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Tumor response to therapy was assessed using the Response Evaluation Criteria in Solid Tumors (RECIST). Local control was defined as achieving either partial response (PR) or stable disease (SD).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>All 77 enrolled patients (mean age: 59\u2009\u00b1\u200912\u00a0years; 52 males) were analyzed according to OS. RECIST was performed in 70 out of 77 patients since follow-up imaging was not available in 7 patients. No major complications were observed. Considering RECIST, PR was achieved in 48.57% and SD in 44.29% of the patients, resulting in a local control rate of 92.86%. A total of 5 patients showed progressive diseases at a rate of 7.14%. The median OS was 12.6\u2009\u00b1\u20091.5\u00a0months. Patients with T1-T3 tumors had significantly longer OS compared to patients with T4.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Palliative TACP has the potential to improve local tumor control and achieve remarkable survival outcomes for patients with head and neck area malignancies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s11547-025-02039-2","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T02:46:55Z","timestamp":1751597215000},"page":"1254-1262","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and safety of transarterial chemoperfusion for head and neck malignancies"],"prefix":"10.1007","volume":"130","author":[{"given":"Thomas J.","family":"Vogl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0489-0508","authenticated-orcid":false,"given":"Andrea","family":"Tr\u00f6ger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Bernatz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"St\u00f6ver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamzah","family":"Adwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"2039_CR1","doi-asserted-by":"publisher","first-page":"c4684","DOI":"10.1136\/bmj.c4684","volume":"341","author":"H Mehanna","year":"2010","unstructured":"Mehanna H, Paleri V, West CM, Nutting C (2010) Head and neck cancer\u2013Part 1: epidemiology, presentation, and prevention. 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