u20131610","journal-title":"J Clin Oncol"},{"issue":"3","key":"2026_CR15","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s00256-022-04119-0","volume":"52","author":"P Torkian","year":"2023","unstructured":"Torkian P et al (2023) Diffusion-weighted imaging (DWI) in diagnosis, staging, and treatment response assessment of multiple myeloma: a systematic review and meta-analysis. Skeletal Radiol 52(3):565\u2013583","journal-title":"Skeletal Radiol"},{"issue":"1","key":"2026_CR16","doi-asserted-by":"publisher","first-page":"163","DOI":"10.2214\/AJR.11.8185","volume":"200","author":"AR Padhani","year":"2013","unstructured":"Padhani AR et al (2013) Assessing the relation between bone marrow signal intensity and apparent diffusion coefficient in diffusion-weighted MRI. AJR Am J Roentgenol 200(1):163\u2013170","journal-title":"AJR Am J Roentgenol"},{"issue":"1","key":"2026_CR17","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.mric.2015.08.011","volume":"24","author":"JFA Jansen","year":"2016","unstructured":"Jansen JFA et al (2016) Evaluation of head and neck tumors with functional MR imaging. Magn Reson Imag Clin N Am 24(1):123\u2013133","journal-title":"Magn Reson Imag Clin N Am"},{"issue":"14","key":"2026_CR18","doi-asserted-by":"publisher","first-page":"3705","DOI":"10.1158\/1078-0432.CCR-14-0044","volume":"20","author":"OF Donati","year":"2014","unstructured":"Donati OF et al (2014) Prostate MRI: evaluating tumor volume and apparent diffusion coefficient as surrogate biomarkers for predicting tumor Gleason score. Clin Cancer Res 20(14):3705\u20133711","journal-title":"Clin Cancer Res"},{"issue":"3","key":"2026_CR19","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1002\/jmri.26011","volume":"48","author":"AG Sorace","year":"2018","unstructured":"Sorace AG et al (2018) Repeatability, reproducibility, and accuracy of quantitative mri of the breast in the community radiology setting. J Magn Resona Imag 48(3):695\u2013707. https:\/\/doi.org\/10.1002\/jmri.26011","journal-title":"J Magn Resona Imag"},{"issue":"2","key":"2026_CR20","doi-asserted-by":"publisher","first-page":"242","DOI":"10.2214\/AJR.14.13964","volume":"205","author":"I Lavdas","year":"2015","unstructured":"Lavdas I et al (2015) Apparent diffusion coefficient of normal abdominal organs and bone marrow from whole-body DWI at 1.5 T: the effect of sex and age. AJR Am J Roentgenol 205(2):242\u2013250","journal-title":"AJR Am J Roentgenol"},{"issue":"1","key":"2026_CR21","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s40644-018-0177-1","volume":"18","author":"L Chen","year":"2018","unstructured":"Chen L et al (2018) Diffusion-weighted imaging of rectal cancer on repeatability and cancer characterization: an effect of b-value distribution study. Cancer Imag 18(1):43","journal-title":"Cancer Imag"},{"issue":"6","key":"2026_CR22","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.2214\/AJR.17.18002","volume":"209","author":"A Ghosh","year":"2017","unstructured":"Ghosh A et al (2017) Comparison of absolute apparent diffusion coefficient (ADC) values in ADC maps generated across different postprocessing software: reproducibility in endometrial carcinoma. AJR Am J Roentgenol 209(6):1312\u20131320","journal-title":"AJR Am J Roentgenol"},{"issue":"3","key":"2026_CR23","doi-asserted-by":"publisher","first-page":"W247","DOI":"10.2214\/AJR.13.10917","volume":"202","author":"Y Peng","year":"2014","unstructured":"Peng Y et al (2014) Apparent diffusion coefficient for prostate cancer imaging: impact of B values. AJR Am J Roentgenol 202(3):W247\u2013W253","journal-title":"AJR Am J Roentgenol"},{"key":"2026_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2023.110782","volume":"162","author":"HJ Rogers","year":"2023","unstructured":"Rogers HJ et al (2023) Test-retest repeatability of ADC in prostate using the multi b-Value VERDICT acquisition. Eur J Radiol 162:110782","journal-title":"Eur J Radiol"},{"issue":"8","key":"2026_CR25","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1007\/s00330-011-2116-4","volume":"21","author":"C Messiou","year":"2011","unstructured":"Messiou C et al (2011) Optimising diffusion weighted MRI for imaging metastatic and myeloma bone disease and assessing reproducibility. Eur Radiol 21(8):1713\u20131718","journal-title":"Eur Radiol"},{"issue":"10","key":"2026_CR26","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1016\/j.crad.2017.05.004","volume":"72","author":"C Lacognata","year":"2017","unstructured":"Lacognata C et al (2017) Diffusion-weighted whole-body MRI for evaluation of early response in multiple myeloma. Clin Radiol 72(10):850\u2013857","journal-title":"Clin Radiol"},{"issue":"1115","key":"2026_CR27","doi-asserted-by":"publisher","first-page":"20200562","DOI":"10.1259\/bjr.20200562","volume":"93","author":"N Tunariu","year":"2020","unstructured":"Tunariu N et al (2020) What\u2019s new for clinical whole-body MRI (WB-MRI) in the 21st century. Br J Radiol 93(1115):20200562","journal-title":"Br J Radiol"},{"issue":"8","key":"2026_CR28","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.3390\/cancers13081938","volume":"13","author":"C Mesguich","year":"2021","unstructured":"Mesguich C et al (2021) Prospective comparison of 18-FDG PET\/CT and whole-body MRI with diffusion-weighted imaging in the evaluation of treatment response of multiple myeloma patients eligible for autologous stem cell transplant. Cancers 13(8):1938","journal-title":"Cancers"}],"container-title":["La radiologia medica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11547-025-02026-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11547-025-02026-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11547-025-02026-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T18:22:15Z","timestamp":1757182935000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11547-025-02026-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,3]]},"references-count":28,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["2026"],"URL":"https:\/\/doi.org\/10.1007\/s11547-025-02026-7","relation":{},"ISSN":["1826-6983"],"issn-type":[{"value":"1826-6983","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,3]]},"assertion":[{"value":"6 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors affirm that human research participants provided informed consent for publication of the images in Figure(s) 1, 2, and 3.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"This single-center retrospective study was approved by our institutional review board, and written informed consent was waived.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}