{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:30:31Z","timestamp":1783549831337,"version":"3.55.0"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiol med"],"DOI":"10.1007\/s11547-025-02143-3","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T16:41:58Z","timestamp":1762620118000},"page":"508-530","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of whole-brain radiation therapy on neurocognitive functions, alopecia and hearing loss: a systematic review and meta-analysis endorsed by the Palliative Care and Neuro-Oncology Study Groups of the Italian Association of Radiotherapy and Clinical Oncology (AIRO)"],"prefix":"10.1007","volume":"131","author":[{"given":"Rossella","family":"Di Franco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6676-1169","authenticated-orcid":false,"given":"Donato","family":"Pezzulla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Chiesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ettore","family":"Rocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Peluso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Maurizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Borzillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esmeralda","family":"Scipilliti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Bonzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Cacciola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Carlo","family":"Mazzola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Bergamaschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Lillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"De Cicco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Argenone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Arcidiacono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Muto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Deodato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Pinzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Maranzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,8]]},"reference":[{"key":"2143_CR1","doi-asserted-by":"publisher","DOI":"10.1177\/15330338211034269","volume":"20","author":"B Wang","year":"2021","unstructured":"Wang B, Fu S, Huang Y, Liu L, Liang Y, An W, Fan Y, Zhao Y (2021) The effect of hippocampal avoidance whole brain radiotherapy on the preservation of long-term neurocognitive function in non-small cell lung cancer patients with brain metastasis. TechnolCancerResTreat 20:15330338211034269. https:\/\/doi.org\/10.1177\/15330338211034269","journal-title":"TechnolCancerResTreat"},{"issue":"8","key":"2143_CR2","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1200\/JCO.2005.04.6185","volume":"24","author":"D Khuntia","year":"2006","unstructured":"Khuntia D, Brown P, Li J, Mehta MP (2006) Whole-brain radiotherapy in the management of brain metastasis. J Clin Oncol 24(8):1295\u20131304. https:\/\/doi.org\/10.1200\/JCO.2005.04.6185","journal-title":"J Clin Oncol"},{"issue":"4","key":"2143_CR3","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1001\/jamaoncol.2015.1145","volume":"1","author":"H Aoyama","year":"2015","unstructured":"Aoyama H, Tago M, Shirato H, Japanese Radiation Oncology Study Group 99\u20131 (JROSG 99\u20131) Investigators (2015) Stereotactic radiosurgery with or without whole-brain radiotherapy for brain metastases: secondary analysis of the JROSG 99\u20131 randomized clinical trial. JAMA Oncol 1(4):457\u2013464. https:\/\/doi.org\/10.1001\/jamaoncol.2015.1145","journal-title":"JAMA Oncol"},{"issue":"4","key":"2143_CR4","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1001\/jama.280.17.1485","volume":"280","author":"RA Patchell","year":"1998","unstructured":"Patchell RA, Tibbs PA, Regine WF, Dempsey RJ, Mohiuddin M, Kryscio RJ, Markesbery WR, Foon KA, Young B (1998) Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial. JAMA 280(4):1485\u20131489. https:\/\/doi.org\/10.1001\/jama.280.17.1485","journal-title":"JAMA"},{"issue":"6\u20137","key":"2143_CR5","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s10585-017-9865-7","volume":"34","author":"A Thiagarajan","year":"2017","unstructured":"Thiagarajan A, Yamada Y (2017) Radiobiology and radiotherapy of brain metastases. Clin Exp Metastasis 34(6\u20137):411\u2013419. https:\/\/doi.org\/10.1007\/s10585-017-9865-7","journal-title":"Clin Exp Metastasis"},{"issue":"32","key":"2143_CR6","doi-asserted-by":"publisher","first-page":"3773","DOI":"10.1200\/JCO.20.01255","volume":"38","author":"PW Sperduto","year":"2020","unstructured":"Sperduto PW, Mesko S, Li J, Cagney D, Aizer A, Lin NU, Nesbit E, Kruser TJ, Chan J, Braunstein S, Lee J, Kirkpatrick JP, Breen W, Brown PD, Shi D, Shih HA, Soliman H, Sahgal A, Shanley R, Sperduto WA, Lou E, Everett A, Boggs DH, Masucci L, Roberge D, Remick J, Plichta K, Buatti JM, Jain S, Gaspar LE, Wu CC, Wang TJC, Bryant J, Chuong M, An Y, Chiang V, Nakano T, Aoyama H, Mehta MP (2020) Survival in patients with brain metastases: summary report on the updated diagnosis-specific graded prognostic assessment and definition of the eligibility quotient. J Clin Oncol 38(32):3773\u20133784. https:\/\/doi.org\/10.1200\/JCO.20.01255","journal-title":"J Clin Oncol"},{"issue":"2","key":"2143_CR7","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.ijrobp.2012.11.031","volume":"85","author":"V Gondi","year":"2013","unstructured":"Gondi V, Hermann BP, Mehta MP, Tom\u00e9 WA (2013) Hippocampal dosimetry predicts neurocognitive function impairment after fractionated stereotactic radiotherapy for benign or low-grade adult brain tumors. Int J Radiat Oncol Biol Phys 85(2):348\u2013354. https:\/\/doi.org\/10.1016\/j.ijrobp.2012.11.031","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2143_CR8","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1186\/1471-2407-12-283","volume":"12","author":"D Steinmann","year":"2012","unstructured":"Steinmann D, Paelecke-Habermann Y, Hans G, Aschoff R, Bayerl A, B\u00f6lling T, Bosch E, Bruns F, Eichenseder-Seiss U, Gerstein J, Gharbi N, Hagg J, Hipp M, Kleff I, M\u00fcller A, Sch\u00e4fer C, Schleicher U, Sehlen S, Theodorou M, Wypior HJ, Zehentmayr F, van Oorschot B, Vordermark D (2012) Prospective evaluation of quality of life effects in patients undergoing palliative radiotherapy for brain metastases. BMC Cancer 12:283. https:\/\/doi.org\/10.1186\/1471-2407-12-283","journal-title":"BMC Cancer"},{"issue":"7","key":"2143_CR9","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/s0936-6555(03)00148-1","volume":"15","author":"GE Gerrard","year":"2003","unstructured":"Gerrard GE, Prestwich RJ, Edwards A, Russon LJ, Richards F, Johnston CF, Kwok-Williams MC (2003) Investigating the palliative efficacy of whole-brain radiotherapy for patients with multiple-brain metastases and poor prognostic features. Clin Oncol (R Coll Radiol) 15(7):422\u2013428. https:\/\/doi.org\/10.1016\/s0936-6555(03)00148-1","journal-title":"Clin Oncol (R Coll Radiol)"},{"issue":"3","key":"2143_CR10","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.ijrobp.2004.04.031","volume":"60","author":"BD Lawenda","year":"2004","unstructured":"Lawenda BD, Gagne HM, Gierga DP, Niemierko A, Wong WM, Tarbell NJ, Chen GTY, Hochberg FH, Loeffler JS (2004) Permanent alopecia after cranial irradiation: dose\u2013response relationship. Int J Radiat Oncol Biol Phys 60(3):879\u2013887. https:\/\/doi.org\/10.1016\/j.ijrobp.2004.04.031","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2143_CR11","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-015-0555-9","volume":"10","author":"A Mahadevan","year":"2015","unstructured":"Mahadevan A, Sampson C, LaRosa S, Floyd SR, Wong ET, Uhlmann EJ, Sengupta S, Kasper EM (2015) Dosimetric analysis of the alopecia preventing effect of hippocampus sparing whole brain radiation therapy. Radiat Oncol 10:245. https:\/\/doi.org\/10.1186\/s13014-015-0555-9","journal-title":"Radiat Oncol"},{"key":"2143_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-9-170","volume":"9","author":"A De Puysseleyr","year":"2014","unstructured":"De Puysseleyr A, Van De Velde J, Speleers B, Vercauteren T, Goedgebeur A, Hoof TV, Boterberg T, De Neve W, De Wagter C, Ost P (2014) Hair-sparing whole brain radiotherapy with volumetric arc therapy in patients treated for brain metastases: dosimetric and clinical results of a phase II trial. Radiat Oncol 9:170. https:\/\/doi.org\/10.1186\/1748-717X-9-170","journal-title":"Radiat Oncol"},{"key":"2143_CR13","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1016\/j.ijrobp.2010.01.039","volume":"78","author":"V Gondi","year":"2010","unstructured":"Gondi V, Tolakanahalli R, Mehta MP, Tewatia D, Rowley H, Kuo JS, Khuntia D, Tom\u00e9 WA (2010) Hippocampal-sparing whole-brain radiotherapy: a \u201chow-to\u201d technique using helical tomotherapy and linear accelerator-based intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys 78:1244\u20131252. https:\/\/doi.org\/10.1016\/j.ijrobp.2010.01.039","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"2143_CR14","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1016\/j.ijrobp.2009.03.032","volume":"76","author":"F Hsu","year":"2010","unstructured":"Hsu F, Carolan H, Nichol A, Cao F, Nuraney N, Lee R, Gete E, Wong F, Schmuland M, Heran M, Otto K (2010) Whole brain radiotherapy with hippocampal avoidance and simultaneous integrated boost for 1\u20133 brain metastases: a feasibility study using volumetric modulated arc therapy. Int J Radiat Oncol Biol Phys 76(5):1480\u20131485. https:\/\/doi.org\/10.1016\/j.ijrobp.2009.03.032","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"2143_CR15","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1177\/153303460500400510","volume":"4","author":"D Roberge","year":"2005","unstructured":"Roberge D, Parker W, Niazi TM, Olivares M (2005) Treating the contents and not the container: dosimetric study of hair-sparing whole brain intensity modulated radiation therapy. Technol Cancer Res Treat 4(5):567\u2013570. https:\/\/doi.org\/10.1177\/153303460500400510","journal-title":"Technol Cancer Res Treat"},{"issue":"3 Suppl","key":"2143_CR16","doi-asserted-by":"publisher","first-page":"S50","DOI":"10.1016\/j.ijrobp.2009.04.096","volume":"76","author":"N Bhandare","year":"2010","unstructured":"Bhandare N, Jackson A, Eisbruch A, Pan CC, Flickinger JC, Antonelli P, Mendenhall WM (2010) Radiation therapy and hearing loss. Int J Radiat Oncol Biol Phys 76(3 Suppl):S50\u2013S57. https:\/\/doi.org\/10.1016\/j.ijrobp.2009.04.096","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"15","key":"2143_CR17","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1002\/cncr.21683","volume":"106","author":"WC Chen","year":"2006","unstructured":"Chen WC, Jackson A, Budnick AS, Pfister DG, Kraus DH, Hunt MA, Stambuk H, Levegrun S, Wolden SL (2006) Sensorineural hearing loss in combined modality treatment of nasopharyngeal carcinoma. Cancer 106(15):820\u2013829. https:\/\/doi.org\/10.1002\/cncr.21683","journal-title":"Cancer"},{"issue":"1","key":"2143_CR18","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/s0167-8140(02)00173-1","volume":"65","author":"HB Honor\u00e9","year":"2002","unstructured":"Honor\u00e9 HB, Bentzen SM, M\u00f8ller K, Grau C (2002) Sensori-neural hearing loss after radiotherapy for nasopharyngeal carcinoma: individualized risk estimation. Radiother Oncol 65(1):9\u201316. https:\/\/doi.org\/10.1016\/s0167-8140(02)00173-1","journal-title":"Radiother Oncol"},{"issue":"12","key":"2143_CR19","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1200\/JCO.2005.05.0096","volume":"24","author":"WK Low","year":"2006","unstructured":"Low WK, Toh ST, Wee J, Fook-Chong SMC, Wang DY (2006) Sensorineural hearing loss after radiotherapy and chemoradiotherapy: a single, blinded, randomized study. J Clin Oncol 24(12):1904\u20131909. https:\/\/doi.org\/10.1200\/JCO.2005.05.0096","journal-title":"J Clin Oncol"},{"key":"2143_CR20","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hr\u00f3bjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. https:\/\/doi.org\/10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"2143_CR21","volume-title":"Development of a quality appraisal tool for case seriesstudies using a modified Delphi technique","author":"C Moga","year":"2012","unstructured":"Moga C, Guo B, Schopflocher D, Harstall C (2012) Development of a quality appraisal tool for case seriesstudies using a modified Delphi technique. Institute of Health Economics, Edmonton"},{"issue":"7","key":"2143_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v030.i07","volume":"30","author":"E Kontopantelis","year":"2009","unstructured":"Kontopantelis E, Reeves D (2009) Metaeasy: a meta-analysis add-in for Microsoft Excel. J Stat Softw 30(7):1\u201325. https:\/\/doi.org\/10.18637\/jss.v030.i07","journal-title":"J Stat Softw"},{"issue":"6","key":"2143_CR23","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1002\/sim.650","volume":"20","author":"SE Brockwell","year":"2001","unstructured":"Brockwell SE, Gordon IR (2001) A comparison of statistical methods for meta-analysis. Stat Med 20(6):825\u2013840. https:\/\/doi.org\/10.1002\/sim.650","journal-title":"Stat Med"},{"issue":"8","key":"2143_CR24","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1002\/(sici)1097-0258(19980430)17:8<841::aid-sim781>3.0.co;2-d","volume":"17","author":"RJ Hardy","year":"1998","unstructured":"Hardy RJ, Thompson SG (1998) Detecting and describing heterogeneity in meta-analysis. Stat Med 17(8):841\u2013856. https:\/\/doi.org\/10.1002\/(sici)1097-0258(19980430)17:8%3c841::aid-sim781%3e3.0.co;2-d","journal-title":"Stat Med"},{"issue":"7414","key":"2143_CR25","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"JPT Higgins","year":"2003","unstructured":"Higgins JPT, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327(7414):557\u2013560. https:\/\/doi.org\/10.1136\/bmj.327.7414.557","journal-title":"BMJ"},{"issue":"24","key":"2143_CR26","doi-asserted-by":"publisher","first-page":"4321","DOI":"10.1002\/sim.2692","volume":"25","author":"M Mittlb\u00f6ck","year":"2006","unstructured":"Mittlb\u00f6ck M, Heinzl H (2006) A simulation study comparing properties of heterogeneity measures in meta-analyses. Stat Med 25(24):4321\u20134333. https:\/\/doi.org\/10.1002\/sim.2692","journal-title":"Stat Med"},{"issue":"5","key":"2143_CR27","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1016\/j.jtho.2020.12.024","volume":"16","author":"JSA Belderbos","year":"2021","unstructured":"Belderbos JSA, De Ruysscher DKM, De Jaeger K, Koppe F, Lambrecht MLF, Lievens YN, Dieleman EMT, Jaspers JPM, Van Meerbeeck JP, Ubbels F, Kwint MH, Kuenen MA, Deprez S, De Ruiter MB, Boogerd W, Sikorska K, Van Tinteren H, Schagen SB (2021) Phase 3 randomized trial of prophylactic cranial irradiation with or without hippocampus avoidance in SCLC (NCT01780675). J Thorac Oncol 16(5):840\u2013849. https:\/\/doi.org\/10.1016\/j.jtho.2020.12.024","journal-title":"J Thorac Oncol"},{"issue":"3","key":"2143_CR28","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.ijrobp.2023.04.030","volume":"117","author":"V Gondi","year":"2023","unstructured":"Gondi V, Deshmukh S, Brown PD, Wefel JS, Armstrong TS, Tome WA, Gilbert MR, Konski A, Robinson CG, Bovi JA, Benzinger TLS, Roberge D, Kundapur V, Kaufman I, Shah S, Usuki KY, Baschnagel AM, Mehta MP, Kachnic LA (2023) Sustained preservation of cognition and prevention of patient-reported symptoms with hippocampal avoidance during whole-brain radiation therapy for brain metastases: final results of NRG oncology CC001. Int J Radiat Oncol Biol Phys 117(3):571\u2013580. https:\/\/doi.org\/10.1016\/j.ijrobp.2023.04.030","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"28","key":"2143_CR29","doi-asserted-by":"publisher","first-page":"3118","DOI":"10.1200\/JCO.21.00639","volume":"39","author":"N de Rodr\u00edguez Dios","year":"2021","unstructured":"de Rodr\u00edguez Dios N, Cou\u00f1ago F, Murcia-Mej\u00eda M, Rico-Oses M, Calvo-Crespo P, Samper P, Vallejo C, Luna J, Trueba I, Sotoca A, Cigarral C, Farr\u00e9 N, Manero RM, Dur\u00e1n X, Gispert JD, S\u00e1nchez-Benavides G, Rognoni T, Torrente M, Capellades J, Jim\u00e9nez M, Cabada T, Blanco M, Alonso A, Mart\u00ednez-San Mill\u00e1n J, Escribano J, Gonz\u00e1lez B, L\u00f3pez-Guerra JL (2021) Randomized phase III trial of prophylactic cranial irradiation with or without hippocampal avoidance for small-cell lung cancer (PREMER): a GICOR-GOECP-SEOR study. J Clin Oncol 39(28):3118\u20133127. https:\/\/doi.org\/10.1200\/JCO.21.00639","journal-title":"J Clin Oncol"},{"issue":"5","key":"2143_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtocrr.2023.100506","volume":"4","author":"EAC Albers","year":"2023","unstructured":"Albers EAC, Zeng H, De Ruysscher DKM, Kuenen MA, Kessels R, Hendriks LEL, Belderbos JSA, Schagen SB (2023) Self-reported cognitive function and quality of life in patients with SCLC in the hippocampal avoidance prophylactic cranial irradiation versus prophylactic cranial irradiation randomized phase 3 trial (NCT01780675). JTO Clin Res Rep 4(5):100506. https:\/\/doi.org\/10.1016\/j.jtocrr.2023.100506","journal-title":"JTO Clin Res Rep"},{"issue":"5","key":"2143_CR31","doi-asserted-by":"publisher","first-page":"439","DOI":"10.4103\/2319-4170.157440","volume":"38","author":"SY Lin","year":"2015","unstructured":"Lin SY, Yang CC, Wu YM, Tseng CK, Wei KC, Chu YC, Hsieh HY, Wu TH, Pai PC, Hsu PW, Chuang CC (2015) Evaluating the impact of hippocampal sparing during whole brain radiotherapy on neurocognitive functions: a preliminary report of a prospective phase II study. Biomed J 38(5):439\u2013449. https:\/\/doi.org\/10.4103\/2319-4170.157440","journal-title":"Biomed J"},{"key":"2143_CR32","doi-asserted-by":"publisher","DOI":"10.1080\/23279095.2025.2465850","author":"CC Yang","year":"2025","unstructured":"Yang CC, Chuang CC, Pai PC, Tsan DL, Chou WC, Wang CL, Wu YM, Lin CH, Lu YJ, Lin SY (2025) Trajectory of long-term neuropsychological performances and cognitive-deterioration-free survival after hippocampus-sparing whole-brain radiotherapy in cancer patients mostly with newly diagnosed brain oligometastases. Appl Neuropsychol Adult. https:\/\/doi.org\/10.1080\/23279095.2025.2465850","journal-title":"Appl Neuropsychol Adult"},{"issue":"1","key":"2143_CR33","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-015-0562-x","volume":"10","author":"PF Tsai","year":"2015","unstructured":"Tsai PF, Yang CC, Chuang CC, Huang TY, Wu YM, Pai PC, Tseng CK, Wu TH, Shen YL, Lin SY (2015) Hippocampal dosimetry correlates with the change in neurocognitive function after hippocampal sparing during whole brain radiotherapy: a prospective study. Radiat Oncol 10(1):253. https:\/\/doi.org\/10.1186\/s13014-015-0562-x","journal-title":"Radiat Oncol"},{"issue":"34","key":"2143_CR34","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1111\/1759-7714.15462","volume":"15","author":"TY Zhan","year":"2024","unstructured":"Zhan TY, Deng L, Wang WQ, Zhang T, Wang JY, Wang X, Liu WY, Zhai YR, Xiao ZF, Feng QF, Bi N, Li YX, Zhou ZM (2024) Implementing the optimized hippo-avoidance prophylactic cranial irradiation for limited-stage small cell lung cancer by tomotherapy and volumetric modulated arc therapy. Thorac Cancer 15(34):2449\u20132455. https:\/\/doi.org\/10.1111\/1759-7714.15462","journal-title":"Thorac Cancer"},{"issue":"34","key":"2143_CR35","doi-asserted-by":"publisher","first-page":"3810","DOI":"10.1200\/JCO.2014.57.2909","volume":"32","author":"V Gondi","year":"2014","unstructured":"Gondi V, Pugh SL, Tome WA, Caine C, Corn B, Kanner A, Rowley H, Kundapur V, DeNittis A, Greenspoon JN, Konski AA, Bauman GS, Shah S, Shi W, Wendland M, Kachnic L, Mehta MP (2014) Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): a phase II multi-institutional trial. J Clin Oncol 32(34):3810\u20133816. https:\/\/doi.org\/10.1200\/JCO.2014.57.2909","journal-title":"J Clin Oncol"},{"issue":"1","key":"2143_CR36","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.ijrobp.2017.03.009","volume":"98","author":"KJ Redmond","year":"2017","unstructured":"Redmond KJ, Hales RK, Anderson-Keightly H, Zhou XC, Kummerlowe M, Sair HI, Duhon M, Kleinberg L, Rosner GL, Vannorsdall T (2017) Prospective study of hippocampal-sparing prophylactic cranial irradiation in limited-stage small cell lung cancer. Int J Radiat Oncol Biol Phys 98(1):603\u2013611. https:\/\/doi.org\/10.1016\/j.ijrobp.2017.03.009","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"2143_CR37","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.ijrobp.2020.02.029","volume":"107","author":"H Vees","year":"2020","unstructured":"Vees H, Caparrotti F, Eboulet EI, Xyrafas A, Fuhrer A, Meier U, Mark M, Elicin O, Aebersold DM, Zwahlen DR, Finazzi T, Allal AS, Putora PM, Martucci F, Rudolf CB, Ribi K, Swiss Group for Clinical Cancer Research (SAKK) (2020) Impact of early prophylactic cranial irradiation with hippocampal avoidance on neurocognitive function in patients with limited disease small cell lung cancer. A multicenter phase 2 trial (SAKK 15\/12). Int J Radiat Oncol Biol Phys 107(2):279\u2013287. https:\/\/doi.org\/10.1016\/j.ijrobp.2020.02.029","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"18","key":"2143_CR38","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1093\/neuonc\/noaa092","volume":"22","author":"KD Westover","year":"2020","unstructured":"Westover KD, Mendel JT, Dan T, Kumar K, Gao A, Pulipparacharuv S, Iyengar P, Nedzi L, Hannan R, Anderson J, Choe KS, Jiang W, Abdulrahman R, Rahimi A, Folkert M, Laine A, Presley C, Cullum CM, Choy H, Ahn C, Timmerman R (2020) Phase II trial of hippocampal-sparing whole brain irradiation with simultaneous integrated boost for metastatic cancer. Neuro Oncol 22(18):1831\u20131839. https:\/\/doi.org\/10.1093\/neuonc\/noaa092","journal-title":"Neuro Oncol"},{"issue":"3","key":"2143_CR39","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1093\/neuonc\/noaa193","volume":"23","author":"WC Yang","year":"2021","unstructured":"Yang WC, Chen YF, Yang CC, Wu PF, Chan HM, Chen JLY, Chen GY, Cheng JCH, Kuo SH, Hsu FM (2021) Hippocampal avoidance whole-brain radiotherapy without memantine in preserving neurocognitive function for brain metastases: a phase II blinded randomized trial. Neuro Oncol 23(3):478\u2013486. https:\/\/doi.org\/10.1093\/neuonc\/noaa193","journal-title":"Neuro Oncol"},{"issue":"1","key":"2143_CR40","first-page":"111","volume":"30","author":"J Du","year":"2024","unstructured":"Du J, Liao Y, Zhang Y, Yang B, Wu Y, Liu C, Liao X (2024) The impact of hippocampal-sparing whole-brain radiotherapy on survival and cognitive function in patients with brain metastases. Altern Ther Health Med 30(1):111\u2013115","journal-title":"Altern Ther Health Med"},{"issue":"11","key":"2143_CR41","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.clon.2024.07.001","volume":"36","author":"GA Whitfield","year":"2024","unstructured":"Whitfield GA, Bulbeck H, Clifton-Hadley L, Edwards D, Jefferies S, Jenkinson MD, Griffin M, Handley J, Megias D, Sanghera P, Shaffer R, Short S, Wilson W (2024) A randomised phase II trial of Hippocampal sparing versus conventional whole brain radiotherapy after surgical resection or radiosurgery in favourable prognosis patients with 1\u201310 brain metastases. Clin Oncol (R Coll Radiol) 36(11):681\u2013689. https:\/\/doi.org\/10.1016\/j.clon.2024.07.001","journal-title":"Clin Oncol (R Coll Radiol)"},{"issue":"1","key":"2143_CR42","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-024-12559-1","volume":"24","author":"Z Li","year":"2024","unstructured":"Li Z, Wang J, Deng L, Zhai Y, Zhang T, Bi N, Wang J, Wang X, Liu W, Xiao Z, Chen D, Lv J, Feng Q, Wang W, Zhou Z (2024) Hippocampal avoidance whole-brain radiotherapy with simultaneous integrated boost in lung cancer brain metastases and utility of the Hopkins verbal learning test for testing cognitive impairment in Chinese patients: a prospective phase II study. BMC Cancer 24(1):899. https:\/\/doi.org\/10.1186\/s12885-024-12559-1","journal-title":"BMC Cancer"},{"issue":"5","key":"2143_CR43","doi-asserted-by":"publisher","first-page":"558","DOI":"10.5603\/rpor.102617","volume":"29","author":"K Loga","year":"2024","unstructured":"Loga K, Wojcik B, Stanislawek A, Papis-Ubych A, Kuncman L, Fijuth J, Gottwald L (2024) Hippocampal protection during preventive cranial irradiation and neurocognitive functions in patients with small cell lung cancer. Rep Pract Oncol Radiother 29(5):558\u2013565. https:\/\/doi.org\/10.5603\/rpor.102617","journal-title":"Rep Pract Oncol Radiother"},{"issue":"5","key":"2143_CR44","doi-asserted-by":"publisher","first-page":"547","DOI":"10.7785\/tcrt.2012.500426","volume":"14","author":"J Kao","year":"2015","unstructured":"Kao J, Darakchiev B, Conboy L, Ogurek S, Sharma N, Ren X, Pettit J (2015) Tumor directed, scalp sparing intensity modulated whole brain radiotherapy for brain metastases. Technol Cancer Res Treat 14(5):547\u2013555. https:\/\/doi.org\/10.7785\/tcrt.2012.500426","journal-title":"Technol Cancer Res Treat"},{"issue":"6","key":"2143_CR45","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1016\/j.jaad.2016.08.042","volume":"75","author":"EA Olsen","year":"2016","unstructured":"Olsen EA, Canfield D (2016) SALT II: a new take on the severity of alopecia tool (SALT) for determining percentage scalp hair loss. J Am Acad Dermatol 75(6):1268\u20131270. https:\/\/doi.org\/10.1016\/j.jaad.2016.08.042","journal-title":"J Am Acad Dermatol"},{"key":"2143_CR46","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1007\/s00066-011-0025-8","volume":"188","author":"C Gani","year":"2012","unstructured":"Gani C, Muller AC, Eckert F, Schroeder C, Bender B, Pantazis G, Bamberg M, Berger B (2012) Outcome after whole brain radiotherapy alone in intracranial leptomeningeal carcinomatosis from solid tumors. Strahlenther Onkol 188:148\u2013153. https:\/\/doi.org\/10.1007\/s00066-011-0025-8","journal-title":"Strahlenther Onkol"},{"issue":"1","key":"2143_CR47","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/BF00435979","volume":"5","author":"D Osoba","year":"1996","unstructured":"Osoba D, Aaronson NK, Muller M, Sneeuw K, Hsu MA, Yung WK, Brada M, Newlands E (1996) The development and psychometric validation of a brain cancer quality-of-life questionnaire for use in combination with general cancer-specific questionnaires. Qual Life Res 5(1):139\u2013150. https:\/\/doi.org\/10.1007\/BF00435979","journal-title":"Qual Life Res"},{"issue":"1","key":"2143_CR48","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s11060-009-0061-8","volume":"96","author":"SN Kalkanis","year":"2010","unstructured":"Kalkanis SN, Kondziolka D, Gaspar LE, Burri SH, Asher AL, Cobbs CS, Ammirati M, Robinson PD, Andrews DW, Loeffler JS, McDermott M, Mehta MP, Mikkelsen T, Olson JJ, Paleologos NA, Patchell RA, Ryken TC, Linskey ME (2010) The role of surgical resection in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol 96(1):33\u201343. https:\/\/doi.org\/10.1007\/s11060-009-0061-8","journal-title":"J Neurooncol"},{"issue":"3","key":"2143_CR49","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.prro.2011.12.004","volume":"2","author":"MN Tsao","year":"2012","unstructured":"Tsao MN, Rades D, Wirth A, Lo SS, Danielson BL, Gaspar LE, Sperduto PW, Vogelbaum MA, Radawski JD, Wang JZ, Gillin MT, Mohideen N, Hahn CA, Chang EL (2012) Radiotherapeutic and surgical management for newly diagnosed brain metastasis(es): an American Society for Radiation Oncology evidence-based guideline. Pract Radiat Oncol 2(3):210\u2013225. https:\/\/doi.org\/10.1016\/j.prro.2011.12.004","journal-title":"Pract Radiat Oncol"},{"issue":"7","key":"2143_CR50","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1001\/jama.295.21.2483","volume":"295","author":"H Aoyama","year":"2006","unstructured":"Aoyama H, Shirato H, Tago M, Nakagawa K, Toyoda T, Hatano K, Kenjyo M, Oya N, Hirota S, Shioura H, Kunieda E, Inomata T, Hayakawa K, Katoh N, Kobashi G (2006) Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial. JAMA 295(7):2483\u20132491. https:\/\/doi.org\/10.1001\/jama.295.21.2483","journal-title":"JAMA"},{"issue":"2","key":"2143_CR51","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1200\/JCO.2010.30.1655","volume":"29","author":"M Kocher","year":"2011","unstructured":"Kocher M, Soffietti R, Abacioglu U, Vill\u00e0 S, Fauchon F, Baumert BG, Fariselli L, Tzuk-Shina T, Kortmann RD, Carrie C, Hassel MB, Kouri M, Valeinis E, van den Berge D, Collette S, Collette L, Mueller RP (2011) Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952\u201326001 study. J Clin Oncol 29(2):134\u2013141. https:\/\/doi.org\/10.1200\/JCO.2010.30.1655","journal-title":"J Clin Oncol"},{"issue":"7","key":"2143_CR52","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1056\/NEJM199908123410703","volume":"341","author":"A Aup\u00e9rin","year":"1999","unstructured":"Aup\u00e9rin A, Arriagada R, Pignon JP, Le P\u00e9choux C, Gregor A, Stephens RJ, Kristjansen PE, Johnson BE, Ueoka H, Wagner H, Aisner J (1999) Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. N Engl J Med 341(7):476\u2013484. https:\/\/doi.org\/10.1056\/NEJM199908123410703","journal-title":"N Engl J Med"},{"issue":"1","key":"2143_CR53","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1002\/cncr.27504","volume":"119","author":"EA Monaco","year":"2013","unstructured":"Monaco EA, Faraji AH, Berkowitz O, Parry PV, Hadelsberg U, Kano H, Niranjan A, Kondziolka D, Lunsford LD (2013) Leukoencephalopathy after whole-brain radiation therapy plus radiosurgery versus radiosurgery alone for metastatic lung cancer. Cancer 119(1):226\u2013232. https:\/\/doi.org\/10.1002\/cncr.27504","journal-title":"Cancer"},{"issue":"4","key":"2143_CR54","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/0360-3016(94)00550-8","volume":"31","author":"DD Roman","year":"1995","unstructured":"Roman DD, Sperduto PW (1995) Neuropsychological effects of cranial radiation: current knowledge and future directions. Int J Radiat Oncol Biol Phys 31(4):983\u2013998. https:\/\/doi.org\/10.1016\/0360-3016(94)00550-8","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"6","key":"2143_CR55","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1212\/wnl.39.6.789","volume":"39","author":"LM DeAngelis","year":"1989","unstructured":"DeAngelis LM, Delattre JY, Posner JB (1989) Radiation-induced dementia in patients cured of brain metastases. Neurology 39(6):789\u2013796. https:\/\/doi.org\/10.1212\/wnl.39.6.789","journal-title":"Neurology"},{"issue":"11","key":"2143_CR56","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/S1470-2045(09)70263-3","volume":"10","author":"EL Chang","year":"2009","unstructured":"Chang EL, Wefel JS, Hess KR, Allen PK, Lang FF, Kornguth DG, Arbuckle RB, Swint JM, Shiu AS, Maor MH, Meyers CA (2009) Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol 10(11):1037\u20131044. https:\/\/doi.org\/10.1016\/S1470-2045(09)70263-3","journal-title":"Lancet Oncol"},{"issue":"1","key":"2143_CR57","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1200\/JCO.2011.41.0639","volume":"31","author":"R Soffietti","year":"2013","unstructured":"Soffietti R, Kocher M, Abacioglu UM, Villa S, Fauchon F, Baumert BG, Fariselli L, Tzuk-Shina T, Kortmann RD, Carrie C, Hassel MB, Kouri M, Valeinis E, van den Berge D, Mueller RP, Tridello G, Collette L, Bottomley A (2013) A European Organization for Research and Treatment of Cancer phase III trial of adjuvant wholebrain radiotherapy versus observation in patients with one to three brain metastases from solid tumors after surgical resection or radiosurgery: quality-of-life results. J Clin Oncol 31(1):65\u201372. https:\/\/doi.org\/10.1200\/JCO.2011.41.0639","journal-title":"J Clin Oncol"},{"issue":"3","key":"2143_CR58","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.radonc.2010.09.013","volume":"97","author":"V Gondi","year":"2010","unstructured":"Gondi V, Tom\u00e9 WA, Mehta MP (2010) Why avoid the hippocampus? A comprehensive review. Radiother Oncol 97(3):370\u2013376. https:\/\/doi.org\/10.1016\/j.radonc.2010.09.013","journal-title":"Radiother Oncol"},{"issue":"8","key":"2143_CR59","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1200\/JCO.2005.04.6086","volume":"24","author":"CA Meyers","year":"2006","unstructured":"Meyers CA, Brown PD (2006) Role and relevance of neurocognitive assessment in clinical trials of patients with CNS tumors. J Clin Oncol 24(8):1305\u20131309. https:\/\/doi.org\/10.1200\/JCO.2005.04.6086","journal-title":"J Clin Oncol"},{"issue":"10","key":"2143_CR60","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1093\/neuonc\/not114","volume":"15","author":"PD Brown","year":"2013","unstructured":"Brown PD, Pugh S, Laack NN, Wefel JS, Khuntia D, Meyers C, Choucair A, Fox S, Suh JH, Roberge D, Kavadi V, Bentzen SM, Mehta MP, Watkins-Bruner D, Radiation Therapy Oncology Group (RTOG) (2013) Memantine for the prevention of cognitive dysfunction in patients receiving whole-brain radiotherapy: a randomized, double-blind, placebo-controlled trial. Neuro Oncol 15(10):1429\u20131437","journal-title":"Neuro Oncol"},{"issue":"2","key":"2143_CR61","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.ijrobp.2007.05.038","volume":"69","author":"AN Guti\u00e9rrez","year":"2007","unstructured":"Guti\u00e9rrez AN, Westerly DC, Tom\u00e9 WA, Jaradat HA, Mackie TR, Bentzen SM, Khuntia D, Mehta MP (2007) Whole brain radiotherapy with hippocampal avoidance and simultaneously integrated brain metastases boost: a planning study. Int J Radiat Oncol Biol Phys 69(2):589\u2013597. https:\/\/doi.org\/10.1016\/j.ijrobp.2007.05.038","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"2143_CR62","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-019-1255-7","volume":"14","author":"A Jiang","year":"2019","unstructured":"Jiang A, Sun W, Zhao F, Wu Z, Shang D, Yu Q, Wang S, Zhu J, Yang F, Yuan S (2019) Dosimetric evaluation of four whole brain radiation therapy approaches with hippocampus and inner ear avoidance and simultaneous integrated boost for limited brain metastases. Radiat Oncol 14(1):46. https:\/\/doi.org\/10.1186\/s13014-019-1255-7","journal-title":"Radiat Oncol"},{"key":"2143_CR63","doi-asserted-by":"publisher","first-page":"153303382311695","DOI":"10.1177\/15330338231169599","volume":"22","author":"D Pezzulla","year":"2023","unstructured":"Pezzulla D, Maurizi F, Rocchi E, Peluso S, De Cicco L, Chiesa S, Di Franco R (2023) Letter to the editor regarding \u201cThe effect of hippocampal avoidance whole brain radiotherapy on the preservation of long-term neurocognitive function in non-small cell lung cancer patients with brain metastasis.\u201d Technol Cancer Res Treat 22:15330338231169600. https:\/\/doi.org\/10.1177\/15330338231169599","journal-title":"Technol Cancer Res Treat"},{"issue":"3","key":"2143_CR64","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s11060-023-04384-6","volume":"163","author":"S Leskinen","year":"2023","unstructured":"Leskinen S, Shah HA, Yaffe B, Schneider SJ, Ben-Shalom N, Boockvar JA, D\u2019Amico RS, Wernicke AG (2023) Hippocampal avoidance in whole brain radiotherapy and prophylactic cranial irradiation: a systematic review and meta-analysis. J Neurooncol 163(3):515\u2013527. https:\/\/doi.org\/10.1007\/s11060-023-04384-6","journal-title":"J Neurooncol"},{"issue":"10","key":"2143_CR65","doi-asserted-by":"publisher","first-page":"467","DOI":"10.3389\/fonc.2020.00467","volume":"8","author":"S Scoccianti","year":"2020","unstructured":"Scoccianti S, Simontacchi G, Greto D, Perna M, Terziani F, Talamonti C, Teriaca MA, Caramia G, Lo Russo M, Olmetto E, Delli Paoli C, Grassi R, Carfora V, Saieva C, Bonomo P, Detti B, Mangoni M, Desideri I, Francolini G, Di Cataldo V, Marrazzo L, Pallotta S, Livi L (2020) Dosimetric predictors of acute and chronic alopecia in primary brain cancer patients treated with volumetric modulated arc therapy. Front Oncol 8(10):467. https:\/\/doi.org\/10.3389\/fonc.2020.00467","journal-title":"Front Oncol"},{"issue":"3","key":"2143_CR66","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s11060-022-04186-2","volume":"160","author":"C Satragno","year":"2022","unstructured":"Satragno C, Verrico A, Giannelli F, Ferrero A, Campora S, Turazzi M, Cavagnetto F, Schiavetti I, Garr\u00e8 ML, Garibotto F, Milanaccio C, Piccolo G, Crocco M, Ramaglia A, Di Profio S, Barra S, Belgioia L (2022) High dose craniospinal irradiation as independent risk factor of permanent alopecia in childhood medulloblastoma survivors: cohort study and literature review. J Neurooncol 160(3):659\u2013668. https:\/\/doi.org\/10.1007\/s11060-022-04186-2","journal-title":"J Neurooncol"},{"issue":"19","key":"2143_CR67","doi-asserted-by":"publisher","first-page":"6411","DOI":"10.1158\/1078-0432.CCR-04-0658","volume":"10","author":"JM Metz","year":"2004","unstructured":"Metz JM, Smith D, Mick R, Lustig R, Mitchell J, Cherakuri M, Glatstein E, Hahn SM (2004) A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy. Clin Cancer Res 10(19):6411\u20136417. https:\/\/doi.org\/10.1158\/1078-0432.CCR-04-0658","journal-title":"Clin Cancer Res"},{"issue":"7 Suppl","key":"2143_CR68","first-page":"2006s","volume":"54","author":"SM Hahn","year":"1994","unstructured":"Hahn SM, Krishna CM, Samuni A, DeGraff W, Cuscela DO, Johnstone P, Mitchell JB (1994) Potential use of nitroxides in radiation oncology. Cancer Res 54(7 Suppl):2006s\u20132010s","journal-title":"Cancer Res"},{"issue":"4","key":"2143_CR69","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1080\/09553009214551291","volume":"61","author":"L Geng","year":"1992","unstructured":"Geng L, Hanson WR, Malkinson FD (1992) Topical or systemic 16, 16 dm prostaglandin E2 or WR-2721 (WR-1065) protects mice from alopecia after fractionated irradiation. Int J Radiat Biol 61(4):533\u2013537. https:\/\/doi.org\/10.1080\/09553009214551291","journal-title":"Int J Radiat Biol"},{"issue":"10","key":"2143_CR70","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000000149","volume":"2","author":"MY Hyun","year":"2014","unstructured":"Hyun MY, Kim BJ, Lee C, Kim JW (2014) Radiation-induced alopecia treated with Botulinum toxin type a injection. Plast Reconstr Surg Glob Open 2(10):e226. https:\/\/doi.org\/10.1097\/GOX.0000000000000149","journal-title":"Plast Reconstr Surg Glob Open"},{"issue":"1","key":"2143_CR71","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1002\/ijc.28961","volume":"136","author":"CM Soref","year":"2015","unstructured":"Soref CM, Fahl WE (2015) A new strategy to prevent chemotherapy and radiotherapy-induced alopecia using topically applied vasoconstrictor. Int J Cancer 136(1):195\u2013203. https:\/\/doi.org\/10.1002\/ijc.28961","journal-title":"Int J Cancer"},{"issue":"1","key":"2143_CR72","doi-asserted-by":"publisher","first-page":"55","DOI":"10.2310\/7750.2012.12033","volume":"17","author":"M Haider","year":"2013","unstructured":"Haider M, Hamadah I, Almutawa A (2013) Radiation- and chemotherapy-induced permanent alopecia: case series. J Cutan Med Surg 17(1):55\u201361. https:\/\/doi.org\/10.2310\/7750.2012.12033","journal-title":"J Cutan Med Surg"}],"container-title":["La radiologia medica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11547-025-02143-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11547-025-02143-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11547-025-02143-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:00:42Z","timestamp":1773295242000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11547-025-02143-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,8]]},"references-count":72,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["2143"],"URL":"https:\/\/doi.org\/10.1007\/s11547-025-02143-3","relation":{},"ISSN":["1826-6983"],"issn-type":[{"value":"1826-6983","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,8]]},"assertion":[{"value":"11 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflict of interest to disclosure.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors presenting the work are more than 10; this is due to the fact that the work consists primarily of three different systematic reviews, which necessitated the involvement of multiple individuals.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}}]}}