{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:14:49Z","timestamp":1790615689901,"version":"4.1.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiol med"],"DOI":"10.1007\/s11547-026-02286-x","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:23:18Z","timestamp":1790612598000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-site efficacy and safety of transarterial microembolization with imipenem\/cilastatin for refractory musculoskeletal pain: a single-centre analysis of hip, knee and shoulder (FIRE-NEM study)"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8345-8663","authenticated-orcid":false,"given":"Andrea","family":"Discalzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Brino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floriana","family":"Nardelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Mancini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elettra","family":"Pasinato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Pettirossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Audisio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Viglione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaira","family":"Albarello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Ficara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"d\u2019Amelio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Bellato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Doriguzzi Breatta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Fonio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"issue":"1","key":"2286_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13010134","volume":"13","author":"B Wang","year":"2022","unstructured":"Wang B, Liang KW, Chen CH, Wang CK (2022) Transcatheter arterial embolization for alleviating chronic musculoskeletal pain and improving physical function: a narrative review. Diagnostics (Basel) 13(1):134. https:\/\/doi.org\/10.3390\/diagnostics13010134","journal-title":"Diagnostics (Basel)"},{"issue":"2","key":"2286_CR2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.24.31626","volume":"224","author":"A Sajan","year":"2025","unstructured":"Sajan A, Epelboym Y, Mart\u00ednez AF, Little M, Talaie R, Isaacson A (2025) Transarterial embolization for musculoskeletal pain management: AJR expert panel narrative review. AJR Am J Roentgenol 224(2):e2431626. https:\/\/doi.org\/10.2214\/AJR.24.31626","journal-title":"AJR Am J Roentgenol"},{"issue":"3","key":"2286_CR3","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.243200","volume":"317","author":"SA Padia","year":"2025","unstructured":"Padia SA (2025) How i do it: embolization for joint pain. Radiology 317(3):e243200. https:\/\/doi.org\/10.1148\/radiol.243200","journal-title":"Radiology"},{"issue":"11","key":"2286_CR4","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1007\/s00270-022-03302-z","volume":"46","author":"TF Barge","year":"2023","unstructured":"Barge TF, Little MW (2023) Musculoskeletal embolotherapy. Cardiovasc Intervent Radiol 46(11):1517\u20131524. https:\/\/doi.org\/10.1007\/s00270-022-03302-z","journal-title":"Cardiovasc Intervent Radiol"},{"issue":"2","key":"2286_CR5","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1007\/s00270-014-0944-8","volume":"38","author":"Y Okuno","year":"2015","unstructured":"Okuno Y, Korchi AM, Shinjo T, Kato S (2015) Transcatheter arterial embolization as a treatment for medial knee pain in patients with mild to moderate osteoarthritis. Cardiovasc Intervent Radiol 38(2):336\u2013343. https:\/\/doi.org\/10.1007\/s00270-014-0944-8","journal-title":"Cardiovasc Intervent Radiol"},{"issue":"4","key":"2286_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2025.107984","volume":"37","author":"A Sajan","year":"2026","unstructured":"Sajan A, Ahmed O, Padia SA, Taslakian B, Golzarian J, Al-Qawasmi F, Krishnasamy V, Epelboym Y, Ghodadra AG, Block JA (2026) Pathophysiology of knee osteoarthritis and mechanisms of genicular artery embolization for interventional radiologists. J Vasc Interv Radiol 37(4):107984. https:\/\/doi.org\/10.1016\/j.jvir.2025.107984","journal-title":"J Vasc Interv Radiol"},{"issue":"12","key":"2286_CR7","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1007\/s00270-025-04188-3","volume":"48","author":"O Ahmed","year":"2025","unstructured":"Ahmed O, Sajan A, Krishnasamy V, Golzarian J, Little M, Fleckenstein F, Okuno Y, Young S, Sapoval M (2025) Genicular artery embolization for symptomatic knee osteoarthritis: a comprehensive review of techniques and clinical outcomes. Cardiovasc Intervent Radiol 48(12):1737\u20131754. https:\/\/doi.org\/10.1007\/s00270-025-04188-3","journal-title":"Cardiovasc Intervent Radiol"},{"issue":"1","key":"2286_CR8","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1007\/s00117-024-01388-9","volume":"64","author":"DD Chlorogiannis","year":"2024","unstructured":"Chlorogiannis DD, Vasilopoulou A, Konstantinidis CI, Pagona AE, Filippiadis DK (2024) Knee pain improvement after genicular artery embolization for the management of knee osteoarthritis: an updated systematic review and meta-analysis of 21 studies. Radiologie (Heidelb) 64(1):32\u201346. https:\/\/doi.org\/10.1007\/s00117-024-01388-9","journal-title":"Radiologie (Heidelb)"},{"issue":"12","key":"2286_CR9","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1007\/s00270-025-04078-8","volume":"48","author":"AM Fern\u00e1ndez Mart\u00ednez","year":"2025","unstructured":"Fern\u00e1ndez Mart\u00ednez AM, Cordero Carnicero P, P\u00e9rez \u00c1lvarez A, Cuesta Marcos MT, Romero Alonso D, Baldi S (2025) Clinical outcomes of shoulder artery embolization for adhesive capsulitis. Cardiovasc Intervent Radiol 48(12):1759\u20131768. https:\/\/doi.org\/10.1007\/s00270-025-04078-8","journal-title":"Cardiovasc Intervent Radiol"},{"issue":"4","key":"2286_CR10","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1007\/s00270-025-03982-3","volume":"48","author":"CB Giordani","year":"2025","unstructured":"Giordani CB, Motta-Leal-Filho JM, Jatczak L, Puton RC, Saleh JN, Noel RS, Borges LB, Bajerski JC, Correa MP (2025) Arterial embolization of joint synovitis: the Latino registry. Midterm follow-up of the Latino-Hip cohort for greater trochanteric pain syndrome. Cardiovasc Intervent Radiol 48(4):538\u2013542. https:\/\/doi.org\/10.1007\/s00270-025-03982-3","journal-title":"Cardiovasc Intervent Radiol"},{"key":"2286_CR11","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-026-04403-9","author":"F Cavalheiro","year":"2026","unstructured":"Cavalheiro F, Marinho Lopes P, Sousa F, Sousa P, Linhares D, Neves N (2026) HipE study-hip embolization for pain control in hip osteoarthritis and greater trochanteric pain syndrome: 12 months follow-up. Cardiovasc Intervent Radiol. https:\/\/doi.org\/10.1007\/s00270-026-04403-9","journal-title":"Cardiovasc Intervent Radiol"},{"issue":"5","key":"2286_CR12","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.jvir.2022.01.013","volume":"33","author":"GH Kim","year":"2022","unstructured":"Kim GH, Shin JH, Nam IC, Chu HH, Kim JH, Yoon HK (2022) Transcatheter arterial embolization for benign chronic inflammatory joint pain: a systematic review and meta-analysis. J Vasc Interv Radiol 33(5):538-545.e3. https:\/\/doi.org\/10.1016\/j.jvir.2022.01.013","journal-title":"J Vasc Interv Radiol"},{"issue":"6","key":"2286_CR13","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/j.jvir.2025.02.031","volume":"36","author":"TA van Zadelhoff","year":"2025","unstructured":"van Zadelhoff TA, Kubo T, Shibuya M, Miyazaki K, Nakata M, Sugihara E, Oei EHG, Okuno Y (2025) Comparative safety of 3 temporary embolic agents in transcatheter arterial embolization for degenerative, inflammatory, and overuse joint disorders. J Vasc Interv Radiol 36(6):979-987.e1. https:\/\/doi.org\/10.1016\/j.jvir.2025.02.031","journal-title":"J Vasc Interv Radiol"},{"issue":"12","key":"2286_CR14","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1007\/s00270-025-04243-z","volume":"48","author":"M Rouzbahani","year":"2025","unstructured":"Rouzbahani M, Astani A, Okuno Y, Golzarian J (2025) Imipenem\/Cilastatin in embolization: from antibiotic to therapeutic agent. Cardiovasc Intervent Radiol 48(12):1771\u20131778. https:\/\/doi.org\/10.1007\/s00270-025-04243-z","journal-title":"Cardiovasc Intervent Radiol"},{"issue":"12","key":"2286_CR15","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1007\/s00270-024-03752-7.PMID:38819473;PMCID:PMC11621196","volume":"47","author":"MW Little","year":"2024","unstructured":"Little MW, O\u2019Grady A, Briggs J et al (2024) Genicular artery embolisation in patients with osteoarthritis of the knee (genesis) using permanent microspheres: long-term results. Cardiovasc Intervent Radiol 47(12):1750\u20131762. https:\/\/doi.org\/10.1007\/s00270-024-03752-7.PMID:38819473;PMCID:PMC11621196","journal-title":"Cardiovasc Intervent Radiol"},{"key":"2286_CR16","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jclinepi.2016.11.016","volume":"82","author":"F Angst","year":"2017","unstructured":"Angst F, Aeschlimann A, Angst J (2017) The minimal clinically important difference raised the significance of outcome effects above the statistical level, with methodological implications for future studies. J Clin Epidemiol 82:128\u2013136. https:\/\/doi.org\/10.1016\/j.jclinepi.2016.11.016","journal-title":"J Clin Epidemiol"},{"issue":"5","key":"2286_CR17","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzae033","volume":"104","author":"L Galardini","year":"2024","unstructured":"Galardini L, Coppari A, Pellicciari L, Ugolini A, Piscitelli D, La Porta F, Bravini E, Vercelli S (2024) Minimal clinically important difference of the Disabilities of the Arm, Shoulder and Hand (DASH) and the Shortened Version of the DASH (QuickDASH) in people with musculoskeletal disorders: a systematic review and meta-analysis. Phys Ther 104(5):pzae033. https:\/\/doi.org\/10.1093\/ptj\/pzae033","journal-title":"Phys Ther"},{"issue":"7","key":"2286_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2026.108803","volume":"37","author":"O Ahmed","year":"2026","unstructured":"Ahmed O, Taslakian B, Okuno Y et al (2026) Society of Interventional Radiology position statement on genicular artery embolization for symptomatic knee osteoarthritis. J Vasc Interv Radiol 37(7):108803. https:\/\/doi.org\/10.1016\/j.jvir.2026.108803","journal-title":"J Vasc Interv Radiol"},{"issue":"1","key":"2286_CR19","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s00270-025-04200-w","volume":"49","author":"D Filippiadis","year":"2026","unstructured":"Filippiadis D, Pereira PL, Hausegger KA, Ryan AG, Binkert CA (2026) CIRSE standards of practice for the classification of complications: the modified CIRSE classification system. Cardiovasc Intervent Radiol 49(1):2\u20136. https:\/\/doi.org\/10.1007\/s00270-025-04200-w","journal-title":"Cardiovasc Intervent Radiol"},{"key":"2286_CR20","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-026-04448-w","author":"FN Fleckenstein","year":"2026","unstructured":"Fleckenstein FN, Maleitzke T, Oehme S, Donner S, Auer TA, Hildebrandt A, Perka C, Vogel-Claussen J, Gebauer B, Winkler T, Collettini F (2026) Transarterial embolization for the treatment of symptomatic hip osteoarthritis. Cardiovasc Intervent Radiol. https:\/\/doi.org\/10.1007\/s00270-026-04448-w","journal-title":"Cardiovasc Intervent Radiol"},{"issue":"1","key":"2286_CR21","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.243648","volume":"316","author":"FN Fleckenstein","year":"2025","unstructured":"Fleckenstein FN, Maleitzke T, Auer TA, Bolle P, Gebauer B, Winkler T, Collettini F (2025) Genicular artery embolization for the treatment of symptomatic knee osteoarthritis. Radiology 316(1):e243648. https:\/\/doi.org\/10.1148\/radiol.243648","journal-title":"Radiology"},{"key":"2286_CR22","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-026-04410-w","author":"A Taheri Amin","year":"2026","unstructured":"Taheri Amin A, H\u00fcbner A, Abu-Gharbieh L, Kemmer E, Kr\u00fcselmann P, Ziayee F, Wilms LM, Fink CB, Jannusch K, Minko P (2026) Repeated genicular artery embolization using permanent microspheres for severe osteoarthritis and postsurgical pain. Cardiovasc Intervent Radiol. https:\/\/doi.org\/10.1007\/s00270-026-04410-w","journal-title":"Cardiovasc Intervent Radiol"}],"container-title":["La radiologia medica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11547-026-02286-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11547-026-02286-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11547-026-02286-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:23:20Z","timestamp":1790612600000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11547-026-02286-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":22,"alternative-id":["2286"],"URL":"https:\/\/doi.org\/10.1007\/s11547-026-02286-x","relation":{},"ISSN":["1826-6983"],"issn-type":[{"value":"1826-6983","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,28]]},"assertion":[{"value":"30 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflicts of interest related to the subject matter of this manuscript.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and national research committees and with the 1964 Helsinki Declaration and its later amendments. The study was approved by the institutional Ethics Committee (Protocol No. 0003513).","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent for the TAME procedure was obtained from all patients prior to treatment. For the retrospective use of anonymized clinical data for research purposes, written informed consent was obtained from all patients who could be contacted; for non-contactable patients, the requirement for consent was waived by the institutional Ethics Committee in accordance with Italian national provisions on the processing of health data for scientific research purposes (art. 110, Legislative Decree 196\/2003 as amended).","order":3,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"During the preparation of this manuscript, the authors used Claude (Anthropic, San Francisco, CA, USA) for language editing and refinement of the written text. The authors reviewed and edited all content generated and take full responsibility for the integrity, accuracy and scientific content of the manuscript. No AI tools were used to generate, interpret or analyse the underlying clinical data.","order":4,"name":"Ethics","label":"Use of Artificial Intelligence (AI) tools","group":{"name":"EthicsHeading","label":"Declarations"}}]}}